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  • proliferation
  • The extracellular matrix protein elastin endows the recoil and compliance required for physiologic arterial function, while disruption of function can lead to aberrant vascular smooth muscle cell proliferation manifesting through stenosis, aneurysm, or vessel dissection. (springer.com)
  • For example, cancer cells undergo epithelial to mesenchymal transition (EMT) that plays important roles in their survival, proliferation, and development of resistance to therapeutic treatments, or switch to a phenotype that mimics stem cell-like features - the so-called Cancer Stem Cells (CSCs) or Tumour-initiating Cells. (wikipedia.org)
  • A major effect of Myc is B cell proliferation. (wikipedia.org)
  • disease
  • These advances in reprogramming will enable the creation of patient-specific stem cell lines to study various disease mechanisms. (hindawi.com)
  • Grskovic M, Javaherian A, Strulovici B, Daley GQ (2011) Induced pluripotent stem cells-opportunities for disease modelling and drug discovery. (springer.com)
  • B. Winner, M. C. Marchetto, J. Winkler, and F. H. Gage, "Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease," Human Molecular Genetics , vol. 23, no. 1, pp. (hindawi.com)
  • Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors," Cell , vol. 136, no. 5, pp. 964-977, 2009. (hindawi.com)
  • Parkinson's disease induced pluripotent stem cells with triplication of the α -synuclein locus," Nature Communications , vol. 2, article 440, 2011. (hindawi.com)
  • LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction," Neurobiology of Disease , vol. 62, pp. 381-386, 2014. (hindawi.com)
  • Cell Death & Disease 6 (7): e1806. (harvard.edu)
  • By offering an unlimited source of patient-specific disease-relevant cells, iPS cells hold great promise for understanding disease mechanisms, identifying molecular targets and developing phenotypic screens for drug discovery. (harvard.edu)
  • Generation of Naivetropic induced pluripotent stem cells from Parkinson's disease patients for high-efficiency genetic manipulation and disease modeling. (springer.com)
  • Induced pluripotent stem cell technology may be uniquely suited to address current obstacles as these present a replenishable supply of patient-specific material with which to study disease. (springer.com)
  • The following review will cover the cutting edge in vascular smooth muscle cell modeling of elastin-associated vasculopathy, and aid in the development of human disease modeling and drug screening approaches to identify potential treatments. (springer.com)
  • Huntington's disease (HD), also known as Huntington's chorea, is an inherited disorder that results in death of brain cells. (wikipedia.org)
  • Current research directions include determining the exact mechanism of the disease, improving animal models to aid with research, testing of medications to treat symptoms or slow the progression of the disease, and studying procedures such as stem cell therapy with the goal of repairing damage caused by the disease. (wikipedia.org)
  • CDI cells enable new strategies for disease modeling and drug discovery work. (wikipedia.org)
  • Researchers can reprogram diseased cells of interest to study how a particular disease affects those cell types and to discover methods of repairing the cells. (wikipedia.org)
  • CDI is actively engaged in a number of large-scale iPS cell reprogramming and banking projects, with the goal of creating broadly available resources of iPS cells that represent normal human diversity, disease states and adverse drug reactions. (wikipedia.org)
  • In 2013, CIRM awarded CDI a US$16,000,000 grant to derive 3 iPS cell lines from each of 3,000 donors that represent a multitude of disease states. (wikipedia.org)
  • epithelial
  • MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition," The Journal of Biological Chemistry , vol. 286, no. 19, pp. 17359-17364, 2011. (hindawi.com)
  • The first person to successfully demonstrate reprogramming was John Gurdon, who in 1962 demonstrated that differentiated somatic cells could be reprogrammed back into an embryonic state when he managed to obtain swimming tadpoles following the transfer of differentiated intestinal epithelial cells into enucleated frog eggs. (wikipedia.org)
  • Cellular
  • This type of research gets to the fabric of the fundamental differences between stem cells and their parental cells," says Akiko Doi, a doctoral candidate in the graduate program in Cellular and Molecular Medicine at Johns Hopkins. (redorbit.com)
  • Thus, the ability to switch states/phenotypes (phenotypic plasticity) is a key feature of development and normal function of cells within most multicellular organisms that enables the cell to respond to various intrinsic and extrinsic cues and stimuli in a concerted fashion enabling them to 'make' appropriate cellular decisions. (wikipedia.org)
  • Jaiswal, Manoj K. (2012), Motoneuron specific calcium dysregulation and perturbed cellular calcium homestasis in amyotrophic lateral sclerosis: recent advances gained from genetically modified animals and cell culture models. (wikipedia.org)
  • Cellular Dynamics International (CD) was founded in 2004 by pluripotent stem cell biologist, James Thomson. (wikipedia.org)
  • Human cells are considered to be a more predictive model and a replacement for other cellular models that serve as proxies, including animal cells, immortalized cell lines, and cadaveric cells. (wikipedia.org)
  • Stemgent mRNA reprogramming kit : Full mRNA reprogramming kit which include the factors set, Pluriton Reprogramming medium, and B18R human recombinant protein (credit * EBioscience, Inc.) Pluriton Reprogramming Medium :defined, xeno-free medium optimized for mRNA based cellular reprogramming of human cells. (wikipedia.org)
  • research
  • Wu and Longaker's research thus far has taken a fairly broad swipe at reprogramming adipose fat stem cells, so the team hopes to refine the process to target only the most efficient candidates. (scientificamerican.com)
