Loading...
  • mesenchymal cells
  • Fibroblasts are prototypical mesenchymal cells responsible for synthesizing the extracellular matrix, thus preserving the structural integrity of connective tissues [ 1 ]. (jcancer.org)
  • For instance, after initial epithelialization of an amputated zebrafish fin stump, epithelial and/or mesenchymal cells induce effectors of pathways mediated by Fgfs, Igfs, Wnts, Hhs, Activin-βA/TGFβ, Retinoic acid, Bmps, and Notch [ 15 - 27 ]. (prolekare.cz)
  • In many cases these maneuvers lead to improvement in conscious state should trigger further bleeding physicians need to be identii ed to determine if you are shown in fig patients with bmikg m a vasopressin v receptors aqp channels in the first visible sign of diabetes during surgery the a abcsa see chapter specific infections e g bupivacaine lignocaine lidocaine each of these embryonic lung mesenchymal cells around the proximal end. (nationalnewstoday.com)
  • regenerative response
  • Because the p53/p21 axis plays a central role in the DNA damage response and cell cycle control, we directly tested the hypothesis that p21 down-regulation could functionally induce a regenerative response in an appendage of an otherwise nonregenerating mouse strain. (pnas.org)
  • Based on their findings, we have begun a new series of experiments that likely will lead to novel therapeutic approaches to inducing a regenerative response in humans. (uci.edu)
  • amputation
  • Transient induction of this component by amputation polarizes the basal layer of the nascent epithelium, and, in turn, facilitates the synthesis of signaling factors, the positioning of ligand receptors, and the patterning of new bone cells. (prolekare.cz)
  • functionally
  • ESCs are obtained from inner cell mass, characterized by unlimited self-renewal and pluripotentiality, which allow them to differentiate into various specialized cells types in a morphologically and functionally way, characteristics that make them attractive for developing differentiated kidney cells (DKCs) [ 9 ]. (biomedcentral.com)
  • ligand
  • Ligand binding induces receptor dimerization and intermolecular transphosphorylation of the receptor subunits, thereby initiating FGFR signaling. (embopress.org)
  • ectopic
  • We discovered that grafting urea-treated anterior ECM into an anterior wound site does not produce an ectopic blastema. (uci.edu)
  • We hypothesize that heparan sulfates within the ECM play a regulatory role in growth factor activity, and that signaling from the ECM is necessary for the induction of ectopic blastemas but is not sufficient for ectopic limb development. (uci.edu)
  • tissues
  • Therefore, we can use extracellular matrix from different tissues to study cell behavior interaction in vitro . (zjrms.com)
  • Once wounded, their cells become activated and start to remodel tissues and organs back to the pre-existing state. (wikipedia.org)
  • Cell tracking has demonstrated the existence of lineage-specific progenitors giving rise to corresponding regenerated tissues ( 1 ). (pnas.org)
  • It is unclear to what extent differentiated cells reverse mature phenotypes and to what extent undifferentiated cells, such as stem cells, residing within differentiated tissues become activated, followed by their incorporation into the blastema. (rupress.org)
  • unclear
  • Moreover, it remains unclear how energy and resources are made available to dividing cells even during starvation. (pnas.org)
  • plasticity
  • It is increasingly clear that epithelial and endothelial cells enjoy some of this plasticity, which is easily demonstrated by studying the process of epithelial-mesenchymal transition (EMT). (jci.org)
  • As we discuss in this Personal Perspective, we believe that context and various changes in plasticity biomarkers can help identify at least three types of EMT and that using a collection of criteria for EMT increases the likelihood that everyone is studying the same phenomenon - namely, the transition of epithelial and endothelial cells to a motile phenotype. (jci.org)
  • migrate
  • In addition, when the behavior of cells in the Dll null clones was observed during the larval stages, they were found to segregate from distal imaginal disc epithelium and to migrate towards the presumptive proximal cells ( Wu and Cohen, 1999 ). (biologists.org)
  • undergo
  • Mitotic cells might undergo senescence by failing to replicate. (hindawi.com)
  • S-phase indices were comparable, irrespective of whether the cells were exposed to IGFs or not, which suggests that WCCS-1 cells undergo cell death at random during the cell cycle rather that from the prereplicative phase. (bmj.com)
  • populations
  • Therefore, the average behavior of cell populations cannot be reliably used to infer the trajectories of the cells they comprise. (jccfund.org)
  • This method opens up the possibility of marking and perturbing gene function inducibly in any definable cell populations in the axolotl, a key functionality required for the precise, rigorous understanding of processes such as regeneration. (pnas.org)
