• We studied autopsy specimens from has been shown to induce apoptosis in vitro ( 4 - 8 ). (cdc.gov)
  • The present study aimed to investigate the effects of S/V on the expression of metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), inflammation and apoptosis in human umbilical vein endothelial cells (HUVECs) induced by oxidized low‑density lipoprotein (ox‑LDL) and to elucidate its possible mechanism. (spandidos-publications.com)
  • Overall, the findings suggested that S/V could downregulate the expression of MALAT1, inhibit inflammation and apoptosis and improve endothelial function in ox‑LDL‑induced HUVECs via inactivating the TLR4/NF‑κB signaling pathway. (spandidos-publications.com)
  • RNAi-mediated attenuation of Tnfrsf1b decreased TNF-α-induced netrin-1 production and augmented epithelial cell apoptosis in culture. (aacrjournals.org)
  • Extending these observations, colon biopsies from E. faecalis -colonized IL-10 −/− mice exhibited crypt hyperplasia and increased staining for macrophages, TNF-α, netrin-1, NF-κB, Tnfrsf1b, and the proliferation marker proliferating cell nuclear antigen while also displaying a reduction in epithelial cell apoptosis. (aacrjournals.org)
  • Expression of the p53 target CDIP correlates with sensitivity to TNFα-induced apoptosis in cancer cells. (nih.gov)
  • Pretreatment with C-BF prevented LPS induced intestinal tight junction disruption and epithelial cell apoptosis. (unboundmedicine.com)
  • Enhances TNF- α -induced apoptosis in a multiple myeloma cell line. (tocris.com)
  • In UV models of ALCs and human lens epithelial cell lines, the expression levels of histone H3, cell apoptosis factors (Bax/Bcl-2, cleaved caspase-3), and inflammation factors (interleukin-6, tumor necrosis factor-α) were all up-regulated. (techscience.com)
  • Knockdown of KDM1B inhibits cell proliferation and induces apoptosis of pancreatic cancer cells. (cancerindex.org)
  • The resulting death-inducing signaling complex (disc) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. (lu.se)
  • Furthermore, lycopene inhibits ICAM-1 expression and abolishes NF-κB activation for up to 12h in TNFα-treated RPE cells. (nih.gov)
  • Insulin, after binding its receptor, induces the phosphorylation of receptor substrates in the liver and muscles, and induces several steps toward the transactivation of GLUT-4, which increases glucose uptake by cells and its storage as glycogen, and inhibits the net production of glucose by the liver, thus blocking glycogenolysis and neoglycogenesis. (isciii.es)
  • Inhibits NF κ B-mediated proinflammatory gene expression in human airway epithelial cells. (tocris.com)
  • Albumin selectively inhibits TNF alpha-induced expression of vascular cell adhesion molecule-1 in human aortic endothelial cells. (oregonstate.edu)
  • In this study, we investigated the effects of the pro-inflammatory cytokine tumor necrosis factor α (TNFα) on TLR2 expression in human gingival fibroblasts. (scilifelab.se)
  • Cells were exposed to FFAs with or without IGF-I pretreatment followed by analysis of cytokine expression and JNK phosphorylation. (elsevierpure.com)
  • Here, we report that the central proinflammatory cytokine TNF-α acts as a diffusible mediator of the bystander effects induced by macrophages, an effect caused by a proliferation of macrophages that trigger epithelial cell production of Netrin-1, a neuronal guidance molecule. (aacrjournals.org)
  • We have previously shown that the sialic acid-containing (Sia + ) fraction of intravenous immune globulin (IVIG) influences cell surface marker expression and cytokine/ chemokine secretion during the differentiation and maturation of human dendritic cells (DC). (scirp.org)
  • The present study examined the effects of Sia + IgG on human peripheral blood mononuclear cell (PBMC)-derived monocyte and macrophage surface marker expression and cytokine/chemokine secretion. (scirp.org)
  • Our data indicate that the Sia + fraction of IVIG possesses the ability to influence inflammatory processes in multiple immune cell types and induces novel signatures in cell surface marker expression and cytokine/chemokine production. (scirp.org)
  • This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. (nih.gov)
  • TNFα is a well-known pro-inflammatory cytokine implicated in the pathogenesis of muscle wasting under diverse clinical settings. (researchgate.net)
  • SPD-MAA treatment significantly stimulated pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) release in the macrophage cell line, RAW264.7. (cdc.gov)
  • Brain inflammation in animal models of these diseases is dominated by chronic microglial activation with minimal proinflammatory cytokine expression. (jneurosci.org)
