Induced antibodies. Medical search. Frequent questions

Antibody responses targeting the M protein have been shown to favor the conserved C region. (lu.se)
No statistically significant differences were observed between the frailty groups in vaccine-induced modulation of leukocyte populations, cytokine responses, and gene expression profiles of peripheral blood mononuclear cells (PBMCs). (frontiersin.org)
The majority of the elderly subjects seroconverted for seasonal influenza upon vaccination, and importantly, influenza vaccination-induced humoral immune responses and seroprotection were similar across the frailty strata, indicating that frail individuals may also benefit from influenza vaccination. (frontiersin.org)
Pre-existing antibodies due to natural exposure appeared to positively influence vaccine-induced antibody responses. (frontiersin.org)
The frequency of responders was similar (≥90%) for IgG binding antibody to gp140 consensus Env across all groups, but the magnitude was higher in the ID + IL-12 group compared with the IM + IL-12 group.CONCLUSION PENNVAX-GP DNA induced robust cellular and humoral immune responses, demonstrating that immunogenicity of DNA vaccines can be enhanced by EP route and inclusion of pIL-12. (jci.org)
ID/EP was dose sparing, inducing equivalent, or in some aspects superior, immune responses compared with IM/EP.TRIAL REGISTRATION ClinicalTrials.gov NCT02431767.FUNDING This work was supported by National Institute of Allergy and Infectious Diseases (NIAID), U.S. Public Health Service grants, an HIV Vaccine Design and Development Team contract, Integrated Preclinical/Clinical AIDS Vaccine Development Program, and an NIH award. (jci.org)
The recent emergence of SARS-CoV-2 variants that are less sensitive to neutralization by convalescent sera or vaccine-induced neutralizing antibody responses has raised concerns. (biorxiv.org)
A bivalent omicron BA.1-containing booster vaccine is safe and elicits higher antibody responses against Omicron BA.1 than the original COVID-19 vaccine, according to new data from a phase 2/3 clinical trial. (idsociety.org)
The antibody responses are consistent between younger and older adults in the study. (idsociety.org)
Our results indicate that the Omicron-containing bivalent booster vaccine has a safety profile that is similar to the original vaccine, and it induces enhanced antibody responses against the variants, compared to the original vaccine. (idsociety.org)
Blockade of CTLA-4 by antibodies has potentiated antitumor T-cell responses in both preclinical models and clinical trials. (aacrjournals.org)
Here we show that mTOR coordinates immunometabolic reconfiguration of marginal zone (MZ) B cells, a pre-activated lymphocyte subset that mounts antibody responses to T-cell-independent antigens through a Toll-like receptor (TLR)-amplified pathway involving transmembrane activator and CAML interactor (TACI). (upf.edu)
Thus, mTOR drives innate-like antibody responses by linking proximal TACI signaling events with distal immunometabolic transcription programs. (upf.edu)
In the present study, we demonstrate that TRPV4 plays an essential role in Taxol-induced nociceptive behavioral responses to mechanical and hypotonic stimulation of the hind paw. (jneurosci.org)
This study demonstrates the impact of adjuvant on the development of T follicular helper (Tfh) and B cells , and their influence on antibody responses in mice vaccinated with SARS-CoV-2 -spike- ferritin - nanoparticle (SpFN) adjuvanted with either Army Liposome Formulation containing QS-21 (SpFN + ALFQ) or Alhydrogel ® (SpFN + AH). (bvsalud.org)
Monoclonal antibodies against CD40, conjugated to antigen, act as potent immunological adjuvants for primary antibody responses. (westminster.ac.uk)
We show here that CD40mAbs can also act as strong adjuvants for memory antibody responses, and for T cell responses as measured by ex vivo T cell proliferation to antigen, and delayed type hypersensitivity. (westminster.ac.uk)
Finally, the adjuvant effect of CD40mAbs for secondary antibody responses is transferred with T cells rather than B cells. (westminster.ac.uk)
Salmonella Typhi Vi capsule prime-boost vaccination induces convergent and functional antibody responses. (ox.ac.uk)
Recently, we demonstrated that recombinant Cry1Ac protoxin (pCry1Ac) administered to mice by the intraperitoneal ( ip ) or intragastric ( ig ) route induces systemic and mucosal antibody responses similar to those obtained with cholera toxin (6). (scielo.br)
The 'gold standard' method to assess humoral antibody responses fol owing vaccination is the neutralization assay. (who.int)

