Induced macrophage. Medical search. Frequent questions

cSiO2 causes phagolysosomal membrane permeabilization (LMP) and NLRP3 inflammasome activation in alveolar macrophages. (nih.gov)
Mtb is an intracellular pathogen able to survive indefinitely under unfavorable conditions inside primary host immune cells, preferably residing in human alveolar macrophages ( 5 , 6 ). (frontiersin.org)
Treatment of human alveolar macrophages (AMs) with the synthetic GC dexamethasone (Dex) did not alter the expression of TLRs −1, −4, and −6. (frontiersin.org)
Alveolar macrophages (AMs) are the tissue-resident macrophages in the lung alveolar space. (frontiersin.org)
Granulocyte macrophage-colony-stimulating factor (GM-CSF), released from alveolar macrophages (AM), is an important regulator of eosinophil, T cell, and macrophage function and survival. (nih.gov)
Two common viral pathogens of swine, namely, porcine circovirus type 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV), were investigated in regard to their effects on monolayer cultures of swine alveolar macrophages (AMs). (scienceopen.com)
After resolution of primary pneumonia, murine alveolar macrophages (AMs) exhibited poor phagocytic capacity for several weeks. (nature.com)
Fig. 2: Recovery from infection is followed by susceptibility to secondary pneumonia and reduction in phagocytosis by alveolar macrophages in mice. (nature.com)
Fig. 3: Phagocytosis function of newly formed resident lung alveolar macrophages is altered locally by secondary inflammatory mediators released during infection. (nature.com)
Fig. 4: T reg cells and TGF-β are not major contributors to the paralysis program of alveolar macrophages. (nature.com)
Fig. 5: Phenotypic analysis origin of paralyzed alveolar macrophages. (nature.com)
Fig. 6: Sirpa is required for the priming, but not the maintenance, of the paralysis program of alveolar macrophages after infection. (nature.com)
Alveolar macrophages are crucial in processing inhaled substances including cigarette chemicals and particulate matter. (wikipedia.org)
Some of the smoker's macrophages are recruited from the circulating monocytes while some are the original alveolar macrophages residing in the lung. (wikipedia.org)
The uptake of tar from cigarettes accumulates in alveolar macrophages and causes autofluorescence. (wikipedia.org)

Activated macrophages exhibiting diverse phenotypes and various functions contribute to the pathogenesis or amelioration of different diseases like cancer, inflammation, and infectious and autoimmune diseases. (nih.gov)
Toll-like receptors (TLRs) enable innate immune cells, such as macrophages, to recognize a wide variety of microbial ligands, thereby promoting inflammation. (frontiersin.org)
Conclusions- Together these data show that EVs from stroke patients are proinflammatory in nature and are capable of inducing inflammation in immune cells. (ox.ac.uk)
As phagocytosis by macrophages plays a critical role in the control of bacteria, we investigated the phagocytic activity of macrophages after resolution of inflammation. (nature.com)
The reprogram of macrophage implies a dysregulated inflammation that can damage healthy lung cells. (wikipedia.org)
TREM-1 acts as an amplifier of inflammation expressed on macrophages. (biomedcentral.com)
Macrophages, the most predominant inflammatory cells in adipose tissue, play an important role in obesity-related inflammation [ 4 ]. (biomedcentral.com)
In contrast to M1, M2 macrophages may play an important role in down-regulation of inflammation by releasing anti-inflammatory cytokines and growth factors such as IL-10 and transforming growth factor (TGF)-β. (biomedcentral.com)
Obesity-mediated inflammation is a major cause of insulin resistance, and macrophages play an important role in this process. (umassmed.edu)
Diet-induced adipose tissue inflammation was reduced, and bone marrow-derived macrophages from Lyz- GRP78(-/-) mice demonstrated a selective increase in IL-6 expression. (umassmed.edu)
Macrophages were used because of their role in generation and secretion of multiple pro-inflammatory cytokines during inflammation, including the ones evaluated here. (emerging-researchers.org)
Although macrophages play a role in inflammation and repair, their specific roles are related to the expression and function of their surface receptors [ 4 - 6 ]. (thno.org)
Our results indicated that WGLWE alleviated joint inflammation in CIA rats and the underlying mechanism may be related to inducing the transformation of bone marrow -derived M1 macrophages to M2 macrophages , leading to an increase in the secretion of anti-inflammatory factors and a decrease in pro-inflammatory factors. (bvsalud.org)
For instance targeted deletion of IKK-β in myeloid lineage cells protected mice from high-fat (HF) diet-induced inflammation and insulin resistance [4]. (techuniq.com)
Similarly JNK1 deletion in hematopoietic cells including macrophages also ameliorated obesity-induced inflammation and insulin resistance in mice [5]. (techuniq.com)
These genetic studies demonstrate that altered macrophage inflammation plays a critical role in obesity-induced inflammation and thereby leads to systemic insulin resistance in obesity. (techuniq.com)
Therefore searching for novel agents that can antagonize macrophage inflammation may represent a therapeutic strategy for the prevention and treatment of insulin resistance and type 2 diabetes. (techuniq.com)
We previously found that two nutrient sensors AMP-activated protein kinase (AMPK) and SIRT1 interact to regulate macrophage inflammation [19]. (techuniq.com)
To understand how ENM-induced pulmonary inflammation is resolved, we analyzed the inflammatory and pro-resolving responses to fibrogenic multi-walled carbon nanotubes (MWCNTs, Mitsui-7) and low-toxicity fullerenes (fullerene C60, C60F). (cdc.gov)
These findings support a mechanism by which persistent ENM-induced neutrophilic inflammation is actively resolved through time-dependent polarization of macrophages and enhanced biosynthesis of specialized LMs via distinct ALOX pathways. (cdc.gov)

