Induce senescence details of cellular senescence. Medical search. Frequent questions

SnCs exhibit irreversible growth arrest accompanied by increased expression of cyclin-dependent kinase inhibitors (CDKi) such as p16 INK4a , and p21 Cip1 , accumulation of DNA damages, and secretion of diverse bioactive molecules known as the senescence-associated secretory phenotype (SASP). (aging-us.com)
Furthermore, senescent cells, with the secretory features known as the senescence-associated secretory phenotype (SASP), could produce proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and monocyte chemoattractant protein1 (MCP-1), to greatly affect the neighboring cells [ 17 , 18 ]. (hindawi.com)
Senescent cells exhibit chronic activation of the transcription factor nuclear factor (NF)-κB, a known mediator of the pro-inflammatory senescence-associated secretory phenotype (SASP) and skeletal muscle atrophy. (jci.org)
Senescent cells cause harm through what is known as the senescence-associated secretory phenotype (SASP) , the secretion of signals that spur inflammation, tissue modeling, and alterations in cellular behavior. (fightaging.org)
Virus-induced senescence (VIS) is indistinguishable from other forms of cellular senescence and accompanied by a senescence-associated secretory phenotype (SASP), composed of pro-inflammatory cytokines, extracellular matrix-active factors and pro-coagulatory mediators 5-7 . (edu.hk)

More in detail, both conditions have been widely associated with the accumulation of genetic and epigenetic alterations responsible for the alteration of cell proliferation and apoptosis responsible for the neoplastic transformation of cells and the development of tumors (Candido et al. (researchgate.net)
RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy. (nature.com)
Although the senescent cells remain viable, they show typical changes with enlarged and flattened cell bodies, apoptosis resistance, increased activity of senescence-associated β -galactosidase (SA- β -gal), and upregulation of cyclin-dependent kinase (CDK) inhibitors including p16 INK4A , ARF proteins, and p21 [ 13 - 16 ]. (hindawi.com)
As senescent cells are stressed cells and are resistant to apoptosis, the first question we set out to ask was whether ADAR1 is related to cellular senescence and secondly, how does it regulate senescence and what is its' potential implication in tissue aging. (thincb2b.com)
The aim of this study was to investigate whether resveratrol (RSV) could ameliorate ischemia- and hypoxia-associated cardiomyocyte apoptosis and injury via inhibiting senescence signaling and inflammasome activation. (hindawi.com)
RSV inhibited the expression of senescence markers (p53, p16, and p19), inflammasome markers (NLRP3 and Cas1 p20), and nuclear translocation of NF- κ B, hence alleviating infarction area, fibrosis, and cell apoptosis. (hindawi.com)
In in vitro experiment, RSV prevented hypoxia-induced NRCM senescence and apoptosis. (hindawi.com)
The p53-associated signaling pathway has been demonstrated to regulate hypoxia-induced apoptosis and senescence [ 5 ]. (hindawi.com)
The rationale of this Program Project is that spontaneous DMA damage drives major components of the aging process, through direct adverse effects, but more likely by inducing genome maintenance responses, resulting in senescence, apoptosis and/or genomic and epigenomic errors. (elsevierpure.com)
Cada célula está programada para realizar determinado número de divisiones celulares y, al finalizar dicho tiempo, la proliferación se interrumpe y la célula entra en un estado de inactividad tras el cual se produce la MUERTE CELULAR a través del proceso de APOPTOSIS. (bvsalud.org)

Similarly, aging has long been known to be associated with the accumulation of mutations, leading to cellular dysfunction and, ultimately, to a senescent phenotype (Lee 2018). (ernolaszlo.com)

Researchers here report on in vitro experiments to show that introducing functional mitochondria into a cell culture containing senescent cells reduces markers of senescence. (fightaging.org)
Those groups are not specifically targeting cellular senescence, but can hardly avoid having senescent cells taking up their therapeutic mitochondria. (fightaging.org)
The understanding that senescent cells existed and were important in human health and aging started sometime around the discovery and subsequent exploration of the Hayflick limit to cellular replication, in the 1960s. (fightaging.org)
By the time that the SENS rejuvenation research proposals were first formalized, more than three decades later, a little after the turn of the century, the research community had a much better understanding of cellular senescence as a phenomenon, as well as a good deal of indirect evidence to show that (a) senescent cells accumulated with age, and (b) their presence contributed to age-related disease and dysfunction. (fightaging.org)
Treatment of senescent cells with trichostatin A, a class I/II histone deacetylase inhibitor, also induced rapid and reversible decondensation of SAHFs. (biomedcentral.com)

