• Target organ toxicity was evaluated by a zebrafish angiogenesis model. (deepdyve.com)
  • While disease-specific biomarkers have found their application in clinical drug development, in particular in oncology, and have been accepted by health authorities in a number of cases, biomarkers for organ toxicity were only very recently endorsed by FDA and European Medicines Agency (EMEA) for use in preclinical toxicity studies (1). (tamirna.com)
  • In conclusion, the data obtained in our investigation confirm the protective effect of S. pachycarpa against acute exposure to CCl 4 -induced organ toxicity in rats. (biomedcentral.com)
  • Can cranberry juice protect against rotenone-induced toxicity in rats? (cranberryinstitute.org)
  • Based on the data in this study, astaxanthin might play a protective role against cisplatin-induced gastrointestinal toxicity in rats. (springermedizin.at)
  • The aim of this study is to assess the effects of the propolis alcohol extract (PAE) against the prostate specific antigen (PSA) disorders and prostate necrosis induced by the cadmium (Cd) toxicity in rats. (paom.pl)
  • Induced pluripotent stem cells are most useful when combined with a high throughput in vitro assay that can recognize hepatotoxicity. (enzolifesciences.com)
  • cell toxicity, in vitro. (grantome.com)
  • however, hIAPP-knockin mice did not exhibit a high-fat-diet-induced compensatory increase in β cell mass, which was due to limited β cell proliferation and enhanced β cell apoptosis. (jci.org)
  • Bax (Bcl2-associated X protein) is an apoptosis-inducing protein that participates in cell death during normal development and in various diseases. (scienceopen.com)
  • These results suggest that 4-OP induces mitochondria-mediated apoptosis by regulation of Bcl-2 family proteins and caspase-3 activation in male Sertoli cells. (preprints.org)
  • Both forskolin and IBMX prevented diclofenac-induced apoptosis. (rug.nl)
  • First, elevated cAMP levels protect against diclofenac-induced apoptosis in primary hepatocytes via maintenance of mitochondrial integrity. (rug.nl)
  • Compared to LD and GSH, GSH-LD had a stronger effect in preventing hydrogen peroxide (H2O2) induced apoptosis in both cell lines. (unich.it)
  • This work evaluates how different functional MRI methods can detect radiotherapy-induced effects in normal tissues as potential toxicity biomarkers. (qbi-lab.org)
  • 1. P. Y. Muller and F. Dieterle, "Tissue-specific, non-invasive toxicity biomarkers: translation from preclinical safety assessment to clinical safety monitoring," pp. 1023-1038, 2009. (tamirna.com)
  • Within this postgenomics era in science, proteomic technologies are positioned to play a major role in discovery of new biomarkers for early detection of diseases and drug-induced toxicity, new molecular targets for therapy, and new end points for therapeutic efficacy and toxicity. (usuhs.edu)
  • For drug-induced interstitial lung disease (DIILD) translational imaging biomarkers are needed to improve detection and management of lung injury and drug-toxicity. (lu.se)
  • We aimed to examine whether ROT-induced oxidative stress could be counteracted by cranberry juice not only in the brain but also in the liver and kidney. (cranberryinstitute.org)
  • Both drug candidates and approved drugs face the issue of induced toxicity to the liver. (enzolifesciences.com)
  • Over 1,000 drugs have known liver toxicity and are responsible for more than one third of acute liver failures in the United States. (enzolifesciences.com)
  • Assessment of the roles of P-glycoprotein and cytochrome P450 in triptolide-induced liver toxicity in sandwich-cultured rat hepatocyte model. (curehunter.com)
  • Modeling clinically relevant tissue responses using cell models poses a significant challenge for drug development, in particular for drug induced liver injury (DILI). (organovo.com)
  • In the past decades, several well-known clinical pathology parameters associated with toxicity of major organs (liver, kidney, heart) were identified and also routinely applied. (tamirna.com)
