Loading...
  • conjugation
  • To investigate the impact that conjugation methods may have on antipolysaccharide immune responses and to determine whether this limited cross-protection is characteristic of the serotype 19F polysaccharide or rather of the 19F-CRM (cross-reacting material) conjugate, we compared naturally induced antibodies against serotypes 19F and 19A with antibodies induced after vaccination with different pneumococcal conjugate vaccines. (asm.org)
  • The effects of HDI on airway epithelial cells remain poorly described despite the documented susceptibility of airway epithelial cell proteins to diisocyanate conjugation (5,6) and their anatomical location at the air-liquid interface in the lung, a primary site of exposure. (thefreelibrary.com)
  • Urm1 conjugation to target proteins in general, and to the evolutionary conserved substrate Peroxiredoxin 5 (Prx5) specifically, is dependent on Uba4. (sdbonline.org)
  • high-affinity
  • The values obtained for the binding constants suggest a high affinity between proteins and FA. (mdpi.com)
  • Since then, a family of five high-affinity glutamate transporters has been characterized that is responsible for the precise regulation of glutamate levels at both synaptic and extrasynaptic sites, although the glutamate transporter 1 (GLT1) is responsible for more than 90% of glutamate uptake in the brain.3 The importance of GLT1 is further highlighted by the large number of neuropsychiatric disorders associated with glutamate-induced neurotoxicity. (wikipedia.org)
  • Inhibition
  • Bradley AJ, Devine DV, Ansell SM, Janzen J, Brooks DE (1998) Inhibition of liposome-induced complement activation by incorporated poly(ethylene glycol)-lipids. (springerprofessional.de)
  • They can be considered a novel class of nerve agent toxins, inducing toxic levels of glutamate through transport inhibition in a manner analogous to the effect of sarin on acetylcholine transporters. (wikipedia.org)
  • cytokines
  • Recent investigations have shown that the immune system and nervous system are linked through several mediators, such as hormones, cytokines, and neurotransmitters ( 1 , 2 ). (jimmunol.org)
  • Of note, the activation of mitogen-activated protein kinases (MAPKs) is important in the production of inflammatory cytokines by LPS stimulation [ 3 ]. (hindawi.com)
  • bound
  • Particle size distribution allowed to study the protein aggregation phenomenon induced by FA bound to the native proteins. (mdpi.com)
  • The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. (wikipedia.org)
  • molecules
  • The vaccine can contain the polysaccharides alone or more frequently polysaccharides conjugated to carrier molecules. (bioportfolio.com)
  • Finally, this study showed that overexpressing other cell adhesion molecules, together with weak attenuation of JNK signaling, strongly inhibits pruning. (sdbonline.org)
  • The flow of auxin molecules through the neighboring cells is driven by carriers (type of membrane transport protein) in the cell-to-cell fashion (from one cell to other cell and then to the next one) and the direction of the flow is determined by the localization of the carriers on the plasma membrane in the concerned cells. (wikipedia.org)
  • susceptibility
  • The lung is the last organ to develop so HP59 is present in the newborn lung for 5-10 days after birth, explaining the susceptibility to GBS induced "early onset" disease. (wikipedia.org)
  • upregulates
  • CGRP inhibits the migration of Langerin + dermal dendritic cells to the lymph nodes in 2,4,6-trinitrochlorobenzene-induced CHS, and upregulates IL-4 production of T cells in the draining lymph nodes in FITC-CHS. (jimmunol.org)
  • epithelial
  • Our laboratory has recently identified specific epithelial cell proteins that selectively become conjugated with HDI after exposure, including keratin 18, dihydrodiol dehydrogenase, actin, and the 78-kDa glucose-regulated stress response protein (6). (thefreelibrary.com)
  • 7) have shown that toluene diisocyanate (TDI) colocalizes with tubulin present in the cilia of differentiated human airway epithelial cells. (thefreelibrary.com)
  • membrane
  • The protein forms a homodimer embedded in the inner mitochondria membrane. (bio-rad.com)
