• Yet despite widespread interest in antioxidants, some physicians are concerned antioxidants might end up protecting tumors. (scienceblog.com)
  • Glioblastomas are intrinsic brain tumors believed to originate from neuroglial stem or progenitor cells. (frontiersin.org)
  • Not only that, but when the body starts growing tumors it's actually trying to protect itself. (healththoroughfare.com)
  • However, the combination of fasting and chemotherapy was much more effective than either alone and delayed the progression of a variety of tumors, including breast cancer and glioma, reduced the number of organs affected by melanoma metastases, and promoted long-term cancer-free survival in up to 40% of mice with neuroblastomas. (kingdomfasting.com)
  • Cycles of starvation were as effective as chemotherapeutic agents in delaying progression of different tumors and increased the effectiveness of these drugs against melanoma, glioma, and breast cancer cells. (kingdomfasting.com)
  • These studies suggest that multiple cycles of fasting promote differential stress sensitization in a wide range of tumors and could potentially replace or augment the efficacy of certain chemotherapy drugs in the treatment of various cancers. (kingdomfasting.com)
  • Reduced tumor-growth in Triphala fed mice was due to increased apoptosis in the tumors cells, which was associated with increased activation of p53 and ERK. (biomedcentral.com)
  • Devising a method for more precise and less invasive treatment of cancer tumors, a team led by researchers from the UCLA Henry Samueli School of Engineering and Applied Science has developed a degradable nanoscale shell to carry proteins to cancer cells and stunt the growth of tumors without damaging healthy cells. (understandingnano.com)
  • Tang's group continues to research ways of more precisely targeting tumors, prolonging the circulation time of the capsules and delivering other highly sought-after proteins to cancer cells. (understandingnano.com)
  • Can ferroptosis be specifically induced in tumors but not in normal tissues? (nature.com)
  • Tumors develop when this balance is disrupted by mutations that either boost the rate of cellular multiplication, or that protect the aberrant cell from appropriate programmed death. (oasisofhope.com)
  • In benign tumors, the cells have not gained the capacity to spread through healthy tissues and establish new distant colonies (metastases). (oasisofhope.com)
  • Extragonadal germinal cell syndromes are rare tumors that predominantly affect young males. (medscape.com)
  • Literature suggests that the only known risk factor for extragonadal germ cell tumors (EGCTs) is Klinefelter syndrome (47XXY), which is associated with mediastinal nonseminomatous germ cell tumors. (medscape.com)
  • In extragonadal germ cell tumors, no evidence of a primary malignancy is present in either the testes or ovaries by radiologic imaging or physical examination. (medscape.com)
  • Extragonadal germ cell tumors produce a rich symptomatology and may reach large volumes if they arise in silent areas. (medscape.com)
  • Controversy remains regarding the origin of extragonadal germ cell tumors (EGGCTs). (medscape.com)
  • The classic theory suggests that germ cell tumors (GCTs) in these areas are derived from local transformation of primordial germ cells misplaced during embryogenesis. (medscape.com)
  • According to this theory, the differences in phenotypes expressed by mediastinal germ cell tumors (MGCTs) and gonadal germ cell tumors may be explained by differences in the cellular environment between the gonad and the anterior mediastinum. (medscape.com)
  • Some retroperitoneal extragonadal germ cell tumors may represent metastases from a testicular cancer, with subsequent spontaneous necrosis of the primary tumour. (medscape.com)
  • Hematologic malignancies are frequently associated with mediastinal germ cell tumors. (medscape.com)
  • Highly differentiated yolk-sac tumors make up 30% of mediastinal germ cell tumors, providing a possible basis for this association. (medscape.com)
  • The balance of the p53-mdm2 interaction has been shown to be disrupted in intracranial germ cell tumors (ICGCTs). (medscape.com)
  • 5] Mutation of ARF, reported in 71% of intracranial germ cell tumors, results in mdm2 accumulation and functional impairment of p53. (medscape.com)
  • This abnormality was reported in 90% of seminomatous and 55% of nonseminomatous intracranial germ cell tumors (NS-ICGCTs) examined. (medscape.com)
  • Extra-gonadal germ cell tumors (EGGCTs) represent 5-10% of all germ cell tumor (GCTs). (medscape.com)
  • Small tumors have a greater percentage of actively dividing cells than do large tumors. (msdmanuals.com)
  • Using constructs downregulating or overexpressing MCL1 we demonstrate that expression of MCL1 prevents induction of apoptosis when PCa cells are grown under steroid-deprived conditions. (oncotarget.com)
  • Knockout (KO) of CDK7 in both basal and classical PDAC cells resulted in cell growth inhibition and induction of apoptosis only in basal PDAC cells. (fredhutch.org)
  • Triphala-mediated reduced cell survival correlated with induction of apoptosis, which was associated with reactive oxygen species (ROS) generation. (biomedcentral.com)
  • More than 15 years ago, cholesterol decrement was first shown to inhibit tumor cell growth, metastasis of tumor cells, and induction of apoptosis (7). (cdc.gov)
  • Clusterin (apolipoprotein J) is a 75-80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis. (wikipedia.org)
  • Overexpression of the secretory CLU isoform protects the cell from apoptosis induced by cellular stress, such as chemotherapy, radiotherapy, or androgen/estrogen depletion. (wikipedia.org)
  • Discussion Pretreatment with honey protect testis against chemotherapy and testicular IR injury, increase FSH and LH and testosterone and decrease the cellular damage and apoptosis. (greenmedinfo.com)
  • Cell proliferation involves the replication of all cellular contents with the required energy for this to happen. (hindawi.com)