  • To achieve this, we assessed proinflammatory cytokine expression, inflammatory cell infiltration, and expression of effector enzymes such as cyclooxygenase 2 (COX-2) and inducible nitric oxide (NO) synthase (iNOS) after intracerebral and intraperitoneal LPS challenges. (jneurosci.org)
  • 9 It also acts as a co-stimulatory cytokine (with a proliferation-inducing ligand (APRIL)) to promote class switching. (bmj.com)
  • In this study, we further evaluated the effects of ketamine on the regulation of LTA-induced TNF-α and IL-6 gene expressions and oxidative stress production in macrophages and its possible mechanisms. (tmu.edu.tw)
  • Exposure of macrophages to a therapeutic concentration of ketamine (100 μM) inhibited LTA-induced TNF-α and IL-6 expressions at protein or mRNA levels. (tmu.edu.tw)
  • Application of toll-like receptor 2 (TLR2) small interfering RNA (si)RNA into macrophages decreased the levels of this receptor, and simultaneously ameliorated LTA-augmented NFκB transactivation and consequent production of TNF-α and IL-6 mRNA. (tmu.edu.tw)
  • Cotreatment with ketamine and TLR2 siRNA synergistically lowered TNF-α and IL-6 mRNA syntheses in LTA-activated macrophages. (tmu.edu.tw)
  • Ketamine and TLR2 siRNA could reduce the LTA-induced increases in production of nitrite and intracellular reactive oxygen species in macrophages, and their combination had better effects than a single exposure. (tmu.edu.tw)
  • TNF-α-mediated bystander assays used a murine coculture system of primary colonic epithelial cells and E. faecalis -infected macrophages ( in vitro ), with an interleukin 10 (IL-10)-deficient mouse model of colon cancer that involves long-term colonization with E. faecalis ( in vivo ). (aacrjournals.org)
  • In macrophage-colony stimulating factor (MCSF) generated macrophages, Sia + IgG induced increased production of numerous cytokines/ chemokines including IL-6, TNFα, CXCL1, and IL-10, and the expression of the macrophage surface marker CD163. (scirp.org)
  • D. Bruder, E. , O. Richards, J. , M. Michel, K. and Oaks, M. (2016) Differential Effects of Alternative Glycoforms of IgG on Human Monocytes and Macrophages: Sialylated IgG Induces Novel Expression Signatures of Cell Surface Markers, Cytokines, and Chemokines. (scirp.org)
  • The loss of TNF α delayed the recruitment of neutrophils and macrophages to the spleen and inhibited the recruitment of neutrophils, macrophages, B cells, and T cells. (hindawi.com)
  • The loss of TNF α receptor 1/2 resulted in reduced recruitment of neutrophils, macrophages, and dendritic cells into the spleen, but only neutrophil recruitment was inhibited in the peritoneal cavity. (hindawi.com)
  • Pristane-induced chronic inflammation has been characterized by the continuous recruitment of leukocytes, including lymphocytes, neutrophils, and macrophages, to the peritoneal cavity and the spleen [ 6 - 8 ]. (hindawi.com)
  • Mice deficient for TNF α develop defective oil granulomas with reduced recruitment of macrophages and neutrophils [ 10 ]. (hindawi.com)
  • The migration of inflammatory leukocytes, including dendritic cells, neutrophils, and macrophages, to the peritoneal mesentery has been shown to be promoted in LAT −/− (lack mature T cells) mice but inhibited in μ MT (lack mature B cells) mice during the pristane-induced immune response [ 10 ]. (hindawi.com)
  • SPDMAA stimulated a significant dose-dependent increase in TNF-alpha and interleukin (IL)-6 release from peritoneal macrophages (PMs) of wild-type (WT) mice. (cdc.gov)
  • C-BF also reduced LPS induced TNF-α expression through the NF-κB signaling pathway in mouse RAW 264.7 macrophages. (unboundmedicine.com)
  • Confronting PM 2.5 , macrophages are able to be activated and induce inflammatory responses. (medsci.org)
  • At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)
  • Activated macrophages kill intracellular organisms and secrete cytokines (eg, tumor necrosis factor-alpha [TNF-alpha], IL-10). (msdmanuals.com)
  • Based on different gene expression profiles, subtypes of macrophages (eg, M1, M2), which have different roles in amplifying or limiting the inflammatory response, have been identified. (msdmanuals.com)
  • In the present study, we investigated the effect of LPS on the releasing function of afferent terminals as measured by calcitonin gene-related peptide (CGRP) release in ex vivo perfused rat trachea, and examined the possible role of the cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) as intermediaries in this effect. (jneurosci.org)
