Induce prolonged expression. Medical search. Frequent questions

We conclude that prolonged copper starvation in these replicating cells leads to mitochondrial damage and oxidative stress and ultimately, apoptosis. (torvergata.it)
New anticancer therapy strategies refer to the inhibition of CDK-cyclin complexes as an important target to prevent uncontrolled proliferation and induce apoptosis in cancer cells ( 2 ). (spandidos-publications.com)
Although purvalanol-induced cell cycle arrest and apoptotic cell death were demonstrated in prostate ( 5 ), breast ( 6 ) and colon cancer cells ( 7 ), the exact molecular mechanism of purvanol-induced apoptosis has not been elucidated yet. (spandidos-publications.com)
Apoptosis can be induced in response to hypoxia. (bmj.com)
Cells adapt to this environmental stress, so that after repeated periods of hypoxia, selection for resistance to hypoxia induced apoptosis occurs. (bmj.com)
The key regulator of this process, hypoxia inducible factor 1 (HIF-1), can initiate apoptosis by inducing high concentrations of proapoptotic proteins, such as BNIP3, and can cause stabilisation of p53. (bmj.com)
During hypoxia, an intricate balance exists between factors that induce or counteract apoptosis, or even stimulate proliferation. (bmj.com)
While the cyclin-dependent kinase inhibitor AT7519 induces neutrophil apoptosis to promote inflammation resolution in preclinical models of lung inflammation, its potential efficacy in ARDS has not been examined. (bmj.com)
AT7519 was able to override this phenotype to induce apoptosis in ARDS neutrophils with reduced expression of the pro-survival protein Mcl-1. (bmj.com)
We demonstrate the first pharmacological compound to induce neutrophil apoptosis in sepsis-related ARDS, highlighting cyclin-dependent kinase inhibitors as potential novel therapeutic agents. (bmj.com)
Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. (cancerindex.org)
CD95 ligand (CD95L)-induced apoptosis was synergistically enhanced by short-term/high concentration but not long-term/low concentration exposure to topotecan, suggesting that topotecan sensitizes human malignant glioma cells to CD95L-induced apoptosis via inhibition of RNA synthesis. (aspetjournals.org)

Since the anticancer drug etoposide, a selective Topo IIα inhibitor, has also been shown to induce intracellular ROS, (-)-xanthatin may exert its anti-proliferative effects on cancer cells in a similar manner to those of etoposide. (elsevierpure.com)
High glucose has been shown to induce inflammatory cytokines, chemokines, p38 mitogen-activated protein kinase, reactive oxygen species (ROS), protein kinase C (PKC), and nuclear factor-κB (NF-κB) activity in both clinical and experimental systems ( 7 - 12 ). (diabetesjournals.org)
LTD4 has been shown to induce cell proliferation, survival and migration in intestinal epithelial cells (Int407) via the CysLT1R. (lu.se)

2022). Male Marfan mice are predisposed to high fat diet induced obesity, diabetes, and fatty liver. (mcgill.ca)

Here, we use phrenic motor facilitation (pMF) as a general term, including pLTF after acute intermittent hypoxia and other forms induced, for example, by spinal administration of receptor agonists. (jneurosci.org)
Mammalian cells have developed a range of adaptations to survive acute and even prolonged hypoxia. (bmj.com)
The present study is aimed at investigating the anti-inflammatory, antioxidative, and antiapoptotic effects of methane on lipopolysaccharide- (LPS-) induced acute orchitis and its potential mechanisms. (hindawi.com)
Acute liver failure (ALF) is a life-threatening clinical syndrome characterized by rapid hepatocellular necrosis due to various acute injuries induced by hepatotoxic drugs, immune-mediated attack, or viral infections. (springer.com)
Acute vibration reduces A beta nerve fiber sensitivity and alters gene expression in the ventral tail nerves of rats. (cdc.gov)
These transient changes in sensory perception and transcript levels induced by acute vibration exposure may be indicators of more prolonged changes in peripheral nerve physiology. (cdc.gov)
An important cause of acute or subacute delirium, Wernicke encephalopathy (WE) is a neurological disorder induced by thiamine, vitamin B1, deficiency. (medscape.com)