The presence of auto-antibodies that target synaptic machinery proteins was documented recently in immune-mediated cerebellar ataxias. (springer.com)
Among these diverse features, it should be acknowledged that auto-antibodies toward glutamate receptors, GABA receptors, and K + channel-related proteins are preferentially found in autoimmune limbic encephalitis but not in IMCAs [ 10 ] (Table 1 ). (springer.com)
Silicone oil, which is used as a lubricant or coating in devices such as syringes, needles and pharmaceutical containers, has been implicated in aggregation and particulation of proteins and antibodies. (nih.gov)
Here, we show that human Abs can induce increased Fn-binding affinity in M proteins, likely by enhancing the weak A-B domain binding. (lu.se)
This study, using a virus-free mouse model, explores the pathogenic roles of certain antibodies specific to the spike proteins of highly pathogenic coronaviruses such as the COVID-19 and the SARS-CoV viruses. (researchsquare.com)
In persons with DILE, the antibodies also tend to attack histones (proteins typically found in cell nuclei). (medscape.com)
The infections are likely related to lower-than-normal levels of special proteins called antibodies or immunoglobulins, particularly immunoglobulin M (IgM) or immunoglobulin G (IgG). (medlineplus.gov)
In normal individuals, the immune system produces antibodies to foreign proteins (antigens) but not to human proteins (autoantigens). (wikipedia.org)
Each of these antibody subtypes binds to different proteins or protein complexes within the nucleus. (wikipedia.org)
These cells coordinate an immune response upon the detection of foreign proteins (antigens), producing antibodies that bind to these antigens. (wikipedia.org)
The ENAs consist of ribonucleoproteins and non-histone proteins, named by either the name of the donor who provided the prototype serum (Sm, Ro, La, Jo), or the name of the disease setting in which the antibodies were found (SS-A, SS-B, Scl-70). (wikipedia.org)
Blocking the interaction between PIF7 and 14-3-3 proteins or reducing the expression of 14-3-3 proteins accelerates shade-induced nuclear localization and de-phosphorylation of PIF7, and enhances the shade phenotype. (elifesciences.org)
The data obtained in the present study confirm that the Cry1Ac protoxin is a potent immunogen able to induce a specific immune response in the mucosal tissue, which has not been observed in response to most other proteins. (scielo.br)
135 antibodies against 65 mainly immunoregulatory proteins, we of a multitude of different genes (8, 9). (lu.se)

In some cases, antibodies to human antigens are produced. (wikipedia.org)
Sometimes, however, this process malfunctions and antibodies are produced against human antigens, which may lead to autoimmune disease. (wikipedia.org)
Extractable nuclear antigens (ENA) are a group of autoantigens that were originally identified as antibody targets in people with autoimmune disorders. (wikipedia.org)
Moreover, in adjuvanticity studies, pCry1Ac elicited serum antibodies against hepatitis B surface antigen and BSA when these antigens were coadministered ig , and IgG antibodies in the intestinal fluid when the antigens were administered ip (7). (scielo.br)
6. Antigens - Substance that induces antibody production and interacts with it in a specific way. (who.int)

Aggregation of therapeutic protein products induced by silicone oil can pose a challenge to their development and commercialization. (nih.gov)
To systematically characterize the role of silicone oil on protein aggregation, the effects of agitation, temperature, pH, and ionic strength on silicone oil-induced loss of monomeric anti-streptavidin IgG 1 antibody were examined. (nih.gov)
A formulation strategy involving optimization of colloidal stability of the antibody as well as incorporation of surfactants such as polysorbate 20 is proposed to reduce silicone oil-induced aggregation of therapeutic protein products. (nih.gov)
However, based on observations that around 85% of epitopes in the spike protein recognized by CD8+ T cells are not affected by the mutations in the Omicron variant, the companies believe two doses may still induce protection against severe disease. (hpnonline.com)
These variants contain mutations arising within the spike protein that are known to increase resistance to antibody neutralization 3 . (biorxiv.org)
MRT5500 induced dose-dependent levels of binding antibodies and neutralizing antibodies specific to the SARS-CoV-2 spike protein. (pharmaceutical-business-review.com)
After the first administration, the majority of NHPs developed neutralizing antibodies reactive to the SARS-CoV-2 spike protein and those antibody titers were further enhanced after a second administration with 100% of NHPs reaching levels significantly higher than those from human convalescent sera by day 35. (pharmaceutical-business-review.com)
We report an 82-year old female patient with encephalitis who presented with aphasia, left temporo-mesial hyperintense lesion on MRI, epileptiform discharges on spot electroencephalography, cerebrospinal fluid (CSF) lymphocytic pleocytosis and who showed positive HSV polymerase chain reaction in CSF as well as antibodies against contactin-associated protein-like 2 (Caspr2). (biomedcentral.com)
The downmodulation of stimulation-induced F-actin assembly in neutrophils through the interaction of ALP with the actin-bundling protein l-plastin caused a blockade of the conformational activation of β 2 -integrins [ 5 ]. (biomedcentral.com)
The present paper describes important features of the immune response induced by the Cry1Ac protein from Bacillus thuringiensis in mice. (scielo.br)
In this PhD dissertation, we aimed to assess the binding efficacy and function of monoclonal antibodies targeting the GAS M protein. (lu.se)
In the second paper we discovered a novel form of antibody binding whereby a monoclonal binds the GAS M protein in a bivalent dual-Fab cis mode. (lu.se)
Even so this antibody bound to a region of the M protein associated with non-opsonic antibodies we found that this Ab could enhance phagocytosis suggesting that this novel binding form can circumvent the M protein's anti-phagocytic properties. (lu.se)