  • These findings suggest that endotoxin treatment generated cytokines such as IL-1β and TNF-α that regulated the peripheral releasing function of primary sensory afferents by sensitizing the terminals and facilitating peptide release. (jneurosci.org)
  • Cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) can be generated by inflammatory and nonimmune cells in response to inflammation, tissue injury, microbial invasion, and immunological reactions ( Dinarello, 1994 ). (jneurosci.org)
  • The CD56 bright population produces immunoregulatory cytokines, including interferon-γ (IFN-γ), tumor necrosis factor-beta (TNF-B), tumor necrosis factor-α (TNF-α), granulocyte macrophage-colony stimulating factor (GMCSF), IL-10, and IL-13 ( 4 ). (frontiersin.org)
  • The levels of proinflammatory cytokines IL-6, IL-1β and TNF in serum as well as mRNA expression in colon were significantly reduced in the uridine treated groups. (amrita.edu)
  • The expressions of cytokines and key molecular markers were detected by qRT-PCR, Western blotting and ELISA. (medsci.org)
  • Systemic inflammation evoked by LPS also produced greater increases in proinflammatory cytokines, pentraxin 3, and inducible nitric oxide synthase transcription in prion-diseased mice than in control mice and induced microglial expression of IL-1β. (jneurosci.org)
  • 6). Lung tissue, bronchoalveolar lavage fluid (BALF) and plasma were analyzed for cellular inflammation, cytokines, immunoglobulin E and heme oxygenase-1 (HO-1) expression. (cdc.gov)
  • Numerous apoptotic enza (H5N1) virus was also shown to induce lymphopenia leukocytes were observed in the lung of a patient who died on day 6 of illness. (cdc.gov)
  • Lymphotoxin alpha (LT α ) and TNF α were shown to induce the expression of homing chemokines in B and T cell areas of the spleen [ 13 ]. (hindawi.com)
  • Bacteria, fungi, viruses and parasites have been shown to induce NET formation, where they are trapped and killed by NETs, preventing dissemination of pathogens ( 1 ). (frontiersin.org)
  • Furthermore, to investigate the target cell of TNF-α for osteoclast formation during OTM with MOPs in vivo, we created four types of chimeric mice in which bone marrow of wild-type (WT) or TNF receptor 1- and 2-deficient mice (KO) was transplanted into lethally irradiated WT or KO mice . (bvsalud.org)
  • Furthermore, mice with TNF-α-responsive stromal cells showed a significant increase in tooth movement and number of osteoclasts by MOPs. (bvsalud.org)
  • Karnina R, Arif SK, Hatta M, Bukhari A, Natzir R, Patellongi I, Kaelan C. Systemic lidocaine administration influences NF-kβ gene expression, NF-kβ and TNF-α protein levels on BALB/c mice with musculoskeletal injury. (jomos.org)
  • Herein, chronic inflammation was induced by intraperitoneal injection of pristane into mice. (hindawi.com)
  • Interleukin-6 (IL-6) seems to regulate both plasmacytoma development in BALB/c mice and oil granuloma formation in C57BL/6 mice during pristane-induced inflammation [ 10 , 12 ]. (hindawi.com)
  • In transgenic mice models the HCV core protein has been found to induce insulin resistance via TNF production. (isciii.es)
  • But significantly less TNF-alpha and IL-6 were released from PMs of SRA -/- mice. (cdc.gov)
  • No further SPD-MAA-induced reduction was seen in PMs from SRA -/- mice. (cdc.gov)
  • The aim of the present study was to investigate the potential protective effect of intracolonic administered uridine against DSS induced colitis in male C57BL/6 mice. (amrita.edu)
  • We show that, using the ME7 model of prion disease, intracerebral challenge with LPS results in dramatic interleukin-1β (IL-1β) expression, neutrophil infiltration, and inducible nitric oxide synthase expression in the brain parenchyma of prion-diseased mice compared with the same challenge in normal mice. (jneurosci.org)
  • Tumour implantation or pre-treatment with tumour EVPs diminished cytochrome P450 gene expression and attenuated drug metabolism in a TNF-dependent manner. (nature.com)
  • RNA-seq raw data and associated processed data files that support the findings of this study have been deposited in the Gene Expression Omnibus under accession codes GSE199863 and GSE220446 . (nature.com)
  • HDAC inhibition ensures that chromatin is left in an open state by prohibiting the open to closed transition, leading to lasting gene expression and other epigenetic activity. (wikipedia.org)
  • 16-membered) on MUC5AC and MUC2 gene expression and secretion from human airway epithelial cells. (karger.com)
  • The MUC5AC and MUC2 gene expression was measured by real-time quantitative RT-PCR. (karger.com)
  • This article reviews the current knowledge and experimental research about the mechanisms by which fatty acids and their derivatives control specific gene expression involved during carcinogenesis. (springer.com)