The pathogenesis of atherosclerosis involves an interplay between macrophage autophagy and apoptosis. (physiciansweekly.com)
We also studied the effects of berberine-induced TFEB activation via SIRT1 on autophagy and apoptosis of peritoneal macrophages. (physiciansweekly.com)
RNAi-mediated attenuation of Tnfrsf1b decreased TNF-α-induced netrin-1 production and augmented epithelial cell apoptosis in culture. (aacrjournals.org)
Extending these observations, colon biopsies from E. faecalis -colonized IL-10 −/− mice exhibited crypt hyperplasia and increased staining for macrophages, TNF-α, netrin-1, NF-κB, Tnfrsf1b, and the proliferation marker proliferating cell nuclear antigen while also displaying a reduction in epithelial cell apoptosis. (aacrjournals.org)
However, a lower PRRSV-induced infectious rate, cell death, and apoptosis were seen in PCV2/PRRSV group. (scienceopen.com)
RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy. (nature.com)
Its inhibitory effect on NF-κB also induces apoptosis of alveolar macrophage. (wikipedia.org)
at 5 M induced a seven-fold increase in the activity of caspase-3/7 and a 75% selective depletion of K-Ras protein levels relative to GAPDH in A549 cells that correlated with PCAIs-induced apoptosis. (vittori-lab.com)
Analysis of PCAIs C induced apoptosis The morphologic analysis, Annexin V/propidium iodide staining was used as per the manufacturers instructions to study the mode of cancer cell death upon exposure to PCAIs. (vittori-lab.com)
Recent studies have demonstrated that AMPK contributes to zinc-induced neurotoxicity and that 1H10, an inhibitor of AMPK, reduces zinc-induced neuronal death and protects against oxidative stress, excitotoxicity, and apoptosis. (mdpi.com)
Flow cytometry analysis showed reduced necrosis and apoptosis in macrophages from the tolerant group compared to the naïve group. (utmb.edu)
Oxysterol-induced macrophage apoptosis may have a role in atherosclerosis. (gasyblog.com)
A) Cells were cultured for 16 h in medium alone (-acLDL) or medium supplemented with (B) 100 μg/ml acLDL (C) 100 μg/ml acLDL and 8 μM AM-251 … Conversation In this study we show that AM-251 and SR144528 inhibit 7KC-induced macrophage apoptosis TSU-68 (SU6668) but not staurosporine-induced apoptosis. (gasyblog.com)
This suggests that AM-251 and SR144528 inhibit 7KC-induced apoptotic signaling rather than apoptosis in an over-all selectively. (gasyblog.com)
The observation that concentrations of AM-251 and SR144528 essential to inhibit 7KC-induced apoptosis also obstructed TSU-68 (SU6668) sterol esterification in macrophages helps the hypothesis that these compounds prevent 7KC-induced apoptosis at least partly as a consequence of their ability to inhibit oxysterol esterification. (gasyblog.com)
CB2 deficiency has been mentioned to reduce the susceptibility of macrophages to oxysterol-induced apoptosis by a mechanism that is self-employed or downstream of ACAT [15]. (gasyblog.com)
Although ACAT inhibition in CB1 deficient macrophages was not evaluated with this study it seems unlikely that AM-251 inhibition of 7KC-induced apoptosis is due to affects on CB1 signaling as the concentration of AM-251 required to block apoptosis is nearly two orders of TSU-68 (SU6668) magnitude greater than the reported Ki ideals for inhibition of CB1 receptor signaling [20]. (gasyblog.com)
The results showed that Sp110 interacts with heat shock protein 5 (Hspa5) to activate endoplasmic reticulum (ER) stress-induced apoptosis, and that this is essential for Sp110 enhanced macrophage resistance to Mtb . (oncotarget.com)
This work has revealed the mechanism of Sp110 enhanced macrophage apoptosis in response to Mtb infection, and provides new insights into the study of host-pathogen interactions. (oncotarget.com)
Apoptosis induced by tungsten carbide-cobalt nanoparticle s in JB6 cells involves ROS generation through both extrinsic and intrinsic apoptosis pathways. (cdc.gov)
In this study, apoptosis and related signaling induced by WC-Co nanoparticle s were investigated in JB6 cells and rat lung macrophages. (cdc.gov)
In addition, both cytochrome c and apoptosis-inducing factor (AIF) were upregulated and released from mitochondria to the cytoplasm. (cdc.gov)
Apoptosis induced by WC-Co nanoparticle s and fine particles involves both extrinsic and intrinsic apoptosis pathways. (cdc.gov)

Intradermal transgenic expression of granulocyte-macrophage colony-stimulating factor induces neutrophilia, epidermal hyperplasia, Langerhans' cell/macrophage accumulation, and dermal fibrosis. (mcmaster.ca)
Granulocyte-macrophage colony stimulating factor induces both HLA-DR expression and cytokine production by human monocytes. (ox.ac.uk)
The effect of recombinant human granulocyte-macrophage colony stimulating factor (GM-CSF) on the expression of HLA-DR, and the production of the cytokines interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha) by human peripheral blood monocyte-enriched populations was investigated. (ox.ac.uk)

