• To better understand cellular interactions of the cerebral angiogenesis induced by hypoxia, a spatiotemporal dynamics of cortical microvascular restructuring during an exposure to continuous hypoxia was characterized with in vivo two-photon microscopy in mouse cortex. (elsevierpure.com)
  • Future studies are needed to elucidate the roles of perivascular cells (e.g., pericyte, microglia, and astroglia) in a process of this hypoxia-induced angiogenesis, such as sprouting, growth, and merger with the existing capillary networks, while maintaining the BBB. (elsevierpure.com)
  • Hypertension impairs hypoxia-induced angiogenesis in men. (bvsalud.org)
  • These results suggest that hypertension -induced impairment in angiogenesis in response to isocapnic hypoxia is related to disrupted NO bioavailability , VEGF chemotactic signaling, and EPC mobilization. (bvsalud.org)
  • Mammalian cells respond to hypoxia by modulating oxygen-sensing transducers that stabilize the transcription factor hypoxia-inducible factor 1α (HIF-1α), which transactivates genes governing angiogenesis and metabolic pathways. (umn.edu)
  • Hypoxia-induced miR-424 was regulated by PU.1-dependent transactivation. (umn.edu)
  • Moreover, FK228 significantly suppressed the induction of vascular endothelial growth factor (VEGF) under hypoxia, suggesting that FK228 contributes to the inhibition of tumor angiogenesis. (elsevierpure.com)
  • In Lewis lung carcinoma model, FK228 also blocked angiogenesis induced by hypoxia. (elsevierpure.com)
  • These results suggest that FK228 can downregulate hypoxia-responsive angiogenesis through suppression of HIF-1α activity. (elsevierpure.com)
  • The contribution of CXCL12 to hypoxia-induced angiogenesis was examined in vivo using a subcutaneous murine model of neovascularization. (haematologica.org)
  • Over-expression of hypoxia-inducible factor in multiple myeloma plasma cells strongly induced in vivo angiogenesis, and administration of a CXCL12 antagonist decreased hypoxia-inducible factor-induced angiogenesis. (haematologica.org)
  • Conclusions Hypoxia-inducible factor-2 is a newly identified regulator of CXCL12 expression in multiple myeloma plasma cells and a major contributor to multiple myeloma plasma cell-induced angiogenesis. (haematologica.org)
  • Targeting the hypoxic niche, and more specifically hypoxia-inducible factor-2, may represent a viable strategy to inhibit angiogenesis in multiple myeloma and progression of this disease. (haematologica.org)
  • 14 , 15 HIF-1 and HIF-2 mediate adaptive responses to hypoxia by inducing the transcription of genes associated with erythropoiesis, glycolytic metabolism, cell survival and angiogenesis. (haematologica.org)
  • c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism. (ox.ac.uk)
  • In vitro, c-Myc activation alone was able to induce VEGF protein release and in conjunction with hypoxia, c-Myc activation further increased VEGF protein. (ox.ac.uk)
  • Hypoxia-induced ELF3 promotes tumor angiogenesis through IGF1/IGF1R. (nih.gov)
  • The relationship between PTN expression and clinicopathological characteristics and survival time was statistically analyzed, and the relationship between PTN and vascular endothelial growth factor (VEGF) in tumor angiogenesis was further analyzed. (nih.gov)
  • PTN promotes VEGF expression and cooperates with VEGF in promoting CRC angiogenesis. (nih.gov)
  • Altogether, by identifying a pro-angiogenic VEGF/miR-101/EZH2 axis in endothelial cells we provide evidence for a functional link between growth factor-mediated signaling, post-transcriptional silencing, and histone-methylation in the angiogenesis process. (plos.org)
  • VEGF has been identified as one of the most potent factors involved in angiogenesis [4] - [6] . (plos.org)
  • Novel anti-angiogenic activity in Rubus coreanus Miquel water extract suppresses VEGF-induced angiogenesis. (logosbio.com)
  • In this study, we used an inducible transgenic mouse model in which c-Myc was targeted to the epidermis and, after activation, gave rise to hyperplastic and dysplastic skin lesions and to dermal angiogenesis, involving both vascular endothelial growth factor (VEGF) receptor-1 and VEGF receptor-2. (ox.ac.uk)
  • Blocking VEGF signaling in vivo significantly reduced dermal angiogenesis, demonstrating the importance of VEGF as a mediating factor for the c-Myc-induced angiogenic phenotype. (ox.ac.uk)
  • Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. (nih.gov)
  • Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice. (ox.ac.uk)
