Induced vegf. Medical search. Frequent questions

The relationship between PTN expression and clinicopathological characteristics and survival time was statistically analyzed, and the relationship between PTN and vascular endothelial growth factor (VEGF) in tumor angiogenesis was further analyzed. (nih.gov)
PTN promotes VEGF expression and cooperates with VEGF in promoting CRC angiogenesis. (nih.gov)
Tsad-deficient mice displayed impaired angiogenesis specifically during tracheal vessel development, but not during retinal vasculogenesis, and in VEGF-loaded Matrigel plugs, but not in those loaded with FGF. (uu.nl)
Novel anti-angiogenic activity in Rubus coreanus Miquel water extract suppresses VEGF-induced angiogenesis. (logosbio.com)
The goal of this study was to examine the immunohistochemical localization and relative levels of VEGF receptor-2 (KDR) in canine retina during postnatal vasculogenesis and during angiogenesis in oxygen-induced retinopathy (OIR) and to investigate the effects of neutralizing KDR on these processes. (johnshopkins.edu)
However, no sigificant difference in the mRNA and protein levels of ANG2, involving inhibition of angiogenesis was found in HUVECs cultured with supernatant of Hep3B cells treated with siRNA cocktail, compared to that of VEGF-siRNA. (biomedcentral.com)
Up-regulation of VEGF and bFGF results in neo-angiogenesis. (aad.org)
i.p) or vehicle administered 24 hours after permanent middle cerebral artery occlusion (pMCAO) on behavior, angiogenesis, ultra-structural integrity of brain capillary endothelial cells, and expression of EPO and VEGF were assessed. (researchgate.net)
Repeated treatments with Catalpol reduced neurological deficits and significantly improved angiogenesis, while significantly increasing brain levels of EPO and VEGF without worsening BBB edema. (researchgate.net)
These results suggested that catalpol might contribute to infarcted-brain angiogenesis and ameliorate the edema of brain capillary endothelial cells (BCECs) by upregulating VEGF and EPO coordinately. (researchgate.net)
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. (nih.gov)
Although angiogenesis has been considered as a potential therapeutic target of obesity, the inhibitory effect of endostatin on adipogenesis and dietary-induced obesity has never been demonstrated. (diabetesjournals.org)
Through the combined functions on adipogenesis and angiogenesis, endostatin prevents dietary-induced obesity and its related metabolic disorders, including insulin resistance, glucose intolerance, and hepatic steatosis. (diabetesjournals.org)
LCN2 was increased by SOX9 and SIRT1 deacetylated SOX9 to promote its nuclear translocation, which further inhibited the viability of human retinal pigment epithelial cells and promoted cell apoptosis and angiogenesis as well as CNV-induced AMD formation. (hindawi.com)
Furthermore, lactate has been proposed to stimulate angiogenesis through HIF-1 α -dependent activation of the VEGF/VEGFR2 signaling pathway. (hindawi.com)
Overall this study reveals key signalling molecules involved in SWCNT-induced fibrogenesis and angiogenesis. (cdc.gov)
The vascular endothelial progress issue (VEGF)/VEGF receptor (VEGFR) axis is an important regulator of angiogenesis and vital therapeutic goal in most cancers. (ncbcs.org)
HCC-induced angiogenesis of human umbilical vein endothelial cells (HUVEC) was assessed by tube formation assay. (bvsalud.org)
As4S4 suppressed the proliferation, migration and invasion of HepG2 and Hep3B cell lines in a concentration-dependent pattern, and inhibited HCC cell -induced angiogenesis of HUVEC in the tube formation assay. (bvsalud.org)

