Induces angiogenesis growth of tumor cells cell cycle. Medical search. Frequent questions

Breast cancer stem cells (BCSCs) play a critical role in chemoresistance, metastasis, and poor prognosis of breast cancer. (hindawi.com)
is known to exert anticancer effects, such as inducing cell cycle arrest, inhibiting metastasis, and overcoming immunotherapy resistance in breast cancer cells. (hindawi.com)
Angiogenesis is essential in the process of carcinogenesis to facilitate tumor progression and metastasis. (spandidos-publications.com)
Additionally, the expression and activity of matrix metalloproteinases (MMPs) are increased in almost every type of human cancer, which may be associated with cell invasion, metastasis and angiogenesis. (spandidos-publications.com)
Most of the reports suggest that complex I activity is suppressed in cancer cells and its inhibition promotes proliferation and metastasis [ 16 - 18 ] . (dcaguide.org)
Curcumin has been found to suppress initiation, progression, and metastasis of a variety of tumors. (beatcancer.org)
It can promote tumor cell apoptosis, inhibit tumor cell growth, inhibit tumor angiogenesis, inhibit tumor cell metastasis, etc., so that it has a wide range of selective anti-tumor effects and immune regulation. (creative-proteomics.com)
It can also down-regulate the synthesis of phosphatidylinositol 3-kinase/protein kinase B, focal adhesion kinase, matrix metalloproteinase 2/9, and inhibit cancer cell invasion and metastasis. (creative-proteomics.com)
In 2002 and 2004, several groups, under different experimental settings, reported identification of the gene, first named as astrocyte elevated gene 1 (AEG-1), now having the GenBank symbol as MTDH, which stands for metadherin, for its involvement in tumor metastasis and adhesion. (biomedcentral.com)
In another study by Brown and Ruoslahti in 2004, phage display strategy was employed in a mouse model of breast cancer metastasis, which revealed that a gene identical to AEG-1 was expressed at high levels in relation to metastasis of breast cancer, and the identified gene was named metadherin after its proposed role in promoting homing of breast cancer cells to the lungs [ 2 ]. (biomedcentral.com)
Exogenous PEDF treatment reduces prostate tumor growth, metastasis, and angiogenesis. (uwm.edu)
Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)
Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)

BCL-6 proteins repress genes involved in terminal differentiation and promote proliferation by blocking expression of a cell-cycle inhibitor (p27KIP1). (wikipedia.org)
Among its different constituents, Astragalus polysaccharides have been most widely studied particularly for their immunopotentiating properties, such as stimulation of murine B cell proliferation and cytokine production ( 6 ). (spandidos-publications.com)
Our results indicated that AST inhibits cell proliferation through phase-specific cell cycle arrest and caspase-dependent apoptosis. (spandidos-publications.com)
Blocking lactate generation in metformin-treated melanoma cells results in diminished cell proliferation and tumor progression in mice. (dcaguide.org)
Overall, our study suggests that LDH and complex I play distinct roles in regulating glycolysis and cell proliferation. (dcaguide.org)
The pathogenic role of del(13q) in CLL has been related to lack of B-cell proliferation control allegedly determined by deletion of the DLEU2 / MIR15A / MIR16-1 locus, which is known to contain negative regulators of the expression of the BCL2 gene (Cimmino et al. (atlasgeneticsoncology.org)
Our results further indicate that MCT4 promotes proliferation and survival by altered cell cycle regulation and cell death mechanisms. (hindawi.com)
For this purpose, we designed an MCT4 overexpression and knockdown/inhibition model to explore the functional consequences of MCT4 expression on cancer cell metabolism, survival, proliferation, migration, invasion potential, and angiogenesis as well as on cell cycle profiles and cell death mechanisms. (hindawi.com)
The proliferation of choroidal endothelial cells (CECs) is one important step in the formation of new vessels. (molvis.org)
Transcriptional coactivator Yes-associated protein (YAP) can promote the proliferation of multiple cancer cells, corneal endothelial cells, and vascular smooth muscle cells, which participate in angiogenesis. (molvis.org)
This study showed that YAP upregulation promoted CNV formation by upregulating the proliferation of endothelial cells, providing evidence for the molecular mechanisms of CNV and suggesting a novel molecular target for nAMD treatment. (molvis.org)
Among them, VEGF-A can promote the division and proliferation of vascular endothelial cells and neovascularization and maintain the survival of new vessels. (molvis.org)
Because colorectal cancer's migration and invasion are one of main factors to the severity of the disease, exploring the molecular mechanisms of proliferation, migration and invasion of CRC cells will contribute to the development of targeted therapy [ 5 ]. (aging-us.com)
It also stops proliferation of cancer cells by arresting them at different phases of the cell cycle and/or by inducing their apoptosis (programmed cell death). (beatcancer.org)
Tight control of the cell cycle in eukaryotic cells exists to control proliferation, differentiation or apoptosis. (benthamscience.com)
However, the underlying mechanisms involved in the induction of genomic instability, genotoxicity, mutations and consequent increased cell proliferation are still a matter of intense research. (benthamscience.com)
IL-24 can inhibit the proliferation of many cancer cells by inducing apoptosis without damaging normal cells. (creative-proteomics.com)
After IL-24 is combined with IL-20 and IL-22 receptor complex, it can activate JAK/ signal transducers and activators of transcription (STAT) signal pathway, and rapidly increase the phosphorylation transduction of tyrosine in JAK/STAT complex Signal, thereby regulating cell proliferation, migration and apoptosis. (creative-proteomics.com)
IL-24 can also induce the secretion of cytokines such as IL-6, TNF-α, IFN-γ, and stimulate T cell proliferation, thereby promoting the activation of the immune system. (creative-proteomics.com)
The current study demonstrated that PD markedly inhibited PAC cell proliferation and triggered their apoptosis. (biomedcentral.com)
Potential synergistic effects of various combinations including these compounds were tested by measuring cancer cell proliferation and apoptosis. (frontiersin.org)
So we established that these pathways were crucial to endothelial cell proliferation under vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) stimulation. (url.edu)
To sum up, our data suggest that the inhibition of metabolic pathways offers a novel and powerful therapeutic approach, which simultaneously inhibits tumor cell proliferation and tumor-induced angiogenesis. (url.edu)
The broad spectrum anti-tumor effects of calcitriol and analogs are mostly based on inhibition of cancer cell proliferation and invasiveness, induction of differentiation and apoptosis, and promotion of angiogenesis. (jcancer.org)
It has been proposed that metformin inhibits proliferation via activation of AMP-activated protein kinase (AMPK) or by blocking proliferation at the G0/G1 phase in the cell cycle with a reduction in cyclin D1. (uwm.edu)
Metformin also reduced cell proliferation and increased lipolysis in PCa cells at physiological obtainable doses (0.02 and 0.5 mM). (uwm.edu)
Tolentino, Miguel Angel, "Metformin-Induced PEDF Expression Regulates Cell Proliferation and Lipid Metabolism in Prostate Cancer Cells" (2013). (uwm.edu)
Cannabinoids were shown to have antitumor properties, prevent tumor cell proliferation, induce tumor cell death, prevent the formation of new malignant tumor cells, and prevent secondary cancer growth sites from establishing (Dariš, Tancer, Knez, Ferk, 2019). (beescannafarm.com)
Lastly, the BJBMS stated that the cannabinoids themselves affect the signaling pathways that are responsible for tumor cells survival and went on to state that the cannabinoids can "…induce cell cycle arrest, promote apoptosis (cell death), and inhibit proliferation, migration, and angiogenesis in tumor cells" (Dariš, Tancer, Knez, Ferk, 2019). (beescannafarm.com)
Cancer cells exhibit copper addiction compared to normal cells, which is the over-reliance on copper for proliferation, which opens a new therapeutic frontier for cancer treatment. (biomedcentral.com)
We show that lower Differential Effects of Resveratrol on concentrations of RSV (1, 5, 10 M) had no effect on proliferation, viability or cell cycle progression in HECa10 and ARPE-19 Cells. (deepdyve.com)
In ARPE-19 cells, lower concentrations of RSV increased the rate of proliferation, while higher concentrations had no effect on proliferation and viability. (deepdyve.com)
RSV signi﫿cantly exhibits anti-in﫿ammatory and anti-angiogenic activities and reg- ulates many cellular signaling pathways associated with cell metabolism, proliferation, differentiation, migration, and invasiveness of normal and cancer cells [7]. (deepdyve.com)
In response to mito- pendence between the key mecha- gens, cell proliferation is triggered by nistic characteristics. (who.int)
H - Ras cell proliferation are also linked with haematopoietic cel s. (who.int)
Many factors are involved in causing and permitting the unregulated proliferation of cells that occurs in cancer. (msdmanuals.com)
Загальні відомості про злоякісні новоутворення Cancer is an unregulated proliferation of cells. (msdmanuals.com)