  • These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. (mdpi.com)
  • ALA treatment resulted in suppression of angiogenesis in both tube formation and aortic ring assays and inhibition of matrix metalloproteinase-2 expression and activation in both HuH7 and A549 cells. (usda.gov)
  • BACKGROUND: TGF-beta1 is an important angiogenic factor involved in the different aspects of angiogenesis and vessel maintenance. (manchester.ac.uk)
  • Angiogenesis is a balanced process controlled by pro- and anti-angiogenic molecules of which the regulation is not fully understood. (plos.org)
  • Angiogenesis is a balanced process controlled by pro- and anti-angiogenic molecules [3] . (plos.org)
  • This review will detail the biochemical, cellular and biomechanical signals for exercise-induced skeletal muscle angiogenesis, including recent work on extracellular vesicles and circulating angiogenic cells. (ku.dk)
  • We show that HBV replication induces the expression of angiogenic proteins interleukin 6 (IL6) and cyclooxygenase-2 (Cox2). (akjournals.com)
  • In this system, released Rosi promotes both transformation of white adipose tissue (WAT) into brown-like adipose tissue and angiogenesis, which facilitates the homing of targeted NPs to adipose angiogenic vessels, thereby amplifying their delivery. (njit.edu)
  • These findings suggest that angiogenesis-targeting moieties with angiogenic stimulator-loaded NPs could be incorporated into effective therapeutic regimens for clinical treatment of obesity and other metabolic diseases. (njit.edu)
  • However, the use of MSCs in angiogenesis has also been limited due to the low angiogenic potency of MSCs. (minervamedica.it)
  • Musk ambrette induced cardiovascular morphological changes, vessel permeability variation, angiogenic changes and cardiotoxicity (10 µg mL−1, 48 hpf). (deepdyve.com)
  • Chronic hepatitis B virus (HBV) carriers may develop hepatocellular carcinoma (HCC) by a wide range of mechanisms including angiogenesis. (akjournals.com)
  • In response to injury and loss, growth regulators induce hepatocellular hyperplasia (producing regenerating nodules) and arterial growth (angiogenesis). (msdmanuals.com)
  • We found that a key translational regulator, eIF3i, is highly expressed in endothelial cells during embryonic and tumor angiogenesis. (temple.edu)
  • Progression of multiple myeloma is accompanied by an increase in bone marrow angiogenesis. (haematologica.org)
  • Additionally, apo-10'-lycopenoic acid functions as a natural activator to a cell nuclear receptor (called peroxisome proliferator-activated receptor-gamma), which is involved in controlling angiogenesis, tumor progression and metastasis. (usda.gov)
  • In conclusion, apo-10'-lycopenoic acid inhibits cancer cell motility and angiogenesis, which could be one of the potential mechanisms for apo-10'-lycopenoic acid protecting against tumor progression. (usda.gov)
  • We hypothesized that ALA inhibits cancer cell motility and angiogenesis by up-regulating peroxisome proliferator-activated receptor gamma (PPARgamma) which is involved in controlling angiogenesis, tumor progression and metastasis. (usda.gov)
  • RC-3095, a BBS/GRP antagonist, attenuated BBS-stimulated tumor growth and angiogenesis in vivo. (qxmd.com)
  • In recent years, one of the main research strategies used to induce angiogenesis in vivo has been via stem cell therapy, especially therapy using mesenchymal stem cells (MSCs). (minervamedica.it)
  • Furthermore, epigenetic changes caused by histone-modifying enzymes were shown to modulate angiogenesis as well. (plos.org)
  • Through the combined functions on adipogenesis and angiogenesis, endostatin prevents dietary-induced obesity and its related metabolic disorders, including insulin resistance, glucose intolerance, and hepatic steatosis. (diabetesjournals.org)
  • Exercise-induced angiogenesis can significantly contribute to improvements in cardiovascular and metabolic health, such as the increase in muscle glucose uptake, important for the prevention of diabetes. (ku.dk)
  • In this study, we showed that WC-Co nanoparticle s at 5 ug/cm2 induced reactive oxygen species (ROS) production which activated AKT and ERK signal pathways in a lung epithelial cell line. (cdc.gov)
  • These novel findings could form a platform for future therapeutic strategies aimed at stimulating angiogenesis following cerebral ischemia. (biomedcentral.com)
  • ELF3 mediates IL-1α induced differentiation of mesenchymal stem cells to inflammatory iCAFs. (nih.gov)