It should be noted that the majority of anti-spike antibodies are non-pathogenic, as only 2 of 7 monoclonal antibodies tested showed significant pathogenic effects. (researchsquare.com)
We report disseminated T. marneffei infection in 4 hematology patients without AIDS who received targeted therapy with monoclonal antibodies against CD20 or kinase inhibitors during the past 2 years. (cdc.gov)

Meanwhile, the inhibitory effect of AK106-001616 was more effective than that of naproxen in the mouse collagen antibody-induced arthritis model with leukotrienes contributing to the pathogenesis. (aspetjournals.org)

In drug-induced lupus erythematosus (DILE), when anti-ssDNA and anti-dsDNA are measured, the prevalence of anti-ssDNA is higher. (medscape.com)
Autoantibodies reactive with chromatin in systemic lupus erythematosus and drug-induced lupus. (medscape.com)
Antibodies to histones are detected in approximately 30% to 60% of patients with systemic lupus erythematosus (SLE), but their presence in about 95% of patients with drug-induced lupus is more important diagnostically. (evexiadiagnostics.com)
Drug-induced lupus (primarily caused by procainamide and hydralazine) is clinically similar to SLE, except that the former patients do not have kidney or central nervous system involvement and they do not demonstrate the multiple types of antinuclear antibodies (ANAs) often found in SLE patients. (evexiadiagnostics.com)
In patients with drug-induced lupus, antihistone antibodies are usually the only ANAs, although antibodies to denaturated DNA have been detected in a small percentage of patients. (evexiadiagnostics.com)
Epstein A, Barland P. The diagnostic value of antihistone antibodies in drug-induced lupus erythematosus. (evexiadiagnostics.com)
This allows the use of ANAs in the diagnosis of some autoimmune disorders, including systemic lupus erythematosus, Sjögren syndrome, scleroderma, mixed connective tissue disease, polymyositis, dermatomyositis, autoimmune hepatitis and drug-induced lupus. (wikipedia.org)

This may be through the suppression of the presentation of MOG61-85 when antibody is bound to MOG when it is taken up by antigen presenting cells. (uwm.edu)
Anti-glomerular basement membrane (anti-GBM) antibody disease is a rare autoimmune disorder in which circulating antibodies are directed against an antigen normally present in the GBM and alveolar basement membrane, specifically the alpha-3 chain of type IV collagen. (medscape.com)
ACIP also recommends that vaccinated HCP receive postvaccination serologic testing (antibody to hepatitis B surface antigen [anti-HBs]) 1-2 months after the final dose of vaccine is administered (CDC. (cdc.gov)
A competitive immunoassay technique is used which involves pre-incubation of anti-HAV in the sample with HAV antigen in the assay reagent, followed by incubation with a conjugate reagent that contains biotinylated mouse monoclonal anti-HAV antibody and horseradish peroxidase (HRP)-labeled mouse monoclonal anti-HAV antibody. (cdc.gov)
A fluorescent-labeled antibody adheres to this antigen-antibody complex and allows visualization of the pattern. (medscape.com)

One such antibody common in people with PLAID is known as antinuclear antibody (ANA). (medlineplus.gov)
Antinuclear antibodies (ANAs, also known as antinuclear factor or ANF) are autoantibodies that bind to contents of the cell nucleus. (wikipedia.org)

