• The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
  • This study demonstrates that debcl and the pro-fission gene drp1 are necessary downstream of buffy to trigger a mitochondrial fragmentation during rbf1 -induced apoptosis. (sdbonline.org)
  • Interestingly, rbf1 -induced apoptosis leads to a debcl - and drp1 -dependent Reactive Oxygen Species production, which in turn activates the Jun Kinase pathway to trigger cell death. (sdbonline.org)
  • RvD1 seems to advertise alveolar epithelial restore by stimulating ATII cells wound repair, proliferation, reducing apoptosis, and inhibiting TGF-β-induced EMT. (perfect-curve.com)
  • Gain of function and loss of function experiments showed that PDCD4 induced turnover (proliferation and apoptosis) of HUVECs. (plos.org)
  • PDCD4 induces turnover (proliferation and apoptosis) of HUVECs. (plos.org)
  • Proven by the use of apoptosis-resistant cellular models and autophagic assays, such isoquinoline alkaloid-induced cytotoxic effect involves energy- and autophagy-related gene 7 (Atg7)-dependent autophagy that resulted from direct activation of AMP activated protein kinase (AMPK). (oncotarget.com)
  • OBJECTIVE: The aim of this study was to test whether acupuncture could modify the threshold of tolerance to thermal and electrical stimuli. (daneurope.org)
  • The electrical stimuli on the skin preferentially activate low-threshold, myelinated nerve fibers. (medscape.com)
  • With the support of various diagnosis technologies including positron emission tomography (PET), magnetic resonance imaging (MRI), and computed tomography (CT), surgery, radiotherapy, chemotherapy, and hormone therapy are generally applied to treat patients with cancer, including those three deadliest carcinomas. (frontiersin.org)
  • Adoptive Cell Therapy can bypass consequences like the hair loss associated to chemotherapy or the burns that happen during radiotherapy. (icmab.es)
  • A temperature range of 42°C to 45°C is used therapeutically as a single agent or as an adjuvant to radiotherapy, chemotherapy or immunotherapy in the cancer treatment [ 2 , 3 ]. (oncotarget.com)
  • Hyperthermia acts as a sensitizer to radiotherapy, chemotherapy and immunotherapy, and thus, this has attracted interest in developing effective combination strategies that exploit using hyperthermia in combination with other therapies. (oncotarget.com)
  • The directed expression of Buffy in the dopamine producing neurons, via aDdc-Gal4 transgene, resulted in flies with increased climbing ability and enhanced survival, while the inhibition of Buffy in the dopaminergic neurons reduced climbing ability over time prematurely, similar to the phenotype observed in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
  • The directed expression of Buffy in DA neurons provides protection and counteracts the alpha-synuclein-induced Parkinson disease-like phenotypes. (sdbonline.org)
  • 3 When our temperature increases, hypothalamic neurons induce sweating and cutaneous vasodilation to dissipate heat. (ajnr.org)
  • Using genetic labeling strategies, we can identify subpopulations of sensory neurons that are involved in the transduction of specific stimuli. (painchannels.com)
  • A high peak concentration may affect neurons, protected by the blood brain barrier, and stem cells in their niches. (rapamycin.news)
  • Low calcium levels decrease the threshold of excitation of neurons, causing them to have repetitive responses to a single stimulus. (medscape.com)
  • In this regard, photoresponsive DDSs that employ light as an external stimulus can offer a precise spatiotemporal control of drug release at desired sites of interest. (biomedcentral.com)
  • In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage. (peacehealth.org)
  • However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage. (peacehealth.org)
  • Magmas, a gene encoding for the mitochondrial import inner membrane translocase subunit, Tim16, protects different cell lines from the antitumoral effects of several pro-apoptotic stimuli (i.e. chemicals and chemotherapeutic agents). (endocrine-abstracts.org)
  • During cellular starvation, AMPK induces autophagy by phosphorylating Ulk1, the mammalian counterpart of ATG1, at Ser 317 and 777 [ 3 , 4 ]. (oncotarget.com)
  • Out of the seven tested recombinant human RNases, we have identified two members, RNase3 and RNase6, which were highly effective against Mycobacterium aurum extra- and intracellularly and induced an autophagy process. (frontiersin.org)
  • Neurologic abnormalities induced by heat stroke involve the brain (especially the basal ganglia and thalami), cerebellum, anterior horn cells in the spinal cord, and peripheral nerves. (ajnr.org)
  • Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent side effect of paclitaxel and oxaliplatin treatment of cancer (70-90% of patients receiving these drugs). (painchannels.com)
  • Chemotherapy induced peripheral neuropathy (CIPN) is a frequent, disabling side effect of anticancer drugs. (painchannels.com)