The present study aimed to investigate whether the protective effect of vitexin protects against sevoflurane-induced neuronal apoptosis and the underlying mechanisms of this protective effect. (spandidos-publications.com)
The results demonstrated that Vitexin pretreatment significantly reduced neuronal apoptosis, and inhibited caspase‑3 activity, apoptosis regulator BAX protein expression and malondialdehyde levels in sevoflurane‑induced newborn rats. (spandidos-publications.com)
Together, the results of the current study suggest that the protective effect of vitexin reduces sevoflurane‑induced neuronal apoptosis through HIF‑1α‑, VEGF‑ and p38‑associated signaling pathways in newborn rats. (spandidos-publications.com)
MTT viability test, Annexin V‐FITC/propidium iodide double staining, and caspase3 activity assay were used to evaluate the apoptosis and relative expression of PTEN and VEGF in PC-3 and DU145 cell lines using real-time PCR. (ac.ir)
Quality of fibrosis was impaired in macrophage fas-induced apoptosis mice but elevated after overexpression of chemokine (C-X-C theme) ligand 9. (researchdataservice.com)
Silencing of VEGF and KSP plays a key role in inhibiting cell proliferation, migration, invasion and inducing apoptosis of Hep3B cells. (biomedcentral.com)
RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy. (nature.com)
Induces apoptosis in human malignant glioma cell lines. (sigmaaldrich.com)
Histone deacetylase inhibitor valproic acid inhibits proliferation and induces apoptosis in KM3 cells via downregulating VEGF receptor. (nel.edu)
Dong X, Song Q, Li L, Zhao C, Wang L. Histone deacetylase inhibitor valproic acid inhibits proliferation and induces apoptosis in KM3 cells via downregulating VEGF receptor. (nel.edu)

Resveratrol also down-regulated the increased expressions of vascular endothelial growth factor (VEGF) and kinase insert domain receptor (KDR, or VEGF receptor-2) induced by high glucose. (springer.com)
Activation of vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) by VEGF binding is critical for vascular morphogenesis. (uu.nl)
Treatment with soluble VEGF receptor reduces disease severity in murine collagen-induced arthritis. (ox.ac.uk)
To block VEGF activity, animals were treated after arthritis onset with a soluble form of the Flt-1 VEGF receptor (sFlt), which was polyethylene glycol (PEG)-linked to increase its in vivo half-life. (ox.ac.uk)
colony-stimulating aspect 1 receptor (CSF1R) as well as the neutrophil cytosolic aspect 1 (NCF1) respectively.23 Although zero changes were seen in NCF1 CSF1r mRNA amounts from DMA tissues lysates had been decreased after VEGF neutralization during fibrosis quality (Amount 3B) indicating a reduction in SAM a cell type implicated in scar tissue fibrolysis. (researchdataservice.com)
Targeted delivery of the TcdB enzymatic domain, through fusion with a detoxified diphtheria toxin, into peptidergic sensory neurons that express exogeneous diphtheria toxin receptor (an approach we term toxogenetics) is sufficient to induce neurogenic inflammation and recapitulates major colonic histopathology associated with CDI. (nature.com)
An aptamer is an oligonucleotide that acts like a high affinity antibody to VEGF, neutralizing it before it can contact its receptor. (medscape.com)
VEGF receptor expression decreases during lung development in congenital diaphragmatic hernia induced by nitrofen. (medscape.com)
It is actually a splice variant of the better known vascular endothelial growth factor receptor 1 (VEGF-R1). (medscape.com)

Our data demonstrate that, in collagen-induced arthritis, expression of the potent angiogenic cytokine VEGF correlates with disease severity. (ox.ac.uk)
This is an important insight into the regulation of VEGF, which is involved in a wide range of different pathologies, and may lead to more effective design of novel anti-inflammatory/angiogenic therapeutics for conditions such as RA. (ox.ac.uk)
VEGF blockade may lead to an increase in other angiogenic signaling pathways as a compensatory mechanism. (medscape.com)
In addition, the TGF β -mediated angiogenic pathway has been found to be induced by lactate [ 29 - 31 ]. (hindawi.com)
Reactive oxygen species-mediated p38 MAPK regulates carbon nanotube -induced fibrogenic and angiogenic responses. (cdc.gov)

Here we reveal that endostatin inhibits adipogenesis and dietary-induced obesity. (diabetesjournals.org)
Journal Article] Low grade inflammation inhibits VEGF induced HUVECs migration in p53 dependent manner. (nii.ac.jp)
Arsenic Sulfide Inhibits Hepatocellular Carcinoma Metastasis by Suppressing the HIF-1α/VEGF Pathway. (bvsalud.org)
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. (lu.se)

Inhibition of VEGF/KDR pathway by using SU5416, a selective inhibitor of KDR, alleviated the hyperpermeability and the cav-1 overexpression induced by high glucose. (springer.com)
The above results demonstrate that RSV ameliorates caveolae-mediated hyperpermeability induced by high glucose via VEGF/KDR pathway. (springer.com)
1999 ). Report showed that VEGF increased the permeability through caveolae-mediated transcellular pathway in the blood-tumor barrier (Zhao et al. (springer.com)
Investigation of the relationship between PTN and VEGF revealed that PTN, through the PTN/RPTPβ/ζ signaling pathway, increased tyrosine phosphorylation of β-catenin, leading to an increase in VEGF. (nih.gov)
VEGF Pathway. (bvsalud.org)
Overall, results above indicate that As4S4 suppresses the metastasis of HCC cells via the HIF-1α/ VEGF pathway. (bvsalud.org)