The tumor microenvironment (TME) promotes BCSC survival and cancer progression, and targeting the TME can aid in successful immunotherapy. (hindawi.com)
Cancer cells have metabolic flexibility in choosing either oxidative phosphorylation (OXPHOS) or glycolysis for ATP generation depending upon the nutrient availability in tumor microenvironment. (dcaguide.org)
In the metabolic symbiosis model, these cells have been proposed to overexpress MCT4 to release high amounts of lactate produced during anaerobic glycolysis into the tumor microenvironment. (hindawi.com)
The T cells have been excluded by components of the tumor microenvironment. (medium.com)
Cellular infiltrates within the tumor microenvironment. (medium.com)
The Cancer Research Institute maintains a current list of the 1,105 checkpoint combination trials geared to induce change in the tumor microenvironment to favor the Type I phenotype - https://cancerresearch.org/scientists/clinical-accelerator/landscape-of-immuno-oncology-drug-development . (medium.com)
Critical among these is the SASP that includes many cytokines, chemokines, proteases, growth factors, and extra cellular matrix (ECM), as it affects not only senescent cells themselves in an autocrine manner but also nearby cells and the tissue microenvironment in a non-cell-autonomous manner. (molcells.org)

Tumor-induced pathological angiogenesis dictates the growth of many solid tumors. (biomedres.us)
In line with this observation, elevated extracellular lactate concentrations up to 40 mM and corresponding low extracellular pH (pH e ) have been found in solid tumors under hypoxic conditions [ 18 - 22 ]. (hindawi.com)
71 Clusterin is a small heat shock glycoprotein overexpressed in most of the solid tumors, which promotes apoptosis by binding to various molecules such as BAX (BCL2-associated X protein) 72 and signal transducer and activator of transcription (STAT)−1. (oncologynurseadvisor.com)
Targeted molecular therapy against EGFR has shown promise as an adjuvant therapy in preliminary studies in several solid tumors, including head and neck cancer. (medscape.com)

Germinal Center B-Cell like (GCB) DLBCLs appear to arise from normal germinal center B cells, while Activated B-cell like (ABC) DLBCLs are thought to arise from postgerminal center B cells that are arrested during plasmacytic differentiation. (wikipedia.org)
Follicular dendritic cells and T cells help to select the B-cells that have a high affinity to the antigen for further differentiation into plasma cells and memory cells. (wikipedia.org)
Normal germinal center B-cells appear to be poised for apoptosis unless they are selected to progress to the next stage of differentiation. (wikipedia.org)
citation needed] Blocking the differentiation of germinal center B cells is dangerous because the cells are programmed to divide rapidly at this stage. (wikipedia.org)
Histone Deacetylase (HDAC) inhibitors induce cancer cell cycle arrest, differentiation and cell death, reduce angiogenesis and modulate immune response. (pharmiweb.com)
Differentiation and apoptosis have cell cycle withdraw in common, while cancer and degenerative processes both show altered control of the cell cycle. (benthamscience.com)
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine, whose numerous cell and tissue activities include cell-cycle control, the regulation of early development, differentiation, extracellular matrix formation, hematopoesis, angiogenesis, chemotaxis, immune functions, and the induction of apoptosis. (nih.gov)
This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. (cancerindex.org)
Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms. (jcancer.org)
70 Mcl1 (myeloid cell leukemia differentiation protein 1) and other members of the BCL family, such as BCL-xl (B-cell lymphoma-extra-large), are also involved in resistance to Interleukin (IL)-6, stromal cell derived factor-1, and cytokine-induced apoptosis. (oncologynurseadvisor.com)
The stimuli to induce adipocyte differentiation in hBM-MSCs increase the gene transcription of the $CB_1$ receptor, TRPV1 and $PPAR{\gamma}$ . (koreascience.kr)
This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)