  • Ethoxyquin (EQ), a quinolone-based antioxidant, has demonstrated neuroprotective properties against several neurotoxic drugs in a phenotypic screening and is shown to protect axons in animal models of chemotherapy-induced peripheral neuropathy. (nature.com)
  • We previously identified ethoxyquin (EQ) as a potent neuroprotective compound through a phenotypic screen against three neurotoxic drugs and demonstrated that it prevents development of peripheral neuropathy in paclitaxel and cisplatin models of chemotherapy-induced peripheral neuropathy (CIPN). (nature.com)
  • Both compounds induced up-regulation of proapoptotic BH3-only proteins Bim and Puma, and subsequent cell death. (ashpublications.org)
  • The synthetic Compound 5 is capable of sensitizing chemoresistant tumor cells overexpressing Magmas to proapoptotic stimuli, indicating that this molecule may be useful to overcome tumor chemoresistance. (endocrine-abstracts.org)
  • Ample evidence shows that pro-atherosclerotic disturbed flow induces sustained activation of atherogenic genes in endothelial cells to promote their oxidation, inflammation, cell cycle progression and proliferation, whereas pulsatile shear stress tends to maintain endothelial cells in a quiescent and less proliferative state with a low level of oxidation and inflammation [16] , [17] . (plos.org)
  • However, thermotolerance induced by thermosensitive genes such as the heat shock proteins can limit the efficacy of hyperthermic treatment. (oncotarget.com)
  • The importance of these pathways in cancer prevention is illustrated by the fact that individuals who inherit mutations in any one of the many genes that participate in these stress-induced signal transduction pathways have a very high incidence of cancer. (the-scientist.com)
  • The transcription factor RBPJ forms a coactivator complex in the presence of a Notch signal, whereas it represses Notch target genes in the absence of a Notch stimulus. (uni-ulm.de)
  • Immunoprecipitation revealed that pulsatile shear stress induced the coupling of ubiquitin with PDCD4 expression. (plos.org)
  • Atherosclerosis plaques preferentially develop at arterial branches and curvatures under low and oscillatory or even static shear stress induced by disturbed blood flow as opposed to in straight parts, featuring protective unidirectional pulsatile shear stress [14] , [15] . (plos.org)
  • The higher (600 mg) dose ameliorated the stress induced by the test, and produced significantly improved self-ratings of calmness and alertness. (lifeextension.com)
  • The prevention of diabetes-induced mtDNA deletions may be a potential mechanism of the neuroprotective effects of EQ in diabetic neuropathy. (nature.com)
  • Finally, diabetes induced by drugs and chemicals (such as steroids used in chemotherapy and organ transplant therapy). (sajbl.org.za)
  • This compound has several uses in a variety of health conditions, and it may be useful in combating nausea and vomiting caused by chemotherapy. (cbdcontent.org)
  • It may be useful in treating chemotherapy-induced nausea, among other conditions. (cbdcontent.org)
  • CBDA inhibits vomiting induced by movement or toxins, and it also delays the onset of nausea. (cbdcontent.org)
  • CBDA also inhibited nausea caused by anticipatory stimuli, including sights, sounds, and the smell of chemotherapy. (cbdcontent.org)
  • It is often recommended for relieving chemotherapy, pregnancy, or motion sickness-related nausea. (easytohealth.com)
  • Importantly, improved intravesical bacterial immunotherapy using MBTVAC induced eradication of fully established bladder tumors, both as a monotherapy and specially in combination with the immune checkpoint inhibitor antiprogrammed cell death ligand 1 (anti PD-L1). (bvsalud.org)
  • This hyperglycemia in turn generates a new stimulus to the pancreas that makes it secrete more insulin than necessary, so that over time the pancreatic reserves of insulin are depleted. (sajbl.org.za)
  • Mechanistically, IV BCG induced tumor-specific CD8+ T cell responses, which were dependent on type 1 conventional dendritic cells, as well as NK cell-mediated immunity. (bvsalud.org)
  • In addition, they modify the body's immune responses to diverse stimuli. (nih.gov)
  • It also stimulates brain responses to sexual stimuli and may improve libido and overall sexual health. (easytohealth.com)
  • Neuropathic pain is one of the most debilitating forms of chronic pain, resulting from an injury or disease of the somatosensory nervous system, which induces abnormal painful sensations including allodynia and hyperalgesia. (researchgate.net)
  • Doxorubicin liposomal is a pegylated formulation that protects the liposomes and, thereby, increases blood circulation time. (medscape.com)
  • Although leukocyte count and serum C-reactive protein did not suggest inflammation, empiric antimicrobial chemotherapy with ceftriaxone, ampicillin, gentamicin, and acyclovir was started immediately. (cdc.gov)