We demonstrated mitochondrial dysfunction in replicative senescence -induced ARPE-19 cells after repeated passage . (fightaging.org)

Knockdown of inwardly rectifying potassium channel Kir2.2 suppresses tumorigenesis by inducing reactive oxygen species-mediated cellular senescence. (nih.gov)
In summary, AP4, miR-22-3p and MDC1 form a conserved and coherent, regulatory feed-forward loop to promote DNA repair, which suppresses DNA damage, senescence and CIN, and contributes to 5-FU resistance. (biomedcentral.com)
However, there had been little evidence supporting a connection of Smurfs to tumorigenesis prior to this work except for some sporadic reports of dysregulation of Smurf2 expression in breast and esophageal cancers and that up-regulation of Smurf2 induces senescence, which suppresses tumor cell proliferation [ 5 ]. (biomedcentral.com)

His work demonstrates how cellular senescence depends on chronic DNA-damage signaling that results from irreparable damage to telomeres. (mayo.edu)
His research has shown that as people age, mitochondria become dysfunctional and produce excessive reactive oxygen species that can accelerate telomere damage, inducing premature senescence. (mayo.edu)
Progerin induces a reduction in heterochromatin, a tightly packed form of DNA, making telomeres in the cell more fragile and susceptible to damage. (medgadget.com)
This study used etoposide, to induce DNA damage-related senescence or chronic exposure to IL-1β to entail inflammation-related senescence in human OA chondrocytes. (aging-us.com)
On the other hand, etoposide treatment reliably induces DNA damage-related senescence in human articular chondrocytes evidenced by loss of proliferative capacity, DNA damage accumulation, and expression of some SASP components. (aging-us.com)
Cellular senescence occurs in response to repeated passages, persistent DNA damage, and oxidative stress and is characterized by permanent growth arrest. (asn-online.org)
RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. (nature.com)
In this issue, we generally review the mechanisms of cellular senescence in diabetic nephropathy, which involve telomere attrition, DNA damage, epigenetic alterations, mitochondrial dysfunction, loss of Klotho, Wnt/ β -catenin signaling activation, persistent inflammation, and accumulation of uremic toxins. (hindawi.com)
A previous study has reported that MSC-derived mitochondrial transplantation protects the cornea against oxidative stress -induced mitochondrial damage. (fightaging.org)
In the context of cancer, certain chemotherapeutics cause DNA damage and cellular senescence. (jci.org)
Inactivation of AP4 in CRC cell lines resulted in increased spontaneous and c-MYC-induced DNA damage, chromosomal instability (CIN) and cellular senescence. (biomedcentral.com)
Inhibition of miR-22-3p or ectopic MDC1 expression reversed the increased senescence, DNA damage, CIN and defective HR observed in AP4 -deficient CRC cells. (biomedcentral.com)
Mirroring COVID-19 hallmark features such as macrophage and neutrophil infiltration, endothelial damage and widespread thrombosis in affected lung tissue 1,8,9 , in vitro assays demonstrated macrophage activation with SASP-reminiscent secretion, complement lysis and SASP-amplifying secondary senescence of endothelial cells, neutrophil extracellular trap (NET) formation as well as activation of platelets and the clotting cascade in response to supernatant of VIS cells, including SARS-CoV-2-induced senescence. (edu.hk)
Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS. (bvsalud.org)
Cellular senescence during AGING or due to extended passages of normal cells in culture and that is triggered by the DNA damage-response to TELOMERE SHORTENING or by repeated exposure to stress signals. (bvsalud.org)

Chronic exposure to IL-1β induces only partial expression of senescence markers and does not allow us to conclude on its ability to induce senescence in chondrocytes. (aging-us.com)
Because a specific marker for cellular senescence has yet to be identified, a combination of markers should be used to identify SnCs [ 14 ]. (aging-us.com)
Calpain-6 was inversely associated with expression of senescence markers but was associated with a dynamic autophagy flux. (hal.science)
This system can be used to identify new markers of cellular senescence in vivo and evaluate the efficacy of senolytic treatments. (asn-online.org)
Herein, we show that treatment with the IKK/NF-κB inhibitor SR12343 during a course of chemotherapy reduces markers of cellular senescence and the SASP in liver, skeletal muscle, and circulation and, correspondingly, attenuates features of skeletal muscle pathology. (jci.org)
COVID-19 patients displayed markers of senescence in their airway mucosa in situ and elevated serum levels of SASP factors. (edu.hk)