Therefore, a therapeutic strategy targeting CSCs may help cure malignant tumors, including SCLC ( 7 ). (spandidos-publications.com)
Mice lacking the tumor suppressors p16(Ink4a) (Cdkn2a, cyclin-dependent kinase inhibitor 2a), p19(Arf) (an alternative reading frame product of Cdkn2a,), and p27(Kip1) (Cdkn1b, cyclin-dependent kinase inhibitor 1b) result in malignant progression of epithelial cancers, sarcomas, and melanomas, respectively. (koreamed.org)
Monocarboxylate transporter 4 (MCT4, SLC16A3 ) is elevated under hypoxic conditions in many malignant tumors including gliomas. (hindawi.com)
Malignant gliomas are the most common primary malignant brain tumors with an increasing incidence of up to nine per 100,000 habitants over the last years [ 1 , 2 ]. (hindawi.com)
Both laboratory and live animal studies demonstrate that the compound can dramatically reduce the occurrence and severity of malignant tumors. (beatcancer.org)
Normalize Cell Growth - Curcumin restores normal growth controls, reverses uncontrolled reproduction of malignant cells, blocks access of cancer cells to growth factors, turns on genes that prevent cell growth and turns off genes that promote cancer growth. (beatcancer.org)
Enhance Immune Surveillance - Curcumin prevents cancer cells from evading normal immune system detection and improves the body's ability to detect and destroy malignant cells. (beatcancer.org)
Reduce Production of Adhesion Molecules - Curcumin keeps malignant tissue from sticking to vessel walls and reduces cancer cells' ability to form distant metastases. (beatcancer.org)
As a multifunctional oncoprotein, AEG-1 has been shown to overexpress in multiple types of human cancer, and the elevation of AEG-1 in tumor cells leads to enhanced phenotypes characteristic of malignant aggressiveness, including increased abilities to proliferate robustly, to invade surrounding tissues, to migrate, to induce neovascularization, and to enhance chemoresistance. (biomedcentral.com)
Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)

In summary, our data highlight MCT4 /SLC16A3 as a key gene for distinct hallmarks of tumor malignancy in glioma cells. (hindawi.com)
We investigated the impact on tumor malignancy in F98 glioma cells using in silico analysis, in vitro cell culture assays, and ex vivo vascular organotypic glioma impact model (VOGIM) [ 35 ] by implanting F98 cells into rat brain slices. (hindawi.com)
Established cancers consist of a wide array of immune cells that contribute to the tumor stroma of a growing malignancy. (medium.com)
The capacity to survive and thrive in conditions of limited resources and high inflammation is a major driver of tumor malignancy. (bvsalud.org)
The mouse gastric malignancy cell collection (MFC) was from Shanghai cell lender of Chinese Academy of Sciences. (findadig.com)
That is, as the size of the gland decreases, the incidence of malignancy of a tumor in the gland increases in approximately these proportions. (medscape.com)

The results showed that formononetin downregulated the expression of the key pro-angiogenic factors, including vascular endothelial growth factor (VEGF) and matrix metalloproteinases. (spandidos-publications.com)
The vascular endothelial growth factor (VEGF) is a well characterized angiogenic factor known to stimulate angiogenesis within a tumor ( 1 ). (spandidos-publications.com)
We show that inhibition of complex I by metformin promotes melanoma growth in mice via elevating lactate and VEGF levels. (dcaguide.org)
The Vascular Endothelial Growth Factor (VEGF) family and receptors have proved to be essential to physiological and pathological angiogenesis [9]. (biomedres.us)
VEGF administration also induces lymph angiogenesis [10-13]. (biomedres.us)
Dual delivery of VEGF and PDGF-BB returned more mature vessel formation than either single growth factor. (biomedres.us)
Furthermore, lactate has been proposed to stimulate angiogenesis through HIF-1 α -dependent activation of the VEGF/VEGFR2 signaling pathway. (hindawi.com)
YAP expression increased following laser exposure, in accordance with vascular endothelial growth factor (VEGF) expression. (molvis.org)
A specific VEGF receptor-2 inhibitor demonstrated the importance of glycogen metabolism and pentose cycle pathway. (url.edu)
77 IL-8 acts through chemokine receptors 1 and 2 (CXCR1 and 2) and is involved in promoting angiogenesis through overexpression of vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF). (oncologynurseadvisor.com)
Both Academic Editors: Joanna ARPE-19 and HECa10 cell lines were affected to different degrees in the secretion of proangiogenic Kapusta-Duch, Teresa Leszczynska ´ cytokines: reducing VEGF and enhancing bFGF secretion. (deepdyve.com)
As the cancer volume increases, the cancer may release angiogenesis factors, such as vascular endothelial growth factor (VEGF), which promote formation of new blood vessels that are required for further growth. (msdmanuals.com)

Small cell lung cancer (SCLC), a poorly differentiated and highly aggressive tumor, constitutes approximately 15% of all lung cancers ( 1 ). (spandidos-publications.com)
Mutations in cyclin-dependent kinase inhibitors controlling the G1 phase of the cell cycle are prevalent in various cancers. (koreamed.org)
These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers. (spandidos-publications.com)
Cold" tumors, are cancers that haven't been recognized or haven't provoked a strong response by the immune system. (medium.com)
These cells coordinately form a complex regulatory network that fosters tumor growth by creating an environment that enables cancers to evade immune surveillance and destruction. (medium.com)
The BJBMS stated that cannabinoids displayed anti-tumor effects against various types of cancers in animal and cell cultures, which further displayed their anti-cancer properties (Dariš, Tancer, Knez, Ferk, 2019). (beescannafarm.com)
A novel form of copper-dependent and reactive oxygen species (ROS)-dependent cell death, cuproptosis, has been described in many cancers. (biomedcentral.com)
non-radiation-induced cancers. (cdc.gov)

However, whether casticin inhibits in vitro carcinogenesis and cancer stem cell (CSC) characteristics, and whether casticin activates FoxO3a in small cell lung cancer (SCLC) cells remain unclear. (spandidos-publications.com)
However, whether casticin inhibits in vitro carcinogenesis and CSC characteristics in the SCLC H446 cell line, and activates FoxO3a remains unclear. (spandidos-publications.com)
In breast cancer, IL-24 inhibits the growth of breast cancer cells through an anti-tumor-bystander effect. (creative-proteomics.com)
Wogonin also inhibits tumour\mediated induction of Treg cells by inhibiting TGF\1 activity 25. (findadig.com)
Another mechanism is up-regulation of pathways that inhibits cell apoptosis. (oncologynurseadvisor.com)
Since BCL2, a protein that indirectly inhibits cell apoptosis, is required for certain chemotherapies to work, the absence of BCL2 obscures their uses in prostate cancer. (oncologynurseadvisor.com)
75,76 Tumor necrosis factor (TNF)-α inhibits apoptosis by activating NF-κB and its downstream pathway, including IL6 and IL8, in androgen-independent prostate cancer cells, whereas it promotes apoptosis in androgen-dependent cancer cells. (oncologynurseadvisor.com)