  • In normal cells, glucose participates in cellular energy production through glycolysis as well as through its complete catabolism via the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). (hindawi.com)
  • This nutrient protects vital cellular energy and shields against diabetes, obesity, cardiovascular disease, and neurodegeneration. (lifeextension.com)
  • Iron accumulation is a key mediator of several cytotoxic mechanisms leading to the impairment of redox homeostasis and cellular death. (unito.it)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Here we set out to analyze whether MCL1, a known mediator of chemotherapy resistance regulates the cellular response to androgen withdrawal. (oncotarget.com)
  • Using PCa cellular models in vitro and in vivo we show that MCL1 expression is upregulated in androgen-deprived PCa cells. (oncotarget.com)
  • Activation of ISR results in a decrease in global translation and the induction of selected genes, including transcription factor ATF4, that together promote cellular recovery or death. (fredhutch.org)
  • Mitochondrial porin , also known as the voltage-dependent anion channel (VDAC), is a multi-functional channel protein that shuttles metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions. (sdbonline.org)
  • Proven by the use of apoptosis-resistant cellular models and autophagic assays, such isoquinoline alkaloid-induced cytotoxic effect involves energy- and autophagy-related gene 7 (Atg7)-dependent autophagy that resulted from direct activation of AMP activated protein kinase (AMPK). (oncotarget.com)
  • During cellular starvation, AMPK induces autophagy by phosphorylating Ulk1, the mammalian counterpart of ATG1, at Ser 317 and 777 [ 3 , 4 ]. (oncotarget.com)
  • PKB has emerged as a crucial regulator of widely divergent cellular processes including apoptosis, proliferation, differentiation and metabolism. (justia.com)
  • Our preclinical studies demonstrate that Triphala is effective in inhibiting the growth of human pancreatic cancer cells in both cellular and in vivo model. (biomedcentral.com)
  • Boswellia sacra essential oil hydrodistilled at 100 o C was more potent than the essential oil prepared at 78 o C in inducing cancer cell death, preventing the cellular network formation (MDA-MB-231) cells on Matrigel, causing the breakdown of multicellular tumor spheroids (T47D cells), and regulating molecules involved in apoptosis, signal transduction, and cell cycle progression. (biomedcentral.com)
  • Suppression of cellular network formation and disruption of spheroid development of breast cancer cells by Boswellia sacra essential oil suggest that the essential oil may be effective for advanced breast cancer. (biomedcentral.com)
  • Mutations can also arise when DNA is mis-copied or inappropriately distributed during cellular replication - which is one reason why cancers are most prone to spring up from tissues in which cells have been dividing rapidly. (oasisofhope.com)
  • The dysfunction is associated with issues with apoptosis and normal cellular metabolic regulation, all regulated through OPA1. (thermofisher.com)
  • Molecular hydrogen appears to stimulate cellular death pathways in cancerous cells. (h2hubb.com)
  • To prevent aberrant cell proliferation, these pathways are tightly regulated. (hindawi.com)
  • This activation is necessary for both cell proliferation as well as glucose uptake and use. (hindawi.com)
  • For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured. (nutrimedical.com)
  • Ellagic acid significantly reduced HOS cell proliferation, and induced apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance. (nutrimedical.com)
  • Recent reports suggest that Ivermectin exhibits strong antitumor properties that may impede the proliferation, metastasis, and angiogenesis of various cancer cell types. (healththoroughfare.com)
  • In the present study, we demonstrate that Triphala significantly inhibit the proliferation of Capan-2 and BxPC-3 human pancreatic cancer cells. (biomedcentral.com)
  • A stem cell, which has acquired mutations that promote its proliferation and survival, may give rise to a tumor. (oasisofhope.com)
  • It also stops proliferation of cancer cells by arresting them at different phases of the cell cycle and/or by inducing their apoptosis (programmed cell death). (beatcancer.org)
  • H2 has been shown to reduce the excessive expressions of MMP genes (MMP proteins are involved in multiple functions in cells, including cell proliferation, cartilage synthesis, apoptosis, angiogenesis, etc). (h2hubb.com)
  • However, potentially erroneous characterization of cytotoxicity and cell proliferation can arise if verification of baseline interaction of test article with method employed is neglected. (cdc.gov)
  • Non-tumorigenic Beas-2B cells were treated with graded concentrations of benzo[a]pyrene (B[a]P) for 24 and 48h prior to cytotoxicity and proliferation assessment with commonly used MTT, MTS, WST1, and Alamar Blue assays. (cdc.gov)
  • Many factors are involved in causing and permitting the unregulated proliferation of cells that occurs in cancer. (msdmanuals.com)
  • Overview of Cancer Cancer is an unregulated proliferation of cells. (msdmanuals.com)
  • In clear cell renal cell carcinoma, CLU functions to regulate ERK 1/2 signaling and matrix metallopeptidase-9 expression to promote tumor cell migration, invasion, and metastasis. (wikipedia.org)
  • Unlike most other cancers, which feature upregulated CLU levels to enhance tumor cell survival, testicular seminoma features downregulated CLU levels, allowing for increased sensitivity to chemotherapy treatments. (wikipedia.org)
  • Taken collectively our results highly claim that FLLL12 induces apoptosis of lung tumor cell lines by post-transcriptional rules of DR5 through activation of proteins tyrosine phosphatase(s). research. (biobender.com)
  • Essential oil prepared by distillation of the gum resin traditionally used for aromatic therapy has also been shown to have tumor cell-specific anti-proliferative and pro-apoptotic activities. (biomedcentral.com)
