• phafin 1) is predicted through gene annotation and contains pleckstrin homology domain. (avivasysbio.com)
  • The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. (origene.com)
  • Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change. (cathdb.info)
  • X-ray crystallography of OIF and NGF-beta confirmed their structural and sequence homology. (the-scientist.com)
  • Exenatide shows 53% sequence homology with native GLP-1, while still binding effectively to GLP-1 receptor on pancreatic β cells for its insulinotropic effects. (hindawi.com)
  • Emicizumab-kxwh has no structural relationship or sequence homology to FVIII and, as such, does not induce or enhance the development of direct inhibitors to FVIII. (rxlist.com)
  • In a recent result, Zemke showed that a ribbon concordance between two knots induces an injective map between their corresponding knot Floer homology. (ucdavis.edu)
  • In this talk, we will show that the map induced by a ribbon concordance on knot Floer homology is an injection. (rutgers.edu)
  • For example, fundamental groups, higher homotopy groups, singular homology, and De Rham cohomology are algebraic structures that are functorial, meaning that their definition provides a functor from (e.g.) the category of topological spaces to (e.g.) the category of groups or rings. (wikipedia.org)
  • We defined the singular n-simplex, and used it to define singular homology. (umich.edu)
  • Isolation of 10 differentially expressed cDNAs in differentiated Neuro2a cells induced through controlled expression of the GD3 synthase gene. (nih.gov)
  • Early estrogen-induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression. (nih.gov)
  • Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis. (nih.gov)
  • The expression levels of dentin sialo-phosphoprotein (DSPP), dentin matrix protein-1 (DMP1), enamelysin/matrix metalloproteinase 20 (MMP20) and phosphate-regulating gene with homologies to endopeptidases on X chromosome (PHEX) were analysed using RT-PCR. (scielo.br)
  • The CGC tool was developed by combining genomic regions in the rat, associated with the autoimmune experimental arthritis phenotype, with rat/human gene homology data, and with descriptions of phenotypic gene effects and selected keywords. (medscape.com)
  • In vitro study showed that exendin-4 (the active ingredient of exenatide) attenuated HUVECs injury induced by high glucose, with improving cell viability and attenuating cell apoptosis. (hindawi.com)
  • VP79s was found to induce apoptosis in NCI-H929 and U266B1 MM cell lines in a dose- and time-dependent manner. (confex.com)
  • The iPSCs were transduced with CRISPR guide RNAs, Cas9 endonuclease and a donor homology template. (nature.com)
  • Here a DSB at the MAT locus is created by a site specific HO endonuclease, which we can induce synchronously in a large population of cells. (brandeis.edu)
  • Here we demonstrate that C-terminal-truncating Asxl1 mutations (ASXL1-MTs) inhibited myeloid differentiation and induced MDS-like disease in mice. (jci.org)
  • ASXL1 mutations inhibit G-CSF-induced myeloid differentiation of 32Dcl3 cells. (jci.org)
  • This study was designed to determine the in vivo performance of three different materials as scaffolds for dental pulp stem cells (DPSC) undergoing induced odontogenic differentiation. (scielo.br)
  • An odontogenic medium modified by the addition of recombinant human bone morphogenetic protein 2 was used in the experimental groups to induce differentiation. (scielo.br)
  • Consequently, PLDL and PDL seemed to be promising scaffold candidates for odontogenic regeneration at least as HA-TCP, when they were applied with the DPSC induced for odontogenic differentiation. (scielo.br)
  • They fractionated semen from llamas (induced ovulators), and subjected the OIF-containing fraction to mass spectrometry to identify its amino acid sequence, which was highly homologous to human, cow, pig, and mouse NGF-beta. (the-scientist.com)
  • This is the process we have studied most intensively, but we are also interested in an alternative process known as break-induced replication (BIR), where only one end of a chromosome break locates a template sequence and assembles a complete replication fork and can copy sequences to the end of a chromosome, producing a nonreciprocal translocation. (brandeis.edu)
  • N-Glycans: Phenotypic Homology and Structural Differences between Myocardial Cells and Induced Pluripotent Stem Cell-Derived Cardiomyocytes. (stembook.org)
  • Shortly after, Levine and Zemke proved the analogous result for ribbon concordances between links and their Khovanov homology. (ucdavis.edu)
  • Induced pluripotent stem cells (iPSCs) generated from patient fibroblasts could potentially be used as a source of autologous cells for transplantation in retinal disease. (nature.com)
  • Using a patient's own cells for transplantation would avoid these pitfalls and is possible with induced pluripotent stem cells (iPSCs). (nature.com)
  • Functional and Electrical Integration of Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Myocardial Infarction Rat Heart. (stembook.org)