  • It stimulates the immune system, helps reduce inflammation, and possesses antimicrobial properties that can help protect against bacterial and viral infections. (easytohealth.com)
  • Findings from the Cusack Laboratory have shown that conventional anti-cancer therapies, such as radiation and chemotherapy, induce resistance mechanisms under the control of the gene transcription factor NF-kappaB. (massgeneral.org)
  • In the Kcne2 potassium channel ancillary subunit knockout model, disruption of this gene induces achlorhydria and is related to reduced parietal cell protein secretion and abnormal parietal cell morphology. (medscape.com)
  • What is the primary stimulus for the secretion of ADH? (essayworldwide.com)
  • 3 Such cellular-suicide mechanisms can eliminate cells that could present problems for the whole organism because of alterations in the DNA or difficulties in dealing with stressful stimuli. (the-scientist.com)
  • For example, research has found strong associations for the Human papiloma virus (HPV) and cervical cancer, Helicobacter pylori bacterial infection and gastric adenocarcinoma , the hepatitis B virus and cirrhosis and hepato-cellular carcinoma, asbestos-induced inflammation and lung cancer, and cigarette smoke-induced inflammation and lung, bowel and pancreatic cancer. (sherrytorkos.com)
  • In other words, inflammation protects the tumour from attack by the immune system. (sherrytorkos.com)
  • Moreover RvD1 inhibited human lung fibroblast proliferation, collagen production, and myofibroblast differentiation induced by both TGF-β and bronchoalveolar lavage fluid from acute respiratory distress syndrome (ARDS) patients. (perfect-curve.com)
  • Factors that promote atherosclerosis, including cigarette smoking, hypertension, atherogenic lipoproteins, and hyperglycemia, give rise to a variety of noxious stimuli that cause the release of chemicals and the activation of cells involved in the inflammatory process. (sherrytorkos.com)
  • Emerging evidence suggests that the component secreted by exosomescan promote tumor survival,angiogenesis and metastasis, and also mediate tumor microenvironment induced drug resistance and immune escape. (bbrc.in)
  • Puzzlingly, rapamycin can induce insulin sensitivity, but may also induce insulin resistance or glucose. (rapamycin.news)
  • The chemotherapy drug cisplatin may cause kidney damage, resulting in depletion of calcium and phosphate. (peacehealth.org)
  • The rise in PTHrP allows for the rise in calcium while protecting the maternal skeleton. (medscape.com)
  • Although these cellular-suicide mechanisms may protect the organism in some physiologic settings, such as by preventing cancer, the double-edged sword is that these same DNA-damage response pathways that help prevent cancer can also contribute to debilitating disease processes. (the-scientist.com)
  • Vitamin C appears to increase the effectiveness of chemotherapy in animals and with human breast cancer cells in test tube research. (peacehealth.org)
  • When associated with dacarbazine, bixin restored the sensitivity of A2058 cells to chemotherapy, enhancing its antiproliferative, anti-migratory and pro-apoptotic effects. (perfect-curve.com)
  • They also apply physicochemical stimuli that help the cells be more rigid and active . (icmab.es)
  • En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in endothelial cells undergoing pulsatile shear stress. (plos.org)
  • People taking it also experienced stabilized body weight and a reduction in the fatigue and inertia that usually accompany this combination of chemotherapy agents. (peacehealth.org)
  • METHODS: Fatigue was induced in a small hand muscle (abductor pollicis brevis) (n = 11). (daneurope.org)
  • It also helps protect sperm from oxidative stress, a leading cause of male infertility. (easytohealth.com)
  • After ovariectomy, expression of OPG mRNA was suppressed however that of RANKL was induced. (perfect-curve.com)
  • Methods: ICH was induced by collagenase injection into the striatum of wild type (C57BL/6J) anticoagulated mice (warfarin or rivaroxaban) and Mmp10 -/- mice. (unav.edu)
  • Dr. Cusack wrote the first clinical trial of combination chemotherapy with the drug bortezomib for solid organ malignancies, reported in the journal Cancer . (massgeneral.org)
  • The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine. (peacehealth.org)
  • The chemotherapy drug cisplatin may cause depletion of sodium due to kidney damage which sometimes occurs in people treated with cisplatin. (peacehealth.org)
  • Acetyl-L-carnitine in the amount of 1,000 mg three times per day for eight weeks has been shown to improve nerve damage (neuropathy) caused by the chemotherapy drug cisplatin. (peacehealth.org)
  • Drug resistance hinder most cancer chemotherapies and leads to disease recurrence and poor survival of patients. (oncotarget.com)
  • In conclusion, isoquinoline alkaloid is a new class of compound that induce autophagic cell death in drug-resistant fibroblasts or cancers by exhibiting its direct activation on AMPK. (oncotarget.com)