  • Knowledge of the mechanisms by which fatty acids control specific gene expression may identify important risk factors for cancer and provide insight into the development of new therapeutic strategies for a better management of whole body lipid metabolism. (springer.com)
  • Effect of dietary fatty acids on inflammatory gene expression in healthy humans. (springer.com)
  • For the correlation analysis between NAMPT and SASP genes in human laser capture and microdissected PanIN lesion samples, gene expression data were obtained from GEO (under accession code GSE43288 ) 1 . (nature.com)
  • Genetic variants at the PTPN2 locus, which encodes the tyrosine phosphatase PTPN2, cause reduced gene expression and are linked to rheumatoid arthritis (RA) and other autoimmune diseases. (researchgate.net)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • The fatty acid cargo of tumour EVPs-particularly palmitic acid-induced secretion of tumour necrosis factor (TNF) by Kupffer cells, generating a pro-inflammatory microenvironment, suppressing fatty acid metabolism and oxidative phosphorylation, and promoting fatty liver formation. (nature.com)
  • Objective To evaluate the efficacy and safety of tabalumab, a monoclonal antibody that neutralises membrane-bound and soluble B-cell activating factor (BAFF), in patients with active rheumatoid arthritis (RA) who showed inadequate response to tumour necrosis factor (TNF) inhibitors. (bmj.com)
  • 1 Biological therapies that selectively target key molecules associated with joint inflammation, such as tumour necrosis factor (TNF) inhibitors, are effective options for RA treatment. (bmj.com)
  • We found that the loss of IL-6 decreased macrophage recruitment to the spleen and the peritoneal cavity during pristane-induced inflammation. (hindawi.com)
  • These data provide insight into the development of chronic inflammation induced by noninfectious substances. (hindawi.com)
  • Noninfectious inflammation can be induced by persistent indigestible substances. (hindawi.com)
  • Colon musocal inflammation and damage were assessed by measuring colon mass, morphologic damage score, colonic myeloperoxidase enzyme (MPO) activity, serum TNF-α and colonic TNF-α mRNA level. (wjgnet.com)
  • Anti-inflammatory activity was assessed using the carrageenan test, and both TDT1 and TDT2 significantly reduced carrageenan-induced inflammation. (iasp-pain.org)
  • Histopathological grading indicated that OVA + PM/OVA treatment induced significant inflammation compared to OVA/OVA. (cdc.gov)
  • Receptor-interacting protein kinase 1 (RIPK1) is a key component of the tumor necrosis factor (TNF) receptor signaling complex that regulates both pro- and anti-apoptotic signaling. (mdpi.com)
  • Signaling pathways involved in the regulation of TNFα-induced toll-like receptor 2 expression in human gingival fibroblasts. (scilifelab.se)
  • In cell cocultures, we observed increased expression of the TNF-α receptor Tnfrsf1b and Netrin-1. (aacrjournals.org)
  • SPD-MAA treatment significantly increased SRA mRNA expression, but had no effect on surface receptor protein expression. (cdc.gov)
  • Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. (lu.se)
  • Crystal structure of the soluble human 55 kd TNF receptor-human TNF complex: implications for TNF receptor activation. (lu.se)
  • Our results showed that TNFα increased TLR2 mRNA and protein expression. (scilifelab.se)
  • PM 2.5 increased the mRNA and protein expression of M1 markers including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and inducible nitric oxide synthase (iNOS) in RAW264.7 cells. (medsci.org)
  • Pansensitive and panresistant genes to 21 NCCN-recommended drugs with concordant mRNA and protein expression were identified. (cdc.gov)
  • Caminero A, Comabella M, Montalban X. Tumor necrosis factor alpha (TNF α), anti TNF α and demyelination revisited: an ongoing story. (jomos.org)
  • Tumor necrosis factor alpha (TNF α ) stimulates the expression of monocyte chemoattractant protein 1 (MCP-1) [ 11 ]. (hindawi.com)
  • To investigate the regulatory effect of electroacupuncture (EA) at Zusanli (ST36) on tumor necrosis factor-alpha (TNF-α) in rats with ulcerative colitis (UC), and further elucidate the therapeutic mechanism of EA on UC. (wjgnet.com)
  • We identified tumour-derived extracellular vesicles and particles (EVPs) as crucial mediators of cancer-induced hepatic reprogramming, which could be reversed by reducing tumour EVP secretion via depletion of Rab27a . (nature.com)
  • Fig. 4: Palmitic acid in tumour EVPs induces TNF secretion from Kupffer cells and promotes fatty liver generation. (nature.com)
  • Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin secretion in human airway epithelial cells. (karger.com)
  • Moreover, C-BF down regulated the expression and secretion of TNF-α, a process involving the NF-κB signaling pathway. (unboundmedicine.com)
  • IGF-I pretreatment reduced FFA-induced JNK1 phosphorylation and TNFα expression in SC but not omental preadipocytes. (elsevierpure.com)
  • Pretreatment with PD98059, an inhibitor of ERK, decreased LTA-enhanced NFκB activation and TNF-α and IL-6 mRNA syntheses. (tmu.edu.tw)
  • We exposed ARPE-19 cells to TNFα after pretreatment with lycopene, and measured monocyte adhesion, ICAM-1 expression, NF-κB nuclear translocation, and transcriptional activity. (nih.gov)
  • These effects were blocked by anti-TNF-α antibody or by pretreatment with an inhibitor of NF-κB signaling. (aacrjournals.org)
  • This study investigated whether C-BF pretreatment could protect the intestinal barrier against dysfunction in a mouse model of endotoxemia, induced by intraperitoneal injection of LPS (10mg/kg). (unboundmedicine.com)
  • Here, we show that human antigen R (HuR), an RNA binding protein which binds preferentially to AU-rich elements (AREs) and stabilizes mRNAs, regulates TNF-α-induced ICAM-1 expression in the MK2/HuR signaling pathway. (biomedcentral.com)
  • Zhang S, Li Y, Tu Y. Lidocaine attenuates CFA-induced inflammatory pain in rats by regulating the MAPK/ERK/NF-κB signaling pathway. (jomos.org)
  • These results indicate that MK2 post-transcriptionally regulates TNF-α-induced ICAM-1 expression by altering the cytoplasmic localization of HuR in HPMECs. (biomedcentral.com)
  • Our previous study showed that mitogen-activated protein kinase (MAPK) p38/ MAPK-activated protein kinase 2 (MK2) regulates the expression of ICAM-1 and IL-8 at the post-transcriptional level in HPMECs after TNF-α stimulation [ 4 ]. (biomedcentral.com)
  • However, the precise mechanism by which MK2 regulates ICAM-1 and IL-8 expression remains elusive. (biomedcentral.com)
  • It has been reported that RNF4 negatively regulates TNF-α-induced activation of the nuclear factor-κB (NF-κB) through downregulation of transforming growth factor β-activated kinase 1 (TAK1) activity, indicating the possibility that RNF4-mediated TAK1 suppression results in enhanced sensitivity to cell death. (mdpi.com)
  • Overall, these results suggest that TDT1 and TDT2 exert their neuroprotective and analgesic potentials by ameliorating CCI-induced allodynia, hyperalgesia, neuroinflammation and neuronal degeneration in a dose-dependent manner. (iasp-pain.org)
  • The finding that a single acute systemic inflammatory event can induce neuronal death in the CNS has implications for therapy in neurodegenerative diseases. (jneurosci.org)
  • Results FFAs increased the expression of tumor necrosis factor (TNF)α, interleukin (IL)-6, and monocyte chemotactic protein (MCP)-1 in SC and omental preadipocytes. (elsevierpure.com)
  • Lycopene could reduce TNF-α-induced monocyte adhesion and H2O2- induced cell damage in RPE cells. (nih.gov)
  • Thus, this study shows that one possible mechanism involved in ketamine-induced inhibition of LTA-induced TNF-α and IL-6 gene expressions and oxidative stress production is through downregulating TLR2-mediated phosphorylation of ERK1/2 and the subsequent translocation and transactivation of NFκB. (tmu.edu.tw)
  • Oxidized low-density lipoprotein (ox-LDL) is widely recognized to participate in the occurrence and development of atherosclerosis through inducing oxidative chain reaction and endothelial dysfunction ( 6 ). (spandidos-publications.com)
  • Thiourea protects against copper-induced oxidative damage by formation of a redox-inactive thiourea-copper complex. (oregonstate.edu)
  • AZM and MDM attenuated PMA-induced MUC5AC and MUC2 gene and protein expression in NCI-H292 cells. (karger.com)
  • Moreover, colon tissue myloperoxidase activities, protein expression of IL-6, TNF- α, COX-2, P-NFkB and P-Ikk-βα in the colon tissues were significantly reduced in medium and high dose groups. (amrita.edu)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Microarray analysis and the inhibition of specific signaling pathways demonstrated that c-Jun N-terminal kinases (JNK) and nuclear factor kappa B (NF-κB) were involved in the regulation of TNFα-induced TLR2 expression in gingival fibroblasts. (scilifelab.se)
  • Our results reveal how tumour-derived EVPs dysregulate hepatic function and their targetable potential, alongside TNF inhibition, for preventing fatty liver formation and enhancing the efficacy of chemotherapy. (nature.com)