A lower dose and slow release of the antibody results in thousand-fold decreased levels of antibody in the serum, reducing adverse events and the risk of autoimmunity. (aacrjournals.org)
This administration method is associated with very low serum levels of antibody, which decreases the risk of treatment-induced side effects. (aacrjournals.org)

Additionally, the neutralizing titer levels against Omicron after immunization with three doses were similar to antibody titer levels after two doses against wild-type and other variants that emerged before Omicron. (hpnonline.com)
This was associated with the generation of high titer, high avidity binding antibodies . (bvsalud.org)
An antibody pattern is reported with a positive titer and gives an indication of the likely diagnosis (see the image below). (medscape.com)
Any detectable titer of neutralizing antibody against poliovirus is considered protective against clinical paralytic diseases. (who.int)

Test for the presence of antinuclear antibodies, which can appear in a homogeneous pattern in as many as 90% of patients with lupus erythematosus. (medscape.com)
Lowe G, Henderson CL, Grau RH, Hansen CB, Sontheimer RD. A systematic review of drug-induced subacute cutaneous lupus erythematosus. (medscape.com)
Antibodies to histones in drug-induced and idiopathic lupus erythematosus. (evexiadiagnostics.com)
Krippner H, Springer B, Merle S, Pirlet K. Antibodies to histones of the IgG and IgM class in systemic lupus erythematosus. (evexiadiagnostics.com)
Specificity of antihistone antibodies in systemic lupus erythematosus. (evexiadiagnostics.com)
Anti-Ro antibodies are also found less frequently in other disorders including autoimmune liver diseases, coeliac disease, autoimmune rheumatic diseases, cardiac neonatal lupus erythematosus and polymyositis. (wikipedia.org)

Auto-antibodies induced neurological diseases show various clinical phenotypes (see details in Table 1 ). (springer.com)
Interestingly, initiation of anti-IL-17 antibody therapy during a later stage of CIA, using mice with higher clinical arthritis scores, still significantly slowed the progression of the disease. (nih.gov)
Novel clinical interventions, through disrupting the host-binding of these pathogenic antibodies, can be developed to fight the COVID-19 pandemic. (researchsquare.com)
Antibody tests have public health value for monitoring and evaluating population levels of immunity, as well as clinical utility for patients. (cdc.gov)
Antibody tests that have received Emergency Use Authorization (EUA) from the U.S. Food and Drug Administration (FDA) may be used for both public health and clinical purposes. (cdc.gov)
In this article, Goodpasture disease and anti-GBM disease are used synonymously and refer to the presence of anti-GBM antibodies in tissues (eg, kidney, lungs, or both), independent of clinical manifestations. (medscape.com)
Better understanding of the clinical features and the mechanisms of alcohol-induced HCC are of critical importance for prevention and the development of novel treatments. (springer.com)
The clinical utility of antihistone antibodies. (medscape.com)
Interaction of these antibodies with the NMDAR leads to cerebral dysfunction and a characteristic clinical syndrome [ 6 ]. (biomedcentral.com)
Bavituximab is a PS-targeting antibody that is being evaluated in multiple late-stage clinical trials in cancer patients. (bmj.com)
rather it compliments clinical signs and symptoms, specific antibody tests, and histopathologic and radiographic findings. (medscape.com)

To investigate the effect of hyperglycemia on anti-tumor function induced by anti-PD-1 antibody treatment, we treated STZ-induced diabetic mice with subcutaneous MC38 colon carcinoma tumors with anti-PD-1 antibody, and examined changes in tumor growth, the number of tumor-infiltrating immune cells, and the expression of chemokines and chemokine receptors. (nature.com)
Mice were intraperitoneally injected with STZ or sodium citrate buffer (CB) 7 days before subcutaneous inoculation with MC38 cells in the right flank on day 0 (Fig. 1 A). Then, the mice were treated with anti-PD-1 antibody or normal rat IgG on days 5, 8, and 11. (nature.com)
The skin inflammation and hyperkeratosis from UVB irradiation in the Nlrp1b KI mice were inhibited by both intraperitoneal and subcutaneous administration of anti-IL-1β antibodies before UVB irradiation. (frontiersin.org)
By injecting the antibodies in a subcutaneous slow-release delivery formulation in the tumor area, we show that an eight-fold lower dose of antibody is as effective in inducing tumor eradication as systemic delivery. (aacrjournals.org)
Epcoritamab is the first subcutaneous bispecific antibody approved for the indication. (medscape.com)