Stimulation of the cells with interferon-gamma and lipopolysaccharide induced the production of nitric oxide and increased BH4 levels further. (aspetjournals.org)
In this study, we found that lipopolysaccharide (LPS) induced CD38 upregulation and its extracellular release in J774 macrophage cells. (molcells.org)
The M1 phenotype macrophages are induced by interferon (IFN)-γ and lipopolysaccharide (LPS). (biomedcentral.com)
Treatment of ω-3 Naringenin PUFAs suppresses lipopolysaccharide (LPS)-induced cytokine manifestation in macrophages. (techuniq.com)
Additionally, alcohol inhibits the lipopolysaccharide (LPS)-induced inflammatory cytokine, interleukin-6 (IL-6), via the p38 ERK1/2 MAPK pathway [ 9 ]. (cdc.gov)
M1, "classically activated," pro-inflammatory macrophages are stimulated by cytokines such as IFN-gamma and by various microbial components (eg, lipopolysaccharide). (msdmanuals.com)

Our findings provide evidence that PPIase CypA promoted macrophages polarization toward pro-inflammatory M1 phenotype via transcriptional activating NF-κB, thus leading to aggravated arthritis. (nih.gov)
A macrophage can be polarized into the classic M1 or M2 phenotype, and this phenomenon can be seen in cigarette consumption. (wikipedia.org)
In vitro studies confirmed that anti-PS re-polarized TAMs from an M2 to M1-like phenotype and drove MDSCs to differentiate into M1-like macrophages and functional dendritic cells. (bmj.com)
Low AKR1B10 expression induced M2 macrophage polarization and promoted the malignant phenotype of GC. (portlandpress.com)
Through in-depth exploration of macrophages, recent research has shown that the phenotype of macrophages exhibits greater plasticity than previously assumed [ 3 ]. (thno.org)
MNK2 governs the macrophage antiinflammatory phenotype. (lu.se)

Moreover, the level of cytokines, such as IL-6, IL-1β, and IL-17, and the number of pro-inflammatory macrophages in synovial fluid were significantly elevated. (nih.gov)
In accordance with our observation, CypA dysregulation could actually influence the M1 macrophages polarization and pro-inflammatory cytokines production. (nih.gov)
The lysosome's role in NLRP3 inflammasome activity and its contributions to macrophage homeostasis make it of significant interest in the development of therapeutic targets for chronic inflammatory human health conditions. (nih.gov)
Analyses of publicly available datasets suggested that TLR2 is induced during the resolution phase of inflammatory diseases, i.e., under conditions associated with high endogenous GC production. (frontiersin.org)
In summary, our data show that sTLR2 and full-length TLR2 are released by macrophages under anti-inflammatory conditions, which may contribute to GC-induced immunosuppression. (frontiersin.org)
Our studies revealed that nSP induced high ROS and pro-inflammatory cytokine production, and these cellular responses may induce excess osteoclast differentiation. (springer.com)
Our data indicate that the Sia + fraction of IVIG possesses the ability to influence inflammatory processes in multiple immune cell types and induces novel signatures in cell surface marker expression and cytokine/chemokine production. (scirp.org)
Atherosclerosis is a chronic inflammatory disease that commonly affects the elderly and is characterized by vascular damage, macrophage infiltration, and plaque formation. (physiciansweekly.com)
Isolated EV fractions were subjected to untargeted proteomic analysis by liquid chromatography mass-spectrometry/mass-spectrometry and then applied to macrophages in culture to investigate inflammatory gene expression. (ox.ac.uk)
EV fractions applied to monocyte-differentiated macrophage cultures induced inflammatory gene expression. (ox.ac.uk)
Intraplaque release of inflammatory cytokines from macrophages is implicated in atherogenesis by inducing the proliferation and migration of media smooth muscle cells (SMCs). (unimi.it)
In the present study, we tested the hypothesis that PCSK9 could elicit a pro-inflammatory effect on macrophages. (unimi.it)
Taken together, the present study provides evidence of a pro-inflammatory action of PCSK9 on macrophages, mainly dependent by the LDLR. (unimi.it)
The diagnostic methods for smoke-related diseases include bronchoalveolar lavage which can also be used for examining smoker's macrophages in addition to augmented inflammatory cells in the alveolar lumen. (wikipedia.org)
To address this hypothesis, we used an in vitro model of mouse macrophage cells to assess whether the flavonoids chrysin, apigenin and/or baicalein suppress expression of the inflammatory genes IL-6, IL-1β and/or TNFα. (emerging-researchers.org)
Sepsis induces a systemic inflammatory response leading to tissue damage and cell death. (utmb.edu)
Macrophages are the core regulators of inflammatory responses, and as such, are involved in the regulation of cardiac inflammatory responses and tissue repair after AMI. (thno.org)
Furthermore, WGLWE compounds induced the transition of M1-type macrophages to M2-type macrophages in synovial tissue , resulting in decreased secretion of inflammatory factors TNF-α, WGLWE improved the synovial inflammatory state . (bvsalud.org)
In this report, we demonstrate that NF-κB, a ubiquitous transcription factor, plays an essential role in silica-induced inflammatory mediator production in the mouse macrophage cell line RAW 264.7. (psu.edu)
HDE-induced lung inflammatory aggregates clearly present in the tissue from HDE only exposed animals were not visually detectable in the HDE/alcohol co-exposure group. (cdc.gov)
M2 "alternatively activated" anti-inflammatory macrophages are stimulated predominantly by cytokines such as IL-4 and IL-13. (msdmanuals.com)

