Loading...
  • Plant Senescence
  • The integrated data from the 4 WPs will increase our knowledge about the fundamental mechanisms that regulate plant senescence in dependence of abiotic stress and will provide valuable insights for future crop breeding. (eracaps.org)
  • Glick, Bernard 2013-04-18 00:00:00 The plant senescence syndrome resembles, in many molecular and phenotypic aspects, plant responses to abiotic stresses. (deepdyve.com)
  • Premature plant senescence is the main cause of losses in grain filling and biomass yield due to leaf yellowing and deteriorated photosynthesis, and is also responsible for the losses resulting from the short shelf life of many vegetables and fruits. (deepdyve.com)
  • onset of senescence
  • Depletion of NQO1 resulted in the delayed onset of senescence. (ijbs.com)
  • The mitochondrial COX1 gene, which encodes the main subunit of the cytochrome c oxidase complex and contains the differentially methylated CpG island 4, was upregulated in MSCs in parallel with the onset of senescence. (hindawi.com)
  • molecular
  • Normal somatic dividing cells have been proven to be a valuable in vitro model to study cellular senescence and unravel molecular mechanisms and pathways implicated in the human aging process. (hindawi.com)
  • Our findings provide novel molecular insights into hPTTG1-induced senescence and identify a novel mechanism by which hPTTG1 promotes metastasis by regulating the senescence-associated microenvironment. (biomedcentral.com)
  • WP4, Molecular mechanisms of senescence in H. rhodopensis. (eracaps.org)
  • Long-term exposures to low concentrations of O 3 are known to accelerate foliar senescence, but the molecular components of this process remain unknown. (epa.gov)
  • This study delineates for the first time the molecular mechanisms that modulate caveolin-1 gene transcription upon oxidative stress and brings new insights into the redox control of cellular senescence in both normal and cancer cells. (aacrjournals.org)
  • promotes
  • We recently demonstrated that insulin increases the expression of negative regulators of the cell cycle, such as p53 and p21, and that it promotes endothelial cell senescence in an Akt-dependent manner. (eurekaselect.com)
  • Accordingly, we propose that type 2 diabetes can be regarded as a type of premature aging syndrome in which the dysregulation of insulin/Akt signaling promotes cellular senescence, leading to various complications that include macroangiopathy. (eurekaselect.com)
  • human
  • Activation of PPARδ by GW501516, a specific ligand of PPARδ, significantly attenuated UVB-mediated generation of ROS (reactive oxygen species) and suppressed senescence of human keratinocytes. (biochemj.org)
  • Previously, we demonstrated that transgenic mice expressing the Met ligand hepatocyte growth factor/scatter factor (HGF/SF) from the metallothionein promoter were prone to both embryonal rhabdomyosarcoma (RMS) and UV-induced cutaneous malignant melanoma that developed in stages highly reminiscent of their human counterparts ( 8 , 9 ). (pnas.org)
  • Conclusions
  • Conclusions: FOXM1, a negative regulator of senescence, has been identified as a key downstream effector and potential clinical biomarker that mediates MET signaling following infliction of DNA damage in gastric tumors. (aacrjournals.org)
  • Signaling
  • Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, Lowe SW (1998) Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. (springer.com)
  • In addition, phosphorylation of TP53 by MAPKAPK5 (PRAK) activated downstream of MAP3K5-p38 MAPK signaling, activates TP53 and contributes to cellular senescence (Sun et al. (reactome.org)
  • Herein, we showed that hPTTG1 overexpression reinforced senescence through the CXCR2/p21 signaling. (biomedcentral.com)
  • roles
  • After decades of scientific focusing on apoptosis, cellular senescence is increasingly recognized as an equally important but biologically and fundamentally different type of ultimate cell-cycle exit program, because of its lastingly persistent nature and cell-intrinsic and extrinsic roles within the tissue and tumor microenvironment. (springer.com)
  • Environmental cues, such as darkness or drought, induce senescence-like processes in which microRNAs also play regulatory roles. (mdpi.com)
  • melanoma
  • Moreover, we demonstrate that ARF, and not p53, efficiently suppresses early melanoma genesis and operates independently of p53 to induce senescence in melanocytes. (pnas.org)
  • Knockdown
  • siRNA (small interfering RNA)-mediated knockdown of PTEN abrogated the effects of PPARδ on cellular senescence, on PI3K/Akt/Rac1 signalling and on generation of ROS in keratinocytes exposed to UVB. (biochemj.org)