The elderly are often stratified according to frailty status where frail individuals are more susceptible to adverse health outcomes than their non-frail counterparts, however, it is not known whether immunity induced by influenza vaccination is impaired in the frail elderly. (frontiersin.org)
Moved "Development of Antibodies and Immunity" section. (cdc.gov)
Antibody testing is not currently recommended to assess for immunity to SARS-CoV-2 following COVID-19 vaccination or to assess the need for vaccination in an unvaccinated person. (cdc.gov)
Antibody tests are not recommended or authorized by the FDA to assess someone's immunity after COVID-19 vaccination or determine if they need to be vaccinated. (cdc.gov)
Therefore seropositivity for anti-HAV reflects either natural or vaccine induced immunity. (cdc.gov)
Furthermore, in the immune-competent TRAMP mouse prostate tumor model, combination treatment of anti-PS antibody with castration induced strong tumor-specific T-cell immunity that resulted in significantly improved tumor free long-term survival and apparent cures in 35% of the animals, compared to no long-term survivors in groups treated with either single agent. (bmj.com)
New combination vaccines should induce similar or superior levels of neutralizing antibody in serum for individual protection against paralytic disease and mucosal immunity that effectively decreases viral replication in the intestine and pharynx for population protection against transmission of poliovirus. (who.int)

Pfizer Inc. and BioNTech SE announced the publication of new results from two laboratory studies demonstrating that three doses of the Pfizer-BioNTech COVID-19 Vaccine (BNT162b2) elicited antibodies that neutralize the Omicron variant (B.1.1.529). (hpnonline.com)

We analyzed the effect of PD-1-Ab on tumor growth in streptozotocin-induced diabetic mice (STZ-mice) subcutaneously inoculated with MC38 (a colon carcinoma cell line). (nature.com)
To induce hyperglycemia, mice were intraperitoneally injected with STZ, which can damage pancreatic β cells resulting in the development of insulin dependent diabetes, a model of type 1 diabetes mellitus (T1DM). (nature.com)
The effect of anti-PD-1 antibody on MC38 tumor is attenuated in STZ-induced diabetic mice. (nature.com)
We generated Nlrp1b (the mouse homologue of human NLRP1 ) gain-of-function knock-in ( Nlrp1b KI) mice with UVB irradiation-induced autoinflammatory skin lesions. (frontiersin.org)
We demonstrated that UVB irradiation induces IL-1β upregulation and IL-1β-dependent inflammation via caspase-1 activation in these Nlrp1b KI mice. (frontiersin.org)
Mice with collagen-induced arthritis (CIA) were treated with polyclonal rabbit anti-murine IL-17 (anti-IL-17) antibody-positive serum or normal rabbit serum after the first signs of arthritis. (nih.gov)
In addition, during a later stage of CIA mice were selected and treated with anti-IL-17 antibody or control serum. (nih.gov)
Furthermore, the pathogenic antibodies can bind to unmatured fetal tissues and cause abortions, postpartum labors, still births, and neonatal deaths of pregnant mice. (researchsquare.com)
When T cells were cultured again with purified antibody, from rMOG primed mice, proliferation decreased in all the wells with antibody added, but when injected into coimmunized mice similar disease was observed as seen in the mice given immune serum. (uwm.edu)
In vivo administration of IL1RAP antibodies in mice transplanted with chronic and blast phase CML cells resulted in therapeutic effects mediated by murine effector cells. (lu.se)
Leukocyte rolling and firm adhesion to the synovial endothelium in an early response to the anti-CII antibody transfer were significantly decreased in ALP-pretreated mice. (biomedcentral.com)
A statistical analysis of intravital microscopic images recorded from the knee joints of untreated control mice during an early time span of 24 hours after the transfer of anti-CII mAbs [ 10 ] revealed an antibody-induced increase in leukocyte adhesion to the vessel walls. (biomedcentral.com)

A potential competitor, Roche's bispecific antibody mosunetuzumab (Lunsumio), was approved in December 2022. (medscape.com)

A systematic review evidenced that anti-SSA/Ro antibodies are found in most patient with DISCLE (about 80% of cases), in whom antihistone antibodies are uncommonly found, and most remained positive after resolution of SCLE skin disease activity. (medscape.com)
Antihistone antibodies are indicated by a homogeneous pattern of antinuclear antibodies. (medscape.com)
In addition, drug-induced antihistone antibodies react strongly with H2a/H2b fragments (in procainamide-induced SLE) as well as H3 and H4 (in hydralazine-induced SLE). (evexiadiagnostics.com)
Antihistone antibodies also occur in approximately 20% of patients with rheumatoid arthritis. (evexiadiagnostics.com)