  • Background: Chronic consumption of the nonsteroidal anti-inflammatory drug diclofenac may induce drug-induced liver injury (DILI). (rug.nl)
  • The mechanism of diclofenac-induced liver injury is partially elucidated and involves mitochondrial damage. (rug.nl)
  • Our findings present cAMP-EPAC as a potential target for the treatment of drug-induced liver injury (DILI) and liver injury involving mitochondrial dysfunction. (rug.nl)
  • CCL4 is one of the most commonly used agents to induce chronic and acute liver failure in experimental animals at doses of 0.5-2.5 mL/kg. (biomedcentral.com)
  • PIs could cause DTMA either by an immune mechanism or dose-dependent/cumulative toxicity. (hindawi.com)
  • Common anticancer chemotherapeutic agents causing drug-induced thrombotic microangiopathy via immune-mediated mechanism or dose-dependent toxicity or both [ 4 , 7 ]. (hindawi.com)
  • In this study, we report that both nano- and micro-CoCrMo induced a time and dose-dependent toxicity in various cell types (i.e. lung epithelial cells, osteoblasts, and macrophages), and the effects of particle size on cell viability and oxidative responses were interesting and cell specific. (whiterose.ac.uk)
  • Trovafloxacin induced significant, dose-dependent toxicity at clinically relevant doses (≤ 4 μM). (organovo.com)
  • Exposure to nanoalumina, but not to nanocarbon, induced a dose-dependent mitochondrial potential collapse, increased autophagy of brain endothelial cells, and decreased expression of the tight-junction proteins occludin and claudin-5. (uky.edu)
  • Results: Diclofenac exposure induced apoptotic cell death and loss of MMP in hepatocytes. (rug.nl)
  • Terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling showed an increase in epidermal cell death within 2h of CX exposure and increased cleaved caspase 3 and cleaved Poly (ADP-ribose) polymerase 1, suggesting apoptotic cell death and rapid skin toxicity. (msu.edu)
  • In summary, this comprehensive study reports novel outcomes indicating that CX-induced apoptotic cell death could involve oxidative stress and programmed signaling leading to DNA damage. (msu.edu)
  • More than 600 drugs are known to cause pulmonary toxicity, and illicit drugs are well-known to result in pulmonary toxicities. (medscape.com)
  • A list of drugs that are reported to cause pulmonary toxicity is available on the continually updated Website PNEUMOTOX online . (medscape.com)
  • Medicinal drugs should not be ruled out completely right from the start just because they possibly could cause pulmonary toxicity. (wikipedia.org)
  • A number of medicinal drugs that could cause pulmonary toxicity can be life-saving for certain patients with specific diseases. (wikipedia.org)
  • The data showed that particulate matter can be a major cause of cardiovascular disease, and can also cause pulmonary toxicity. (wikipedia.org)
  • Lung symptoms in a patient who is taking a medicinal drug that can cause pulmonary toxicity should not automatically lead to a diagnosis of "pulmonary toxicity due to the medicinal drug", because some patients can have another (i.e., simultaneous) lung disease, e.g. an infection of the lungs not related to the medicinal drugs the patient is taking. (wikipedia.org)
  • Cramarossa G, Liu H, Pope J. Risk Factors for Antimalarial-Induced Retinal Toxicity in Systemic Lupus Erythematosus and Other Rheumatic Diseases [abstract]. (acrabstracts.org)
  • miR-133a-3p is a specific markers of muscle toxicity. (tamirna.com)
  • In combination with miR-208a-3p, miR-133a-3p can be used to differentiate cardiac from skeletal muscle toxicity (7). (tamirna.com)
  • miR-210-3p is commonly upregulated by exposure to three aldehydes, propanal, butanal and pentanal in lung toxicity (9). (tamirna.com)
  • Thus, although some of the effects of exposure to 17 hours of more than 95 per cent oxygen are reversible, hyperoxia for even this short period lowers the structural or functional barriers that normally prevent alveolar-capillary "leak" and induces processes that can culminate in fibrosis of the alveolar wall. (nebraska.edu)