FOXO3a is considered an evolutionarily conserved transcription factor involved in various cellular processes, including cell cycle arrest, DNA repair and tumor suppression ( 8 ). (spandidos-publications.com)
1 - 4 Multiple mechanisms may be involved in its potent antitumor effect, including induction of apoptosis, cell cycle arrest, telomerase inhibition, antiangiogenesis activity, and an antimetastasis effect. (dovepress.com)
This study aimed to explore the potential targets and molecular mechanisms of HNK on metastatic BCSC (mBCSC)-cell cycle arrest and the impact of the TME. (hindawi.com)
In contrast, it leads to the growth arrest in vitro because of enhanced extracellular acidification as a result of increased glycolysis. (dcaguide.org)
Inhibition of LDH or lactate generation causes decrease in glycolysis with concomitant growth arrest both in vitro and in vivo . (dcaguide.org)
In addition to cell cycle arrest, senescent cells have additional effector programs such as an enlarged flattened morphology, an altered chromatin structure called senescence-associated heterochromatin formation (SAHF), and a massive secretion of several factors called senescence-associated secretory phenotype (SASP). (molcells.org)
For example, SASP factors can reinforce cell cycle arrest of senescent cells and mobilize the immune system to suppress tumorigenesis and promote an optimal tissue repair. (molcells.org)
Our results demonstrate that Pulsatillae chinensis and particularly its bioactive ingredient β-peltatin suppress PAC by triggering cell cycle arrest at G2/M phase and apoptosis. (biomedcentral.com)
Wogonin also up\regulates the manifestation of p21, p27 and p53 to induce tumour cell cycle arrest in the G1/S phase 15. (findadig.com)

Conversely, FOXO3a overexpression suppresses cancer cell growth, induces apoptosis, and reduces tumor size by regulating downstream effectors ( 10 ). (spandidos-publications.com)
Those patients with large 13q losses showed downregulation of ten genes including TPT1 (TCTP), which in involved in prosurvival and growth signaling through inhibition of BAX -induced apoptosis and overexpression of 53 genes. (atlasgeneticsoncology.org)
Stable F98 glioma cell lines with MCT4 overexpression, normal expression, and knockdown were generated. (hindawi.com)
Moreover, MCT4 overexpression enhances cell migration and invasiveness via reorganization of the actin cytoskeleton. (hindawi.com)
Using inducible lineage tracing and transcriptomics, we demonstrated that metabolically altered ADAM12+ MSCs induced pathological angiogenesis and immunosuppression by promoting macrophage efferocytosis and polarization through overexpression of genes such as Gas6, Lgals3 and Csf1. (bvsalud.org)
Overexpression of Cmb causes the formation of a multiple hair cell phenotype (MHC), similar to loss of rok and mwh. (uni-wuerzburg.de)

Another important mechanism for the progression of colorectal cancer is the ability of the transformed cells to invade and traverse the basement membrane, which in turn facilitates the conversion of adenomas into carcinomas and then metastases ( 1 ). (spandidos-publications.com)
Liu Y , Sun M , Zhang B , Zhao W , . KIF18A improves migration and invasion of colorectal cancer (CRC) cells through inhibiting PTEN signaling. (aging-us.com)
In this review, we will discuss the mechanisms according to which T2D induces cellular senescence and the role of type 2 diabetes-induced cellular senescence in the pathogenesis and progression of colorectal cancer. (frontiersin.org)

It has been proven that the miR-183 expression is up-regulated in tumor tissues and patient serum in BC, which indicates its possibly an oncogenic role 15 , 16 . (nature.com)
The tumor size and the number of proliferating cells were reduced in the tumor tissues obtained from the formononetin-treated group. (spandidos-publications.com)
IL-22R1 is mainly expressed in normal liver and kidney tissues and various tumor cells. (creative-proteomics.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Our study indicates that the pre-screening of potential SL gene pairs based on the large genomics data repertoire of tumor tissues and cancer cell lines could substantially expedite the identification of synthetic lethal gene pairs for cancer therapy. (oncotarget.com)
Local growth is facilitated by enzymes (eg, proteases) that destroy adjacent tissues. (msdmanuals.com)

Gene expression profiling has revealed that diffuse large B-cell lymphoma (DLBCL) is composed of at least 3 different sub-groups, each having distinct oncogenic mechanisms that respond to therapies in different ways. (wikipedia.org)
However, the molecular mechanisms of action of HNK in BCSCs, as well as its effects on the cell cycle, remain unclear. (hindawi.com)
Recent discoveries also elucidate the connection and common mechanisms between angiogenesis and other networks [3-6]. (biomedres.us)
The aim of this review is (1) to summarize and classify data in the TGF-beta apoptosis literature with respect to the affected cell types, (2) to provide insights into the intracellular mechanisms involved in TGF-beta-mediated apoptosis, and (3) to set TGF-beta-mediated apoptosis in a physiological context. (nih.gov)
There are several proposed mechanisms for resistance, including increased androgen receptor (AR) signaling caused by increased AR expression, gene amplification, gene transcription, and tumor growth. (oncologynurseadvisor.com)
In conclusion, prostate cancer cells have resistance mechanisms to overcome cytotoxic therapies such as docetaxel and cabazitaxel. (oncologynurseadvisor.com)
Hence, understanding known mechanisms could be a start in coming up with novel therapies to combat resistant prostate cancer cells. (oncologynurseadvisor.com)
Since copper-induced death mechanisms are shared by genetic models of copper homeostasis dysregulation, copper homeostasis-related classification may impact on prognosis and the immune response of patients with HNSCC [ 3 ]. (biomedcentral.com)
With the increased understanding of molecular mechanisms and basic pathways in the pathogenesis of squamous cell cancer of the head and neck , these pathways may be modified, and rational approaches in cancer therapy at the molecular level may be created. (medscape.com)
of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)

When naïve B-cells encounter an antigen, one of the pathways that they can follow is through the germinal center environment. (wikipedia.org)
HNK controls various intracellular signaling pathways involved in cancer, including those related to nuclear factor kappa B (NF- B), signal transducers and activators of transcription 3 (STAT3), epidermal growth factor receptor (EGFR), and mammalian targets of rapamycin (mTOR) [ 12 ]. (hindawi.com)
Cancer cells derive ATP, biosynthetic intermediates, and reducing equivalents by unusually engaging in biochemical pathways such as glycolysis, glutaminolysis, and the pentose phosphate pathway [5] . (dcaguide.org)
Owing to the metabolic flexibility in choosing various metabolic pathways, particularly glutamine metabolism [22] , melanoma cells can escape from perturbation of a molecule in a metabolic pathway [23] . (dcaguide.org)
A multitude of pathways control cyclin-dependent kinase activities as the major event for cell cycle progression. (benthamscience.com)
Despite the fact that these molecular pathways, vary and depend on both sex and the type of cancer, I briefly discuss the possible roles of three hormonal systems, the adipose derived hormones, the Insulin-Like Growth Factor (IGF) axis and sex steroids, in linking obesity and cancer risk. (benthamscience.com)
Generally, the ablation of two genes located in parallel pathways (leading to cell survival or a common essential product) is one of the important patterns causing synthetic lethality (SL) [ 2 ]. (oncotarget.com)
The metabolism of [1,2- 13 C 2 ]-glucose by HUVEC allows us to trace many of the main glucose metabolic pathways, including glycogen synthesis, the pentose cycle and the glycolytic pathways. (url.edu)