  • The objective of this study was to optimize conditions for preparing Boswellea sacra essential oil with the highest biological activity in inducing tumor cell-specific cytotoxicity and suppressing aggressive tumor phenotypes in human breast cancer cells. (biomedcentral.com)
  • The initiation and development of tumor cell is accompanied by elevated stresses, such as oncogene activation, DNA damage, genome instability, and reprogrammed tumor metabolism. (nature.com)
  • Studies have suggested that statins may inhibit tumor cell growth and possibly prevent carcinogenesis. (cdc.gov)
  • Current treatments for gliomas use chemotherapy, radiotherapy, tyrosine kinase inhibitors, monoclonal antibodies and surgery, but each of the treatment strategies has several serious side effects. (frontiersin.org)
  • CLU promotes cell survival by a number of means, including inhibition of BAX on the mitochondrial membrane, activation of the phosphatidylinositol 3-kinase/protein kinase B pathway, modulation of extracellular signal-regulated kinase (ERK) 1/2 signaling and matrix metallopeptidase-9 expression, promotion of angiogenesis, and mediation of the nuclear factor kappa B (NF-κB) pathway. (wikipedia.org)
  • Meanwhile, its downregulation allows for p53 activation, which then skews the proapoptotic:antiapoptotic ratio of present Bcl-2 family members, resulting in mitochondrial dysfunction and cell death. (wikipedia.org)
  • CLU may promote tumorigenesis by facilitating BAX-KLU70 binding and, consequently, preventing BAX from localizing to the outer mitochondrial membrane to stimulate cell death. (wikipedia.org)
  • In contrast to normal cells, most cancer cells predominantly produce energy by a high rate of glycolysis followed by lactate fermentation, even in the presence of oxygen, a less efficient metabolism compared to a low rate of glycolysis followed by mitochondrial oxidation of pyruvate [ 2 ]. (hindawi.com)
  • Lipoic acid increases the abundance of other protective antioxidants while improving mitochondrial function and preventing glycation-induced damage in the kidney and blood vessels of those with diabetes-thus defending against diabetic kidney disease, vision loss, and vascular dysfunction. (lifeextension.com)
  • All three triggered mitochondrial damage, caspase activation, and cell death. (medhelp.org)
  • The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
  • This study demonstrates that debcl and the pro-fission gene drp1 are necessary downstream of buffy to trigger a mitochondrial fragmentation during rbf1 -induced apoptosis. (sdbonline.org)
  • Notably, Debcl modulates Drp1 mitochondrial localization during apoptosis. (sdbonline.org)
  • These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)
  • Oxidative stress and mitochondrial damage triggers cytochrome-c mediated caspase dependent apoptosis while microtubule disruption results in p53 and poly (ADP-ribose) polymerase activated cell death in peripheral neurons. (edu.hk)
  • Development of mechanical and thermal allodynia with decreased sensory nerve conduction velocity due to mitochondrial dysfunction and intra-epidermal nerve fiber (IENF) loss has been reported as a distinct pathobiological feature of Paclitaxel induced peripheral neuropathy in animal models. (edu.hk)
  • The Cdk5-AMT signal pathway involved in regulation of DDR by TIGAR defines a new role of TIGAR in cancer cell survival and it suggests that TIGAR may be a therapeutic target for cancers. (nature.com)
  • Unlike most other cancers, where metastases from the site of origin is the main cause of death, GBM very rarely metastasizes outside the neuraxis. (frontiersin.org)
  • Abnormal metabolism and the evasion of apoptosis are considered hallmarks of cancers. (hindawi.com)
  • In conclusion, isoquinoline alkaloid is a new class of compound that induce autophagic cell death in drug-resistant fibroblasts or cancers by exhibiting its direct activation on AMPK. (oncotarget.com)
  • Also, PKB is overexpressed in 15% of ovarian cancers, 12% of pancreatic cancers and 3% of breast cancers, and was shown to produce a survival signal that protects cells from apoptosis thus contributing to resistance to chemotherapy. (justia.com)
  • Some mutations, often observed during the early evolution of cancers, increase the propensity of cells to accumulate further mutations. (oasisofhope.com)
  • Pre-cancerous cells - as well as fully evolved cancers - tend to be very genetically labile. (oasisofhope.com)
  • Such cells are prone to give rise to full-blown cancers, which may be relatively difficult to kill with chemotherapy or radiation. (oasisofhope.com)
  • They are believed to repopulate cancers after chemotherapy and/or radiation treatment. (msdmanuals.com)
  • Cancers such as doxorubicin are commonly used in cancer leukaemia, colorectal, breast, lung, and so on are chemotherapy. (who.int)
  • Honey can decrease the side effects of chemotherapy on reproductive system and prevent sterility. (greenmedinfo.com)
  • PMID: 29791311 Abstract Title: Protective effects of persian honey, Apis Mellifera Meda Skorikov on side effects of chemotherapy and ischemia/reperfusion induced testicular injury. (greenmedinfo.com)
  • Abstract: Introduction The aim of the present study was to survey the protective effect of pretreatment with Persian honey on amelioration of side effects of chemotherapy and ischemia/reperfusion induced testicular injury. (greenmedinfo.com)
  • Two to 4 days of fasting before chemotherapy treatment is safe and protect animals, and possibly humans, against the side effects of chemotherapy. (kingdomfasting.com)
  • Because of this broad ability to promote stress resistance, DR could in theory be applied in the clinic to protect patients from toxic side effects of chemotherapy. (kingdomfasting.com)
  • Reduced the function of proteins in the pancreatic cancer cell membranes that are responsible for pumping chemotherapy out of the cell, making the cells chemo-sensitive. (scienceblog.com)