In macrophage-colony stimulating factor (MCSF) generated macrophages, Sia + IgG induced increased production of numerous cytokines/ chemokines including IL-6, TNFα, CXCL1, and IL-10, and the expression of the macrophage surface marker CD163. (scirp.org)
D. Bruder, E. , O. Richards, J. , M. Michel, K. and Oaks, M. (2016) Differential Effects of Alternative Glycoforms of IgG on Human Monocytes and Macrophages: Sialylated IgG Induces Novel Expression Signatures of Cell Surface Markers, Cytokines, and Chemokines. (scirp.org)
GM-CSF was shown to induce both the expression of HLA-DR and the cytokines IL-1 and TNF alpha in a dose-dependent manner. (ox.ac.uk)
Northern blotting showed that mRNA levels of IL-1 and TNF alpha were transiently induced, similar to other cytokines. (ox.ac.uk)
In vitro experiments demonstrated that WGLWE promoted the transformation of M1 macrophages into M2 macrophages and suppressed the release of proinflammatory cytokines TNF-α and IL-6 . (bvsalud.org)
MWCNTs and C60F induced time-dependent polarization of M1 macrophages with a peak at day 1 and subsequently of M2 macrophages with a peak at day 7 in the lung, accompanied by elevated levels of type 1 or type 2 cytokines, respectively. (cdc.gov)
At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)

Sia + IgG induced increased expression of CD80 and dendritic cell immunoreceptor (DCIR) on monocytes, whereas the expression of HLA-DR was decreased. (scirp.org)
Our data extended prior observations of Sia + IgG on DC function and showed that Sia + IgG was able to differentially modulate multiple pathways in monocytes and macrophages. (scirp.org)
The C-C chemokine receptor types 2 and 5 (CCR2 and CCR5), and their respective ligands, C-C chemokine ligand types 2 (CCL2/MCP-1) and 5 (CCL5/RANTES) play an important role in polarizing monocytes to M1 macrophages [ 12 ]. (biomedcentral.com)
Mechanism involved in interleukin-21-induced phagocytosis in human monocytes and macrophages Clinical & Experimental Immunology , vol. 187 , nº 2. (inrs.ca)
Although the biological activities of IL-21 and its cell signalling events have been largely studied in immunocytes, its interaction with human monocytes and macrophages have been neglected. (inrs.ca)
Previously, we reported that IL-21 enhances Fc gamma receptor (FcRγ)-mediated phagocytosis in human monocytes and in human monocyte-derived macrophages (HMDM) and identified Syk as a novel molecular target of IL-21. (inrs.ca)
These results obtained in human monocytes and macrophages have to be considered for a better exploitation of the IL-21/IL-21R system for therapeutic purposes. (inrs.ca)
Notably, CRIg is expressed in monocyte-derived macrophages but not in human and mouse monocytes. (thno.org)
Monocytes in the circulation are precursors to tissue macrophages. (msdmanuals.com)
Monocytes migrate into tissues, where over approximately 8 hours, they develop into macrophages. (msdmanuals.com)

The present study examined the effects of Sia + IgG on human peripheral blood mononuclear cell (PBMC)-derived monocyte and macrophage surface marker expression and cytokine/chemokine secretion. (scirp.org)
Here, we report that the central proinflammatory cytokine TNF-α acts as a diffusible mediator of the bystander effects induced by macrophages, an effect caused by a proliferation of macrophages that trigger epithelial cell production of Netrin-1, a neuronal guidance molecule. (aacrjournals.org)
Tetrahydrobiopterin is required for cytokine-induced nitric oxide production in a murine macrophage cell line (RAW 264). (aspetjournals.org)
The results presented here support previous suggestions, based on experiments with isolated enzymes, that BH4 is absolutely required for cytokine-stimulated nitric oxide production in macrophages and they suggest that only a small fraction of the total intracellular BH4 pool in macrophages is utilized in the production of fully active nitric oxide synthase. (aspetjournals.org)
To address this hypothesis we measured cytokine expression and examined NF-κB signaling in ω-3 PUFA-treated macrophages using luciferase reporter assays electrophoretic mobility shift assays (EMSA) and Chromatin immunoprecipitation (ChIP) assays. (techuniq.com)
In contrast, mice on a fiber-rich diet were completely protected from irradiation-induced bacterial infiltration and exhibited a similar serum cytokine profile as sham-irradiated mice on a fiber-rich diet. (lu.se)