It has been proved that inhalation of methane also modulates leukocyte activation, affects key events of ischemia-reperfusion-induced oxidative stress, and has anti-inflammatory effects against ischemia-reperfusion damage [ 12 ]. (hindawi.com)
The potential role of antioxidants in mitigating skin hyperpigmentation resulting from ultraviolet and visible light-induced oxidative stress. (uc.edu)

Mechanistically, topoisomerase IIα (Topo IIα) inhibition by (-)-xanthatin was shown to be the upstream trigger that stimulated the expression of GADD45γ mRNA and concomitantly produced reactive oxygen species (ROS) to maintain this expression. (elsevierpure.com)
They further link to the activation of protein kinase C- (PKC-) induced generation of reactive oxygen species (ROS) [ 6 , 7 ], which further mediates the activation of downstream transcription factor nuclear factor kappa-light-chain enhancer of activated B cells (NF- κ B). Thus, the main treatments of DN refer to modulate glycemic and blood pressure through insulin and RAS inhibitors. (hindawi.com)

We reported that (-)-xanthatin, a xanthanolide sesquiterpene lactone present in the Cocklebur plant, exhibited potent anti-proliferative effects on human breast cancer cells, in which GADD45γ, a novel tumor suppressor gene, was induced. (elsevierpure.com)
Previously, we reported a dietary mouse NASH model with a choline-deficient, methionine-lowered, L-amino-acid-defined, high-fat diet containing shortening without trans fatty acids (CDAA-HF-T[-]), which rapidly induces fibrosis and proliferative lesions in the liver. (bvsalud.org)

OBJECTIVE- Hyperglycemia-induced inflammation is central in diabetes complications, and monocytes are important in orchestrating these effects. (diabetesjournals.org)
Prolonged colonic inflammation, seen often in Ulcerative Colitis (UC), is a risk factor for CRC development. (emerging-researchers.org)
6). Lung tissue, bronchoalveolar lavage fluid (BALF) and plasma were analyzed for cellular inflammation, cytokines, immunoglobulin E and heme oxygenase-1 (HO-1) expression. (cdc.gov)
Histopathological grading indicated that OVA + PM/OVA treatment induced significant inflammation compared to OVA/OVA. (cdc.gov)
Collectively, HF diet appeared to have a greater impact on global immune status and exposure-induced lung injury in SD rats, but a more pronounced effect on inflammation resolution in BN rats. (cdc.gov)

Treatment of Socs3(Δ/Δcol2) mouse cartilage explants and chondrocytes with gp130 cytokines prolonged JAK/STAT signaling, enhanced cartilage degradation, increased the expression of Adamts4, Adamts5, and RANKL, and elevated the production of IL-6, granulocyte colony-stimulating factor, CXCL1, and CCL2. (nih.gov)

VEGF-induced pMF was attenuated by the MEK/ERK inhibitor U0126 [1,4-diamino-2,3-dicyano-1,4-bis( o -aminophenylmercapto)butadiene] and was abolished by the phosphotidinositol 3 kinase/Akt inhibitor LY294002 [2-(4-morpholinyl)-8-phenyl-1(4 H )-benzopyran-4-one hydrochloride], demonstrating that ERK mitogen-activated protein kinases and Akt are both required for full expression of VEGF-induced pMF. (jneurosci.org)
Siguazodan plus rolipram was also more effective at inducing cAMP-dependent transcription than either inhibitor alone. (aspetjournals.org)

3- 5 Therefore, during severe hypoxia or anoxia, the cell initiates a cascade of events that leads to apoptotic cell death, thereby preventing the accumulation of cells with hypoxia induced mutations. (bmj.com)
Low ATP concentrations in hypoxic tumour cells disable the apoptotic cascade and induce cell death by necrosis. (bmj.com)
It was found that methane significantly prolonged rat survival, decreased the W/D ratio, alleviated LPS-induced histological changes, and reduced apoptotic cells in the testes. (hindawi.com)