  • Similarly, Triphala induced apoptosis in another pancreatic cancer cell line BxPC-3 by activating ERK. (biomedcentral.com)
  • Oddly enough inhibition of global phosphatase activity aswell as proteins tyrosine phosphatases (PTPs) however not of alkaline Ecdysone phosphatases highly inhibited DR5 manifestation and considerably inhibited apoptosis (p (biobender.com)
  • Whole grains provide fiber and important nutrients, while lean proteins such as fish, poultry, and legumes offer essential amino acids for cell repair and maintenance. (brainboost.blog)
  • Both proteins can localize at the mitochondrion , but the way they control apoptosis still remains unclear. (sdbonline.org)
  • Western blot analysis was performed to study Boswellia sacra essential oil-regulated proteins involved in apoptosis, signaling pathways, and cell cycle regulation. (biomedcentral.com)
  • The polymer shells are developed under mild physiological conditions so as not to alter the chemical structure of the proteins or cause them to clump, preserving their effectiveness on the cancer cells. (understandingnano.com)
  • Some of these "oncogenic" (cancer-causing mutations) boost the intensity of growth signals that cause the cell to multiply, or disable key proteins that restrain these growth signals. (oasisofhope.com)
  • Others impair the function of proteins that are required for efficient apoptosis. (oasisofhope.com)
  • Previous study revealed that the protective effect of TIGAR in cell survival is mediated through the increase in PPP (pentose phosphate pathway) flux. (nature.com)
  • We have previously reported that TIGAR plays a pro-survival role in cancer cells through increase PPP flux 19 . (nature.com)
  • Only two Bcl-2 family genes have been found in Drosophila melanogaster including the pro-cell survival, human Bok-related orthologue, Buffy. (sdbonline.org)
  • The directed expression of Buffy in the dopamine producing neurons, via aDdc-Gal4 transgene, resulted in flies with increased climbing ability and enhanced survival, while the inhibition of Buffy in the dopaminergic neurons reduced climbing ability over time prematurely, similar to the phenotype observed in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
  • Taken all together this demonstrates a role for Buffy, a Bcl-2 pro-cell survival gene, in neuroprotection. (sdbonline.org)
  • Drug resistance hinder most cancer chemotherapies and leads to disease recurrence and poor survival of patients. (oncotarget.com)
  • Protein kinases are involved in signal transduction pathways linking growth factors, hormones and other cell regulation molecules to cell growth, survival and metabolism under both normal and pathological conditions. (justia.com)
  • In mice injected with human breast and ovarian cancer cells, fasting cycles promoted survival extension by protecting the mice from chemotherapy while causing a strong inhibition of tumor progression. (kingdomfasting.com)
  • In mouse models of neuroblastoma, fasting cycles plus chemotherapy drugs-but not either treatment alone-resulted in long-term cancer-free survival. (kingdomfasting.com)
  • Exposure of Capan-2 cells to the aqueous extract of Triphala for 24 h resulted in the significant decrease in the survival of cells in a dose-dependent manner with an IC50 of about 50 μg/ml. (biomedcentral.com)
  • Most of these mutations are either innocuous, having no significant impact on the behavior or survival of the cell, or are deleterious to the cell, dooming it to an early death. (oasisofhope.com)
  • The levels of pAkt and pGSK3β (cell survival pathways), mainly expressed in neurons, were markedly up-regulated. (h2hubb.com)
  • These nutrients replenish the body's level of antioxidants, protecting the patients from infectious diseases. (healthydietbase.com)
  • Finally, dried oyster mushrooms are an excellent source of antioxidants, which help to protect the body against free radical damage. (magicmushroombars.biz)
  • These foods are not only delicious but also packed with nutrients and antioxidants that may help protect against cancer. (brainboost.blog)
  • Similarly, berries such as strawberries, blueberries, and raspberries are rich in antioxidants that help protect cells from damage and inhibit the growth of cancer cells. (brainboost.blog)
  • This includes essential antioxidants, which protect against and treat chronic diseases. (healthbymushrooms.com)
  • These powerful antioxidants keep harmful free radicals at bay, preserving cell health. (healthbymushrooms.com)
  • Antioxidants protect against the damage that causes premature ageing, cancer, and inflammatory diseases. (healthbymushrooms.com)
  • Other pathways CLU participates in to downplay apoptosis in tumor cells include the PI3K/AKT/mTOR pathway and NF-κB pathway. (wikipedia.org)
  • Ablation of the expression of the components of the extrinsic apoptotic pathway (DR5 caspase-8 and Bid) by siRNA significantly protected cells from FLLL12-induced apoptosis (p (biobender.com)
  • We examined the effect on megakaryocytes of three agents that activate the intrinsic apoptosis pathway in other cell types: etoposide, staurosporine, and the BH3 mimetic ABT-737. (medhelp.org)
  • According to Bishop and Lynch: "After infecting endothelial cells, HHV-8 activates the mTOR pathway, alters the cells to have mesenchymal differentiation, and promotes aberrant angiogenesis. (aad.org)
  • KEGG pathway term mTOR signaling pathway is observed to be meliorated in this tricluster and has been reported to be associated Inhibitors,Modulators,Libraries with estrogen induced breast cancer cell. (ampk-signal.com)
  • Androgen deprivation therapy induces apoptosis or cell cycle arrest in prostate cancer (PCa) cells. (oncotarget.com)
  • Ideally, a drug that inhibits PKB should cause both cell cycle arrest and promote apoptosis. (justia.com)
  • Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. (nature.com)
  • Is p53-dependent ferroptosis sufficient for tumor suppression in the absence of cell cycle arrest, senescence, and apoptosis? (nature.com)