  • The inducing agents and exposure (dose and duration) differed from non-physiological to clinically relevant doses. (lu.se)
  • Barium toxicity after exposure to contaminated contrast solution-Goias State, Brazil, 2003. (cdc.gov)
  • In this current series of studies [10], with guidance from extensive facility exposure assessments, we selected six multi-walled carbon nanotubes (MWCNT) and two carbon nanofibers (CNF), collectively termed CNT/F, either manufactured or handled by U.S. companies, to evaluate four primary parameters of toxicity. (cdc.gov)
  • In this study, excitatory toxicity was induced by NMDA, which binds the NMDA receptor in primarily cultured rat cortical neurons. (scienceopen.com)
  • Optimizing the therapeutic ratio for radiation therapy (RT) in head and neck squamous cell carcinoma (HNSCC) is uniquely challenging owing to high rates of early and late toxicity involving nearby organs at risk. (biomedcentral.com)
  • The aim of the present study was to investigate the protective effect of the Sophora pachycarpa (S. pachycarpa) seed extract against carbon tetrachloride-induced toxicity on body organs, blood, and biochemical factors. (biomedcentral.com)
  • The primary mechanism of toxicity would be direct damage to DNA from alpha particle interactions. (cdc.gov)
  • In this study, we investigated the molecular mechanism of toxicity of 4-OP in mouse TM4 Sertoli cells. (preprints.org)
  • This thesis demonstrates that amyloid ß-peptide (Aß)-induced peroxynitrite contributes to the switch of the Aβ42/Aβ40 ratio that occurs in Alzheimer's disease (AD). (upf.edu)
  • Our preliminary data suggest that both occur, and that the ECM molecule hyaluronan (HA) produced by the islet endothelial cell is a major mediator of amyloid-induced toxicity. (grantome.com)
  • The aim was to investigate the protective effect of the pre-treatment with lithium on amyloid-beta (Aβ)-induced toxicity and telomere length in neurons. (mdpi.com)
  • Amyloid toxicity was induced 24 h before the end of lithium treatment. (mdpi.com)
  • We found that NMDA (100 μmol/L) dramatically induced the decrease of cell viability and caused mitochondrial dysfunction. (scienceopen.com)
  • Theseresults suggest that disruption of Igf-1/Akt signaling is a causative factor insimvastatin-induced mitochondrial dysfunction in C2C12 myotubes, whereas HepG2cells are protected by maintaining Igf-1/Akt signaling. (unibas.ch)
  • The diagnosis of drug-mediated pulmonary toxicity is usually established based on clinical findings. (medscape.com)
  • Severe treatment-induced toxicities can have clinical consequences such as hospitalisation or treatment modifications, which in turn may deteriorate the prognosis of patients with cancer. (psu.edu)
  • Whereas toxicities are systematically recorded and graded per protocol in most clinical trials, observational studies often depend on retrospective data collection from medical records collected as standard care. (psu.edu)
  • From the Clinical Editor: In this paper, the effects of nanoalumina on the permeability of the blood-brain barrier is reported, suggesting that autophagy is an important mechanism in nanoalumina-induced neurovascular toxicity. (uky.edu)
  • Bronchoalveolar lavage (BAL) can contribute to the expected clinicopathologic pattern of a given drug-induced lung disease such as identifying eosinophils in a drug-induced eosinophilic pneumonia. (medscape.com)
  • Common solid tumors that have been linked to cancer-induced TMA include gastric, breast, lung, and prostate adenocarcinomas, with gastric adenocarcinoma being the most reported. (hindawi.com)
  • The four parameters of toxicity included genotoxicity, inflammation, pathological changes, and the presence of CNT/F in areas of the body outside the lung, termed extrapulmonary translocation. (cdc.gov)
  • It is important to test for mitochondrial toxicity early in drug development as impairment of mitochondrial function can induce various pathological conditions that are life threatening or can increase the progression of existing mitochondrial diseases. (nih.gov)