Pathological angiogenesis has a causal role in these eye diseases. (deepdyve.com)
These results suggest that RSV may be and Ewa Piatkowska ˛ useful in the prevention or treatment of pathological angiogenesis in eye disorders. (deepdyve.com)

GCB DLBCL shows amplification of the oncogenic mir-17-92 microRNA cluster and deletion of the tumor suppressor PTEN but these events have not been found in ABC DLBCL B-cells form in the bone marrow and undergo gene rearrangement in order to develop B-cell receptors (BCRs) that bind to a specific antigen. (wikipedia.org)
These gene editing technologies were targeted to the first exon of each gene, to induce frameshifts producing premature termination codons. (koreamed.org)
Unlike preexisting embryonic stem cell-based knockout mice, our mouse models are free from selectable markers or other external gene insertions, permitting more precise study of cell cycle-related diseases without confounding influences of foreign DNA. (koreamed.org)
1. Artelt P, Grannemann R, Stocking C, Friel J, Bartsch J, Hauser H. The prokaryotic neomycin-resistance-encoding gene acts as a transcriptional silencer in eukaryotic cells. (koreamed.org)
The intersection between the differentially expressed genes (DEGs) and the HNK-targets was determined using a Venn diagram, and the results were analyzed using a protein-protein interaction network, hub gene selection, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, genetic alteration analysis, survival rate, and immune cell infiltration levels. (hindawi.com)
Phosphatase and tensin homolog (PTEN) is well recognized as a tumor suppressor gene. (nature.com)
The RB1 gene is involved in the regulation of cell cycle progression and genomic stability. (atlasgeneticsoncology.org)
In tumor cells, IL-24 can induce the transcription of GADD gene, which is related to protein misfolding and DNA damage, such as lung cancer. (creative-proteomics.com)
This gene thus plays a role in both cell-cycle and epigenetic regulation. (cancerindex.org)
In this study, we propose an efficient and comprehensive in-silico pipeline to rank novel SL gene pairs by mining vast amounts of accumulated tumor high-throughput sequencing data in The Cancer Genome Atlas (TCGA), coupled with other protein interaction networks and cell line information. (oncotarget.com)
Targeted molecular therapy, like therapy with monoclonal antibodies, gene therapy, and other therapies, has limited or nonexistent side effects on normal cells of the body, unlike present modalities such as surgery, chemotherapy, and radiotherapy. (medscape.com)
Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)
The goal of gene therapy is to introduce new genetic material into cancer cells that selectively kills them without causing toxicity to the surrounding cells. (medscape.com)
One and 28 d after acute exposure, and 1, 28, and 90 d following sub-chronic exposure, bronchoalveolar lavage was performed on the left lung to collect cells and fluid for analyses, the apical right lobe was preserved for histopathology, and the right cardiac and diaphragmatic lobes were processed for gene expression analyses. (cdc.gov)

Moreover, it was revealed that miRNAs can act as tumor suppressors or oncogenes. (nature.com)
Most GBM exhibit homozygous deletions of the CDKN2A and CDKN2B tumor suppressors at 9p21.3, although loss of CDKN2A/B alone is insufficient to drive gliomagenesis. (oncotarget.com)

A comprehensive vascular analysis is crucial for extending our understanding of angiogenesis and to evaluate the efficacy of anti-angiogenic therapies in cancer. (biomedres.us)
We have developed several morphological imaging markers to analyze entire vascular structures from a human nonsmall cell lung carcinoma subcutaneous xenograft using micro-computed tomography. (biomedres.us)
When normal physiological vascular networks around tumors cannot compensate for the demand, unregulated growth factors from tumor cells trigger abnormal nascent vessel sprouting and irregular pruning leading to over vascularization. (biomedres.us)
Inhibit Angiogenesis - Curcumin slows new blood vessel growth by blocking vascular growth factors. (beatcancer.org)
This scheme is straightforward and essentially divides the vasoformative tumors into 2 broad groups: hemangiomas and vascular malformations (see Table 1 below). (medscape.com)

PTEN can inhibit cell cycle progression and induce cell death to stimulate angiogenesis [ 6 ]. (aging-us.com)
Stimulate Apoptosis - Curcumin encourages programmed cancer cell death. (beatcancer.org)

In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
We also discovered that the invasiveness of metastatic colon cancer cells was alleviated following drug treatment. (spandidos-publications.com)
Copper as a cofactor plays an important role in the motility and invasiveness of tumor cells, as well as many angiogenic mediators [ 3 ]. (biomedcentral.com)

Patients with TNBC lack the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). (nerdygang.com)
An epidermal growth factor receptor (EGFR) is a typical influencer, where phenotypic changes occur by over expression, amplification, and mutation [5]. (genesispub.org)

Further, GA-mPEG 2000 micelles were effective in inhibiting tumor growth and prolonged survival in subcutaneous B16-F10 and C26 tumor models. (dovepress.com)
PTEN insufficiency promotes the PI3K/AKT path, which is a vital signal for the survival of cancer cells. (nature.com)
Besides, upregulated MCT4 has been linked to altered tumor metabolism as well as to increased growth and survival in breast and pancreatic cancer [ 33 , 34 ]. (hindawi.com)
However, there has only been one previous functional study investigating MCT4 in glioblastoma (GBM) neurospheres, mainly focusing on tumor growth and survival dependent on the oxygen level [ 14 ]. (hindawi.com)
Elevated AEG-1 expression is seen in nearly all tumor types, and in most cases AEG-1 positively correlates with tumor progression and poorer patient survival. (biomedcentral.com)
Moreover, upon reintroduction, miR-31 significantly reduces tumor burden and lengthens survival times in animal models. (oncotarget.com)
Squamous cell carcinoma of the head and neck is the sixth most common cancer worldwide, and the 5-year survival rate is less than 50% despite surgery [ 1 ]. (biomedcentral.com)
The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)

The genetic blockage of this lineage increased the intestinal stem cell pool while decreasing epithelial and immune maturation at weaning age, leading to reduced postnatal growth and dysregulated repair responses. (bvsalud.org)
The importance of TGF-beta in the control of liver cell apoptosis and cell death of prostate epithelial cells has been confirmed in many studies. (nih.gov)
retinal pigment epithelial cell line). (deepdyve.com)

MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide) tests demonstrated that the GA-mPEG 2000 micelle formulation had obvious cytotoxicity to tumor cells and human umbilical vein endothelial cells. (dovepress.com)
We studied the metabolic changes of endothelial cell activation by growth factors using human umbilical vein endothelial cells (HUVECs), [1,2- 13 C 2 ]-glucose and mass isotopomer distribution analysis. (url.edu)

Emerging evidence suggests that cancer stem cells (CSCs), a subpopulation of tumor cells, have the properties of self-renewal, heterogeneous progeny, drug-resistance, and carcinogenesis in vitro and in vivo ( 4 , 5 ). (spandidos-publications.com)
To this day, many low dose radiation carcinogenesis studies assume that the probability that one cell of a multicellular organism will acquire multiple mutations transforming it into cancer and the ability of that cancer to thrive can be described by a curve plotted against an axis that shows total radiation dose. (cdc.gov)

Although the goal of Glioblastoma is not only to treat the disease but to cure it, current animal in vivo studies have shown promising therapeutic effects in mesenchymal stem cells, induced neural stem cells, and induced pluripotent stem cells. (genesispub.org)

Altogether, our data show that depletion of tumor-induced slow-cycling PDGFRα+ MSCs through ADAM12 restores antitumor immunity. (bvsalud.org)
Currently, several antitumor drugs can induce apoptosis of cancer cells. (biomedcentral.com)

In addition, the scratch wound assay and Transwell assay were conducted to detect the effect of KIF18A on the migration and invasion of CRC cells. (aging-us.com)
The results of Western blot illustrated that KIF18A could forward the migration and invasion of CRC cells, and inhibit PTEN , which promoted the activation of PI3K/Akt signaling pathway, thus bringing about the expression of MMP2 and MMP9 . (aging-us.com)
The study stated that cannabinoids expressed the ability to control cancer cell growth, invasion, and induce cancer cell death in numerous studies, which displayed the cannabinoids' ability to affect the cancer cells lines (Dariš, Tancer, Knez, Ferk, 2019). (beescannafarm.com)

To detect the effects of miR-183 on the migration of BC cell lines, wound healing was used along with a Trans-well migration assay. (nature.com)
MiR-183 can exert an oncogenic effect by promoting cell viability, migration, and cell cycle progression. (nature.com)
In the present study, the effect of miR-183 on cell viability, cell cycle progression, and migration was investigated, and the interaction between miR-183 and PTEN in BC cells was examined. (nature.com)

No analysis based upon the entire tumor vasculature has been established. (biomedres.us)
Genetic depletion of ADAM12+ cells restored a functional tumor vasculature, reduced hypoxia and acidosis and normalized CAFs, inducing infiltration of effector T cells and growth inhibition of melanomas and pancreatic neuroendocrine cancer, in a process dependent on TGF-ß. (bvsalud.org)

Complex I plays important role in ATP generation in normal cells and is a main site of ROS generation, however, its role in tumorigenesis is largely unclear. (dcaguide.org)
Because age-related cellular senescence and type 2 diabetes (T2D) have been recognised as risk factors for CRC development, the recent finding that type 2 diabetic patients present an elevated circulating volume of senescent cells raises the question whether type 2 diabetes facilitates the process of CRC tumorigenesis by inducing premature cell senescence. (frontiersin.org)

IL-24 has anti-angiogenic activity and reduces tumor micro vessel density by inhibiting angiogenesis. (creative-proteomics.com)

Monoclonal antibodies are made by injecting human cancer cells into mice so that their immune systems create antibodies against foreign antigens. (wikipedia.org)
The reduction in tumor volume as well as pro-apoptotic and anti-proliferative effects in HT-29 nude mice xenograft are comparable to those produced by 5-FU. (spandidos-publications.com)
Proliferating cell nuclear antigen (PCNA) expression in CNV mice without or with YAP siRNA intravitreal injection and the colocalization of PCNA and CD31 were measured with western blotting and immunofluorescent double staining, respectively. (molvis.org)
The in vivo effects of β-peltatin and podophyllotoxin were evaluated on a subcutaneously-xenografted BxPC-3 cell nude mice model. (biomedcentral.com)
Wogonin (30 mg/kg) also prevented lipopolysaccharide\induced acute lung injury and swelling in mice peroxisome proliferator\activated receptor gamma\mediated attenuation of NF\B pathway 20. (findadig.com)
We found that wogonin given at 50 and 100 mg/kg inhibited tumour growth and advertised the recruitment of DC, T, and NK cells in the tumour cells in the xenograft tumour model of mice 26. (findadig.com)
Materials and methods Animals and cell lines C57BL/6 mice, aged 6C8 weeks, were purchased from your Comparative Medicine Centre of Yangzhou University or college (Yangzhou, China). (findadig.com)
Furthermore, severe copper deficiency induced by a low copper diet depresses the immune system of mice, which increases cancer burden. (biomedcentral.com)
It also normalises the concentration of glucose in diet-induced obese and diabetic mice suggesting a similar eventual effect in humans [6]. (deepdyve.com)
Nasal insufflation of IL-11 causes AHR in wild-type mice while lung inflammation induced by antigen sensitization and challenge, which mimics features of atopic asthma in humans, is attenuated in mice genetically deficient in IL-11 receptor subunit alpha-1 (IL-11R1-deficient mice), a transmembrane receptor that is required conjointly with glycoprotein 130 to transduce IL-11 signaling. (cdc.gov)

B-cells within the germinal center proliferate and undergo immunoglobulin somatic hypermutation (SHM) of IgV region genes to revise their antigen receptors. (wikipedia.org)
The rearranging of genes makes the cells capable of generating antibodies with a higher or lower affinity to the specified antigen. (wikipedia.org)
BCL-6 genes are involved in several cell processes that can affect the ability of the B-cell to differentiate and proliferate. (wikipedia.org)
Prevent DNA Damage - Curcumin protects against DNA damage to genes regulating cell replication by toxins, radiation, and other environmental factors. (beatcancer.org)
Ablating PDGFRα in the LTBR stromal lineage demonstrates that PDGFRα has a major impact on the lineage fate and function, inducing a transcriptomic switch from prostemness genes, such as Rspo3 and Grem1, to prodifferentiation factors, including BMPs, retinoic acid, and laminins, and on spatial organization within the crypt-villus and repair responses. (bvsalud.org)
Queuine is efficiently incorporated into E. histolytica tRNAs by a tRNA-guanine transglycosylase (EhTGT) and this incorporation stimulates the methylation of C38 in [Formula: see text] Queuine protects the parasite against oxidative stress (OS) and antagonizes the negative effect that oxidation has on translation by inducing the expression of genes involved in the OS response, such as heat shock protein 70 (Hsp70), antioxidant enzymes, and enzymes involved in DNA repair. (bvsalud.org)
Aberrations of AR, erythroblast transformation-specific ( ETS ) genes, Tumor protein 53 (TP53), and Phosphatase and tensin homolog (PTEN) occurred in 40%-60% of 150 mCRPC cases in a recent study. (oncologynurseadvisor.com)
This task can be accomplished by replacing tumor suppressor genes that have been lost or mutated, selectively inserting genes that produce cytotoxic substances, or modifying the immune system to destroy the tumor cells. (medscape.com)