  • To date, various mechanisms have been suggested to explain the powerful tumor-suppressive effect of p53, including the induction of cell cycle arrest, senescence, and apoptosis. (nature.com)
  • They also perform opposing functions: the nuclear CLU binds Ku70 to release BAX and induce apoptosis, whereas the cytosolic and secretory isoforms inhibit apoptosis. (wikipedia.org)
  • These plant-based nutrients inhibit the growth of cancer cells and induce cell death (apoptosis) among malignant in both pre-cancerous and malignant cell lines. (healthydietbase.com)
  • Research suggests that compounds found in oyster mushrooms may inhibit the growth of cancer cells and even induce apoptosis, or programmed cell death, which helps reduce the risk of cancer. (magicmushroombars.biz)
  • It's also interesting to note that ivermectin can inhibit tumor stem cells and reverse multidrug resistance, and is most effective when used alongside other chemotherapy drugs. (healththoroughfare.com)
  • Inhibit Cancer Stem Cells - Curcumin makes cancer stem cells (normally resistant to chemotherapy and radiation) more sensitive to treatment and thereby less likely to allow cancer to regrow. (beatcancer.org)
  • ERW [hydrogen water] causes telomere shortening in cancer cells and suppresses tumor angiogenesis by scavenging intracellular ROS and suppressing the gene expression and secretion of vascular endothelial growth factor. (h2hubb.com)
  • assays (annexin V staining cleavage of PARP and caspase-3) suggest that FLLL12 is 5-10-fold more potent than curcumin against a panel of premalignant and malignant lung cancer cell lines depending on the cell line. (biobender.com)
  • After treatment of cells with FLLL12 for 24 h cells had been normalized at space temp for ~10 min and incubated with 100 μL of caspase-Glo 8 reagent for 2 h. (biobender.com)
  • Bax expression was induced and caspase-3 was activated by ellagic acid treatment. (nutrimedical.com)
  • CONCLUSION: Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of caspase-3. (nutrimedical.com)
  • In 4T1 breast cancer cells, short-term starvation resulted in increased phosphorylation of the stress-sensitizing Akt and S6 kinases, increased oxidative stress, caspase-3 cleavage, DNA damage, and apoptosis. (kingdomfasting.com)
  • It has been shown that Hsp27 prevents both the caspase dependent and p53 activated apoptosis. (edu.hk)
  • Treatment with both H2 waters (HHW and NHW) increased the expression of p-AMPK, AIF and Caspase 3 (cell apoptosis pathways) in colon 26 cells. (h2hubb.com)
  • Similar to our previous observations in human bladder cancer cells, Boswellia sacra essential oil induces breast cancer cell-specific cytotoxicity. (biomedcentral.com)
  • Studies revealed that inhibition of CLU resulted in increased effectiveness of chemotherapeutic agents to kill tumor cells. (wikipedia.org)
  • Whether the elevated TIGAR expression protects DNA damage induced by chemotherapeutic agents or hypoxia has not been explored. (nature.com)
  • Although clinical trials testing the effect of fasting in cancer treatment are still in the early stages, they suggest that fasting cycles may boost the efficacy of chemotherapeutic agents and could be as effective as chemotherapy drugs in the killing of specific tumor cells. (kingdomfasting.com)
  • Here, we show that treatment with starvation conditions sensitized yeast cells (Saccharomyces cerevisiae) expressing the oncogene-like RAS2val19 to oxidative stress and 15 of 17 mammalian cancer cell lines to chemotherapeutic agents. (kingdomfasting.com)
  • By contrast, a limited exposure to a severely restricted diet (short-term starvation or fasting) can protect yeast, mammalian cells, mice, and possibly patients from the toxic effects of oxidative and chemotherapeutic agents without causing chronic weight loss (10-14). (kingdomfasting.com)
  • LANA also maintains the viral episome and prevents Fas-induced programmed cell death. (aad.org)
  • Enhance Immune Surveillance - Curcumin prevents cancer cells from evading normal immune system detection and improves the body's ability to detect and destroy malignant cells. (beatcancer.org)
  • and prevents cell apoptosis in normal cells. (h2hubb.com)
  • Abstract: CONTEXT: Effects of a radioprotective, standardized leaf extract (code SBL-1) from traditional medicinal plant, sea buckthorn [Hippophae rhamnoides L. (Elaeagnaceae)], on neurotransmitters and brain injuries in rats showing radiation-induced conditioned taste aversion (CTA), are not known. (greenmedinfo.com)
  • The datasets of this article present the experimental parameters resulting from the assessment of δ-cells in the islet organs of the endocrine pancreas as a potential biomarker of endocrine disruption (ED) mediated by graphene oxide (GO), using Japanese medaka fish as the model. (bvsalud.org)
  • Cells had been released by mechanised disruption by moving the cells 15C20 moments through a cup pipette. (bms-911543.com)
  • HS (hydrogen-rich saline) significantly reduced neuronal apoptosis (cell death) and improved neurological function at 24 hours after SAH (subarachnoid hemorrhage). (h2hubb.com)
  • Brain infection is thought to occur by means of direct neuronal transmission of the virus from a peripheral site to the brain via the trigeminal or olfactory nerve and indirect immune-mediated processes inducing neuroinflammation. (medscape.com)
  • Subsequently, we revealed that PDL-1 expression is upregulated in chemotherapy-treated CAFs and is associated with poor prognosis. (cdc.gov)
  • The team also wanted to investigate why pancreatic cancer cells seem to be particularly resistant to chemotherapy. (scienceblog.com)
  • A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. (hindawi.com)
  • The BH3-mimetic Obatoclax induces apoptosis and decreases MCL1 expression in androgen-sensitive PCa cells, while castration-resistant PCa cells are less sensitive and react with an upregulation of MCL1 expression. (oncotarget.com)
  • All three human breast cancer cell lines were sensitive to essential oil treatment with reduced cell viability and elevated cell death, whereas the immortalized normal human breast cell line was more resistant to essential oil treatment. (biomedcentral.com)