  • 95% CI=[1.2, 2.3]) were significantly associated with ocular toxicity after adjusting for CQ/HCQ dosages, age, sex, weight, and renal impairment. (acrabstracts.org)
  • MnCl2 in drinking water did not cause hearing impairment or hair cell pathologies by itself and it did not potentiate noise -induced hearing loss or hair cell pathologies. (cdc.gov)
  • For this section of the evaluation of CNT/F toxicities, all materials were extensively characterized, and genotoxicity in cultured cells was evaluated [10]. (cdc.gov)
  • Genotoxicity was assessed by the ability of the CNT/F to induce inflammation, oxidative stress, micronuclei formation, and DNA double-strand breakage. (cdc.gov)
  • Most drug-induced pulmonary toxicities involve the parenchyma, thus, interstitial infiltrates may be demonstrated on radiographs. (medscape.com)
  • A seventh MWCNT, Mitsui-7/MWCNT-7, was added as a benchmark material given its IARC classification as possibly carcinogenic to humans (Group 2B) and the large amount of historical toxicity data available for the four toxicity parameters. (cdc.gov)
  • The toxicity data of protein kinase inhibitors in humans is also well established [5]. (who.int)
  • Furthermore, several gene alterations were associated with improved toxicity outcomes. (biomedcentral.com)
  • Identifying factors associated with toxicity outcomes offers a new avenue for personalized precision RT therapy and prophylactic management. (biomedcentral.com)
  • Existing population-based or patient cohorts are a valuable source of information, even when relying on retrospective data collection, but comparisons across studies are hampered by a lack of a uniform definition for toxicity outcomes. (psu.edu)
  • Here we investigated the effect of GSH-LD on H2O2-induced cellular toxicity in undifferentiated and differentiated lymphoma U-937 and dopaminergic neuroblastoma SH-SY5Y cell lines, used respectively as models to study the involvement of macrophages/microglia and dopaminergic neurons in PD. (unich.it)
  • Evaluation of efficacy of natural astaxanthin and vitamin E in prevention of colistin-induced nephrotoxicity in the rat model. (springermedizin.at)
  • Objective: Development of patient-specific targeted therapeutics with reduced toxicity and increased efficacy using cells or sera from patients with disease. (usuhs.edu)
  • In order to investigate the effectiveness of HePC ointment as a topical anti-leishmanial preparation, we tested its efficacy on experimentally induced lesions in hamsters. (who.int)
  • Daily doses of calcium folinate should be adjusted depending on the hematological toxicity of trimetrexate. (janusinfo.se)
  • Though the current process for toxicity testing largely evolves around the use of in vivo animal work, more and more studies rely on human induced pluripotent stem cell (iPSC)-derived hepatocytes as a viable and up-and-coming alternative of determining toxicity. (enzolifesciences.com)
  • Induced pluripotent stem cell-derived hepatocytes have a primary tissue-like phenotype, constant and indefinite disposal, and the potential to establish genotype-specific cells from different individuals, which make them an interesting means of predicting drug-induced toxicity. (enzolifesciences.com)
  • Elevated cAMP protects hepatocytes against bile acid-induced injury. (rug.nl)
  • Aim: Investigate whether cAMP and/or its downstream targets protect against diclofenac-induced injury in hepatocytes. (rug.nl)
  • Conclusion: cAMP elevation protects hepatocytes against diclofenac-induced cell death, a process primarily involving EPACs. (rug.nl)
  • The current study focused on blood-brain barrier disruption and neurovascular damage induced by engineered nanomaterials. (uky.edu)
  • If used in combination with high-throughput systems and toxicity assays, high-content imaging has the benefit of being able to screen many compounds at a time to assess multiple parameters including small phenotypic changes. (enzolifesciences.com)
  • Genetic alterations in BRCA2, ERBB3, NOTCH1 and CCND1 were all associated with higher mean grade of toxicity with BRCA2 alteration implicated in all toxicity parameters evaluated including mucositis, early dysphagia, xerostomia and to a lesser extent, late dysphagia. (biomedcentral.com)