Despite the antimicrobial activity of macrophages, Mtb has been able to establish a series of strategies to handle the host immune machinery, interfere with, and arrest the phagosome maturation, counteract mycobactericidal molecules and ultimately survive in a hostile intracellular environment ( 8 - 10 ). (frontiersin.org)
These altered immune cells are derived from several signaling pathways and are able to induce numerous respiratory diseases. (wikipedia.org)
Externalized PS interacts with immune cells where it actively promotes immunosuppression and tumor progression by expansion of myeloid derived suppressor cells (MDSCs) and M2-like tumor associated macrophages (TAMs). (bmj.com)
Furthermore, in the immune-competent TRAMP mouse prostate tumor model, combination treatment of anti-PS antibody with castration induced strong tumor-specific T-cell immunity that resulted in significantly improved tumor free long-term survival and apparent cures in 35% of the animals, compared to no long-term survivors in groups treated with either single agent. (bmj.com)
The M. marinum surface-exposed lipooligosaccharides (LOS) are immunogenic molecules that participate in the early interactions with macrophages and modulate the host immune system. (biomedcentral.com)
It can also induce granulomatous infection in humans called "fish tank disease" [ 2 ] and, as other nontuberculous mycobacteria, is responsible for opportunistic infections in immune-deficient patients [ 4 ]. (biomedcentral.com)
The uptake of mycobacteria by professional phagocytes, such as macrophages, is dependent upon the early recognition of the pathogen-associated molecular patterns (PAMPs) by specific pathogen recognition receptors (PRRs) that are crucial in initiating and driving the host immune response. (biomedcentral.com)
To comprehend potential new mechanisms of immune regulation in endotoxemia, we examined macrophage mRNA expression by macroarray affected by LPS tolerance. (utmb.edu)
Results: Macrophage polarization was the main immune infiltration pattern in GC, and the state of macrophage polarization was closely related to the pathological grading of GC and the clinical stage of patients. (portlandpress.com)
Conclusion: M2 macrophage polarization is the main immune infiltration pattern in GC. (portlandpress.com)
3. Makeeva A. Bacillus pumilus ribonuclease binase induces proinflammatory immune response in macrophages [Text] / Makeeva A., Surchenko Y., Cabrera-Fuentes H.A., Rodriguez-Montesinos J., Zelenikhin P., Preissner K., Ilinskaya O. // Europian journal of clinical investigation. (kpfu.ru)
RAE-1-NKG2D interactions provide a mechanism by which NK cells and infected macrophages communicate directly during an innate immune response to infection. (elsevierpure.com)

Our findings reveal that hypoxic exosomal PKM2 induces M2 macrophage polarization via AMPK/p38 pathway, and thus exerts a simulative effect on the growth and metastasis of lung carcinoma. (researchsquare.com)
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. (lu.se)

TNF-α-mediated bystander assays used a murine coculture system of primary colonic epithelial cells and E. faecalis -infected macrophages ( in vitro ), with an interleukin 10 (IL-10)-deficient mouse model of colon cancer that involves long-term colonization with E. faecalis ( in vivo ). (aacrjournals.org)
RAE-1 proteins are found on the surface of activated, but not resting, macrophages and can be detected by NKG2D on NK cells resulting in down-regulation of this receptor both in vitro and in vivo. (elsevierpure.com)
The material from each step isscreened using acellular and in vitro assays for evaluating general toxicity, mechanisms of toxicity, and macrophage function. (cdc.gov)
Polarization of macrophages in vitro differentially induced ALOX5AP in M1 macrophages or ALOX15 in M2 macrophages resulting in increased preferential biosynthesis of proinflammatory LMs or SPMs. (cdc.gov)

Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages. (physiciansweekly.com)
Taken together, our data indicate that GRP78 deficiency activates UPR by increasing ATF-4, and promotes M2-polarization of macrophages with a selective increase in IL-6 secretion. (umassmed.edu)
Low AKR1B10 expression induces M2 macrophage polarization and promotes the malignant transformation of GC. (portlandpress.com)
Moreover, we revealed that hypoxia promotes VSIG4 expression in cultured bone marrow M2 macrophages, ultimately leading to the conversion of CFs to myofibroblasts. (thno.org)

The ligand is specific for the 4-1BB RECEPTOR and may play a role in inducing the proliferation of activated peripheral blood T-LYMPHOCYTES. (bvsalud.org)
Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages. (lu.se)

V-set and immunoglobulin domain-containing 4 (VSIG4) is a complement receptor of the immunoglobulin superfamily (CRIg) that is specifically expressed in resting tissue-resident macrophages [ 7 , 8 ]. (thno.org)

The interaction of GCs with macrophages in the immunosuppressive resolution phase upon prolonged TLR activation is widely unknown. (frontiersin.org)
the second stimulus is DAMPs that induce the activation of caspase-1 ( 3 , 5 , 8 , 9 ). (spandidos-publications.com)
Without glycoconjugate (GC) activation, murine macrophages were killed by Bacillus toxins. (listlabs.com)
Increased levels of inducible nitric oxide (NO) production by macrophages in presence of GCs suggest that GCs provide an activation signal for macrophages and stimulate their function. (listlabs.com)
Results hint to GCs that promote neutralization of Bacillus toxins, block toxin-induced macrophage death, while increasing macrophage activation. (listlabs.com)
LPS induced an increase in NF-kappaB activation as examined by p50 translocation assay without suppression by PD 098059 or by SB 203580. (nih.gov)
ObjectiveThe aim of this study was to investigate (a) macrophage migration inhibitory factor (MIF) levels in polytrauma patients and rats after haemorrhagic shock (HS), (b) the potential of the MIF inhibitor ISO-1 to reduce multiple organ dysfunction syndrome (MODS) in acute (short-term and long-term follow-up) HS rat models and (c) whether treatment with ISO-1 attenuates NF-kappa B and NLRP3 activation in HS. (unito.it)
Therefore, MAP kinases ERK and JNK control PMA-induced macrophage differentiation of HL-60 leukemia cells through AMPK/mTORC1-independent, TFEB/FOXO-mediated transcriptional and beclin-1-dependent post-translational activation of autophagy. (ac.rs)
In addition, macrophages from transgenic cattle with increased Sp110 expression confirmed that activation of the ER stress response is the main pathway through which Sp110-enhanced macrophages impart resistance to Mtb . (oncotarget.com)
macrophage swelling via activation of AMPK/SIRT1 pathway. (techuniq.com)
In conclusion ω-3 PUFAs negatively regulate macrophage swelling by deacetylating NF-κB which functions through activation of AMPK/SIRT1 pathway. (techuniq.com)