  • Transplantation of human induced pluripotent stem cell-derived cardiomyocytes is superior to somatic stem cell therapy for restoring cardiac function and oxygen consumption in a porcine model of myocardial infarction. (stembook.org)
  • MHC-mismatched Allotransplantation of Induced Pluripotent Stem Cell-Derived Cardiomyocyte Sheets to Improve Cardiac Function in A Primate Ischemic Cardiomyopathy Model. (stembook.org)
  • Vasculogenically conditioned peripheral blood mononuclear cells inhibit mouse immune response to induced pluripotent stem cell-derived allogeneic cardiac grafts. (stembook.org)
  • Co-Treatment of Prostate Cancer Cells with Mscs Expressing Trail and Iap Inhibitors Reduce Trail Resistance and Production of Trail-Induced Cytokines. (essex.ac.uk)
  • A family of structurally related proteins that are induced by CYTOKINES and negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. (bvsalud.org)
  • Our results indicate that the expression and distribution of BAI3 in normal brain, but not its developmental expression, are very similar to those of BAI1 and BAI2, and that BAI3 may participate in the early phases of ischemia-induced brain angiogenesis and in brain tumor progression. (nih.gov)
  • Although angiogenesis has been considered as a potential therapeutic target of obesity, the inhibitory effect of endostatin on adipogenesis and dietary-induced obesity has never been demonstrated. (diabetesjournals.org)
  • Through the combined functions on adipogenesis and angiogenesis, endostatin prevents dietary-induced obesity and its related metabolic disorders, including insulin resistance, glucose intolerance, and hepatic steatosis. (diabetesjournals.org)
  • CytoB-IVM parthenogenesis could help to obtain embryos with a higher degree of homology to the oocyte donor. (techscience.com)
  • the advantages of using a murine model included small size, easy breeding, short time between generations, production of identical offspring, and the fact that much of their genome has been mapped for homologies with the human genome. (cdc.gov)
  • CRISPR gRNAs were selected to minimize the off-target profile and to maximize the degree of homology with a target sequence directly centered on the mutation site. (nature.com)
  • Developmental biologist Rita Levi-Montalcini , who in the beginning of 1950's moved from her homeland Italy, to Viktor Hamburger's laboratory in St. Louis, USA, showed in 1952 that when tumours from mice were transplanted to chick embryos they induced potent growth of the chick embryo nervous system, specifically sensory and sympathetic nerves. (nobelprize.org)
  • Rats are very useful for this purpose because autoimmune experimental arthritis phenotypes can be induced in susceptible strains by several agents, such as collagen, pristane, oil, streptococcal cell wall and even adjuvant alone. (medscape.com)
  • We also readily detected off-target alterations induced by four out of six RGNs targeted to endogenous loci in human cells by examination of partially mismatched sites. (nature.com)
  • Out of the seven tested recombinant human RNases, we have identified two members, RNase3 and RNase6, which were highly effective against Mycobacterium aurum extra- and intracellularly and induced an autophagy process. (frontiersin.org)
  • Recombinant human G-CSF has been approved for the amelioration of chemotherapy induced neutropenia as well as for severe chronic neutropenia following marrow transplant. (rndsystems.com)
  • We have shown that there are differences between this repair-induced replication fork and the normal replication process, but there is much more work to do. (brandeis.edu)
  • The differences in susceptibility to noise induced hearing loss (NIHL) which may be attributed to genetic factors were discussed. (cdc.gov)
  • SH2 (Src Homology 2) is a protein domain found in many intracellular signal-transducing proteins. (nersc.gov)
  • Despite significant homology between IRS-1 and IRS-2, recent studies have revealed distinct functions for these adaptor proteins in regulating breast cancer progression. (spandidos-publications.com)
  • SOCS proteins contain a central SH2 DOMAIN and a C-terminal region of homology known as the SOCS box. (bvsalud.org)
  • Phosphopeptides are modified self antigens that can induce an immune response. (nersc.gov)
  • In the present investigation, RNA-dependent RNA polymerase sequence was retrieved from NCBI followed by its domain analysis to find out the effective part of the sequence later on 3D structure of the domain modeling by comparative homology modeling approach, including a thorough screening of the homologous sequences to domain by sequence alignment technique. (academicjournals.org)
  • Comparative studies of behavioral homologies help understand several aspects of psychiatric disorders. (bvsalud.org)
  • VP79s was more potent in inducing cell death in a panel of drug sensitive and drug resistant MM cell lines compared to standard and emerging therapeutic agents for MM. VP79s rapidly inhibited both constitutively active and IL-6-induced STAT3 signalling in MM cells. (confex.com)
  • Chromosomal AmpC expression can become induced by certain antibacterials or may become constitutively expressed (ie, overproduced) in de-repressed mutants. (msdmanuals.com)