Right here anti-VEGF therapy considerably suppressed liver organ fibrosis as assessed by Sirius Crimson (Amount 2C and D) and hydroxyproline articles (Amount 2E). (researchdataservice.com)
Currently, the treatment of choice for CNV secondary to exudative AMD is intravitreal anti-VEGF therapy. (medscape.com)
[ 36 ] Anti-bevacizumab and anti-ranibizumab auto-antibodies have been documented in the systemic circulation of patients undergoing chronic anti-VEGF therapy for exudative AMD. (medscape.com)
Fruzaqla is specifically indicated for the treatment of adult patients with metastatic colorectal cancer (mCRC) who have been previously treated with fluoropyrimidine‑, oxaliplatin‑, and irinotecan‑based chemotherapy, an anti‑VEGF therapy, and, if RAS wild‑type and medically appropriate, an anti-EGFR therapy. (centerwatch.com)

Click on one of the biological effects of VEGF-VEGF R2 signaling shown in the Explore Pathways box below to see the specific molecules involved in promoting each effect and the phosphorylation sites on VEGF R2 that are necessary for recruitment of key downstream adaptor proteins or kinases. (rndsystems.com)
In vitro and in vivo studies showed fruquintinib inhibited VEGF-induced VEGFR-2 phosphorylation. (centerwatch.com)
SWCNTs induce fibrogenesis through reactive oxygen species-regulated phosphorylation of p38 mitogen-activated protein kinase (MAPK). (cdc.gov)

Blocks estradiol-stimulated VEGF production in breast tumor cells. (sigmaaldrich.com)
Knockdown of HIF-2alpha in neuroblastoma and glioma tumor stem/initiating cells leads to reduced levels of VEGF and poorly vascularized, highly necrotic tumors. (lu.se)

We noticed that VEGF regulates vascular permeability monocyte infiltration and scar-associated macrophages function. (researchdataservice.com)
VEGF is 50,000 times more potent than histamine in inducing vascular permeability. (medscape.com)

Onset of arthritis was associated with expression of VEGF mRNA and protein. (ox.ac.uk)
siRNA cocktail showed a further downregulation on KSP mRNA and protein levels compared to KSP-siRNA or VEGF-siRNA, but not on VEGF expression. (biomedcentral.com)

Tyrosine kinase activity is essential to LPS-induced cytokine production, and we have previously implicated a role for the Tec kinase, Bmx, in inflammatory cytokine production. (ox.ac.uk)

During fibrosis quality VEGF inhibition impaired liver organ sinusoidal permeability that was associated with decreased monocyte migration adhesion and infiltration of fibrotic liver organ. (researchdataservice.com)
analyses (Supplementary Amount 3) we transformed our focus on potential ramifications of VEGF inhibition on permeability and inflammatory cell infiltration that take place during fibrosis quality. (researchdataservice.com)
The relieving role of LCN2 inhibition on CNV-induced AMD without toxicity for mice was also demonstrated by in vivo experiments. (hindawi.com)

VEGF is purified from bovine pituitary follicular cells in 1959 and is a vascular endothelial cell-specific mitogen that promotes the growth of vascular endothelial cells. (spandidos-publications.com)
Vascular endothelial cell growth factor (VEGF) has been implicated in vascular development and in proliferative retinopathies. (johnshopkins.edu)
In vitro studies showed fruquintinib inhibited VEGF-mediated endothelial cell proliferation and tubular formation. (centerwatch.com)

Resveratrol treatment alleviated the hyperpermeability and the overexpression of cav-1 induced by high glucose in a dose-dependent manner. (springer.com)
Overexpression of VEGF was found in the progression of nephritic and ophthalmic complications in diabetes (Kim et al. (springer.com)
Reconstructed anatomy 14 days after CJ is normally proven ( A ). Hydroxyproline articles ( … Amount 2 VEGF overexpression promotes fibrosis quality. (researchdataservice.com)
Cystic adenomatoid malformations are induced by localized FGF10 overexpression in fetal rat lung. (medscape.com)