The damaged telomeres in turn trigger premature cellular aging. (medgadget.com)
The book includes key research on the molecular mechanisms underlying stress-induced cellular senescence, in addition to those governing the accumulation of reactive oxygen species, and the induction of premature senescence. (kean.edu)
Deletion of AP4 causes premature senescence and defects in mitogen-induced proliferation in mouse embryonic fibroblasts (MEFs) [ 5 , 7 ]. (biomedcentral.com)

They further link to the activation of protein kinase C- (PKC-) induced generation of reactive oxygen species (ROS) [ 6 , 7 ], which further mediates the activation of downstream transcription factor nuclear factor kappa-light-chain enhancer of activated B cells (NF- κ B). Thus, the main treatments of DN refer to modulate glycemic and blood pressure through insulin and RAS inhibitors. (hindawi.com)

Exogenous mitochondrial transplantation improved mitochondrial dysfunction and alleviated cellular senescence hallmarks, such as increased cell size, increased senescence-associated β-galactosidase activity, augmented NF-κB activity, increased inflammatory cytokines , and upregulated the cyclin-dependent kinase inhibitors p21 and p16 . (fightaging.org)

Several hallmarks of cellular senescence, such as cell cycle arrest, expression of cyclin-dependent kinase inhibitors, DNA damages, and senescence-associated secretory profile were evaluated. (aging-us.com)

These cells were tumor-initiating cells and behaved like stem cells at the apex of the cellular hierarchy. (hal.science)
Calpain-6 knockdown blocked tumor development and induced depletion of sarcoma stem cells. (hal.science)
It also provides information on suppressing cellular senescence in the most common, and most aggressive malignant primary brain tumor in humans, glioblastoma multiforme. (kean.edu)
Zhang H, Teng Y, Kong Y, Kowalski PE, Cohen SN: Suppression of human tumor cell proliferation by Smurf2-induced senescence. (biomedcentral.com)
Cellular senescence is a stress response of mammalian cells leading to a durable arrest of cell proliferation that has been implicated in tumor suppression, wound healing, and aging. (biomedcentral.com)

Dr. Passos' research has shown a role for telomere-induced senescence in multiple tissues with aging and age-related diseases. (mayo.edu)
2019). In the last decades, it was widely demonstrated how these two pivotal determinants of human pathologies are strongly associated with each other in a dual relationship where aging induces a pro-inflammatory state in the organism and inflammation, in turn, leads to the activation of cellular and molecular pathways involved in cell senescence and aging (Chung et al. (researchgate.net)
2018). Due to the strict relationship existing between inflammation and aging, the new term "inflammaging" has been coined to describe a condition characterized by chronic and systemic low-grade inflammation occurring during aging and potentially associated with the alteration of several cellular and molecular pathways and the development of different pathologies (Franceschi et al. (researchgate.net)
2021). Similarly, cell senescence due to aging has been widely associated with the impairment of mitochondrial as well as proteosome and lysosome functions responsible for the accumulation of aberrant or misfolded proteins often observed in different neurodegenerative disorders (Sikora et al. (researchgate.net)
On these bases, the aim of the Research Topic entitled "Inflammation and Aging in Chronic and Degenerative Diseases: Current and Future Therapeutic Strategies" was to collect the latest update on the molecular and cellular determinants responsible for inflammatory processes during aging as well as the role of aging in the onset of chronic-degenerative diseases. (researchgate.net)
Cellular senescence has been described as one of the major drivers of aging [ 6 ] and has been implicated in the pathogenesis of many age-related diseases [ 7 ]. (aging-us.com)
Cellular aging or cellular senescence is the critical factor for the process of aging. (hindawi.com)
To better understand how senescence is regulated is of high significance to promote healthy aging and treat age-associated disorders. (thincb2b.com)
In a research paper published today in Nature Cell Biology , Rugang Zhang, Ph.D., deputy director of the Ellen and Ronald Caplan Cancer Center, Christopher M. Davis Endowed Professor, and program leader of the Immunology, Microenvironment & Metastasis Program, at The Wistar Institute, and his team revealed a novel ADAR1-SIRT1-p16INK4a axis in regulating cellular senescence and its potential implications in tissue aging. (thincb2b.com)
Understanding the basic mechanism underlying tissue aging is challenging and cellular senescence offers an angle into the complex biology that drives tissue aging. (thincb2b.com)
These mechanistic insights gained by studying senescence regulation during tissue aging can in turn be used to promote healthy aging and combat age-associated disorders. (thincb2b.com)
Central to this quest is a protein called p16INK4a because its expression both increases during tissue aging and it drives senescence. (thincb2b.com)
Intriguingly, the team discovered that ADAR1 loss promotes p16INK4a expression through SIRT1, another protein known to regulate both senescence and tissue aging. (thincb2b.com)
Zhang says, "Our study starts to reveal the missing link between ADAR1 and tissue aging through p16INK4a expression during senescence. (thincb2b.com)
One of the ways to potentially restore ADAR1 expression as a means to suppress p16INK4a and senescence observed during tissue aging is by inhibiting autophagy. (thincb2b.com)
It is an issue of screwing up the body's cellular control mechanisms in a way that creates aging. (anti-agingfirewalls.com)
The key point is that telomerase activation might keep telomere lengths from getting critically shorter, and that would be enough to stave off cell senescence and deregulation of the epigenome and, perhaps even, much of what we know as aging. (anti-agingfirewalls.com)
Deacetylation of H4-K16Ac during senescence may explain reported decreases in this mark during mammalian aging and in cancer cells. (biomedcentral.com)
Successful pursuit of these Specific Aims should provide new insight into the role of genome maintenance as a determinant of aging, with a focus on the relationships among various molecular and cellular end points. (elsevierpure.com)

