• In this review, we discuss the dualistic effects of histamine: how histamine affects inflammation of the immune system through the activation of intracellular pathways that induce the production of inflammatory mediators and cytokines in different immune cells and how histamine exerts regulatory functions in innate and adaptive immune responses. (hindawi.com)
  • Degradation of IκB frees NF-κB for translocation into the nucleus, where it binds to specific consensus sequences in promoter regions of NF-κB-dependent genes to initiate transcription of pro-inflammatory cytokines [ 6 ]. (biomedcentral.com)
  • In Gram-negative bacterial sepsis, production of excess pro-inflammatory cytokines results in hyperinflammation and tissue injury. (nature.com)
  • Anti-inflammatory cytokines such as IL-10 inhibit inflammation and enhance tissue healing. (nature.com)
  • Here, we report a novel approach to treat septicemia associated with intra-abdominal infection in a murine model by delicately balancing pro- and anti-inflammatory cytokines. (nature.com)
  • Proinflammatory cytokines (TNF-α, MIP-1, i-NOS) were decreased significantly and restoration of tissue damage was observed in all organs. (nature.com)
  • We approached this issue with a small natural product derived oligosaccharide with TLR4 modulating activity that delicately balances the immune system and the production of anti-inflammatory and pro-inflammatory cytokines in a murine model of peritonitis. (nature.com)
  • Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
  • Generally, CD8 + cytotoxic T-cells and CD4 + helper T-cells, which belong to the adaptive immune system, control the development of cancer via mechanisms like the production of pro-inflammatory cytokines (eg. (cambridgemedicine.org)
  • However, the tumour may evade immune responses through regulatory T-cell-mediated immune suppression in the tumour microenvironment, defective antigen presentation, and production of immunosuppressive cytokines (5). (cambridgemedicine.org)
  • We previously showed that genotoxic stress induced an active extracellular release of nucleophosmin (NPM) in human cardiac mesenchymal progenitor cells, and that serum deprivation provokes NPM secretion from human endothelial cells, eliciting inflammation via nuclear factor kappa B (NF-kB) transcriptional activation. (frontiersin.org)
  • Overall, exploiting the impact of histamine on innate and adaptive immune responses may be helpful for understanding receptor signaling and trends during inflammation or regulation. (hindawi.com)
  • Radiation-induced inflammation is mainly caused by activation of NF-κB, a preformed dimeric transcription factor sequestered in the cytosol by its inhibitor molecules of the IκB-family. (biomedcentral.com)
  • Interestingly, succinate plays key dual roles during inflammatory responses, leading to net inflammation or anti-inflammation depending on factors like the cellular context. (haematologica.org)
  • Eicosanoids consist of at least several hundred individual molecules and play important roles in the inflammatory response and inflammation-related cancers. (bvsalud.org)
  • This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (worldsbest.rehab)
  • CBD and THC, the two most common cannabinoids have potent anti-inflammatory properties i.e. they can reduce inflammation in the body thus affecting the intensity and frequency of pain. (itshemp.in)
  • CBD reduces inflammation by blocking the inflammatory mediators and changing the nature of repair cells from pro-inflammatory to anti-inflammatory . (itshemp.in)
  • We showed that the intratracheal administration of bvPLA2 markedly suppressed the OVA-induced allergic airway inflammation by reducing AHR, overall area of inflammation, and goblet cell hyperplasia. (blogspot.com)
  • Knockdown of KDM1B inhibits cell proliferation and induces apoptosis of pancreatic cancer cells. (cancerindex.org)
  • Hence inducing apoptosis is a desired mode of treating cancer (Tansuwanwong et. (nutraculture.com)
  • Nutraculture™ Phycocyanin™ induces apoptosis in the existing and proliferating cancer cells and being a natural antioxidant, it also helps getting rid of any cancer promoting oxidative stress. (nutraculture.com)
  • It is established that Phycocyanin induces apoptosis in cancer cells by changing the Bcl-2/Bax ratio (Bcl-2 is an anti apoptotic protein, Bax is a pro-apoptotic protein, the ratio of Bcl-2/Bax represents the degree of apoptosis) and the release of Cyt-c in the cytosol (Lu et. (nutraculture.com)
  • Our results show that 2HF induced apoptosis in both histological types of lung cancer and inhibited proliferation and growth through suppression of CDK4, CCNB1, PIK3CA, AKT and RPS6KB1 (P70S6K) signaling. (oncotarget.com)
  • To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (worldsbest.rehab)
  • It is a natural, water soluble and non-toxic molecule with potent anti-cancer , anti oxidant and anti-inflammatory properties. (nutraculture.com)
  • According to researchers at the University of Minnesota, several studies have evidenced that "propolis has strong hepatoprotective, antitumor, antioxidative, antimicrobial and anti-inflammatory properties. (blogspot.com)
  • Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. (hindawi.com)
  • Inflammatory mediators play a critical role in the pathogenesis and potential management of intra-abdominal sepsis. (nature.com)
  • Both the innate stimuli, such as lipopolysaccharides and Poly inositol-cytosine and adaptive stimuli, that is, cytokine mix, were able to induce the extracellular release of NPM in immortalized keratinocytes and human skin fibroblasts in the absence of cytotoxicity. (frontiersin.org)