  • In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
  • Metabolic adaptations of cancer cells. (hindawi.com)
  • Lipoic acid displays striking benefits in components of metabolic syndrome, including inducing weight loss, improving insulin resistance, and lowering blood pressure. (lifeextension.com)
  • E6 and Metabolic syndrome and risks of colon and rectal renal cell carcinoma. (who.int)
  • In occasional cells, this crossing over may lead to increased 12p copy number and overexpression of cyclin D2. (medscape.com)
  • Mechanistically, SIRT6 binds to ATF4 and localizes it to nuclear speckles, which protects ATF4 from proteasomal degradation. (fredhutch.org)
  • In classical PDAC, SIRT6 binds and localizes ATF4 to nuclear speckles, which protects ATF4 from degradation by the proteasome. (fredhutch.org)
  • The lack of SIRT6 in basal PDAC cells results in ATF4 degradation and an inability to activate the ISR in the presence of CDK7/9 inhibitors driving cell death. (fredhutch.org)
  • In normal cells, mdm2 availability is controlled by ARF, the product of the p14ARF gene located on INK4a/ARF locus, which binds with mdm2 and induces its degradation. (medscape.com)
  • A diagram of the synthesis of degradable nanocapsules into cell nuclei to induce apoptosis, or programmed cell death, in cancer cells. (understandingnano.com)
  • Histologically, ALCL is characterized by sheets of large pleomorphic cells with abundant cytoplasm, horseshoe- or wreath-shaped nuclei, and multiple prominent nucleoli. (medscape.com)
  • The gene is highly conserved in species, and the protein is widely distributed in many tissues and organs, where it participates in a number of biological processes, including lipid transport, membrane recycling, cell adhesion, programmed cell death, and complement-mediated cell lysis. (wikipedia.org)
  • Analysis of MCL1 protein and mRNA expression in PCa tissue and primary cell culture specimens of luminal and basal origin, respectively, reveals higher expression in cancerous tissue compared to benign origin. (oncotarget.com)
  • In stark contrast, deletion of the prosurvival protein Bcl-xL resulted in megakaryocyte apoptosis and a failure of platelet shedding. (medhelp.org)
  • They found that THZ1 treatment significantly decreased MYC protein expression, a well-established driver of tumorigenesis, in both classical and basal PDAC cells. (fredhutch.org)
  • Given that protein aggregates in liver cells are closely linked to alcoholic liver disease, these findings suggest that quercetin could be a useful treatment for patients with this condition. (qualitycounts.com)
  • Molecular 'switch' reverses chronic inflammation and aging - Science Daily, 2/6/20 - 'By studying mice and immune cells called macrophages, the team found that a protein called SIRT2 is responsible for deacetylating the NLRP3 inflammasome. (qualitycounts.com)
  • The present invention provides inhibitors of protein kinases comprising a molecule having at least a first moiety competent for penetration of the molecule into cells, and a second moiety for having a protein kinase inhibiting effect within the cells. (justia.com)
  • The complex molecules are preferably peptide conjugates having improved cell-permeability, serum stability and kinase selectivity compared to known protein kinase inhibitors. (justia.com)
  • The present invention relates to cell permeable, stable conjugates comprising a cell-permeability enhancement moiety and a peptide or peptidomimetic, as selective inhibitors of protein kinases, to pharmaceutical compositions containing them, as well as to processes for the preparation and use of such complex molecules. (justia.com)
  • In a new study, published online Feb. 1 in the peer-reviewed journal Nano Today, a group led by Yi Tang, a professor of chemical and biomolecular engineering and a member of the California NanoSystems Institute at UCLA, reports developing tiny shells composed of a water-soluble polymer that safely deliver a protein complex to the nucleus of cancer cells to induce their death. (understandingnano.com)
  • The cell-destroying material, apoptin, is a protein complex derived from an anemia virus in birds. (understandingnano.com)
  • This protein cargo accumulates in the nucleus of cancer cells and signals to the cell to undergo programmed self-destruction. (understandingnano.com)
  • Delivering a large protein complex such as apoptin to the innermost compartment of tumor cells was a challenge, but the reversible polymer encapsulation strategy was very effective in protecting and escorting the cargo in its functional form," said Muxun Zhao, lead author of the research and a graduate student in chemical and biomolecular engineering at UCLA. (understandingnano.com)
  • The protein quantity V in a cell is defined as the total fluorescent intensity in a segmented region of correspond ing cell. (ampk-signal.com)
  • But, apoptotic cells in IR and B groups significantly increased (p<0.001), while in HIR and BH groups, the number of apoptotic cells decreased and the positive cells of TUNEL (TdT-mediated dUTP-X nick end labelling) staining were detected in spermatocytes and spermatid. (greenmedinfo.com)
  • SOD, CAT and GPX activities were significantly increased in ellagic acid-treated V79-4 cells. (nutrimedical.com)
  • Above mentioned effects were significantly blocked when the cells were pretreated with an antioxidant N-acetylcysteine (NAC), suggesting the involvement of ROS generation. (biomedcentral.com)
  • Pretreatment of cells with pifithrin-α or U0126, specific inhibitors of p53 or MEK-1/2, significantly attenuated Triphala-induced apoptosis. (biomedcentral.com)
  • Major damages predominantly occur in the liver and the heart, leading to a specific form of cell death recently named ferroptosis. (unito.it)
  • Susceptibility to ferroptosis is dependent on intracellular antioxidant capacity and varies according to the different cell types. (unito.it)