  • In either prokaryotes or mitochondria they are localized to the outer membrane, and have been shown to bind and transport dicarboxylic tetrapyrrole intermediates of the haem biosynthetic pathway. (wikipedia.org)
  • Hence the export of auxin from the cell requires an active component in plasma membrane - i.e. some membrane transport protein. (wikipedia.org)
  • While the PGP auxin efflux carriers are evenly distributed, the PIN proteins are most often maintaining polar (i.e. asymmetric) localisation on the plasma membrane. (wikipedia.org)
  • For example, the cells located in the vasculature (at the center) of the root all show PIN1 proteins on their basal membrane only (i.e. on their lower side). (wikipedia.org)
  • Ftr1p is a protein of 404 amino acyl residues which may span the membrane seven times. (wikipedia.org)
  • Still another possibility is that Fet3p functions only indirectly in transport by allowing membrane insertion, localization or stability of Ftr1p due to the formation of a complex between these two proteins. (wikipedia.org)
  • The malaria parasite, Plasmodium falciparum, grows within its host erythrocyte and induces an increase in the permeability of the erythrocyte membrane to a range of solutes including Na+ and K+. (wikipedia.org)
  • microorganisms
  • Dentin pulp complex injuries are often induced by invasion of microorganisms and their components via dentinal tubules towards the pulp. (hindawi.com)
  • 1991
  • al-Ramadi BK, Brodikin MA, Mosser DM, Einstein TK (1991) Immunosuppression induced by attenuated Salmonella: evidence for mediation by macrophage precursors. (springerprofessional.de)
  • vitro
  • Atromentin possesses in vitro antibacterial activity, inhibiting the enzyme enoyl-acyl carrier protein reductase (essential for the biosynthesis of fatty acids) in the bacteria Streptococcus pneumoniae. (wikipedia.org)
  • vivo
  • This study characterizes the Drosophila homologues of Urm1 (CG33276) and its E1 activating enzyme Uba4 (CG13090) and shows that they function together to induce protein urmylation in vivo. (sdbonline.org)
  • mice
  • The mimotopes were conjugated to immunogenic carrier proteins and used to intraperitoneally immunize BALB/c mice. (biomedcentral.com)
  • Administration of anti-HMGB1 Abs protects mice from LPS-induced lethality even if the therapy is delayed several hours and is given after the appearance of the early proinflammatory cytokine response ( 2 , 7 , 9 , 13 ). (jimmunol.org)
  • The cells induced a wide, functional and long-lasting transdifferentiation process that reduced the effects of hyperglycemia in diabetic mice. (wikipedia.org)
  • CM101 has been shown in a published Phase I, FDA-approved clinical trial under IND to have clinical safety and effectivity on select stage IV cancer patients, specifically targeting tumor vasculature HP59 is expressed in the adult in wound healing, and in tumor angiogenesis, as shown in mice. (wikipedia.org)
  • Mechanism
  • The mechanism below describes the process in which auxin is trapped in the cell by the so-called acid trap and how it can then leave the cell only by activity of specific carriers, which control the directionality of the flow from cells and generally the direction of auxin transport through the whole plant body. (wikipedia.org)
  • Regardless of these possibilities, it is not known if a channel or carrier mechanism operates. (wikipedia.org)
  • In E.coli, negative autoregulation of SoxS protein serves as a dampening mechanism for the soxRS redox stress response. (wikipedia.org)
  • receptors
  • TC# 2.A.20.2.7) have been reported to function as viral receptors, but they undoubtedly function as transport proteins as well. (wikipedia.org)
  • rats
  • In studies on rats with metaphit-induced epilepsy DSIP acted as an anticonvulsant, significantly decreasing the incidence and duration of fits suggesting DSIP as a potential treatment for epilepsy. (wikipedia.org)
  • 2016
  • An additional review by Agrawal and Sinha of BMP-2 and its common delivery systems in early 2016 showed how "problems like ectopic growth, lesser protein delivery, [and] inactivation of the protein" reveal a further need "to modify the available carrier systems as well as explore other biomaterials with desired properties. (wikipedia.org)
  • As of early 2016, it appears no crystal structures are available for PiT proteins. (wikipedia.org)