  • Consistent with these findings, in vitro studies showed that TNF-α induced endothelial proliferation and upregulation of α5β1 and αVβ3 integrins was abrogated by anti-TNFR1 but not anti-TNFR2 antibodies in cultured HBMECs. (biomedcentral.com)
  • Furthermore, miR-424 promoted angiogenesis in vitro and in mice, which was blocked by a specific morpholino. (umn.edu)
  • Recently, our understanding of the mechanisms by which angiogenesis occurs with exercise has grown substantially. (ku.dk)
  • The response profile and its temporal relationships provide insight into the molecular mechanisms that lead to vascular occlusion and antiangiogenesis induced by TTT. (johnshopkins.edu)
  • Both exercise-induced molecular mechanisms and physiological cardiac remodeling have been previously studied on a whole heart level. (researchgate.net)
  • Taken together, CITED4 expression is necessary for exercise-induced regional remodeling of the heart's microstructural helicity revealing how a key molecular regulator of cardiac remodeling manifests into downstream local tissue-level changes. (researchgate.net)
  • Expression of transcription factor CITED4 is necessary for exercise-induced regional remodeling of the heart's microstructural helicity, revealing how a key molecular regulator of cardiac remodeling mediates local tissue-level changes. (researchgate.net)
  • Given that adipose tissue expansion and transformation require active growth of new blood vasculature, angiogenesis offers a potential target for the treatment of obesityassociated disorders. (njit.edu)
  • We show that i.v. administration of these NPs can target WAT vasculature, stimulate the angiogenesis that is required for the transformation of adipose tissue, and transform WAT into brown-like adipose tissue, by the up-regulation of angiogenesis and brown adipose tissue markers. (njit.edu)
  • Exercise-induced skeletal muscle angiogenesis is a well-known physiological adaptation that occurs in humans in response to exercise training and can lead to endurance performance benefits, as well as improvements in cardiovascular and skeletal tissue health. (ku.dk)
  • Angiogenesis is a prominent feature of central nervous system (CNS) disease and has roles in both the continued promotion of inflammation and the subsequent repair processes. (listlabs.com)
  • N-retinylidene-N-retinylethanolamine (A2E) plays a central role in age-related macular degeneration (AMD) by inducing angiogenesis and inflammation. (sorbonne-universite.fr)
  • Conclusions: This study demonstrates upregulation of angiogenesis- and coagulation-related genes following TTT. (johnshopkins.edu)
  • Although angiogenesis has been considered as a potential therapeutic target of obesity, the inhibitory effect of endostatin on adipogenesis and dietary-induced obesity has never been demonstrated. (diabetesjournals.org)
  • To investigate the inhibitory effect of d-α-tocopheryl acid succinate (vitamin E succinate)(VES) on angiogenesis in a rabbit corneal neovascularization model. (elsevierpure.com)
  • VES has an inhibitory effect on corneal angiogenesis. (elsevierpure.com)
  • CONCLUSION: Acute WTS appears to induce impairment in lung function and exercise capacity. (who.int)
  • In addition, blocking antibodies to α5β1 and αVβ3 integrins significantly inhibited TNF-α-induced HBMEC proliferation. (biomedcentral.com)
  • WC-Co nanoparticle s also affected the cells to induce angiogenesis. (cdc.gov)
  • These results identify multiple signaling molecules that are induced by WC-Co nanoparticle treatment, and elucidate the potential molecular mechanism of their regulation in the cells. (cdc.gov)
  • Therefore, our work established a selective translational regulatory mechanism during tumor induced angiogenesis and suggested that targeting eIF3i may be applicable for anticancer therapy. (temple.edu)
  • These results suggest that miR-322/424 plays an important physiological role in post-ischemic vascular remodeling and angiogenesis. (umn.edu)
  • Quality of fibrosis was impaired in macrophage fas-induced apoptosis mice but elevated after overexpression of chemokine (C-X-C theme) ligand 9. (researchdataservice.com)
  • Here we reveal that endostatin inhibits adipogenesis and dietary-induced obesity. (diabetesjournals.org)
  • 9'-cis-norbixin, a di-apocarotenoid is also a ligand of these nuclear receptors (NR). Norbixin inhibits PPAR and RXR transactivation induced by A2E. (sorbonne-universite.fr)