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. (rndsystems.com)
ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1. (babraham.ac.uk)

We envisage further development of cellular models and suitable animal models mimicking endothelial dysfunction aspect of COVID-19 being able to accelerate the discovery of new drugs targeting endothelial dysfunction in pan-vasculature from COVID-19 patients. (nature.com)
Fig. 1: SARS-CoV-2 induced endothelial dysfunction. (nature.com)

Considering the role of cellular senescence in age-related diseases including OA, the therapeutic potential of senolytic (drugs that induced SnCs death) and senomorphic (drugs that modulate the SASP) compounds have been contemplated with growing interest [ 15 ]. (aging-us.com)

Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). (wuxibiortus.com)

Further, cellular senescence properties were improved by exogenous mitochondrial transplantation in oxidative stress -induced senescent ARPE-19 cells. (fightaging.org)

For the ageing of whole organisms including animals, see Senescence. (stevechase.org)

These results indicate that exogenous mitochondrial transplantation modulates cellular senescence and may be considered a novel therapeutic strategy for AMD. (fightaging.org)
Exogenous copper and iron stimulate the ascorbate-induced [Ca2+]cyt. (deepdyve.com)
Exogenous ascorbate also induces a moderate increase in programmed cell death symptoms in intact roots, but it does not activate Ca2+ influx currents in patch-clamped root protoplasts. (deepdyve.com)

Changes in cellular gene expression in response to small-molecule or genetic perturbations have yielded signatures that can connect unknown mechanisms of action (MoA) to ones previously established. (harvard.edu)
In Specific Aim 2 we will further study DMA double-strand breaks, as a potentially important intermediate in generating genome instability, dysregulated gene expression and cellular senescence in mouse and human primary fibroblast cultures (with projects 3, 4 and 5). (elsevierpure.com)

Acute or chronic inflammation induced by ischemia has also been suggested to play an important role in the process of malignant cardiac remodeling [ 3 ]. (hindawi.com)

Calpain-6 knockdown induced cell entry into senescence and suppressed autophagy flux. (hal.science)
Our results reveal that calpain-6 identifies sarcoma stem-cell and plays an important role as a regulator of cancer cell fate driving a switch between autophagy and senescence. (hal.science)
They also found that downregulation of ADAR1 by a process called autophagy (the degradation and recycling of damaged or unneeded cell components) during senescence decreased the stability of SIRT1 mRNA, which in turn upregulated the translation of p16INK4a to induce senescence. (thincb2b.com)

Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. (wuxibiortus.com)

Cellular senescence is a state of cell cycle arrest that is accompanied by secretion of inflammatory cytokines, immune modulators, growth factors and proteases. (nki.nl)

SIRT2, an NAD-dependent class III histone deacetylase, contributes to H4-K16Ac deacetylation and DNA compaction in human fibroblast cell lines that assemble striking senescence-associated heterochromatin foci (SAHFs). (biomedcentral.com)
In contrast, this mechanism was inoperative in a fibroblast cell line that did not assemble extensive heterochromatin during senescence. (biomedcentral.com)

Rapamycin is one other drug used before, that demonstrated to reverse nuclear blebbing, retard cellular senescence, and facilitate degradation of progerin. (medgadget.com)