  • Koontongkaew S, Monthanapisut P, Saensuk T: Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression. (karger.com)
  • TNF α is mainly secreted by primitive neutrophils and participates in the inflammatory response involved in rheumatoid arthritis and inflammatory bowel disease [ 17 ]. (hindawi.com)
  • Treatment with the JNK1/2 inhibitor SP600125 reduced FFA-induced expression of TNFα. (elsevierpure.com)
  • MiR-146a-3p mimic and inhibitor were pre-transfected into RAW264.7 cells and the effects on M1 polarization induced by PM 2.5 were evaluated. (medsci.org)
  • Intervention of electroacupuncture on spinal p38 mapk/atf 2/vr 1 pathway in treating inflammatory pain induced by CFA in rats. (jomos.org)
  • Meutia Sari L, Mubarak Z, Keumala Sari D. Evaluation of clinical, histology, TNF-α, and collagen expressions on oral ulcer in rats after treatment with areca nut and chrysanthemum oral gel. (jomos.org)
  • Systemic injection of LPS (0.75 mg/kg, i.p.) in adult rats induced an increase in body temperature followed by hypothermia, indicating ongoing infection. (jneurosci.org)
  • Tian L, Huang YX, Tian M, Gao W, Chang Q. Downregulation of electroacupuncture at ST36 on TNF-α in rats with ulcerative colitis. (wjgnet.com)
  • Micro-Osteoperforations Induce TNF-α Expression and Accelerate Orthodontic Tooth Movement via TNF-α-Responsive Stromal Cells. (bvsalud.org)
  • We conclude that MOPs increase TNF-α expression, and tooth movement is dependent on TNF-α-responsive stromal cells . (bvsalud.org)
  • Fig. 3: Uptake of tumour-derived EVPs by Kupffer cells induces fatty liver formation. (nature.com)
  • Previous studies have shown that the expression of MALAT1 is increased in endothelial cells induced by ox-LDL and its expression level can reflect the damage degree of endothelial cells ( 11 , 12 ). (spandidos-publications.com)
  • Enzyme-linked immunosorbent assay was used to determine MUC5AC, MUC2 and TNF-α released by the cells. (karger.com)
  • They also suppressed PMA-mediated TNF-α in the cells. (karger.com)
  • The present study demonstrates that AZM and MDM suppress the synthesis of mucin and TNF-α from human airway epithelial cells. (karger.com)
  • The purpose of this study was to determine how expression of Lcn2 is regulated in fat cells and to ascertain whether Lcn2 could be involved in metabolic dysregulation associated with obesity. (diabetesjournals.org)
  • TNF α plays an important role in the formation of primary B cell follicles and follicular dendritic cells [ 16 ]. (hindawi.com)
  • Raw RNA-seq data for RAS-induced senescence and control conditions in IMR90 cells were downloaded from GEO (under accession code GSE74324 ) 41 . (nature.com)
  • Therapeutic intervention aims to reverse tumor-induced NK cell suppression and sustain NK cells' tumorlytic capacities. (frontiersin.org)
  • Human NK cells are phenotypically characterized by the expression of CD56 and the absence of CD3 and can be further subdivided into a CD56 bright population and a CD56 dim population. (frontiersin.org)
  • Human mast cells induce osteoclastogenesis through cell surface RANKL. (nih.gov)
  • When insulin is unable to induce glucose uptake, pancreatic beta-cells increase insulin production and the hyperinsulinemic state prevents hyperglycemia. (isciii.es)
  • Upon activation, immature dendritic cells mature and increase the expression of class II MHC and co-stimulatory molecules important for effective antigen presentation to naïve T cells. (rndsystems.com)
  • Immature dendritic cells (left, blue) and TNF-α-treated mature dendritic cells (right, red), derived from bone marrow cells cultured with the CellXVivo ™ Mouse Dendritic Cell Differentiation Kit, were stained for flow cytometry with antibodies for CD11c, B7-2/CD86, MHC class II (I-A/I-E), or CD40 (open histograms). (rndsystems.com)
  • Immature dendritic cells have the phenotype of CD11c + , with intermediate expression of B7-2/CD86, MHC class II, and little to no CD40. (rndsystems.com)
  • Mature dendritic cells have the phenotype of CD11c + , with increased expression of B7-2/CD86, MHC class II, and CD40. (rndsystems.com)
  • Kit-derived Mature Mouse Dendritic Cells Induce Proliferation of Allogeneic T Cells. (rndsystems.com)
  • Serial dilutions of TNF-α-treated mature dendritic cells were incubated with allogeneic mouse T cells for 3 days. (rndsystems.com)
  • Zhong Y, Liao J, Hu Y, Wang Y, Sun C, Zhang C, Wang G. PM 2.5 Upregulates MicroRNA-146a-3p and Induces M1 Polarization in RAW264.7 Cells by Targeting Sirtuin1. (medsci.org)
  • Overexpression of miR-146a-3p downregulated the expression of SIRT1 protein in untreated RAW264.7 cells. (medsci.org)