  • The connotation of the word chemotherapy excludes more selective agents that block extracellular signals (signal transduction). (worldsbest.rehab)
  • Moreover, NPM is crucial for inflammatory gene expression induced by tumor necrosis factor alpha (TNF-α) and lipopolysaccharides (LPS) in fibroblasts and macrophages ( 6 ). (frontiersin.org)
  • Moreover, clinical management of radiation-induced skin toxicity often requires radiotherapy treatment gaps, thereby reducing the probability of loco-regional tumor control [ 2 ]. (biomedcentral.com)
  • Dosage of chemotherapy can be difficult: If the dose is too low, it will be ineffective against the tumor, whereas, at excessive doses, the toxicity (side-effects) will be intolerable to the person receiving it. (worldsbest.rehab)
  • Pre-clinical evidence suggests that MDSC suppress anti-tumor immune responses. (iospress.com)
  • An immune cell in the tumor microenvironment that may be important for inhibiting the immune response against bladder cancer is the myeloid derived suppressor cell (MDSC). (iospress.com)
  • The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. (worldsbest.rehab)
  • First-generation CAR T-cells consist only of the TCR-derived CD3ζ intracellular signalling domain, which induces T-cell activation as illustrated in Figure 1 (6, 8). (cambridgemedicine.org)
  • The second-generation CAR T-cells consist of one additional co-stimulatory component (mainly CD28, CD137 or CD134) in the intracellular domain, which amplifies anti-tumour responses in vivo (8). (cambridgemedicine.org)
  • To date, three broad approaches to adjunctive (non-antibiotic) therapy have been considered for the treatment of sepsis: (1) optimizing oxygen delivery through oxygenation/ventilation strategies and fluid/vasopressor use to maintain peripheral perfusion, (2) reducing bacterial virulence factors via anti-endotoxin antibodies and endotoxin removal columns and (3) targeting host response factors using corticosteroids, anti-cytokine drugs, and anticoagulants. (nature.com)
  • In clinical conditions, parietal cell dysfunction can be induced by antiparietal cell antibodies. (medscape.com)
  • Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (worldsbest.rehab)
  • This induces metabolic and hormonal changes that. (hrb.ie)
  • Following the cecal ligation and puncture (CLP) procedure, intravenous dosing of AVR-25 (10 mg/kg, 6-12 h post-CLP) alone and in combination with antibiotic imipenem protected both young adult (10-12 week old) and aged (16-18 month old) mice against polymicrobial infection, organ dysfunction, and death. (nature.com)
  • Senescence-associated secretory phenotype (SASP) can be induced by telomere dysfunction. (oaepublish.com)
  • Telomeric DNA damage-induced mitochondrial dysfunction and increased reactive oxygen species production are hallmarks of premature senescence. (oaepublish.com)
  • All chemotherapy regimens require that the recipient be capable of undergoing the treatment. (worldsbest.rehab)
  • Current chemotherapy regimens apply drug treatment in cycles, with the frequency and duration of treatments limited by toxicity. (worldsbest.rehab)
  • The use of rifabutin-containing antituberculosis regimens should always include an assessment of the patient's response to treatment to decide the appropriate duration of therapy (i.e., 6 months or 9 months). (cdc.gov)
  • Interestingly, NPM interacts with Toll-like receptor (TLR)4 in these cells and activates an NF-kB-dependent inflammatory pathway upregulating interleukin IL-6 and COX-2 gene expression. (frontiersin.org)
  • In this study, we explored the effect of topically-applied tea extracts on the duration of radiation-induced skin toxicity. (biomedcentral.com)
  • Tea extracts are an efficient, broadly available treatment option for patients suffering from acute radiation-induced skin toxicity. (biomedcentral.com)
  • To date, the majority of previous studies have aimed to prevent or attenuate skin reactions but did not focus on the duration of radiation-induced skin toxicity, if present. (biomedcentral.com)
  • 2010). Polycyclic aromatic hydrocarbon exposure standard mammogram form and the interactive kinase in response to estradiol in breast cancer in oesophageal tissue and risk of oesophageal threshold measurement methods. (who.int)
  • Allergic asthma was induced in female BALB/c mice by intraperitoneal administration of ovalbumin (OVA) on days 0 and 14, followed by intratracheal challenge with 1% OVA six times between days 22 and 30. (blogspot.com)
  • Malaria-specific antibody responses and parasite persistence after infection of mice with Plasmodium chabaudi chabaudi. (mdc-berlin.de)
  • Thus, new therapeutic approaches are needed to effectively inhibit the hyperinflammation produced by the overwhelming cytokine response during bacterial infection without developing resistance to secondary infection in abdominal infections like peritonitis. (nature.com)
  • Zinc is necessary for normal cell functioning, nerve signaling, and for the body to protect against infection or disease. (mskcc.org)
  • Chronic inflammatory changes related to gastric Helicobacter pylori infection can also induce parietal cell changes. (medscape.com)
  • This cytokine response may be responsible for the uncontrolled activation of the systemic inflammatory cascade. (nature.com)
  • Surface staining of thioglycolate-induced peritoneal exudate cells (PECs) with Anti-Mouse CD115 (c-fms) PE. (thermofisher.com)