  • Other researchers in the field will be watching to see what further tests might reveal about the practicality of using fat cells instead of skin cells for iPS research. (scientificamerican.com)
  • Induced pluripotent stem (iPS) cells which represent reprogramming of somatic cells into pluripotent stem cells represent a significant advancement in research armament. (hindawi.com)
  • The research team transformed tumor-generating cell types into iPS-like cells by manipulating their genetic makeup. (redorbit.com)
  • Human stem cell research is a new field with much promise, but progress towards a clinical setting has been complicated by scientific and ethical challenges. (jhu.edu)
  • The most heated discussion over stem cell research has focused on the source of human embryonic stem cells (ESCs). (jhu.edu)
  • I argue that a new approach is needed to deal with the serious uncertainties and indeterminate probabilities intrinsic to stem cell research and decision-making surrounding it. (jhu.edu)
  • I conclude that in the current state of knowledge, stem cell research needs to continue and be allowed to unfold as the narrative of a story. (jhu.edu)
  • Robinton DA, Daley GQ (2012) The promise of induced pluripotent stem cells in research and therapy. (springer.com)
  • Information on induced pluripotent stem cell research products, defined as all research tools including but not limited to: induced pluripotent stem cells and various differentiated cells derived from induced pluripotent stem cells, various related assays and kits, culture media and medium components such as serum, growth factors and inhibitors, antibodies, enzymes, and many others that can be applied for the specific purpose of executing induced pluripotent stem cell research. (bccresearch.com)
  • various related assays and kits, culture media and medium components, such as serum, growth factors and inhibitors, antibodies, enzymes, and many others that can be applied for the specific purpose of executing induced pluripotent stem cell research. (bccresearch.com)
  • Only then will we be confident that iPS cells are a safe replacement for ES cells in research and therapy. (redorbit.com)
  • Their research results were published in the October issue of Stem Cells. (innovations-report.com)
  • For this research coup and his leading role pioneering stem cell work, Yamanaka - who holds academic appointments at Kyoto University and UC San Francisco - was the co-recipient of the 2012 Nobel Prize in Medicine or Physiology . (ucsf.edu)
  • This review will discuss the potential impact of using iPS cell-derived models in multiple sclerosis (MS) research and highlight some of the current challenges and prospective for generating novel therapeutic treatments for MS patients. (harvard.edu)
  • Shantanu Sengupta is an Indian cell biologist and a professor at the Institute of Genomics and Integrative Biology (IGIB) of the Council of Scientific and Industrial Research. (wikipedia.org)
  • May 2010, Stemgent and Miltenyi Biotec announced a strategic collaboration for co-development and commercialization of stem cell research products. (wikipedia.org)
  • In November 2011, Stemgent was nominated for a Life Science Industry Award (LSIA) in the "Breakthrough Product for Stem Cell Research" category. (wikipedia.org)
  • Stemgent currently sells over 220 products for stem cell research. (wikipedia.org)
  • germ cells
  • After fertilization some cells of the newly formed embryo migrate to the germinal ridge and will eventually become the germ cells (sperm and oocytes). (wikipedia.org)
  • Therefore, during the process of gametogenesis the primordial germ cells must have their original biparental DNA methylation patterns erased and re-established based on the sex of the transmitting parent. (wikipedia.org)
  • autologous
  • The reprogramming method paves a pathway for autologous and allogeneic cell therapy that satisfies regulatory requirements. (eurekalert.org)
  • fibroblast
  • Indeed, they were: According to the team's findings, adipose stem cells can be turned into iPS cells twice as quickly as fibroblast skin cells and with 20 times the efficiency. (scientificamerican.com)
  • However, the molecular makeup of these cells, including gene expression and epigenetic marks, was somewhere between that of a fibroblast and an ESC, and the cells failed to produce viable chimeras when injected into developing embryos. (wikipedia.org)
  • 2018
  • The global market for cell-based assays should grow from $20.1 billion in 2018 to $32.7 billion by 2023 at a compound annual growth rate (CAGR) of 10.2% from 2018 through 2023. (bccresearch.com)
  • tissues
  • They can also be taken from a patient's own skin and induced to produce other needed tissues, making the chances of immunologic rejection extremely low, eliminating the need to take immunosuppressive drugs. (redorbit.com)
  • epigenetic
  • Chou BK, Mali P, Huang X et al (2011) Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures. (springer.com)
  • Relatively little study has been done on the epigenetic nature of stem cells," says Andrew Feinberg, M.D., M.P.H., a professor of medicine at the Johns Hopkins University School of Medicine. (redorbit.com)
  • If we can use the epigenetic information to characterize these cells, this could inform how we might use them therapeutically. (redorbit.com)
  • skip
  • Being able to skip the mouse feeder cell step necessary with skin cells, along with the shortened culturing period, may make the new method more palatable to the U.S. Food and Drug Administration (FDA), which must approve such treatments for human use and prefers methods that reduce opportunities for contamination. (scientificamerican.com)
  • patient-derived
  • Recently, patient-derived iPS cells, containing donor genetic background, have offered a breakthrough approach to study human genetics of neurodegenerative diseases. (harvard.edu)
  • facilitate
  • In this system, the red operon from bacteriophage λ is transfected into E. coli cells to facilitate incorporation of linear target DNA into the E. coli genome. (wikipedia.org)