WM 1119 induces cell-cycle exit and cellular senescence, and inhibits growth of B-cell lymphoma cells in vitro (IC 50 = 0.25 μM). (rndsystems.com)
In vitro, hPF4 also inhibits cfDNA-induced endothelial tissue factor surface expression and von Willebrand factor release. (jci.org)

We hypothesize that cellular senescence plays a role in the onset of cognitive problems following chemotherapy. (nki.nl)
Lastly, we demonstrate SR12343 mitigates chemotherapy-induced reductions in body weight, lean mass, fat mass, and muscle strength. (jci.org)

Analyses of signaling pathways identified JNK and p38 MAPK as antagonistic effectors of cellular senescence. (uzh.ch)

Hao elaborates, "Our study revealed a novel ADAR1-SIRT1- p16 INK4a axis that plays an important role in cellular senescence at translational level, and this newly defined function of ADAR1 is independent of its RNA editing function. (thincb2b.com)
Our findings revealed that RSV protected against ischemia-induced mouse heart injury in vivo and hypoxia-induced NRCM injury in vitro via regulating Sirt1/p53-mediated cell senescence and inhibiting NLRP3-mediated inflammasome activation. (hindawi.com)

Different involvement of extracellular calcium in two modes of cell death induced by nanosecond pulsed electric fields [med. (emf-portal.org)

In ischemic heart tissue, senescence-associated β -galactosidase (SA- β -gal) activity and proteins (such as p16, p19, and p53) are significantly upregulated [ 6 ]. (hindawi.com)

The PIC-based RNAseq study showed that G0 + CycD1 high cells exhibited the characteristic features of "Injured PTC" and "Senescence" compared with G0 + cells in the vehicle group. (asn-online.org)
We also isolated primary proximal tubular cells from G0 marker mice and induced senescence. (asn-online.org)
Niacinamide supplementation to human cells enhances replicative lifespan and halts the progression of senescence. (reportsanddata.com)
this process often begins with mutations that inactivate normal cellular mechanisms for monitoring the fidelity of DNA replication, resulting in the rapid accumulation of mutations in genes involved in controlling the growth and death of cells. (ernolaszlo.com)
Here, we investigated the effects of extrinsic mitochondrial transplantation on senescence-induced ARPE-19 cells, an RPE cell line. (fightaging.org)
Here we show that SARS-CoV-2, like other viruses, evokes cellular senescence as a primary stress response in infected cells. (edu.hk)
Decreased H4-K16Ac was observed in both replicative and oncogene-induced senescence of these cells. (biomedcentral.com)
We have been working since the beginning on embryonic stem cells (ES) and, since their appearance at the end of 2007, on pluripotency-induced cells (iPS). (istem.eu)
These two populations of human pluripotent stem cells have the cardinal characteristics that underpin the interest, the ability to proliferate identically (each mother cell giving birth to two identical daughter cells) without limit, without ever entering senescence as all other cells in the body do, and the ability, under other culture conditions, to differentiate to give rise to any of the cellular phenotypes of the body. (istem.eu)
Nanosecond pulsed electric fields induce poly(ADP-ribose) formation and non-apoptotic cell death in HeLa S3 cells [med. (emf-portal.org)
Taking advantage of the developmental gradient in the bread wheat leaf, we provide a simultaneous quantitative analysis for the development of mesophyll cells and of chloroplasts as a cellular compartment. (biomedcentral.com)
Understanding the build-up of photosynthetic capacity requires detailed knowledge of how these cells, and chloroplasts within, are produced and develop. (biomedcentral.com)
Differentiation subsequently occurs in leaf primordia basipetally, resulting in a gradient of easily distinguishable cellular morphologies of distal differentiated cells towards the tip of the leaf, basal progenitor proliferating cells adjacent to the shoot apical meristem, and all possible intermediate stages in between. (biomedcentral.com)

Thermal stability assays show that ERKi do not destabilise ERK2 (or ERK1) in vitro, suggesting that ERK2 turnover is a cellular consequence of ERKi binding. (babraham.ac.uk)
The generation of cellular models of monogenic diseases, which can be analyzed in vitro on demand, has been at the heart of I-Stem's activity since the beginning. (istem.eu)

A rise in the levels of the p53 protein induces the expression of p21 cyclin-dependent kinase inhibitor. (reactome.org)
Aquaporin-1 water channel protein in lung: ontogeny, steroid-induced expression, and distribution in rat. (hopkinsmedicine.org)