Data published in the peer-reviewed journal Science , includes readouts of sera data from 51 vaccinated individuals that received two or three doses of BNT162b2 as well as a study evaluating the neutralization potential of serum antibodies from a subset of vaccinated individuals against the live virus. (hpnonline.com)
Both data sets confirm previously announced initial study results demonstrating that serum antibodies induced by BNT162b2 neutralize the SARS-CoV-2 Omicron variant after immunization with three doses. (hpnonline.com)

Histologic analysis confirmed the suppression of joint inflammation and showed prevention of cartilage and bone destruction after anti-IL-17 antibody therapy. (nih.gov)
Moreover, the pathogenic antibodies also induced inflammation and hemorrhage of the kidneys, brain, and heart. (researchsquare.com)

Ten-year antibody persistence induced by hepatitis A and B vaccine (Twinrix) in adults. (druglib.com)
The age ranges and constraints for hepatitis A testing are as follows: The hepatitis A antibody test is performed on all participants aged 2 years or older. (cdc.gov)

Neutralizing antibody titers were observed across all dose levels after receiving the two-dose-administration regimen. (pharmaceutical-business-review.com)
His antibody titers decreased to 152 pM 5 months after treatment and to 135 pM 6 months after treatment (reference range, 0-100 pM). (psychiatrist.com)
Earlier studies showed that the UK variant spike-bearing pseudovirus was neutralized by the antibodies elicited by the Pfizer vaccine, but with somewhat lower titers relative to the reference Wuhan strain. (news-medical.net)
While mAb102 was able to neutralize all three strains at low titers, mAb48 neutralized only the D614G strain, showing that antibody sensitivity varies with strain. (news-medical.net)

The reactivity of these disease-associated autoantibodies was compared with that of antibodies raised in rats and rabbits, by immunization with various preparations derived from the 2-OADC enzymes, using immunization protocols that have successfully induced various organ-specific autoimmune diseases in animals. (edu.au)
Most people with PLAID have abnormal antibodies called autoantibodies in their blood. (medlineplus.gov)

Differing epitope selection of experimentally-induced and natural antibodies to a disease-specific a. (edu.au)
Differing epitope selection of experimentally-induced and natural antibodies to a disease-specific autoantigen, the E2 subunit of pyruvate dehydrogenase complex (PDC-E2). (edu.au)
The techniques for antibody analysis included immunofluorescence, immunoblotting on mitochondrial extracts, ELISAs using entire PDC, PDC-E2, or synthetic peptides, epitope mapping by peptide scanning on overlapping octameric peptides representing the human PDC-E2 sequence, affinity purification on PDC-E2, and inhibition in vitro by sera of the catalytic function of PDC. (edu.au)
The same epitope observed in WT antibodies. (uwm.edu)
The anti-GBM antibodies can target the EA and EB epitope separately. (medscape.com)
[ 5 ] The more abundant D-hexamers have dimer-reinforced crosslinks between NC1 domains that help to retain the cryptic nature of the Goodpasture epitopes, whereas the less abundant M-hexamers, composed of only monomeric subunits, allow epitope unmasking and antibody binding under inflammatory states. (medscape.com)

Statistical associations were evaluated between frailty status and pre- and post-vaccination antibody titres in sera measured by Hemagglutination inhibition (HAI) and microneutralization (MN) assays. (frontiersin.org)

Until now, scientists had only identified broadly neutralizing antibodies targeting the flu virus stem in humans following natural infection, and the new research provides clear evidence that these antibodies can be induced by a vaccine, as indicated in the Science Daily report. (rtmagazine.com)
It is important to remember that some people with antibodies to SARS-CoV-2 may become infected after vaccination (vaccine breakthrough infection) or after recovering from a past infection ( reinfection ). (cdc.gov)
As their antibodies wane, a person may become more vulnerable to SARS-CoV-2 infection. (cdc.gov)
Antibody tests can detect the presence of these antibodies in serum within days to weeks following acute infection or vaccination. (cdc.gov)
Determine if a person has COVID-19 antibodies, which suggests past infection or vaccination. (cdc.gov)
A new study by researchers in France reports impaired neutralization of two new SARS-CoV-2 variants by antibodies induced by vaccination or natural infection. (news-medical.net)
It is noteworthy that all of them share some escape mutations already known to have emerged under the selection pressure of antibody exposure, both from immune serum or therapeutic antibody use in prolonged survival within immunocompromised individuals, and from the antibodies elicited by natural infection. (news-medical.net)
They are found in many disorders including autoimmunity, cancer and infection, with different prevalences of antibodies depending on the condition. (wikipedia.org)
We found that the binding of antibodies from the blood of donors who had recently recovered from a severe GAS infection could greatly enhance this fibronectin binding. (lu.se)