We provide the first evidence that LOSs inhibit the interaction between mycobacterial cell wall ligands and appropriate macrophage pattern recognition receptors, affecting uptake and elimination of the bacteria by host phagocytes. (biomedcentral.com)
Macrophages recognize the presence of infection by using the Toll-like receptor (TLR) family of proteins that detect ligands on bacterial, viral, and fungal pathogens. (elsevierpure.com)
We show that murine macrophages stimulated with pathogen products known to signal through TLRs express ligands for the NKG2D receptor, found on NK cells activated CD8 + T cells and activated macrophages. (elsevierpure.com)
Hamerman, JA , Ogasawara, K & Lanier, LL 2004, ' Cutting Edge: Toll-Like Receptor Signaling in Macrophages Induces Ligands for the NKG2D Receptor ', Journal of Immunology , vol. 172, no. 4, pp. 2001-2005. (elsevierpure.com)

CD38, an ADP ribosyl cyclase, is a 45 kDa type II transmembrane protein having a short N-terminal cytoplasmic domain and a long C-terminal extracellular domain, expressed on the surface of various cells including macrophages, lymphocytes, and pancreatic β cells. (molcells.org)

3) levels of interferon-alpha (IFN-α) and tumor necrosis factor-alpha (TNF-α) produced and their association with the extent of virus-induced cytopathology. (scienceopen.com)
TNF induces pathogenic programmed macrophage necrosis in tuberculosis through a mitochondrial-lysosomal-endoplasmic reticulum circuit. (nihr.ac.uk)

Further studies provided solid evidence that adipose cells in obesity displays improved infiltration of macrophages and that a major source of the adipose swelling comes from infiltrated macrophages [2] [3]. (techuniq.com)

Knockdown or overexpression of CypA macrophage cells was used to study the functions of CypA on macrophage polarization. (nih.gov)
Our results revealed that nSP exerted higher cytotoxicity in macrophage cells compared with submicron-sized silica particles. (springer.com)
However, tartrate-resistant acid phosphatase (TRAP) activity and the number of osteoclast cells (TRAP-positive multinucleated cells) were not changed by nSP treatment in the presence of receptor activator of nuclear factor κB ligand (RANKL) at doses that did not induce cytotoxicity by silica particles. (springer.com)
Collectively, the results suggested that nanosilica exerts no effect on RANKL-induced osteoclast differentiation of RAW264.7 cells, although a detailed mechanistic examination of the nSP70-mediated cytotoxic effect is needed. (springer.com)
Furthermore, it is possible that nSP circulating in the blood can reach the alveolar bone, which is presented in the submucosal layer, as well as various cells such as macrophages and osteoblasts. (springer.com)
Ovarian cancer stem cells induce the M2 polarization of macrophages through the PPARγ and NF-κB pathways. (stembook.org)
The PRRSV-induced cytopathic effect (CPE) on MARC-145 cells or swine AMs was markedly reduced by pre-incubation of the cells with UV-treated or non-UV-treated supernatants of PCV2-infected AMs. (scienceopen.com)
RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. (nature.com)
Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells. (cdc.gov)
Further, LPS-induced IL-1β upregulation was inhibited by 50% when cells were pre-treated with apigenin. (emerging-researchers.org)
My contribution to the research included culturing mouse macrophage cells to be used for the experiment. (emerging-researchers.org)
However, a deeper shortening of the LOS structure was associated with increased entry of M. marinum into host cells and increased elimination of the bacilli by the macrophages. (biomedcentral.com)
MAP kinase-dependent autophagy controls phorbol myristate acetate-induced macrophage differentiation of HL-60 leukemia cells. (ac.rs)
We investigated the mechanisms and the role of autophagy in the differentiation of HL-60 human acute myeloid leukemia cells induced by protein kinase C (PKC) activator phorbol myristate acetate (PMA). (ac.rs)
PMA-triggered differentiation of HL-60 cells into macrophage-like cells was confirmed by cell-cycle arrest accompanied by elevated expression of macrophage markers CD11b, CD13, CD14, CD45, EGR1, CSF1R, and IL-8. (ac.rs)
Pharmacological or genetic inhibition of ERK or JNK suppressed PMA-triggered nuclear translocation of TFEB and FOXO1/3, ATG expression, dissociation of pro-autophagic beclin-1 from its inhibitor BCL2, autophagy induction, and differentiation of HL-60 cells into macrophage-like cells. (ac.rs)
Pharmacological or genetic inhibition of autophagy also blocked PMA-induced macrophage differentiation of HL-60 cells. (ac.rs)
Mandic M, Misirkic Marjanovic M, Vucicevic L, Jovanovic M, Bosnjak M, Perovic V, Ristic B, Ciric D, Harhaji-Trajkovic L, Trajkovic V. MAP kinase-dependent autophagy controls phorbol myristate acetate-induced macrophage differentiation of HL-60 leukemia cells. (ac.rs)
Inhibition of Lipid Droplet Accumulation in Macrophages by AM-251 and SR144528 The hallmark of early atherosclerosis is the formation of macrophage-derived foam cells. (gasyblog.com)
Co-culture with hypoxia/exos-treated macrophages enhanced the migration, invasion, and epithelial-mesenchymal transition (EMT) in A549 cells. (researchsquare.com)
It is progressively identified that adipose cells plays a key part in obesity-induced swelling [1]. (techuniq.com)
This development occurs under the influence of macrophage colony-stimulating factor (M-CSF), which is secreted by various cell types (eg, endothelial cells, fibroblasts). (msdmanuals.com)
Macrophages are phagocytic cells present in tissues throughout the body. (msdmanuals.com)
Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity. (lu.se)