Cellular senescence is a programmed response that prevents a cell from dividing after some number of cell divisions. (wikipedia.org)
To this end, mammalian cells are equipped with two critical stress responses, autophagy and cellular senescence. (molcells.org)
Telomere shortening leads to the attainment of the Hayflick limit, the transition of cells to a state of senescence. (actanaturae.ru)
Age-related and metabolic diseases such as type 2 diabetes (T2D) represent a source of cellular stress due to their disruptive effect on normal physiological processes and, therefore, can induce premature senescence ( 10 ). (frontiersin.org)
In fact, several studies have shown that T2D induces senescence in multiple types of cells, including fibroblasts and endothelial cells ( 11 , 12 ). (frontiersin.org)

Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)

These Tregs turn down the volume on the normal immune response by secreting immunosuppressive chemical messengers like cytokines that impede the movement of T cells into the tumor. (medium.com)
Its anti-cancer effects are predominantly mediated through its negative regulation of tumor growth factors, inflammatory cytokines, and other oncogenic molecules. (beatcancer.org)
Over lifetime, due to the action of several stressors such as DNA damage and telomere shortening, senescent cells accumulate in the organism and release a variety of pro-inflammatory cytokines responsible for low-grade inflammation. (frontiersin.org)
During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. (cdc.gov)
However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. (cdc.gov)
The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. (cdc.gov)

Bcl-2 proteins prevent the activation of the caspases that lead to programmed cell death (apoptosis). (wikipedia.org)

BCSCs can develop into many cell types and repopulate heterogeneous tumors following conventional chemotherapy or radiotherapy [ 4 , 6 ]. (hindawi.com)
This process enables tumor cells, including those within the core of the heterogeneous tumor mass to survive, despite being at a distance from blood vessels that supply their metabolic needs [ 16 , 17 ]. (hindawi.com)

A study of DLBCL cell lines indicated that 14-3-3ζ proteins may play a role in mediating resistance of DLBCL cells to CHOP. (wikipedia.org)
Conversely, it has also been reported that melanoma cells display increased OXPHOS function which causes drug resistance [ 19 - 21 ] . (dcaguide.org)
The result is tumor resistance, tolerance and evasion. (medium.com)
Silencing of EhTGT prevents incorporation of queuine into tRNAs and strongly impairs methylation of C38 in [Formula: see text], parasite growth, resistance to OS, and cytopathic activity. (bvsalud.org)
This compound at dosages of Avosentan (SPP301) 50C200 M kills tumours by up\regulating intracellular reactive oxygen varieties 4, arresting cell cycle, inducing apoptosis 5, 6, reversing drug resistance 7 and inhibiting angiogenesis 8, 9. (findadig.com)
Inherited resistance is noted in prostate cancer cells that do not express BCL2, indicating that taxanes' mechanism of action relies at least partly on BCL2 inhibition. (oncologynurseadvisor.com)
To overcome tumor cell resistance and uncover new and efficient prognostic biomarkers for HNSCC, it is particularly important to investigate other forms of cell death. (biomedcentral.com)

In accordance with TNBC heterogeneity, we have previously demonstrated that these tumors present with a wide variety of sonographic features ( 8 ) that correlate with cancer grade and score based on immunohistochemical (IHC) biomarkers, such as Ki-67 and HER2. (nerdygang.com)

TCGA data revealed that T cell functions, such as HLA, cytolytic activity, inflammation regulation, co-inhibition, and co-stimulation, differed significantly between members of the low and high groups. (biomedcentral.com)
e.g. inflammation, genotoxicity, and This chapter focuses on issues as- ellers, growth factors, growth factor epigenetic alterations) and can have sociated with the understanding and receptors, signal transducers, and both genetic and epigenetic origins. (who.int)
Collectively, HF diet appeared to have a greater impact on global immune status and exposure-induced lung injury in SD rats, but a more pronounced effect on inflammation resolution in BN rats. (cdc.gov)

Through qRT-PCR analysis, miR-183 and PTEN mRNA levels in breast cancer cell lines were measured. (nature.com)
Promoting PTEN expression in CRC cell lines will stop the activation of the phosphatidylinositol-3-kinase ( PI3K )/sinkserine/threonine kinase ( Akt ) signaling pathway, which affects CRC cell growth, promotes apoptosis, and improves sensitivity to targeted therapy, immunotherapy, and conventional therapy. (aging-us.com)
Therefore, targeting drugs molecules in the PTEN signaling pathway may be another strategy to suppress tumor cells by inhibiting tumor activity [ 7 , 8 ]. (aging-us.com)

This brain tumor type is highly proliferative and shows an infiltrative growth pattern, accounting for the high recurrence rates in patients. (hindawi.com)
3. Sonographic features of TNBCs correlated with the risk of tumor recurrence predicted using the mRNA and lncRNA signatures. (nerdygang.com)
Moreover, we have determined a correlation between sonographic features and risk of tumor recurrence. (nerdygang.com)

Activation of the nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) pathway is found only in ABC DLBCLs and not GCB DLBCLs. (wikipedia.org)
We mainly concentrated on the PI3K/AKT pathway, which is one of the most vital signaling paths included in the growth and control of tumors in breast cancer. (nature.com)
In addition, the TGF β -mediated angiogenic pathway has been found to be induced by lactate [ 29 - 31 ]. (hindawi.com)
It can kill sensitive prostate cancer cells through the extra cellular signal-regulated kinase1/2 (ERK1/2) signaling pathway. (creative-proteomics.com)
IL-24 can also induce apoptosis through the endoplasmic reticulum stress pathway. (creative-proteomics.com)
Wogonin down\regulates the PI3K\Akt pathway, therefore suppressing LPS\ or H2O2\induced angiogenesis 10. (findadig.com)
The flavonoid (30 M) could attenuate endotoxin\induced prostaglandin E2 and nitric oxide production the Src\Erk1/2\NF\B pathway in BV\2 microglial cells 18. (findadig.com)
Planar Cell Polarity (PCP), the polarization within the plane of an epithelium, is perpendicular to apical-basal polarity and established by the non-canonical Wnt/Fz-PCP signaling pathway. (uni-wuerzburg.de)
Triple treatment showed synergism in terms of exhibiting anti-tumorigenic effects by activating the Hippo YAP signaling pathway in the HCT116 cell line. (frontiersin.org)