  • Chemotherapy-induced cardiotoxicity has been proven to be mediated predominantly by iron accumulation and ferroptosis, whereas there is evidence about the role of ferritin in protecting cardiomyocytes from ferroptosis and consequent heart failure. (unito.it)
  • Among these unconventional activities, an iron-dependent form of non-apoptotic cell death, termed ferroptosis, attracts great interest. (nature.com)
  • Resistance of cancer cells towards apoptosis is the major cause of these symptomatic behaviours. (oncotarget.com)
  • Such activity would result in increased cell death of tumor tissue where PKB is elevated, and in decreased resistance to chemotherapy agents. (justia.com)
  • Direct correlation between resistance to chemotherapy and activation of PKB was shown in several prostate cancer cell lines and in human tumorogenic tissues, and elevation of PKB levels in prostate tumor tissues, is clinically associated with HRPC (Yongde et al. (justia.com)
  • Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. (hindawi.com)
  • I have been looking around, mostly on pubmed ( https://www.ncbi.nlm.nih.gov/pubmed/ ), for non-chemotherapy strategies to reduce cancer recurrence and mortality. (cancer.org)
  • Most of the early prostate cancer ha s no obvious symptoms, but its malignancy metastasis will cause largely deaths. (scirp.org)
  • Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)
  • Studies show that a low level of glutathione in the body makes healthy cells vulnerable to the effects of chemotherapy. (healthydietbase.com)
  • Activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were measured in ellagic acid-treated V79-4 cells. (nutrimedical.com)
  • In addition, ERW induces apoptosis together with glutathione in human leukemia HL60 cells (Tsai et al. (h2hubb.com)
  • To answer this question, we first investigated the ability of ellagic acid to influence the activity of the estrogen receptor subtypes ERalpha and ERbeta in HeLa cells. (nutrimedical.com)
  • Cells co-transfected with an estrogen response element (ERE)-driven luciferase (Luc) reporter gene and an ERalpha- or ERbeta-expression vector were exposed to graded concentrations of ellagic acid. (nutrimedical.com)
  • Further evaluation revealed that ellagic acid was a potent antiestrogen in MCF-7 breast cancer-derived cells, increasing, like the pure estrogen antagonist ICI182780, IGFBP-3 levels. (nutrimedical.com)
  • However, cell death was observed only in basal PDAC cells, suggesting that THZ1-induced cell death is independent of MYC suppression. (fredhutch.org)
  • Through immune suppression and inflammation, the HHV-8 infected cells can persist and proliferate. (aad.org)
  • Expression of latency-associated nuclear antigen (LANA) causes binding of p53 and suppression of apoptosis. (aad.org)
  • Lipids, amino acids, and nucleotides necessary for the biosynthesis of the daughter cells are mostly provided by intermediate metabolites of these pathways. (hindawi.com)
  • Consistently, the essential oil represses signaling pathways and cell cycle regulators that have been proposed as therapeutic targets for breast cancer. (biomedcentral.com)
  • Once activated, p53 coordinates multiple downstream pathways, thereby maintaining the homeostasis of the host cell or organism (if the stress is mild, transient, and repairable) or eliminating damaged cells (if the stress is acute, prolonged, and difficult to resist). (nature.com)
  • In fact, the research suggests resveratrol not only reaches its intended target, injuring the nexus of malignant cells, but at the same time protects normal tissue from the harmful effects of radiation. (scienceblog.com)
  • Normalize Cell Growth - Curcumin restores normal growth controls, reverses uncontrolled reproduction of malignant cells, blocks access of cancer cells to growth factors, turns on genes that prevent cell growth and turns off genes that promote cancer growth. (beatcancer.org)
  • Reduce Production of Adhesion Molecules - Curcumin keeps malignant tissue from sticking to vessel walls and reduces cancer cells' ability to form distant metastases. (beatcancer.org)
  • Malignant transformation of germ cells is the result of a multistep process of genetic changes. (medscape.com)
  • PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
  • In summary, our data suggest that Hsp27 could be a potential therapeutic target for chemotherapy induced peripheral neuropathy. (edu.hk)
  • Our finding supports PDL-1 in CAFs as a chemotherapy response biomarker and as a drug delivery and therapeutic target for chemoresistant NSCLC. (cdc.gov)
  • This enables classical PDAC cells to survive the stress induced by CDK7/9 inhibitors. (fredhutch.org)
  • TACE induced a reduction in tumor size mainly due to ischemia resulting from embolization 11 which expose tumor to acute hypoxia. (nature.com)
  • Studies have shown that Quercetin acts to stabilize cells in the body that release histamine - the chemical that triggers immune cells to secrete mucus in the sinuses. (yourwellbeing.co.za)
  • The study also concluded that Quercetin in combination with chemotherapy and radiation acts as a sensitizer and protects healthy cells from side effects of these cancer therapies. (yourwellbeing.co.za)
  • The good herb: Buckwheat liquor helps cells clean house - Science Daily, 8/16/21 - 'When the researchers looked more closely at specific components of tartary buckwheat extract, they found that one component, quercetin, had the same effects as the extract. (qualitycounts.com)
  • Free radicals are unstable molecules that can damage cells, leading to age-related diseases and chronic inflammation. (magicmushroombars.biz)
  • It is important to keep inflammation under control as chronic inflammation can eventually lead to damaged cells, tissue and organs. (yourwellbeing.co.za)
  • On the other hand, incorporating a variety of cancer-fighting foods into our diet can help strengthen our immune system, reduce inflammation, and provide essential nutrients that combat the growth of cancer cells. (brainboost.blog)
  • Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
  • Elimination of senescent cells can counter chronic inflammation, said Steven N. Austad, director of aging studies at the University of Alabama at Birmingham. (qualitycounts.com)
  • But, this protective apoptotic response can sometimes be "vetoed" if the cell is exposed to excessive levels of certain growth-promoting hormones that suppress apoptosis. (oasisofhope.com)
  • The process does not present the risk of genetic mutation posed by gene therapies for cancer, or the risk to healthy cells caused by chemotherapy, which does not effectively discriminate between healthy and cancerous cells, Tang said. (understandingnano.com)
  • DNA damage in HepG2 cells after TIGAR knockdown with or without treatment of epirubicin or CoCl 2 was detected by Comet assay. (nature.com)
  • Endometrium-derived epithelial cells (Ishikawa) showed no response to the natural compound by using a cell viability assay (MTT). (nutrimedical.com)
  • Growth-inhibitory effects of Triphala were evaluated in Capan-2, BxPC-3 and HPDE-6 cells by Sulphoradamine-B assay. (biomedcentral.com)
  • Apoptosis was determined by cell death assay and western blotting. (biomedcentral.com)
  • Annexin V-phycoerythrin staining for apoptosis Lung tumor cells had been treated with different concentrations of FLLL12 and curcumin for the indicated period after that trypsinized and cleaned in cool 1× PBS. (biobender.com)
  • Finally, the oligosaccharides were added at various concentrations to cultured human HT29 colon cancer cells, while a common chemo drug was added to others. (nutritionnews.com)
  • In every test using different concentrations, oligosaccharides induced programmed cell death ( apoptosis ) at greater levels than the chemo drug . (nutritionnews.com)
  • Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
  • The authors then examined mRNA translation in classical and basal PDAC cells. (fredhutch.org)
  • In this study, we investigated programmed death-ligand 1 (PDL-1) as a potential biomarker for CAF-induced chemoresistance and evaluated its role and the underlying mechanisms of chemoresistance in non-small cell lung cancer (NSCLC). (cdc.gov)
  • Silencing PDL-1 expression suppressed CAFs' ability to promote stem cell-like properties and invasiveness of lung cancer cells, favoring chemoresistance. (cdc.gov)
  • Mechanistically, an upregulation of PDL-1 in chemotherapy-treated CAFs led to an increase in hepatocyte growth factor (HGF) secretion, which stimulates cancer progression, cell invasion, and stemness of lung cancer cells, while inhibiting apoptosis. (cdc.gov)
  • Rochester researchers showed for the first time that a natural antioxidant found in grape skins and red wine can help destroy pancreatic cancer cells by reaching to the cell's core energy source, or mitochondria, and crippling its function. (scienceblog.com)
  • The study also showed that when the pancreatic cancer cells were doubly assaulted - pre-treated with the antioxidant, resveratrol, and irradiated - the combination induced a type of cell death called apoptosis, an important goal of cancer therapy. (scienceblog.com)
  • Antioxidant and apoptosis-inducing activities of ellagic acid. (nutrimedical.com)
  • BACKGROUND: Antioxidant, antiproliferative and apoptosis inducing activities of a natural polyphenolic compound, ellagic acid, were studied. (nutrimedical.com)
  • This extract is rich in vitamin E, which is a powerful antioxidant that protects cells from damage. (effective-treatments.com)
  • First, molecular hydrogen caused growth inhibition of human tongue carcinoma cells HSC-4 (cancerous) and human fibrosarcoma cells HT-1080 (cancerous) but did not compromise growth of normal human tongue epithelial-like cells DOK [ 14 ]. (h2hubb.com)
  • That is because many mutations that boost growth signals are somehow "sensed" by the cell as abnormal, inducing the cell to commit suicide. (oasisofhope.com)
  • The first suggests that fetal gonocytes whose development into spermatogonia is blocked may undergo abnormal cell division and then invasive growth mediated by postnatal and pubertal gonadotrophin stimulation. (medscape.com)
  • For example, fasting for 48 to 60 hours protected mice of three different genetic backgrounds from the chemotherapy drug etoposide (12). (kingdomfasting.com)
  • However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)
  • In contrast, cancer cells shift their metabolism toward lactate production even in the presence of oxygen [ 4 ], partly through genetic modifications that stabilize the transcription factor Hypoxia Inducible Factor (HIF) involved in the adaptation of the cells to hypoxia, under nonhypoxic conditions as well as generating an adaptive response to the hypoxic microenvironment (Figure 1 ). (hindawi.com)
  • Throughout life, the human body accumulates mutations in the genetic material of its stem cells - cells that retain the capacity to divide. (oasisofhope.com)
  • In other words, their genetic material mutates faster than that of most healthy cells. (oasisofhope.com)
  • But just as reseveratrol interferes with the cancer cells' energy source, it also may decrease the power available to pump chemotherapy out of the cell. (scienceblog.com)
  • These findings demonstrate that hydrogen-rich saline could decrease DOX-induced cell apoptosis. (h2hubb.com)
  • The intricate molecular mechanisms involved in the regenerative process of the normal intestine and the identity of putative somatic intestinal stem cells have become clear. (mdpi.com)
  • Fortunately, cells have mechanisms for repairing damaged DNA - but these mechanisms are less than perfect, so that permanent alterations of DNA structure are progressively acquired by stem cells. (oasisofhope.com)
  • The directed expression of Buffy in DA neurons provides protection and counteracts the alpha-synuclein-induced Parkinson disease-like phenotypes. (sdbonline.org)
  • On the other hand, Triphala failed to induce apoptosis or activate ERK or p53 in normal human pancreatic ductal epithelial (HPDE-6) cells. (biomedcentral.com)