Cultured macrophages can take on foam cell characteristics when they ingest acLDL via TSU-68 (SU6668) receptor-mediated mechanisms and in an ACAT-dependent mechanism store the acLDL-derived cholesterol as cholesteryl esters within lipid droplets in the cytosol. (gasyblog.com)
However, the association and mechanism of macrophages polarization involved in lung cancer progression remain to be elucidated. (researchsquare.com)

Collagen-induced arthritis (CIA) was employed to address the pro-arthritic effects of CypA. (nih.gov)
A rat model of collagen-induced arthritis (CIA) was established by injecting an emulsion of bovine type II collagen mixed with an equal volume of incomplete Freund's adjuvant into the tail , paw and back of rats . (bvsalud.org)

Regardless of active or passive smokers, macrophage accumulation is found in the lungs. (wikipedia.org)
Macrophages cultured in the presence of acLDL and AM-251 (Fig. 4C) or SR144528 (Fig. 4D) displayed substantially reduced accumulation of lipid droplets. (gasyblog.com)
Fig. 4 Lipid droplet accumulation in Natural 264.7 macrophages is inhibited by AM-251 and SR144528. (gasyblog.com)

In contrast, interferon-gamma (IFN-gamma), which induced major histocompatibility complex (MHC) class II expression, did not induce IL-1 or TNF alpha production. (ox.ac.uk)

Both ENMs induced high levels of proinflammatory leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) with peaks at day 1, and high levels of SPMs resolvin D1 (RvD1) and E1 (RvE1) with peaks at day 7. (cdc.gov)

In this work, we have tested the human canonical members of the RNase family using a spot-culture growth inhibition assay based mycobacteria-infected macrophage model for evaluating their anti-tubercular properties. (frontiersin.org)
Comparable inhibition of acLDL-stimulated lipid droplet formation by AM-251 and SR144528 was observed with murine peritoneal macrophages (data not shown). (gasyblog.com)
As inhibition of ACAT slows macrophage foam cell. (gasyblog.com)

Our data suggests that TREM-1 overexpression and M1 macrophage polarization are associated with obesity-induced IR. (biomedcentral.com)

The murine macrophage cell line RAW 264 constitutively synthesizes tetrahydrobiopterin (BH4), the cofactor required for the hydroxylation of the aromatic amino acids and for the production of nitric oxide. (aspetjournals.org)

We found that berberine promoted autophagy of peritoneal macrophages by activating SIRT1 via the NAD synthesis pathway and, in turn, promoting TFEB nuclear translocation and deacetylation. (physiciansweekly.com)

Out of the seven tested recombinant human RNases, we have identified two members, RNase3 and RNase6, which were highly effective against Mycobacterium aurum extra- and intracellularly and induced an autophagy process. (frontiersin.org)
Among the PRRs, Toll-like receptor 2 (TLR2) and complement receptor 3 (CR3) have been demonstrated to play key roles in macrophage- Mycobacterium interactions [ 6 ]. (biomedcentral.com)

Similar time and dose dependent effects of CSE are exerted on macrophage polarization through the MAPK signaling pathway which involves JNK and ERK as intermediate signaling molecules. (wikipedia.org)
The apoptotic signaling pathway induced by oxLDL/oxysterols in macrophages depends upon ACAT-mediated oxysterol esterification[10]. (gasyblog.com)
Hypoxic exosomal PKM2 induced M2 polarization of macrophages by activating AMPK/p38 pathway. (researchsquare.com)
Moreover, we found that hypoxic exosomal PKM2 induced M2 polarization of macrophages through AMPK/p38 pathway, thus contributing to the promotion of tumor progression. (researchsquare.com)

Genes that are upregulated by GC treatment, such as dual-specificity phosphatase 1 (DUSP1), GC-induced leucine zipper (GILZ), and interleukin (IL)-10, are highly immunosuppressive and contribute to the overall effect of GC treatment ( 1 - 3 ). (frontiersin.org)

Serum from patients with systemic vasculitis induces alternatively activated macrophage M2c polarization. (lu.se)

In addition, we found that the M. aurum infection of human THP1 macrophages modulates the expression of endogenous RNase3 and RNase6, suggesting a function in vivo . (frontiersin.org)
Sia + IgG also increased the expression of cell surface markers associated with macrophage polarization (e.g. (scirp.org)
10 microM), also prevented GM-CSF expression and release induced by LPS, indicating that GM-CSF release is NF-kappaB-dependent. (nih.gov)
Macrophage-derived IL-6 stimulates the myocyte expression of IL-13 and regulates muscle glucose metabolism in a paracrine manner. (umassmed.edu)
The data demonstrate that apigenin significantly suppressed LPS-induced expression of IL-1β. (emerging-researchers.org)
Macrophages were isolated from the spleen and the expression of 1200 genes was quantitatively analyzed by the macroarray technique. (utmb.edu)
Consequently, the expression of Bcl2, usually stabilized by Ncl, was downregulated in Sp110 overexpressing macrophages. (oncotarget.com)
By itself, GM-CSF did not induce surface class II expression on the human monocytic tumour cell line THP-1, whereas it synergized with IFN-gamma to induce surface expression. (ox.ac.uk)
We also examined the effects of ω-3 PUFAs on AMPK expression phosphorylation and activity and SIRT1 expression in macrophages. (techuniq.com)
M1 macrophages exhibited preferential induction of arachidonate 5-lipoxygenase activating protein (ALOX5AP), whereas M2 macrophages had a high level expression of arachidonate 15-lipoxygenase (ALOX15). (cdc.gov)