Our objective in this study was to measure the kinetics of VEGF production in a murine model of collagen-induced arthritis and to determine whether VEGF blockade reduces disease progression. (ox.ac.uk)
Furthermore, specific blockade of VEGF activity results in attenuation of arthritis in both macroscopic and microscopic parameters. (ox.ac.uk)
These observations indicate that blood vessel formation is integral to the development of arthritis and that blockade of VEGF activity might be of therapeutic benefit in rheumatoid arthritis. (ox.ac.uk)
Unlike our preliminary prediction that blockade of VEGF would enhance fibrosis quality we discovered that blockade of VEGF considerably delayed tissues repair (Amount 1D E and F). For gain-of-function we administered an adenoviral vector-encoding murine VEGF into mice after CJ and BDL. (researchdataservice.com)

In this review, we will discuss the mechanisms according to which T2D induces cellular senescence and the role of type 2 diabetes-induced cellular senescence in the pathogenesis and progression of colorectal cancer. (frontiersin.org)

Bmx regulates LPS-induced IL-6 and VEGF production via mRNA stability in rheumatoid synovial fibroblasts. (ox.ac.uk)

Furthermore, it was revealed that treatment with vitexin induced hypoxia inducible factor 1α subunit (HIF‑1α) and vascular endothelial growth factor (VEGF) protein expression, and suppressed phosphorylated‑p38 MAP kinase (p38) protein expression in sevoflurane‑induced newborn rat. (spandidos-publications.com)
Here we show that Bmx kinase activity in RASF is increased following LPS stimulation and that Bmx is involved in the regulation of LPS-induced IL-6 and VEGF production via mRNA stabilisation. (ox.ac.uk)

We found that Wnt5a could activate regulated secretion of IL-6 and VEGF, dependent on cytoskeletal re-arrangements mediated via calcium signaling and Cdc42 activation. (lu.se)

In contrast EphBs typically bind with lower affinity than EphAs/ephring-As since they utilize an "induced fit" mechanism that requires a greater conformational change of EphBs to bind ephrin-Bs. (wikipedia.org)
Hence, this study is aimed at exploring the potential role of SIRT1 in choroidal neovascularization- (CNV-) induced age-related macular degeneration (AMD) development and the associated mechanism. (hindawi.com)
Hence, the present study was conducted to verify the hypothesis and explore the specific mechanism among SIRT1, SOX9, and LCN2 in the development of CNV-induced AMD, which will be greatly helpful to enlarge the understanding of CNV-induced AMD and to validate a novel therapy. (hindawi.com)

Vascular endothelial growth factor (VEGF) is involved in the growth of new blood vessels that feed tumors and kinesin spindle protein (KSP) plays a critical role in mitosis involving in cell proliferation. (biomedcentral.com)

Outcomes VEGF-Neutralizing Antibody Impairs Fibrosis Quality in Vivo We initial set up a murine style of fibrosis quality through the use of the gallbladder dilation occurring after BDL in mice to attain an usage of reconstruct bile stream by DMA virtue of CJ. (researchdataservice.com)

Amount 1 Anti-VEGF antibody disrupts fibrosis quality. (researchdataservice.com)

Activation of p38 MAPK by SWCNTs led to the induction of transforming growth factor (TGF)-b1 as well as vascular endothelial growth factor (VEGF). (cdc.gov)

In fact, several studies have shown that T2D induces senescence in multiple types of cells, including fibroblasts and endothelial cells ( 11 , 12 ). (frontiersin.org)

however, there are evidences indicating that caveolae was indispensable to the process, and it was suggested that VEGF-induced permeability was mediated by caveolae (Feng et al. (springer.com)

Synovial cells isolated from the knee joints of naive or sham-immunized mice, or from mice immunized with collagen but without arthritis, released little or no detectable VEGF. (ox.ac.uk)
The levels of VEGF secreted by synovial cells isolated from the joints of mice with severe arthritis were significantly higher than from mice with mild disease. (ox.ac.uk)
Protective effect of rutin against cadmium induced hepatotoxicity in swiss albino mice. (scialert.net)