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (worldsbest.rehab)
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (worldsbest.rehab)
  • Myeloid derived suppressor cells (MDSC) are immune cells that dampen immune responses. (iospress.com)
  • THC interacts with the CB2 receptors in the immune cells and reduces the body's pain-inducing response to an injury. (itshemp.in)
  • In response, CAR T-cells have been designed with receptors that can proliferate and retain their function following antigen exposure (6). (cambridgemedicine.org)
  • In the Kcne2 potassium channel ancillary subunit knockout model, disruption of this gene induces achlorhydria and is related to reduced parietal cell protein secretion and abnormal parietal cell morphology. (medscape.com)
  • This promising field may open new avenues to modulate inflammatory responses and to preserve blood cell homeostasis in the clinical setting. (haematologica.org)
  • The choice of chemotherapy depends on several factors, including the patient's performance status, age, renal function, desire for inpatient or outpatient therapy, and likelihood of receiving future autologous stem cell transplantation. (medscape.com)
  • Growing evidence demonstrates that various cancer treatment modalities, including chemotherapy, radiation therapy, targeted therapy, immunotherapy, hormone therapy, stem cell or bone marrow transplant, and surgery [ 3 - 5 ] , cause premature senescence, as reviewed elsewhere [ 6 - 8 ] . (oaepublish.com)
  • However, there are notable challenges with CAR T-cell therapy, including non-sustained responses, antigen escape, and life-threatening adverse effects. (cambridgemedicine.org)
  • The efficiency of chemotherapy depends on the type of cancer and the stage. (worldsbest.rehab)
  • It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing chemotherapy and Weed. (worldsbest.rehab)
  • Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). (worldsbest.rehab)
  • Chemotherapy may be given with a curative intent or it may aim to prolong life or to palliate symptoms. (worldsbest.rehab)
  • Telomeric DNA damage response induced by some cancer treatments can persist for months, possibly accounting for long-term sequelae of cancer treatments. (oaepublish.com)
  • The pain management oil from Ananta Hemp Works is a Vijaya leaf extract formulation that helps manage inflammatory and neuropathic pain. (itshemp.in)
  • How does Vijaya extract reduce Inflammatory Pain? (itshemp.in)
  • Doxorubicin liposomal is a pegylated formulation that protects the liposomes and, thereby, increases blood circulation time. (medscape.com)
  • Histamine shows a dichotomous nature, whereby it is able to promote inflammatory and regulatory responses that contribute to pathological processes, such as allergy induction, as well as homeostatic functions, such as intestinal regulation. (hindawi.com)
  • Recent evidence obtained in mouse models shows its essential role regulating blood cell function through various mechanisms that include pseudohypoxia responses by hypoxia-inducible factor-1α activation, post-translational modifications like succinylation, and communication mediated by succinate receptor 1. (haematologica.org)
  • Inflammatory conditions (e.g., allergy, asthma, and autoimmune diseases) have long been thought to be mainly mediated by the activation of histamine receptor 1 (H1R). (hindawi.com)
  • First, achlorhydria has been defined by a peak acid output in response to a maximally effective stimulus that results in an intragastric pH greater than 5.09 in men and greater than 6.81 in women. (medscape.com)
  • In this review, we summarize recent findings about the regulation of the immune response by histamine. (hindawi.com)
  • We found that NPM was induced in 6 skin biopsies compared to 6 normal skin biopsies and was markedly increased in lesional (LS) vs. non-lesional skin (NLS) biopsies. (frontiersin.org)
  • 1998). This natural molecule is an innovative revolution not only to address the unique health care needs of newly diagnosed cancer patients and patients already undergoing cancer treatment (including chemotherapies , radiotherapies etc) but is also a cancer preventive measure. (nutraculture.com)
  • Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx ) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. (worldsbest.rehab)
  • Numerous studies have revealed the critical role of premature senescence induced by various cancer treatment modalities in the pathogenesis of aging-related diseases. (oaepublish.com)
  • In the current times where dissipated lifestyle and other counting factors such as dietary, physical, mental mismanagements, drug administration intoxicifications in the form of chemotherapies and chemical toxicities are adding up to the cumulative risk of cancer occurrence, consumption of Nutraculture™ Phycocyanin™ is essentially required. (nutraculture.com)
  • Among the origins of achlorhydria that are related to medical care, medications like proton pump inhibitors that block H + /K + -ATPase activity can induce achlorhydria. (medscape.com)
  • Cisplatin-based chemotherapy has been the best option for decades, but only 50% of patients benefit in the form of objective responses, and just 13-25% experience a complete response [ 1 ]. (iospress.com)
  • Immune checkpoint blockade can lead to durable complete responses for some patients, but overall objective response rates are only 15-31% [ 2-4 ]. (iospress.com)
  • Pain is the human body's most common response to discomfort. (itshemp.in)
  • Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called medical oncology . (worldsbest.rehab)