Additional studies revealed that PKC-α, PKC-δ, and p47Phox knockdown significantly abrogated high-glucose-induced NF-κB activation and inflammatory cytokine secretion. (diabetesjournals.org)

These included PTEN-dependent DNA damage repair in response to SHP2 inhibition, AKT-mediated bypass resistance in response to chronic SHP2 inhibition, and SHP2 control of hypoxia-inducible factor expression through multiple MAPKs. (aacrjournals.org)
Conversely, the concentration-response curve describing the enhancement of dexamethasone-induced, glucocorticoid response element-dependent transcription by formoterol was displaced to the left by PDE4, but not PDE3, inhibition. (aspetjournals.org)

High glucose increased TLR expression, myeloid differentiation factor 88, interleukin-1 receptor-associated kinase-1, and nuclear factor-κB (NF-κB) p65-dependent activation in THP-1 cells. (diabetesjournals.org)
Different groups have established several protocols to induce the differentiation of MSCs into HLCs in vitro . (springer.com)
MMC significantly blocked TGFβ-induced cell proliferation and myofibroblast differentiation in cultured quiescent keratocytes and altered the transcriptional regulation of macrophage chemotactic protein-1 (MCP-1) and alpha smooth muscle actin (αSMA). (molvis.org)
In patients with breast cancer, expression of FLI1 is strongly correlated with advanced stage, poor differentiation, and lymph node metastasis. (biomedcentral.com)

Expression of FOS-IR in MNCs with attenuated ER-β-IR, and the absence of FOS-IR in parvocellular neurons that retain ER-β-IR suggest a role for neuronal activation in the regulation of ER-β expression in MNCs. (jneurosci.org)
2012 ) Role of orbitofrontal cortex neuronal ensembles in the expression of incubation of heroin craving. (neurotree.org)
This study investigated calcium/calmodulin kinase II (CaMKII) activity related to long-standing neuronal injury of the hippocampus in kainate (KA)-induced experimental temporal lobe epilepsy. (koreamed.org)

Thus, in the present study, we examined TLR2 and TLR4 mRNA and protein expression and mechanism of their induction in monocytic cells under high-glucose conditions. (diabetesjournals.org)
Small inhibitory RNA to p47Phox in THP-1 cells abrogated high-glucose-induced TLR2 and TLR4 expression. (diabetesjournals.org)
CONCLUSIONS- Collectively, these data suggest that high glucose induces TLR2 and -4 expression via PKC-α and PKC-δ, respectively, by stimulating NADPH oxidase in human monocytes. (diabetesjournals.org)
Analyses of publicly available data sets suggested that TLR2 is induced during the resolution phase of inflammatory diseases, i.e., under conditions associated with high endogenous GC production. (bsz-bw.de)
In summary, our data show that sTLR2 and full-length TLR2 are released by macrophages under anti-inflammatory conditions, which may contribute to GC-induced immunosuppression. (bsz-bw.de)

The long-term ability of quiescent keratocytes to repair MMC induced damage in vivo was evaluated in rabbits treated with MMC 2 months before 100 μm deep lamellar keratectomy (LK) injury. (molvis.org)
High micromolar concentrations of topotecan, which are unlikely to be achieved in plasma in human patients in vivo , were cytotoxic within 48 hr, induced DNA fragmentation, did not induce major cell cycle changes, failed to consistently alter BCL-2 or BAX protein levels but inhibited RNA synthesis and induced cleavable DNA/topoisomerase I complex formation. (aspetjournals.org)
For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)

In conclusion, HFD-induced obese Ldlr −/− .Leiden mice develop an aberrant ITO and alterations in the spermatogenic cycle in crucial stages (stages VII and VII). (nature.com)
These alterations possibly induce severe vessel stenosis, causing prolonged phases of locally limited blood supply. (ajnr.org)
2013 ) Unique gene alterations are induced in FACS-purified Fos-positive neurons activated during cue-induced relapse to heroin seeking. (neurotree.org)
In BN rats, resolution of immune alterations was further compromised by HF diet, as many exposure-induced alterations in local/systemic immune markers were still evident in HF/WF animals at 24wk. (cdc.gov)