Vascular endothelial growth factor (VEGF), an endothelial mitogen expressed by cells within the synovial membrane, is thought to contribute to the formation of synovial blood vessels. (ox.ac.uk)
Outcomes VEGF-neutralizing antibodies prevented advancement of fibrosis but disrupted hepatic cells restoration and fibrosis quality also. (researchdataservice.com)
VEGF-Neutralizing Antibody Impairs Monocyte Infiltration During Fibrosis Quality Fibrosis quality is connected with inflammatory cell infiltration.12 22 We observed significant inflammatory cells within and next to regions of fibrosis after BDL (Amount 3A). (researchdataservice.com)
Simultaneous silencing of VEGF and KSP using siRNA cocktail yields promising results for eradicating hepatocellular carcinoma cells, a new direction for liver cancer treatment. (biomedcentral.com)
RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. (nature.com)
Because age-related cellular senescence and type 2 diabetes (T2D) have been recognised as risk factors for CRC development, the recent finding that type 2 diabetic patients present an elevated circulating volume of senescent cells raises the question whether type 2 diabetes facilitates the process of CRC tumorigenesis by inducing premature cell senescence. (frontiersin.org)
It induces c-kit expression and produces the spindled morphology of Kaposi sarcoma cells from their original cuboidal monolayer. (aad.org)
AT1 receptors activation enhances the expression of MMP-2, MMP-13 and VEGF but not MMP-9 in B16F10 melanoma cells. (scialert.net)
Treatment with As4S4 also decreased the expression of crucial elements involved in the metastasis of HCC cells , including HIF-1α and VEGF , while reducing epithelial-mesenchymal transition , as shown by Western blot , ELISA and immunofluorescence staining . (bvsalud.org)
At 24hours after the exposure, significant increases in the pro-inflammatory markers IL-12p70, IL-13, IL-15, IFN-, TNF-, IL-17A, VEGF, MCP-1, and MIP-1 were noted in the basolateral cell culture medium of ABS-exposed cells compared to non-exposed chamber control cells. (cdc.gov)
Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity. (lu.se)

Conclusions Within a mouse style of liver organ fibrosis quality VEGF marketed fibrogenesis but was also necessary for hepatic tissues fix and fibrosis quality. (researchdataservice.com)

In keeping with data attained using the neutralizing antibody compelled appearance of VEGF marketed tissues repair (Amount 2A and B) a week after trojan administration. (researchdataservice.com)
We also verified earlier research6 13 that discovered a fibrogenic aftereffect of VEGF during fibrosis advancement by administering VEGF-neutralizing antibody for 14 days commencing one day after BDL or sham medical procedures. (researchdataservice.com)

Simultaneous silencing of VEGF and KSP, an attractive and viable approach in cancer, leads on restricting cancer progression. (biomedcentral.com)
FRESCO-2, an international, multicenter randomized, double-blind, placebo-controlled trial, evaluated 691 patients with mCRC who had disease progression during or after prior fluoropyrimidine-, oxaliplatin-, irinotecan-based chemotherapy, an anti-VEGF biological therapy an anti-EGFR biological therapy if RAS wild type, and at least one of trifluridine/tipiracil or regorafenib. (centerwatch.com)
Therefore, it can be hypothesized that SIRT1/SOX9/LCN2 axis may exert great functions on the progression of CNV in AMD, but their specific interactions in CNV-induced AMD remain unclear. (hindawi.com)

In addition, the addition of VEGF to the culture medium can increase the survival rate of neurons in the cerebral cortex as well as the number and length of ganglion cell processes, to promote nerve growth. (spandidos-publications.com)

High level of PTN is a predictor of a poor prognosis and high expression of PTN is accompanied by high expression of VEGF in CRC patients. (nih.gov)
As high HIF-2alpha expression further correlates with disseminated disease as demonstrated in neuroblastoma, glioma, and breast carcinoma, we propose that targeting HIF-2alpha and/or the pseudo-hypoxic phenotype induced by HIF-2 under normoxic conditions has great clinical potential. (lu.se)

Both TGF-b1 and VEGF contributed significantly to the fibroproliferative and collagen-inducing effects of SWCNTs. (cdc.gov)
Dermatitis patients had significantly higher levels of serum and lesional skin VEGF and IFN- than controls. (who.int)
Results showed exposure of NHBEs to ABS emissions did not significantly affect epithelium integrity, ciliation, mucus production, nor induce cytotoxicity. (cdc.gov)

It has also been used to study its effect on lipopolysaccharide (LPS)-induced microglial activation 92 . (sigmaaldrich.com)

Functional studies show that SFRP3 can inhibit Wnt5a signaling and induce a decrease in migration and invasion. (lu.se)