  • However, due to the lack of targeted gene knockin approaches, it has been difficult to label and manipulate some of the cell populations that are crucial for understanding the mechanisms underlying regeneration. (pnas.org)
  • IGFs
  • Aim -To study the effects of insulin-like growth factors (IGFs) on the growth phenotype of a Wilms's tumour cell line (WCCS-1). (bmj.com)
  • Wilms's tumour cells grown in vitro respond to either of the IGFs by an increased rate of cell death. (bmj.com)
  • Even though growth inhibitory effects have been recorded previously for IGF-II, 12 and IGF II can act as a tumour suppressor in vivo, we show for the first time that both IGFs can induce cell death-in one Wilms's tumour derived cell line at least-rather than unequivocally acting as a survival factor for tumour cells. (bmj.com)
  • apoptosis
  • The occurrence of apoptosis as well as necrosis was confirmed by annexin-V staining of cell cultures. (bmj.com)
  • By analogy to other organisms, apoptosis has been thought to be the mechanism by which cell number is reduced during the remodeling processes associated with the continuous adaptation of the animal to new body sizes during starvation. (pnas.org)
  • Histological analysis indicated that the loss due to BMP-2 overexpression was the result of increased cell condensation and apoptosis while the loss caused by Noggin was due to a decrease in cell division. (biomedcentral.com)
  • Lee, Lee, Jung, Park, Park, Hahm: Late reactivation of sonic hedgehog by Helicobacter pylori results in population of gastric epithelial cells that are resistant to apoptosis: implication for gastric carcinogenesis. (anticorps-enligne.fr)
  • cellular
  • At the molecular level, in fact, a gradual weakening of the cellular processes regulating cardiovascular homeostasis occurs in aging cells. (hindawi.com)
  • Because of its function, the name "nurse cell" has been given to the cellular components. (biomedcentral.com)
  • Due to its remarkable ability of regeneration, an injured muscle cell initiates a finely orchestrated set of cellular responses, resulting in the regeneration of a well-innervated, fully vascularized and contractile muscle apparatus. (biomedcentral.com)
  • and it has remained unsettled whether adult newts possess a cellular population that is equal to mammalian satellite cells. (rupress.org)
  • adult
  • Embryonic or adult SCs by definition are characterized by their self-renewal and potentiality, peculiarities that allow them to give rise to more SCs and differentiate into various cell lineages under appropriate conditions. (biomedcentral.com)
  • Reversible change in which one adult cell type is replaced by another adult cell type of the same germ cell line. (brainscape.com)
  • Earlier studies identified a cell population that is closely apposed to the myofiber in the adult newt limb as well. (rupress.org)
  • intrinsic
  • It is crucial, therefore, to understand the molecular mechanisms of regeneration and the intrinsic and extrinsic signals that induce and promote this process. (biomedcentral.com)
  • Additionally, a neutral and alkaline comet assay displayed a persistent level of intrinsic DNA damage in cells derived from the MRL mouse. (pnas.org)
  • HeLa
  • DAP-1, together with DAP-kinase, has been identified as a positive mediator of programmed cell death induced by γ-IFN in HeLa cells. (pnas.org)
  • To address the mechanisms by which viruses induce and interact with the autophagy pathway, I am using poliovirus infection in HeLa cells that have several key autophagy genes knocked out by Crispr-Cas9. (jccfund.org)
  • stem cell
  • Our findings provide insights into the complex interconnections among cell proliferation, homeostasis, and cell death in planarians and perspectives for the understanding of neoblast stem cell dynamics. (pnas.org)
  • In this study, we have established efficient CRISPR/Cas9 mediated gene knockin approaches in the axolotl ( Ambystoma mexicanum ), which has allowed us to genetically mark two critical stem cell pools for limb and spinal cord regeneration. (pnas.org)
  • regulate
  • Always suspect medication when there is a thickening on the blood film for red blood cells present in kidney development cell a liu s m celsi g glucocorticoids regulate the gbm and on the. (nationalnewstoday.com)
  • mammalian
  • I seek to improve this system and implement it in mouse embryos to study dynamics of cell state transitions in early mammalian development. (jccfund.org)
  • structures
  • As we know interaction between cells and ECM provides suitable three-dimensional structures. (zjrms.com)
  • While it is commonly accepted as an aging-related phenomenon, senescence might happen also during the embryonic development with the biological meaning of replacing transient structures or specific cell types with other ones [ 3 - 5 ]. (hindawi.com)