Glucocorticoids, also known as corticosteroids, induce effector gene transcription as a part of their anti-inflammatory mechanisms of action. (aspetjournals.org)
Beyond Red Hair and Sunburns: Uncovering the Molecular Mechanisms of MC1R Signaling and Repair of UV-Induced DNA Damage. (uc.edu)
Carbohydrate intake during exercise can delay the onset of fatigue and improve performance of prolonged exercise as well as exercise of shorter duration and greater intensity (e.g., continuous exercise lasting about 1 h and intermittent high-intensity exercise), but the mechanisms by which performance is improved are different. (gssiweb.org)
It may induce thiamine deficiency through several potential mechanisms: genetic predisposition, replacement of vitamin-containing foods by the high calorific value of alcohol, impaired absorption of thiamine from the gut, impairment of storage by the liver, thiamine transport problems, other nutritional deficiencies, decreased phosphorylation to thiamine pyrophosphate and excessive requirements for the metabolism of alcohol. (medscape.com)
With more treatment options available for Parkinson's disease, physicians need to understand the pathogenetic mechanisms underlying levodopa-induced dyskinesia. (bcmj.org)
The association between torsade and a prolonged QT interval has long been known, but the mechanisms involved at the cellular and ionic levels have been made clearer in approximately the last decade. (medscape.com)

We induced high fat diet (HFD) obesity in low-density lipoprotein receptor knock-out Leiden (Ldlr −/− .Leiden) mice, and studied the morphological structure of the testes and histologically examined the proportion of Sertoli cells, spermatocytes and spermatids in the seminiferous tubules. (nature.com)
HFD-induced obesity caused high plasma leptin and abnormal testosterone levels and induced an aberrant intra-tubular organisation (ITO) which is associated with an altered spermatids/spermatocytes ratio (2:1 instead of 3:1). (nature.com)
[ 2 ] The numerous reports of severe thiamine deficiency after obesity surgery have led to the expression "bariatric beriberi. (medscape.com)

The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)

Intermittent hypoxia-induced pLTF is associated with greater ERK phosphorylation (activation) in the region of the phrenic motor nucleus ( Wilkerson and Mitchell, 2009 ), and pLTF requires ERK (not Akt) activation in its underlying mechanism (M. S. Hoffman and G. S. Mitchell, unpublished observation). (jneurosci.org)
HCT 116 colon cancer cells were exposed to purvalanol, which activated ER stress via upregulation of PERK, IRE1α gene expression, eIF-2α phosphorylation and ATF-6 cleavage at early time-points in the HCT 116 colon cancer cells. (spandidos-publications.com)
Measuring protein phosphorylation and expression in glioblastoma cells across 40 signaling pathway nodes in response to different drugs and for different oxygen tensions revealed that SHP2 antagonism has network-level, context-dependent signaling consequences that affect cell phenotypes (e.g., cell death) in unanticipated ways. (aacrjournals.org)
MMC also induced phosphorylation of the nuclear histone marker of DNA damage, γH2AX (a member of the H2A histone family), without induction of cell cycle entry or immediate DNA repair measured by Comet assay. (molvis.org)

Untreated peripheral blood sepsis-related ARDS neutrophils demonstrated prolonged survival after 20 hours in vitro culture. (bmj.com)
To address this hypothesis, we used an in vitro model of mouse macrophage cells to assess whether the flavonoids chrysin, apigenin and/or baicalein suppress expression of the inflammatory genes IL-6, IL-1β and/or TNFα. (emerging-researchers.org)
These in vitro, and their expression in these human tumour virus. (who.int)

Prolonged exposure for 72 hr to high nanomolar to low micromolar concentrations of topotecan augmented p21 protein levels and induced G2/M arrest but failed to consistently alter BCL-2 and BAX protein levels, did not induce significant DNA/topoisomerase I complex formation and did not inhibit RNA synthesis. (aspetjournals.org)

0.05) decrease in high-glucose-induced NF-κB activity, suggesting an additive effect. (diabetesjournals.org)
0.05) expressed in the cerebellar cortex, piriform lobe, medulla, and corpus callosum of the adult yak while in the young yak brain tissues, the protein expressions were significantly found in the white matter of the cerebellum, pineal gland, corpus callosum, and cerebellar cortex. (scielo.br)