  • Furthermore, transfection of CRYAA in FHL-124 cells induced overexpression of histone H3. (techscience.com)
  • Significant downregulation of beta-defensin1 gene (DEFB1) expression was observed when human bronchial epithelial cells (HBEpCs) were exposed to IAV. (cdc.gov)
  • B-cell activating factor (BAFF) is a ligand in the TNF family that exists in a membrane-bound and soluble form and is required for B-cell survival as they leave the bone marrow and enter the periphery. (bmj.com)
  • According to the etiology, cataract is classified as age-related cataract (ARC), childhood cataract, traumatic cataract, cataract associated with systemic disease, complicated cataract, and drug-induced cataract, among which ARC was the most common type ( Richard, 2019 ). (techscience.com)
  • Sabir A, Sumidarti A. Interleukin-6 expression on inflamed rat dental pulp tissue after capped with Trigona sp. (jomos.org)
  • The results showed that MOPs increased TNF-α expression, the distance of tooth movement and osteoclast formation significantly. (bvsalud.org)
  • Compared with the ox‑LDL group, S/V treatment significantly increased the cell viability, NO concentration and Bcl‑2 expression, decreased the levels of IL‑1β, IL‑6 and TNF‑α and reduced the expressions of MALAT1, ICAM‑1, VCAM‑1, cleaved‑caspase‑3, Bax, TLR4 and p‑p65. (spandidos-publications.com)
  • We observed that capsaicin-induced (0.1 μ m ) tracheal CGRP release was significantly enhanced in the LPS-treated animals after 5 hr. (jneurosci.org)
  • In a PCR array analysis of 84 transcription factors, either overexpressing DEFB1 or siRNA silencing of DEFB1 expression significantly modulated the expression of signal transducer and activator of transcription 3 (STAT3). (cdc.gov)
  • We also observed fatty liver and decreased cytochrome P450 expression at diagnosis in tumour-free livers of patients with pancreatic cancer who later developed extrahepatic metastasis, highlighting the clinical relevance of our findings. (nature.com)
  • Our findings suggest that these pathways and mediators, through the regulation of TLR2 expression in gingival fibroblasts, may be involved in the pathogenesis of periodontitis. (scilifelab.se)
  • Exposure of the peripheral C-fiber terminals to inflammatory mediators such as bradykinin, serotonin, prostaglandins, leukotriences, and protons induces depolarization of the terminals as evidenced by the generation of action potentials and/or sensitization of the terminals ( Basbaum, 1991 ). (jneurosci.org)
  • Sia + IgG induced increased expression of CD80 and dendritic cell immunoreceptor (DCIR) on monocytes, whereas the expression of HLA-DR was decreased. (scirp.org)
  • Opened or reconstituted Mouse Dendritic Cell Base Media, Recombinant Mouse GM-CSF, Recombinant Mouse IL-4, or Recombinant Human TNF-alpha should be stored at 2-8 ° C under sterile conditions for up to 30 days or at -20 ° C to -70 ° C in a manual defrost freezer for up to 3 months. (rndsystems.com)
  • Attenuates LPS-induced TNF- α production in vivo . (tocris.com)
  • PM 2.5 decreased the protein level of SIRT1 but not the mRNA expression in vitro and in vivo experiments. (medsci.org)
  • Fig. 1: Remote primary tumours induce metabolic dysfunction in the liver. (nature.com)
  • Fig. 2: Tumour-derived EVPs induce liver metabolic dysfunction. (nature.com)
  • Thus, helping overcome cancer-induced cell dysfunction. (wikipedia.org)
  • These findings indicate that C-BF can prevent gut barrier dysfunction induced by LPS, suggesting that C-BF may be used to develop a prophylactic agent for intestinal injury in endotoxemia. (unboundmedicine.com)
  • Macrophage-induced bystander effects have been implicated as an important mediator of chromosomal instability and colon cancer triggered by Enterococcus faecalis , a human intestinal commensal bacteria. (aacrjournals.org)
  • C-BF reduced LPS induced intestinal histological damage and gut permeability to 4 KD Fluorescein-isothiocyanate-conjugated dextran. (unboundmedicine.com)
  • Sia + IgG also increased the expression of cell surface markers associated with macrophage polarization (e.g. (scirp.org)
  • Afterwards, whether Sirtuin1 (SIRT1) an important intermediate regulator in various physiological processes takes part in the macrophage polarization induced by PM 2.5 is unknown. (medsci.org)
  • Binding of TNF to the extracellular domain leads to homotrimerization. (lu.se)
  • We found that lycopene increases intracellular GSH levels and GCL expression. (nih.gov)
  • Besides, virus C infection may induce insulin resistance by blocking intracellular signaling, and lastly, insulin resistance has been associated with a decreased rate of sustained response to peginterferon alpha plus ribavirin in patients with chronic hepatitis C. (isciii.es)