  • Cutaneous toxicity is common with docetaxel, occurring in up to 75% of cases. (biomedcentral.com)
  • Initially, the rash was attributed to docetaxel cutaneous toxicity however a microbiological diagnosis of Trichophyton rubrum was subsequently made. (biomedcentral.com)
  • Cutaneous toxicity with docetaxel is well recognised, manifesting in numerous ways including palmar/plantar erythrodysaesthesia (PPE) and nail changes (onycholysis, paronychia). (biomedcentral.com)
  • Initially docetaxel cutaneous toxicity was suspected, however subsequently a microbiological diagnosis of Trichophyton rubrum was made. (biomedcentral.com)
  • The time course, distribution and appearance of the rash in our patient were not helpful in conclusively differentiating docetaxel cutaneous toxicity from a fungal infection. (biomedcentral.com)
  • Cutaneous lesions were experimentally induced by inoculation with leishmania promastigotes in 60 golden hamsters. (who.int)
  • The aim of the present study was to demonstrate astaxanthin's attenuating effects against cisplatin (CIS)-induced gastrointestinal toxicity in a rat model. (springermedizin.at)
  • Zurück zum Zitat Shahid F, Farooqui Z, Khan F. Cisplatin-induced gastrointestinal toxicity: an update on possible mechanisms and on available gastroprotective strategies. (springermedizin.at)
  • Objective To investigate the protective effects of scrotal cooling on cisplatin-induced gonadal toxicity in an animal model. (psu.edu)
  • Exploring the effects of maternal immune activation on cisplatin-induced toxicities. (tdl.org)
  • As MIA has been associated with alterations in stress responsivity, inflammation, and metabolism, we wanted to determine if MIA would exacerbate cisplatin-induced fatigue and affective problems in adulthood. (tdl.org)
  • TMA caused by drugs is called drug-induced TMA (DTMA) [ 4 ], and cancer therapeutic agents are among the most common medications reported to cause DTMA. (hindawi.com)
  • Changes in the maternal gastrointestinal and cardiovas- tive therapeutic levels and toxicity may be altered by preg- cular systems affect drug absorption. (cdc.gov)
  • These include above all amiodarone, as well as beta blockers, ACE inhibitors (however, pulmonary toxicity of ACE inhibitors usually lasts only 3-4 months and then usually disappears by itself), procainamide, quinidine, tocainide, and minoxidil. (wikipedia.org)
  • To date, there are few data indicating that toxicity of ROT is not limited to the brain but can also affect other tissues. (cranberryinstitute.org)
  • Humanin (HN) is a 24-amino acid peptide originally cloned from the brain of patients with AD and it prevents stress-induced cell death in many cells/tissues. (scienceopen.com)
  • Unlike what was seen in 2D hepatocyte cultures, the tissues maintained levels of ATP, Albumin as well as expression and drug-induced enzyme activity of Cytochrome P450s over 4 weeks in culture. (organovo.com)
  • Dose limitations are uniquely challenging in HNSCC due to the proximity of critical OARs with early and late toxicity resulting in mucositis, dysphagia, xerostomia, tooth decay, vocal dysfunction and loss of taste [ 11 ]. (biomedcentral.com)
  • These toxicities have a profound impact on treatment compliance and quality of life. (biomedcentral.com)
  • In addition glucocorticoids induce profound lymphopaenia, predominantly of T-cells and particularly CD4 cells. (biomedcentral.com)
  • Overall, our study reveals that autophagy constitutes an important mechanism involved in nanoalumina-induced neurovascular toxicity in the central nervous system. (uky.edu)
  • Patients who develop drug toxicity should be advised to avoid the drug in the future. (medscape.com)
  • A point-of-care pilot randomized intervention to connect patients with cancer-induced financial toxicity to telehealth financial counseling. (bvsalud.org)