Niacinamide has a critical function in DNA repair, cellular energy metabolism, and transcription regulation. (reportsanddata.com)
Variable DNA compaction observed during senescence is explained in part by cell-type specific regulation of H4 deacetylation and HMGA1/2 expression. (biomedcentral.com)

Cancer patients may experience cognitive problems including memory lapses, problems concentrating, learning, multi-tasking or remembering details or common words. (nki.nl)
With detail supplied by numerous international researchers at the forefront of cancer research, the book examines a host of differing aspects of the topic. (kean.edu)
Work across many laboratories is geared toward elucidating the genetics behind cancer, discovering cellular mechanisms that lead to cancer, and elucidating intracellular and intercellular interactions that allow this progression. (medscape.com)
This is the multihit theory of tumorigenesis, in which a series of multiple triggering events in the genetic and cellular makeup of a cell ultimately cause cancer. (medscape.com)

Furthermore, Dr. Passos uncovered a key role for mitochondria in the induction of cellular senescence. (mayo.edu)

Treatment with 1-deoxysphinganine induced dose-dependent cytotoxicity with senescent, necrotic and apoptotic characteristics and compromised glucose-stimulated insulin secretion. (uzh.ch)
Details] Decrease in glucose-stimulated insulin secretion following exposure to magnetic fields [med. (emf-portal.org)

These TEMs are thought to play a role in many cellular processes including exosome biogenesis. (wikipedia.org)
CD9 has a diverse role in cellular processes as it has also been shown to trigger platelet activation and aggregation. (wikipedia.org)

This pitfall may be due to the lack of understanding of the mechanisms underlying chondrocyte senescence. (aging-us.com)
The research results linked below fall into the latter category: the researchers improve the understanding of the way in which diabetes produces blindness by showing that cellular senescence is a bridging mechanism in the retina . (fightaging.org)

Cellular senescence, which recently has gained broad attention, is thought to be an important player in the onset and development of diabetic nephropathy. (hindawi.com)
Moreover, we highlight the potential therapeutic targets of cellular senescence in diabetic nephropathy and provide important clues for clinical strategies. (hindawi.com)

However, expression of CD9 on the cellular membrane seems to decrease the viral entry of HIV-1. (wikipedia.org)
We found that both deacetylation of H4-K16Ac and expression of HMGA1/2 can contribute to DNA compaction during senescence. (biomedcentral.com)

Dr. Passos has identified a key role for mitochondria in cellular senescence. (mayo.edu)
Recently, the emerging role of cellular senescence in DN has attracted a broad attention. (hindawi.com)
In the present review, we will focus on the role of cellular senescence and its related mechanisms in DN. (hindawi.com)

En outre, conformément à l'absorption rapide décrite de BABA synthétique par les racines et à sa translocation rapide dans les feuilles, j'ai observé une altération protéique rapide et massive au niveau des tissues et dans le temps de diverses voies, dont la respiration cellulaire, la signalisation de l'acide salicylique, et la signalisation de stress. (unine.ch)

It is an interesting point to consider that a range of diseases, age-related and otherwise, may provoke greater cellular senescence as a part of the progression of pathology, even though cellular senescence is not one of the main root causes of these condition. (fightaging.org)

Furthermore, we will explore the potential therapeutic targets of cellular senescence and provide important clues for clinical strategies in the management of DN. (hindawi.com)

Given the elderly generally have weaker immune responses after vaccination, more detailed investigation is necessary ( 4 , 5 ). (cdc.gov)

Anatomy32

Organisms11

Diseases16

Chemicals and Drugs95

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes76

Disciplines and Occupations1

Information Science3

Health Care1

Secretory phenotype5

Apoptosis10

Phenotype1

Senescent cells5

Replicative senescence1

Suppresses3

Damage15

Markers6

Premature3

Reactive1

Mitochondrial dysfunction1

Cyclin-dependent kinase1

Tumor5

Aging19

Inhibitors2

Dysfunction2

SASP1

Proliferation1

Stress-induced1

Ageing1

Exogenous3

Gene expression2

Chronic1

Autophagy3

Oxidative1

Arrest1

Heterochromatin2

Degradation1

Inhibits2

Chemotherapy2

Pathways1

SIRT12

Extracellular1

Tissue1

Cells13

Vitro2

Protein2

Regulation2

Cancer4

Induction1

Secretion2

Processes2

Understanding2

Diabetic2

Expression2

Role3

Tissues1

Diseases1

Targets1

Responses1