We observed the proteins internalization within macrophages and their capacity to eradicate the intracellular mycobacterial infection at a low micro-molar range. (frontiersin.org)
To assess the impact of AM-251 and SR144528 on foam cell formation we stained macrophages with oil reddish O a dye selective for intracellular neutral lipids. (gasyblog.com)

The objective of this study was to evaluate the relationship between TREM-1 and macrophage polarization, and association of TREM-1 and M1 macrophage polarization with insulin resistance (IR) in obese population compared to non-obese population. (biomedcentral.com)
Here, we show that mice with macrophage-selective ablation of GRP78 (Lyz- GRP78(-/-)) are protected from skeletal muscle insulin resistance without changes in obesity compared with wild-type mice after 9 wk of high-fat diet. (umassmed.edu)
Thus, our findings identify a novel crosstalk between macrophages and skeletal muscle in the modulation of obesity-mediated insulin resistance. (umassmed.edu)

A recently discovered transcription factor, transcription factor EB (TFEB) is known to activate autophagy in macrophages. (physiciansweekly.com)

Such adaptation was not induced by direct encounter of the pathogen but by secondary immunosuppressive signals established locally upon resolution of primary infection. (nature.com)

Signal-regulatory protein α (SIRPα) played a critical role in the establishment of the microenvironment that induced tolerogenic training. (nature.com)
The 78-kDa glucose-regulated protein (GRP78) is a major endoplasmic reticulum chaperone that modulates unfolded protein response (UPR), and mice with GRP78 heterozygosity were resistant to diet-induced obesity. (umassmed.edu)

Luciferase reporter assays electrophoretic mobility shift assays (EMSA) and Chromatin immunoprecipitation (ChIP) assays display that treatment of macrophages with ω-3 PUFAs significantly inhibits LPS-induced NF-κB signaling. (techuniq.com)

The effect of hPCSK9 on TNF-α mRNA in murine LDLR-/- bone marrow macrophages (BMM) was significantly impaired as compared to wild-type BMM (4.3 ± 1.6 fold vs 31.1 ± 6.1 fold for LDLR-/- and LDLR+/+, respectively). (unimi.it)

The short-term exposure attracts macrophages and neutrophils to the lung with a 4-fold increase in cellularity. (wikipedia.org)

Current literature shows that particulate-induced NLRP3 inflammasome activity correlates to a decrease in cytosolic K+, which is assumed to be K+ efflux from the cytosol to the extracellular matrix. (nih.gov)

Flow cytometry was performed to investigate the populations of M1 and M2 macrophages in synovial tissues of the mice. (nih.gov)
Microscopic lesions consistent with postweaning multisystemic wasting syndrome (PMWS) were present in both PCV2- and PCV2/PRRSV-inoculated pigs and included lymphoid depletion, necrotizing hepatitis, mild necrotizing bronchiolitis, and infiltrates of macrophages that occasionally contained basophilic intracytoplasmic inclusion bodies in lymphoid and other tissues. (scienceopen.com)

Co-culture of THP-1 macrophages with HepG2 overexpressing hPCSK9 also showed the induction of TNF-α (2.4 ± 0.5 fold) and IL-1β (8.6 ± 1.8 fold) mRNA in macrophages. (unimi.it)

Catalase exhibited an inhibitory effect on WC-Co nanoparticle -induced ROS as well as mitochondrial membrane permeability damage. (cdc.gov)

Here, we have identified 253 proteins in mouse macrophages that interact with Sp110, of which 251 proteins were previously uncharacterized. (oncotarget.com)

The polarization effect of WGLWE on bone marrow-derived macrophages (BMDM) was determined. (bvsalud.org)

Anatomy38

Organisms26

Diseases10

Chemicals and Drugs112

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes50

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

Alveolar macrophages15

Inflammation20

Apoptosis23

Granulocyte-Macrop3

Lipopolysaccharide6

Phenotype6

Inflammatory21

Cytokines7

Monocytes10

Cytokine6

Immune12

Metastasis2

Vitro4

Promotes4

Proliferation2

Tissue-resident macrophages1

Activation11

Ligands4

Lymphocytes1

Necrosis2

Infiltration1

Cells24

Mechanism2

Collagen-Induced Arthritis2

Accumulation3

Interferon-gamma1

Proinflammatory1

Inhibition3

Overexpression1

Murine macrophage1

Peritoneal macrophages1

Mycobacterium2

Pathway4

Interleukin1

Systemic1

Expression10

Intracellular2

Insulin resistance3

Autophagy1

Immunosuppressive1

Protein2

Inhibits1

Significantly1

Neutrophils1

Extracellular1

Tissues2

MRNA1

Inhibitory effect1

Proteins1

Bone1