  • We conducted a three-armed parallel randomized pilot study , allocating newly referred patients with cancer and financial toxicity to individual, group accredited telehealth financial counseling , or usual care with educational material (111). (bvsalud.org)
  • Definite AM-induced retinal toxicity was observed in 12 patients, 11 of whom had SLE and 7 had been prescribed CQ (Figure 1). (acrabstracts.org)
  • There may be higher rates of AM-induced retinopathy in SLE patients due to longer duration of treatment, more chloroquine use in this population, and SLE may be an independent risk factor. (acrabstracts.org)
  • In this cohort, toxicity of grades 3 to 5 was reported in 27% of patients overall. (medscape.com)
  • Toxicity, and more specifically hepatotoxicity, is a major concern for the pharmaceutical industry. (enzolifesciences.com)
  • Enzo Life Sciences offers a comprehensive product portfolio for advancing your discoveries in toxicity research with a whole portfolio of toxicity research reagents and kits, including the SCREEN-WELL® Hepatotoxicity library . (enzolifesciences.com)
  • The TP-induced hepatotoxicity increased by twofold when CYP activity was blocked by 1-aminobenzotriazole , suggesting that CYP and P-gp may both contribute to the detoxification of TP in the SCRH model. (curehunter.com)
  • Our results for the first time demonstrated that in addition to CYP-mediated metabolism, P-gp also plays an important role in the disposition of TP and TP-induced hepatotoxicity. (curehunter.com)
  • Drug-induced pulmonary toxicity is a diagnosis of exclusion. (medscape.com)
  • In general, bronchoscopy with transbronchial biopsy is not helpful in establishing the diagnosis of drug-induced pulmonary toxicity. (medscape.com)
  • The earliest diagnosis of toxicity occurred after 5.4 years of AM therapy, and the prevalence beyond five years was 2.7% but increased over time. (acrabstracts.org)
  • Bone marrow stem cells are targets for benzene-induced cytotoxicity and DNA damage that could result in changes to the genome of these progenitor cells, thereby leading to hematopoietic disorders and cancers. (rti.org)
  • Manganese (Mn) toxicity is characterized by movement disorders resembling Parkinson's disease. (cdc.gov)
  • Cadmium toxicity induced a decrease in body weight gain and an increase in prostate gland weight, blood PSA and Cd 2+ levels. (paom.pl)
  • Cd also induced prostate necrosis in which it was noted a marked irregular acini and solid parenchyma. (paom.pl)
  • Propolis has beneficial effects and could antagonize Cd-induced prostate toxicity. (paom.pl)
  • We investigated the acute toxicity of musk ambrette using wild-type AB and transgenic Tg(fli1a:EGFP) y1 zebrafish. (deepdyve.com)
  • It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health. (cdc.gov)
  • Conclusions: The application of all new proteomic technologies should enhance our efforts in designing rational drug therapy strategies that are based on an individual patient's molecular profiling of cellular proteins in the disease state and can identify proteomic fingerprints associated with drug-induced toxicity directly in sera samples. (usuhs.edu)
  • Here, we report the first case of ixazomib-induced DTMA due to cumulative toxicity rather than immune-mediated mechanism. (hindawi.com)
  • A well-accepted theory for renal toxicity is the release of uranium from serum bicarbonate complex in the kidney that allows uranium to bind to available phosphate and protein. (cdc.gov)
  • Results: The use of high-throughput SELDI-TOF protein pattern generation techniques should prove valuable for new molecular classification of human tumors, disease stages, and drug-induced toxicity. (usuhs.edu)
  • Based on these data, we hypothesize that hIAPP aggregation induces HA production from islet endothelial cells, which exacerbates hIAPP fibril formation and cytotoxicity, and acts to recruit and prime macrophages. (grantome.com)
  • Other (non-medical) causes of pulmonary toxicity can be chemical compounds and airborne particulate matter. (wikipedia.org)
  • 3rd Place winner Joseph Puthussery shows his research regarding Toxicity in the air through Ambient Particulate Matter or PM. Congratulations Joseph! (illinois.edu)