  • Herein, we summarize the recent development of NIR photoresponsive DDSs with on-demand drug release profiles for cancer photo-chemotherapy. (biomedcentral.com)
  • Drug-induced secondary adrenocortical insufficiency may result from too rapid withdrawal of corticosteroids and may be minimized by gradual reduction of dosage. (nih.gov)
  • When we get cold, the hypothalamus does the opposite and induces shivering that increases heat production. (ajnr.org)
  • Today, it constitutes the standard of care for many cancer patients, along with surgery and chemotherapy. (springer.com)
  • Patients with inoperable head and neck cancer were treated with a spleen peptide preparation (Polyerga) in a double-blind trial during chemotherapy with cisplatin and 5-FU. (peacehealth.org)
  • Although general therapeutic strategies and existent nanomedicine have been applied in relating cancer treatments, the side effects and potential damage induced by the off-target effect greatly lower the therapeutic efficiency. (frontiersin.org)
  • In this review, the development of NIR photoresponsive DDSs in last several years for cancer photo-chemotherapy are summarized. (biomedcentral.com)
  • In addition, erythropoietin is used to treat anemia, either alone or in conjunction with chemotherapy. (medscape.com)
  • TRPM8-deficiency increased the amplitude of Tc oscillations and, under dim constant light, induced a greater phase delay and instability of Tc rhythmicity. (painchannels.com)
  • The choice of chemotherapy depends on several factors, including the patient's performance status, age, renal function, desire for inpatient or outpatient therapy, and likelihood of receiving future autologous stem cell transplantation. (medscape.com)
  • The aim of this study was to investigate whether or not RvD1 exerts protective results on alveolar epithelial cell perform/differentiation and protects towards fibroproliferative stimuli. (perfect-curve.com)
  • In a double-blind study, Japanese researchers found that the combination of vitamin E , vitamin C, and N-acetyl cysteine (NAC) -all antioxidants-protected against chemotherapy-induced heart damage without interfering with the action of the chemotherapy. (peacehealth.org)
  • Exposing people to what researchers have called a "scapegoat stimulus" just before the administration of chemotherapy can direct the food aversion to the "scapegoat" food instead of more important parts of the diet. (peacehealth.org)
  • It remains unclear how important this effect is or if people taking chemotherapy should take taurine supplements. (peacehealth.org)
  • In another 2004 study, lemon balm was examined for its effect on laboratory-induced stress in humans. (lifeextension.com)
  • Cooling may be achieved via invasive means (catheters that pump cold saline solution into veins) or noninvasively (water blankets and cool caps that contain crylon gel at −30°C). Cool caps are used for neonatal encephalopathy but also for less serious problems such as alopecia induced by chemotherapy (in the latter, the cold results in decreased scalp blood flow protecting the hair follicles). (ajnr.org)
  • First, achlorhydria has been defined by a peak acid output in response to a maximally effective stimulus that results in an intragastric pH greater than 5.09 in men and greater than 6.81 in women. (medscape.com)
  • Analysis revealed that Buffy acted to rescue the associated loss of locomotor ability observed in the alpha-synuclein-induced model of PD, while Buffy RNA interference resulted in an enhanced alpha-synuclein-induced loss of climbing ability. (sdbonline.org)
  • The noise-induced hearing loss is well known in studies related to the workplace. (bvsalud.org)
  • This habit in this young population is increasing the risk for the acquisition of music-induced hearing loss, the author of this study noted that 14% of youth surveyed reported risk behavior for acquiring auditory loss 4 . (bvsalud.org)
  • It aids recovery and promotes faster healing of exercise-induced muscle damage. (easytohealth.com)
  • In one trial, fruit drinks administered just before chemotherapy were most effective in protecting against aversions to other foods. (peacehealth.org)
  • Dr. Cusack organized the Mass General Peritoneal Surface Malignancy Program in 2011 and treated his first patient with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in October 2011. (massgeneral.org)
  • First, the Roux-en-Y gastric bypass surgery involves formation of a 15- to 30-mL fundal pouch. (medscape.com)
  • A modified form of vitamin A has been reported to work synergistically with chemotherapy in test tube research. (peacehealth.org)
  • Although research remains incomplete, the idea that people taking chemotherapy should avoid antioxidants is not supported by scientific research. (peacehealth.org)
  • Any person or institution that provides vaccination services should adopt these standards to improve immunization delivery and protect children, adolescents, and adults from vaccine-preventable diseases. (cdc.gov)