These findings support the notion that the newly uncovered properties of ALP to interfere with cytokine signalling and upregulation of adhesion molecules in endothelial cells are likely to contribute to the therapeutic potential of ALP in immune-complex-induced tissue injury. (biomedcentral.com)

The main findings of the preclinical studies demonstrate the potential of MRT5500 to elicit neutralizing antibodies against SARS-CoV-2. (pharmaceutical-business-review.com)
We use different preclinical mouse models of cancer to investigate the local administration of CTLA-4 blocking antibody and its effect on cancer progression and the antitumor T-cell response. (aacrjournals.org)

Immune responsiveness declines in the elderly as a consequence of alterations in the distribution and function of immune cells with age and changes induced by chronic viral infections (such as cytomegalovirus) and inflammatory diseases ( 1 , 2 ). (frontiersin.org)
As the B.1.617.1 variant continues to evolve, it will be important to monitor how additional mutations within the spike impact antibody resistance, viral transmission and vaccine efficacy. (biorxiv.org)
The mutations in both the B.1.351 and P.1 strains, including E484K and K417N/T, are thought to enhance viral fitness and may confer antibody resistance in part, at least. (news-medical.net)

There are many subtypes of ANAs such as anti-Ro antibodies, anti-La antibodies, anti-Sm antibodies, anti-nRNP antibodies, anti-Scl-70 antibodies, anti-dsDNA antibodies, anti-histone antibodies, antibodies to nuclear pore complexes, anti-centromere antibodies and anti-sp100 antibodies. (wikipedia.org)

Our data showed that these pathogenic antibodies, through a mechanism of Antibody Dependent Auto-Attack (ADAA), target and bind to host vulnerable cells or tissues such as damaged lung epithelium cells, initiate a self-attack immune response, and lead to serious conditions including ARDS, cytokine release, and death. (researchsquare.com)
On the basis of its potential to block anti-collagen type II (CII) antibody-induced arthritis (CAIA) and to suppress the conformational activation of β 2 -integrins in leukocytes, the present study was undertaken to investigate its interference with leukocyte adherence to cytokine-activated endothelium. (biomedcentral.com)
Electromobility shift and luciferase reporter gene assays permitted the analysis of cytokine-induced activation of the NF-κB pathway. (biomedcentral.com)

Anti-GBM antibodies are almost exclusively of the immunoglobulin G (IgG) isotype. (medscape.com)
The resulting mTOR activation instigates MZ B-cell proliferation, immunoglobulin G (IgG) class switching, and plasmablast differentiation through a rapamycin-sensitive pathway that integrates metabolic and antibody-inducing transcription programs, including NF-κB. (upf.edu)

Pulmonary and/or renal manifestations can be encountered in various conditions, such as antineutrophilic cytoplasmic antibody (ANCA)-positive vasculitis and other autoimmune disorders. (medscape.com)
Most patients with active generalized disease have antineutrophil cytoplasmic antibodies (ANCA). (msdmanuals.com)

They are present in more than 75% of patients with DILE induced by hydralazine and procainamide. (medscape.com)
Klajman A, Kafri B, Shohat T, Drucker I, Moalem T, Jaretzky A. The prevalence of antibodies to histones induced by procainamide in old people, in cancer patients, and in rheumatoid-like disease. (evexiadiagnostics.com)
Reactivity of anti-histone antibodies induced by procainamide and hydralazine. (evexiadiagnostics.com)

The biologic simultaneously binds CD3 on cytotoxic T cells to CD20 on lymphomic B cells, inducing T-cell mediated destruction. (medscape.com)

Scientists have identified three types of vaccine-induced antibodies that can neutralize diverse strains of influenza virus that infect humans. (rtmagazine.com)
The scientists discovered the B cells encoded three classes of antibodies that can neutralize diverse influenza virus subtypes and, therefore, could form the basis of a universal flu vaccine, according to the Science Daily news report. (rtmagazine.com)