  • A total of 99 anterior lens capsules (ALCs) of patients with ARC of various nuclear grades, ultraviolet models of ALCs, and two human lens epithelial cell lines (FHL-124 and SRA01/04) were used, and the expression of histone H3, CRYAA, GLB1, and p53 were detected by immunoblotting and reverse transcription and real time-quantitative polymerase chain reaction. (techscience.com)
  • The immunohistochemical results showed prominent expression of CD44 in 13 of the patients and CD117 in 9 of the patients with new blister formation. (who.int)
  • In summary, hepatitis C promotes insulin resistance and insulin resistance induces steatosis, fibrosis, and interferon resistance. (isciii.es)
  • Cotreatment with ketamine and PD98059 synergistically suppressed the LTA-induced translocation and transactivation of NFκB and biosyntheses of TNF-α and IL-6 mRNA. (tmu.edu.tw)
  • Notably, Kupffer cell ablation or TNF blockade markedly decreased tumour-induced fatty liver generation. (nature.com)
  • T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. (nih.gov)
  • Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. (cancerindex.org)
  • Methods Patients on stable methotrexate and with inadequate response to one or more TNF inhibitors were randomised to placebo (n=35), 30 mg tabalumab (n=35) or 80 mg tabalumab (n=30) given intravenously at 0, 3 and 6 weeks. (bmj.com)
  • 2 Many patients continue to have active disease despite treatment with biological disease-modifying antirheumatic drugs (bDMARDs), including TNF inhibitors, and are in need of new treatment options. (bmj.com)
  • Our findings revealed that CCI induced clear-cut allodynia and hyperalgesia which was reversed by TDT1 and TDT2. (iasp-pain.org)
  • Expression of myr-AKT in omental preadipocytes inhibited FFA-stimulated JNK1 phosphorylation. (elsevierpure.com)
  • The use of Nrf2 siRNA blocks the inhibitory effect of lycopene in TNF-α-induced ICAM-1 expression and NF-κB activation. (nih.gov)
  • Objective Free fatty acids (FFAs) are increased in visceral fat and contribute to insulin resistance through multiple mechanisms, including c-Jun N-terminal kinase (JNK) activation and expression of TNFα. (elsevierpure.com)
  • Our previous studies showed that ketamine has anti-inflammatory and antioxidant effects on gram-negative LPS-induced macrophage activation. (tmu.edu.tw)
  • Pristane administration induces macrophage activation [ 1 , 2 ]. (hindawi.com)
  • Contributes to the induction of noncytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. (lu.se)
  • Fig. 5: AMPK signalling mediates the proinflammatory SASP induced by NAD + metabolism. (nature.com)
  • In addition, we examined the signaling pathways involved in the regulation of TNFα-induced TLR2 expression. (scilifelab.se)
  • This mini-review summarizes the pathophysiological mechanisms and aims to establish the basis of "auto-antibody-induced cerebellar synaptopathies. (springer.com)
  • molecular docking studies predicted that both compounds had an effective binding affinity for TNF-α and COX-2. (iasp-pain.org)
  • Following lycopene treatment, TNF-α-induced ROS production was abolished. (nih.gov)
  • In addition, the production of IL-6, TNFα, IL-1β, and CXCL1 by monocytes was profoundly increased by treatment with Sia + IgG. (scirp.org)
  • Interestingly, TDT1 and TDT2 substantially reduced the mRNA expression and protein level of Iba1, implying that TDT1 and TDT2 may mitigate CCI-induced astrogliosis. (iasp-pain.org)
  • Serum TNF-α concentration was determined by radioimmunoassay (RIA). (wjgnet.com)
  • En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)
  • Auto-antibodies induced neurological diseases show various clinical phenotypes (see details in Table 1 ). (springer.com)
  • Nishina K, Mikawa K, Takao Y, Shiga M, Maekawa N, Obara H. Intravenous lidocaine attenuates acute lung injury induced by hydrochloric acid aspiration in rabbits. (jomos.org)
  • Once inhaled, PM 2.5 deposits in lung tissues and diffuses in blood inducing lung and systematic injuries [ 3 , 4 ]. (medsci.org)
  • Based on the consistent expression patterns associated with patient survival outcomes and in tumors vs. normal lung tissues, 10 miRNAs were considered to be putatively tumor suppressive and 4 miRNAs were deemed as oncogenic in lung cancer. (cdc.gov)
  • These results suggested that PM 2.5 induces the inflammatory M1 polarization and TLR4/NF-κB signal transduction pathway might be involved in the process. (medsci.org)
  • Pre-treatment with SIRT1 agonist SRT1720 rescued the PM 2.5 induced M1 response. (medsci.org)