  • More than 40 QTLs that regulate experimentally induced arthritis have been identified in different rat crosses. (medscape.com)
  • Thus, ASXL1-MT-induced MDS-like disease in mice is associated with derepression of Hoxa9 and miR-125a and with Clec5a dysregulation. (jci.org)
  • Recent evidence has indicated that the vascular endothelial injury induced by hyperglycemia is associated with the enhanced nitrooxidative stress both in vivo and in vitro [ 3 - 6 ]. (hindawi.com)
  • Indeed, we demonstrate that Hmga2 can induce Spemann Organizer cell fates even when β-catenin, a critical effector of the Wnt signaling pathway, is depleted. (xenbase.org)
  • In conclusion, the novel agent VP79s inhibits the JAK/STAT3 signalling pathway resulting in rapid downregulation of MCL-1 expression and inducing potent anti-MM activity. (confex.com)
  • Our studies suggest that IRS-2 plays a significant role by activating, at least in part, NF-κB via PI3K/Akt pathway in IGF-1-induced responses in breast cancer cells and the crosstalk between nuclear IRS-2 and NF-κB might be responsible for transcriptional progression of the breast cancer cells. (spandidos-publications.com)
  • Rather, we found that phosphorylated activation loop Y842 serves as a binding site of SHP2, which is required for FLT3-induced activation of RAS/ERK pathway. (lu.se)
  • Thus, to find genes contributing to experimentally induced arthritis, we consider the CGC application to be a helpful tool in facilitating the evaluation of large amounts of textual information. (medscape.com)
  • A ROTAV SGII infected younger children and induced more review of studies in Africa published during 1997-2006 severe symptoms. (cdc.gov)
  • VP79s was shown to overcome adhesion mediated drug resistance in MM cells in a co-culture model system with bone marrow stromal cells which induces MM cell resistance to treatment with the proteasome inhibitor bortezomib. (confex.com)
  • Developmental rates did not differ between diploidization strategies, even when three agents were employed to induce activation. (techscience.com)
  • We demonstrated that depletion of endogenous IRS-2 by antisense strategies impaired cell proliferation after serum withdrawal, blunted PI3K/Akt and NF-κB activation in IGF-1 induced response in MCF-7 and BT-20 breast cancer cells. (spandidos-publications.com)
  • Homology models of RNA-dependent RNA polymerase domain was finally taken into consideration to focus on the prediction of the specific ligand binding site by docking against antiviral drug Ribavirin, with an aid of AutoDock4.2. (academicjournals.org)
  • Several studies have shown promise in targeting prosurvival BCL2 family members with BCL2 homology domain 3 (BH3) mimetics in MM. (confex.com)
  • Sterile /Armadillo/Toll-Interleukin receptor homology domain protein (SARM1) can induce Wallerian degeneration. (bvsalud.org)
  • Exendin-4 also significantly alleviated the increased malondialdehyde (MDA), nitrotyrosine content, and inducible nitric oxide synthase (iNOS) expression induced by high glucose in HUVECs. (hindawi.com)
  • For example, a continuous map from a topological space X to a topological space Y induces a group homomorphism from the fundamental group of X to the fundamental group of Y. More generally, in category theory, any functor by definition provides an induced morphism in the target category for each morphism in the source category. (wikipedia.org)
  • for example, two maps that are inverse to each other up to homotopy induce homomorphisms that are inverse to each other. (wikipedia.org)
  • Thanks to this, relations between spaces and continuous maps, often very intricate, can be inferred from relations between the homomorphisms they induce. (wikipedia.org)
  • We then showed that homotopic maps induce the same maps on homology. (umich.edu)
  • Indeed, π gives a functor from the category of pointed spaces to the category of groups: it associates the fundamental group π1(X, x0) to each pointed space (X, x0) and it associates the induced homomorphism π ( h ) = h ∗ {\displaystyle \pi (h)=h_{*}} to each base-point preserving continuous map h: (X, x0) → (Y, y0). (wikipedia.org)
  • This implies that if h is not only a continuous map but in fact a homeomorphism between X and Y, then the induced homomorphism π ( h ) {\displaystyle \pi (h)} is an isomorphism between fundamental groups (because the homomorphism induced by the inverse of h is the inverse of π ( h ) {\displaystyle \pi (h)} , by the above equation). (wikipedia.org)
  • It groups beta-lactamases by class on the basis of molecular homology. (msdmanuals.com)
  • Here, we provide an overview of the cumulative data on the field of viroid-induced RdDM and discuss three possible scenarios concerning the mechanistic details of its establishment. (degruyter.com)
  • In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. (origene.com)
  • This means that each space is associated with an algebraic structure, while each continuous map between spaces is associated with a structure-preserving map between structures, called an induced homomorphism. (wikipedia.org)
  • The present study evaluated the effect of REM-sleep deprivation on the catalepsy induced by lactate administration plus forced muscular activity. (bvsalud.org)