Such antibodies (Abs) circumvent antigenic escape and efficiently bind to various M types. (lu.se)
The researchers used two anti-RBD antibodies, mAb102 and mAb48, that bind to the RBDs in the 'up' conformation and thereby prevent RBD-ACE2 binding. (news-medical.net)
Antinuclear antibody (ANA) tests identify antibodies present in serum that bind to autoantigens present in the nuclei of mammalian cells. (medscape.com)

Despite their immune diversity, the majority of IMCAs is commonly associated with auto-antibodies against cerebellar autoantigens. (springer.com)

however, it remains unknown whether the anti-tumor effects of anti-programmed cell death-1 antibody (PD-1-Ab) treatment are changed in hyperglycemic conditions. (nature.com)
These results suggest that the STZ-induced hyperglycemia impairs the effect of PD-1-Ab treatment on MC38 tumor growth, and is accompanied by reduced infiltration of DCs and CD8 + T cells and decreased expression of CCL7 and CXCL9. (nature.com)
Immune checkpoint inhibitors (ICIs), including antibodies against programmed cell death-1 (PD-1) and PD-1 ligand-1 (PD-L1), induce their anti-tumor effects by improving the function of immune cells 11 . (nature.com)
The main target and effector cells of the CTLA-4 blockade treatment in the studied tumor models are tumor-specific endogenous CD8 + T cells that are capable of eradicating also distant tumors, whereas CD4 + T cells do not play a prominent role in the antibody-mediated tumor eradication. (aacrjournals.org)
Injecting CTLA-4 blocking antibody in a slow-release formulation close to the tumor is an effective way of activating the antitumor T-cell response. (aacrjournals.org)
The IFA method used in most laboratories uses human tumor cell-line substrate (the HEp-2 cell line) to detect the presence of these antibodies in human serum. (medscape.com)

IL1RAP antibodies that inhibit IL-1 signaling could block these effects. (lu.se)

In Arabidopsis , the shade-induced de-phosphorylation of the transcription factor PIF7 (PHYTOCHROME-INTERACTING FACTOR 7) is the key event linking light perception to stem elongation. (elifesciences.org)
Here, we show that shade light induces the de-phosphorylation and nuclear accumulation of PIF7. (elifesciences.org)
Phosphorylation-resistant site mutations in PIF7 result in increased nuclear localization and shade-induced gene expression, and consequently augment hypocotyl elongation. (elifesciences.org)

This makes it a high priority that standardized assays using authentic virus be used in addition to pseudoviruses, to measure the sensitivity of the virus to antibodies. (news-medical.net)

The Pasteur team was able to develop and test a vaccine in a non-humane primate that protects against two distant viruses while also inducing neutralizing Abs against all pathogenic South American NWAs. (star-oddi.com)

Most of the changes induced by CAE were reversed after alcohol withdrawal. (springer.com)

This mini-review summarizes the pathophysiological mechanisms and aims to establish the basis of "auto-antibody-induced cerebellar synaptopathies. (springer.com)

More recently it has been demonstrated that treatment with ALP significantly decreased the incidence and severity of anti-collagen type II (CII) antibody-induced arthritis (CAIA). (biomedcentral.com)
AK106-001616 alleviated paw swelling in a rat adjuvant-induced arthritis (AIA) model. (aspetjournals.org)

Anatomy21

Organisms20

Diseases6

Chemicals and Drugs113

Analytical, Diagnostic and Therapeutic Techniques and Equipment56

Phenomena and Processes45

Disciplines and Occupations2

Information Science3

Health Care5

Responses21

Proteins14

Antigens5

Protein13

Monoclonal antibodies2

Collagen antibody-induced1

Drug-induced lupus7

Antigen5

Known as antinuclear2

Levels of antibody2

Titer4

Lupus erythematosus6

Clinical11

Subcutaneous5

Immunity7

COVID-19 Vaccine1

Mice12

Bispecific Antibody1

Antihistone antibodies4

Serum antibodies2

Inflammation2

Hepatitis2

Titers4

Autoantibodies2

Epitope6

Titres1

Infection9

Therapeutic1

Preclinical2

Viral3

Anti-dsDNA1

Cytokine3

Immunoglobulin2

ANCA2

Procainamide3

Binds1

Neutralize2

Bind3

Autoantigens1

Tumor6

Inhibit1

Phosphorylation3

Assays1

Pathogenic1

Changes induced1

Mechanisms1

Arthritis2