  • Importantly, these findings suggest that novel therapeutic agents, targeting BBS-mediated angiogenesis, may be useful adjuncts in patients with advanced-stage neuroblastomas. (qxmd.com)
  • These findings reveal an important function of angiogenesis in neuronal rewiring and suggest that prostacyclin is a promising molecule for enhancing functional recovery from CNS disease. (listlabs.com)
  • The findings indicate that treatment with DMOG has a potential therapeutic use in promoting angiogenesis in ischaemic diseases, and perhaps for improving muscle recovery after injury, exercise or training. (ox.ac.uk)
  • Taken together, our findings provide new insights on the angiogenesis induced by HBV replication. (akjournals.com)
  • Drug-induced hypertension is high blood pressure caused by a chemical substance or medicine. (medlineplus.gov)
  • Drug-induced hypertension is a form of secondary hypertension caused by a response to a chemical substance or medicine. (medlineplus.gov)
  • Pregnancy-induced hypertension. (medlineplus.gov)
  • Grossman A, Messerli FH, Grossman E. Drug induced hypertension--an unappreciated cause of secondary hypertension. (medlineplus.gov)
  • Interestingly, brain endothelial cell (BEC) proliferation followed the same time-course, suggesting a mechanistic relationship, with the Fn-α5β1/αVβ3 integrin axis driving BEC proliferation and angiogenesis. (biomedcentral.com)
  • However, a possible interplay between miRNAs and histone-modulating enzymes during angiogenesis has not been described. (plos.org)
  • ALK1 signalling analysis identifies angiogenesis related genes and reveals disparity between TGF-beta and constitutively active receptor induced gene expression. (manchester.ac.uk)
  • Dive into the research topics of 'ALK1 signalling analysis identifies angiogenesis related genes and reveals disparity between TGF-beta and constitutively active receptor induced gene expression. (manchester.ac.uk)
  • Besides classical gene regulation, miRNAs have emerged as post-transcriptional regulators of angiogenesis. (plos.org)
  • CONCLUSION: Gene array analysis identified 49 genes to be regulated by ALK1 signalling and at least 14 genes are reported to be involved in angiogenesis. (manchester.ac.uk)
  • Angiogenesis - the formation of new blood vessels - occurs during tissue growth and development, but also during wound healing and cancer [1] , [2] . (plos.org)
  • In the present study, we present evidence that apo-10'-lycopenoic acid, is effective at inhibiting angiogenesis, migration and invasion of human cancer cells. (usda.gov)
  • 6 , 7 CXCL12 is an important mediator of several aspects of MM biology including transendothelial migration, 8 , 9 MM plasma cell migration and retention within the bone marrow, 10 , 11 angiogenesis, 7 and osteoclastic bone resorption. (haematologica.org)
  • RESULTS: We defined chronic regimens of L-dopa monotreatment and L-dopa-ropinirole cotreatment inducing overall similar abnormal involuntary movement scores. (lu.se)
  • Further on, disparity between constitutively active ALK1 and TGF-beta1 induced gene expression in HMEC-1 cells and primary HUVECs was observed. (manchester.ac.uk)
  • Striatal expression of ∆FosB and angiogenesis markers were studied immunohistochemically. (lu.se)
  • The expression of angiogenesis markers and blood-brain barrier hyperpermeability was markedly reduced after L-dopa-ropinirole cotreatment compared with L-dopa monotreatment. (lu.se)
  • In a diet-induced obese mouse model, these angiogenesis-targeted NPs have inhibited body weight gain and modulated several serological markers including cholesterol, triglyceride, and insulin, compared with the control group. (njit.edu)
  • HIF-1 plays a pivotal role in cellular response to low oxygen concentration, such as angiogenesis in tumor. (elsevierpure.com)
  • Studies from our laboratory suggest a role for the CXCL12 chemokine in this process, with circulating levels of CXCL12 correlating with bone marrow angiogenesis in patients with multiple myeloma. (haematologica.org)
  • BACKGROUND: Angiogenesis plays an important role in tissue repair. (minervamedica.it)
  • The angiogenesis related genes might be potential HHT modifier genes. (manchester.ac.uk)
  • Solid tumours need a blood supply, and a large body of evidence has previously suggested that they can grow only if they induce the development of new blood vessels, a process known as tumour angiogenesis. (nature.com)
  • Each eye was examined daily, for angiogenesis by measuring the length of new blood vessels. (elsevierpure.com)