  • To minimize the potential morbidity and mortality from drug-induced respiratory diseases, healthcare providers should be familiar with the possible adverse effects of the medications they prescribe. (medscape.com)
  • Pulmonary toxicity is the medical name for side effects on the lungs. (wikipedia.org)
  • Although most cases of pulmonary toxicity in medicine are due to side effects of medicinal drugs, many cases can be due to side effects of radiation (radiotherapy). (wikipedia.org)
  • These results show that human CD34(+) cells are sensitive targets for 1,4-BQ toxicity that use the p53 DNA damage response pathway in response to genotoxic stress. (rti.org)
  • Elevated costs of cancer treatment can result in economic and psychological " financial toxicity " distress. (bvsalud.org)
  • Within all classes of medicinal drugs that possibly can lead to pulmonary toxicity as a side effect, most pulmonary toxicity is due to chemotherapy for cancer. (wikipedia.org)
  • Taking advantage of this coagonist segregation, we demonstrate that long-term potentiation and NMDA-induced neurotoxicity rely on synaptic NMDARs only. (scienceopen.com)
  • We propose a new standardised approach to summarise toxicities in observational studies that rely on medical records for outcome assessment. (psu.edu)
  • Severe hypokalemia induced by barium toxicity can cause ventricular dysrhythmias (1-7). (cdc.gov)
  • Transient transfection of constitutively active Rap1 into C2C12 myotubes led to a partial rescue ofsimvastatin-induced inhibition of mitochondrial respiration, providing a novellink between signaling and respiration. (unibas.ch)
  • Toxicity-induced modification of treatment: what is in a name? (psu.edu)
  • Identification of determinants of treatment-induced toxicities is essential to develop strategies that promote therapy compliance and enhance the quality of life. (psu.edu)
  • We recommend the term 'toxicity-induced modification of treatment' (TIMT) to cover all toxicities that are responsible for changes in a planned treatment schedule. (psu.edu)
  • We define a TIMT as (i) a dose reduction, (ii) temporary interruption, (iii) discontinuation of therapy or (iv) an unanticipated switch to another regimen, as a result of treatment-induced toxicities and not because of progressive disease. (psu.edu)
  • Dive into the research topics of 'Toxicity-induced modification of treatment: what is in a name? (psu.edu)
  • Plasma miR-208a-3p was robustly increased from the first sampling point through 24 h after treatment with isoproterenol in drug-induced cardiotoxicity (6). (tamirna.com)
  • This should provide us with the detailed knowledge necessary to develop novel therapeutics for the treatment of diseases and/or detection of diseases and toxicity at an early stage. (usuhs.edu)
  • The role of copper in disulfiram-induced toxicity was investigated by clonogenic assay after treatment of human SK-N-BE(2c) neuroblastoma and UVW/noradrenaline transporter (NAT) glioma cells. (strath.ac.uk)
  • Furthermore, disulfiram treatment enhanced the toxicity of (131)I-MIBG to spheroids and xenografts expressing the noradrenaline transporter. (strath.ac.uk)
  • The treatment of pulmonary toxicity due to medicinal drugs is to discontinue (= to stop taking) the medicinal drug in question. (wikipedia.org)
  • Therefore, TPI nitrotyrosination may explain the temporal progression from Aß toxicity to NFT formation in AD brain. (upf.edu)
  • Musk ambrette negatively affects early life-stage survival and demonstrates various toxicities in zebrafish. (deepdyve.com)
  • Thus, this study demonstrates that zinc reversed the effect of copper, combating against Cu induced oxidative damage and improvement of duckweed's growth and toxicity under natural condition. (unboundmedicine.com)
  • MicroRNAs are early indicators and useful tools to detect drug-induced toxicity. (tamirna.com)
  • Toxicity can be analyzed in more detail using this system by combining the results of a variety of cellular feedbacks to a compound of interest. (enzolifesciences.com)