Enzyme-linked immunosorbent assay ( ELISA ), western blot , quantitative polymerase chain reaction and immunofluorescence staining were utilized to evaluate key molecules involved in metastasis , including hypoxia-inducible factor 1 α (HIF-1α), vascular endothelial growth factor ( VEGF ), Vimentin , N-cadherin and E-cadherin . (bvsalud.org)

sFlt-1 freely circulates and reduces the level of both VEGF and placental growth factor (PIGF). (medscape.com)

Age-related and metabolic diseases such as type 2 diabetes (T2D) represent a source of cellular stress due to their disruptive effect on normal physiological processes and, therefore, can induce premature senescence ( 10 ). (frontiersin.org)
Furthermore, by analyzing the effects of Wnt5a on the malignant melanoma proteome, we provide evidence for a cell context dependent reprogramming of cellular metabolism induced by Wnt5a. (lu.se)

Here we report that TcdB induces neurogenic inflammation by targeting gut-innervating afferent neurons and pericytes through receptors, including the Frizzled receptors (FZD1, FZD2 and FZD7) in neurons and chondroitin sulfate proteoglycan 4 (CSPG4) in pericytes. (nature.com)
Fig. 3: Delivery of TcdB-GTD into peptidergic sensory neurons using the toxogenetic approach is sufficient to induce neurogenic inflammation. (nature.com)

ABSTRACT Allergic contact dermatitis to cement is a delayed-type hypersensitivity reaction in which cytokines interferon-gamma (IFN-) and vascular endothelial growth factor (VEGF) may be involved in persisting erythema and oedema. (who.int)

LANA also maintains the viral episome and prevents Fas-induced programmed cell death. (aad.org)

[ 41 ] Up-regulation of VEGF production by macrophages within CNV has also been proposed. (medscape.com)

VEGF and IFN- levels in serum and skin lesions were measured in 32 Egyptian building workers with chronic allergic contact dermatitis due to occupational exposure to cement and 20 healthy controls. (who.int)

Therefore, this study is aimed at providing a novel therapeutic target for CNV-induced AMD management. (hindawi.com)

1 day after CJ adenovirus-expressing mouse VEGF or LacZ (one dosage 0.8 × 109 PFU/kg) was injected through tail vein injection. (researchdataservice.com)
The major limitation of anti-VEGF treatment is the injection burden. (medscape.com)

Taken together these data suggests that, in melanoma, an altered Wnt5a signal can induce different pro-tumorigenic effects. (lu.se)

A significant positive correlation was found between tissue VEGF and the eczema area and severity index (EASI) score in dermatitis patients ( r = 0.86). (who.int)
Une étroite corrélation positive a été établie entre le taux de VEGF dans les tissus et le score de la surface eczémateuse et de l'indice de gravité (ou EASI pour eczema area and severity index) chez les patients atteints de dermite ( r = 0,86). (who.int)

Endothelial hyperpermeability induced by hyperglycemia is the initial step in the development of atherosclerosis, one of the most serious cardiovascular complications in diabetes. (springer.com)
Effect of insulin-like growth factors on lung development in a nitrofen-induced CDH rat model. (medscape.com)

OxPL are acutely produced in infected tissue and act as endogenous, proalgesic (pain-inducing) metabolites. (ncbcs.org)

These auto-antibodies may neutralize the effect of anti-VEGF agents. (medscape.com)

Anatomy38

Organisms14

Diseases33

Chemicals and Drugs98

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes38

Disciplines and Occupations1

Information Science2

Health Care1

Angiogenesis19

Apoptosis10

Receptor9

Angiogenic5

Inhibits4

Pathway6

Anti-VEGF therapy4

Phosphorylation3

Tumor2

Vascular permeability2

MRNA and protein2

Cytokine1

Inhibition3

Endothelial cell3

Overexpression4

Blockade4

Colorectal cancer1

Regulates1

Kinase2

Secretion1

Mechanism3

Protein1

Murine1

Disrupts1

MAPK1

Fibroblasts1

Permeability1

Mice3

Cells11

Fibrogenesis1

Antibody2

Progression3

Cerebral1

Expression2

Significantly3

Activation1

Migration1

Metastasis1

Reduces1

Cellular2

Inflammation2

Abstract1

Cell1

Production1

Levels1

Therapeutic1

Injection2

Melanoma1

Severity2

Development2

Tissue1

Effect1