Our study shown that high\dose wogonin treatments would enhance immune activity by revitalizing the effector T cells and by down\regulating regulatory T cells. (findadig.com)

Most normal germinal center B-cells express low levels of anti-apoptotic proteins such as Bcl-2. (wikipedia.org)
These proteins work with other transcription factors (BLIMP1, PAX5, XBP1) to form a regulatory circuit that controls the progression of germinal center B cells to plasma cells. (wikipedia.org)
Docetaxel, in addition to stabilizing microtubules, also induces apoptosis by downregulating antiapoptotic proteins. (oncologynurseadvisor.com)

A subpopulation of cells within a cancer has the properties of stem cells. (msdmanuals.com)
Th9 cells were first identified as a Th2 subpopulation have many important roles. (cdc.gov)

While secondary GBs can arise in children, primary GB is the most common, fatal brain tumor in adults [2, 3]. (genesispub.org)

They express changes in DNA coding that cause the cancer cells to produce distinctive new molecules called "neoantigens" on their cell surface. (medium.com)
The genetic information in eukaryotic cells is stored in linear DNA molecules known as chromosomes [ 1 ]. (actanaturae.ru)
Shortening of the 5'-terminus of the daughter strand, caused by the removal of the terminal RNA-primer and the subsequent incomplete replication of linear DNA molecules, is observed during the genome replication occurring upon cell fission. (actanaturae.ru)

Here we identified slow-cycling ADAM12+PDGFRα+ mesenchymal stromal cells (MSCs) induced at the tumor margins in mouse models of melanoma, pancreatic cancer and prostate cancer. (bvsalud.org)
These stem cells have self-renewal capabilities, and stem cells, like the mesenchymal stem cells, can differentiate into various lineages from the mesoderm. (genesispub.org)

Breast cancer stem cells (BCSCs) are one of the main factors driving chemoresistance, thereby contributing to poor prognosis and clinical outcomes [ 3 - 5 ]. (hindawi.com)
Inhibit Cancer Stem Cells - Curcumin makes cancer stem cells (normally resistant to chemotherapy and radiation) more sensitive to treatment and thereby less likely to allow cancer to regrow. (beatcancer.org)

Immunofluorescent double staining was used to detect YAP cellular localization with CD31 (an endothelial cell marker) antibody. (molvis.org)
50, 100 M) were compared in two types of cell lines: HECa10 (endothelial cell line) and ARPE-19 Synowiec, A. (deepdyve.com)
The malformations have a normal endothelial cell growth cycle that affects the veins, the capillaries, or the lymphatics, and they do not involute. (medscape.com)

Interestingly, inhibition of either LDH or complex I alone does not induce apoptosis, whereas inhibiting both together causes depletion in cellular ATP pool resulting in metabolic catastrophe induced apoptosis. (dcaguide.org)
Interestingly, significant differences in the cell growth of mTOR siRNA or EGFR siRNA knock-down were detected between cancer cells with wild type TP53 and mutant TP53. (oncotarget.com)

Currently, use of cannabinoids is limited to improve adverse effects of chemotherapy and their palliative administration during treatment is curiously concomitant with improved prognosis and regressed progression in patients with different tumor types. (frontiersin.org)

TGF-beta-mediated growth inhibition and apoptosis can be correlated with its function as a tumor suppressor. (nih.gov)
In cervical cancer, colon cancer, nasopharyngeal cancer and osteosarcoma and other tumor cells, IL-24 has played a significant role in growth inhibition and apoptosis. (creative-proteomics.com)

The leukemic cells are typically small, mature appearing lymphocytes with a dense nucleus, partially aggregated (clumped) chromatin, and without discernible nucleoli. (atlasgeneticsoncology.org)

It can also resist angiogenesis, immune regulation, and increase the sensitivity of radiotherapy and chemotherapy. (creative-proteomics.com)

It was approved by the FDA in January of 2006 to treat renal cell carcinoma and imatigib-resistant Gastrointestinal Stromal Tumors (GIST). (biomedres.us)
Our results show that the PDGFRα-induced transcriptomic switch in intestinal stromal cells is required in the first weeks after birth to coordinate postnatal intestinal maturation and function. (bvsalud.org)

Angiogenesis is associated with numerous diseases and physiological processes in the body [1-3]. (biomedres.us)
Two biochemical processes, protein phosphorylation/dephosphorylation and ubiquitin-mediated degradation drive cell cycle control. (benthamscience.com)

Histone Deacetylase (HDAC) inhibitors are anti-cancer compounds that helps the body's own immune cells to recognize and attack tumour cells. (pharmiweb.com)
Remarkably, Clec4a4+ eosinophils were instructed by the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that imprints many gut immune cells. (stanford.edu)

Gliomas often originate from three types of glial cells: oligodendrocytes, ependymal cells, and astrocytes - however, astrocytic gliomas hold 70% of all glioma origins [4]. (genesispub.org)

Anatomy28

Organisms7

Diseases48

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes56

Disciplines and Occupations1

Information Science3

Health Care1

Metastasis14

Proliferation37

Microenvironment7

Solid tumors4

Differentiation13

Malignant11

Malignancy6

VEGF12

Cancers8

Inhibits7

Arrest9

Overexpression6

Colorectal3

Tissues6

Mechanisms10

Pathways8

Pathological2

Gene14

Suppressors2

Vascular5

Stimulate2

Invasiveness3

Epidermal growth f2

Survival8

Epithelial3

Human umbilical vein endothelial cells2

Carcinogenesis2

Pluripotent stem1

Antitumor2

Invasion3

Migration3

Vasculature2

Tumorigenesis2

Reduces1

Mice10

Genes8

Senescence5

Necrosis factor1

Cytokines7

Programmed cell1

Heterogeneous2

Resistance7

Biomarkers1

Inflammation3

PTEN3

Recurrence3

Pathway9

Effector T cel1

Proteins3

Subpopulation2

Brain tumor1

Molecules3

Mesenchymal2

Cancer stem2

Endothelial cell3

Interestingly2

Progression in patients1

Inhibition and apoptosis2

Lymphocytes1

Regulation1

Stromal2

Processes2

Immune cells2

Gliomas1