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  • mutations
  • DNA alkylation induces mutations, inhibits replication, and is implicated in carcinogenesis, in the development of neurodegenerative diseases, and in aging. (aacrjournals.org)
  • In contrast to the protected state entered by normal cells during fasting, cancer cells are unable to adapt, a phenomenon called differential stress sensitization (DSS), based on the notion that most mutations are deleterious and that the many mutations accumulated in cancer cells promote growth under standard conditions but render them much less effective in adapting to extreme environments (Lee et al. (anti-aging-plan.com)
  • In the presence of single-stranded DNA regions, due to the action of different external cues (that induce mutations), the major bacterial recombinase (RecA) binds to this DNA regions and is activated by the presence of free nucleotide triphosphates. (wikipedia.org)
  • survival
  • 2012). In mouse models of metastatic tumors, combinations of fasting and chemotherapy that cause DSR and DSS, result in 20 to 60% cancer-free survival compared to the same levels of chemotherapy or fasting alone, which are not sufficient to cause any cancer-free survival (Lee et al. (anti-aging-plan.com)
  • Although bacteria have evolved complex molecular strategies to maintain their shape, many are able to alter their shape as a survival strategy in response to protist predators, antibiotics, the immune response, and other threats. (wikipedia.org)
  • Under this mechanism, daughter cells are protected from receiving damaged copies of the bacterial chromosome, and at the same time promoting bacterial survival. (wikipedia.org)
  • P = .05) were associated with HCC tumor recurrence.Liver transplant combined with chemotherapy is an excellent treatment that provides long-term disease-free survival in children diagnosed with advanced HBL and HCC. (stanford.edu)
  • phosphorylation
  • This response was characterized by transient phosphorylation of extracellular signal-related kinase (ERK) and Akt (protein kinase B [PKB]), lack of activation of c-JUN NH2-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), and variable activation of phospholipase Cγ2 (PLCγ2) and nuclear factor-κB (NF-κB). (bloodjournal.org)
  • Pretreatment with the JNK inhibitor, SP600125, suppressed DMAC-induced JNK phosphorylation, which was accompanied by a reversal of Bcl-XL expression. (jove.com)
  • protein
  • In addition, suppressing c-Jun N-terminal protein kinase (JNK), but not extracellular-regulated protein kinase (ERK) or p38, substantially diminished DMAC-induced cell death and caspase-3 and PARP cleavage. (jove.com)
  • cycles
  • By contrast, animal data from multiple laboratories indicate that the combination of fasting cycles with chemotherapy is highly and consistently effective in enhancing chemotherapeutic index and has high translation potential. (anti-aging-plan.com)
  • functional
  • We propose that the expression of selected RNA-based HIV-1 inhibitors in the CD4+ cells derived from GM-HSPC will protect them from HIV-1 infection and results in a sufficient immune repertoire to control HIV-1 viremia resulting in a functional cure for HIV-1/AIDS. (mdpi.com)
  • Moreover
  • Moreover, analysis of early signaling events induced by IgM ligation indicate that the 2 subsets may also differ in their capacity to transmit BCR-derived stimuli. (bloodjournal.org)
  • inflammatory response
  • The skin also participates in the inflammatory response to protect the rest of the body from potential pathogens. (personalcaretruth.com)
  • In conclusion, PDT mediated by Lipo-AlClPc is capable of activating an inflammatory response, providing support to be used at least as an adjunct therapy to surgical treatments, allowing greater tumor control for long periods and, possibly, greater control of metastatic foci. (omicsonline.org)
  • drugs
  • Studies of organ specific radioprotection and in total body irradiation-induced hematopoietic syndrome in the mouse model for protection/mitigation facilitate rational means by which to move candidate small molecule drugs along the drug discovery pipeline into clinical development. (frontiersin.org)
  • development
  • This review highlights aims to provide a narrative for the involvement of Toll-like receptor (TLR4) in the development of chemotherapy-induced GI mucositis, an already emerging theme within this field. (deepdyve.com)
  • suggest
  • Our data suggest that this might be an incomplete view that needs to be implemented with measurements of other estrogen receptor functions as well, such as those that are related to AP-1. (redorbit.com)