2013 ) BDNF overexpression in the ventral tegmental area prolongs social defeat stress-induced cross-sensitization to amphetamine and increases Î"FosB expression in mesocorticolimbic regions of rats. (neurotree.org)

FBN2 silencing recapitulates hypoxic conditions and induces elastic fiber impairment in human dermal fibroblasts. (mcgill.ca)

Results: TNFα supplementation resulted in catabolic stimulation with increased levels of NO and IL-6, upregulation of catabolic gene expression, and downregulation of anabolic markers. (bvsalud.org)
Further, LPS-induced IL-1β upregulation was inhibited by 50% when cells were pre-treated with apigenin. (emerging-researchers.org)

However, WE may develop in nonalcoholic conditions, such as prolonged starvation, hyperemesis gravidarum, bariatric surgery, and human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), and can even develop in healthy infants given the thiamine deficient formulas. (medscape.com)
WE may develop in nonalcoholic conditions, such as prolonged starvation, hyperemesis gravidarum, and bariatric surgery. (medscape.com)

2012 ) Association of time-dependent changes in mu opioid receptor mRNA, but not BDNF, TrkB, or MeCP2 mRNA and protein expression in the rat nucleus accumbens with incubation of heroin craving. (neurotree.org)

Furthermore, because VEGFA-165 expression is hypoxia sensitive, it may play a role in respiratory plasticity after prolonged exposures to low oxygen. (jneurosci.org)
2 In addition, hypoxia induces genetic instability by the induction of fragile sites causing gene amplification. (bmj.com)
MicroRNA-30c expression was suppressed by hypoxia-inducible factor-1α activation and related to decreased mTOR activity as well as glycolysis in human GC TAMs. (cancerindex.org)
Hypoxia-regulated miR-30c downregulated REDD-1 expression by targeting its 3'UTR. (cancerindex.org)
The study examined the expression of Neuroglobin (Ngb) and Hypoxia-inducible factor-1α (Hif-1α) in adult and young yak brain tissues, and provided researchers with meaningful insight into the anatomy, physiology, and biochemistry of this mammal. (scielo.br)

Better understanding of the pharmacological actions of dopaminergic drugs in the basal ganglia will lead to better management of patients with levodopa-induced dyskinesia. (bcmj.org)

When compared to normal ECs, tumor-associated ECs are abnormal in terms of phenotype, genetic expression profile, and functions. (bvsalud.org)

Purvalanol induced mitochondrial membrane potential loss, caspase-7 and caspase-3 activation and PARP cleavage following a 48 h treatment. (spandidos-publications.com)

These psychic effects of khat chewing similar studies have shown that failure to recall those of amphetamine [19], but a abstain from khat use might prolong a psy- major role of environmental factors in the chotic episode, even during treatment with expression of khat effects has also been psychiatric medication [11,24-28,30]. (who.int)

Therefore, the measurement of hemodynamic parameters may provide an interesting link to the phenotypic expression of the known genetic defect. (ajnr.org)

This decrease in A beta fiber sensitivity was associated with a reduction in expression of nitric oxide synthase-1, and a modest increase in calcitonin gene-reiated peptide transcript levels in tail nerves 24 h after vibration exposure. (cdc.gov)

Furthermore, increased expression of the CysLT1R in colon cancer patient material is correlated with a poorer survival prognosis. (lu.se)
Conversley, increased expression of the CysLT2R is correlated with a better survival prognosis. (lu.se)

Prolonged inflammatory conditions of the GI have been suggested to increase the risk for developing colon cancer. (lu.se)

E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. (genome.jp)

Multiple roles in the brain tissues of the adult and young yaks are involved in the expression and distribution and are proposed to play a significant role in the adaptation of the yak to the high altitude environment. (scielo.br)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)

These findings show that the vast majority of HIV-1 proviruses within expanded T cell clones, including intact proviruses, may be transcriptionally silent at any given time, implying that infected T cells may be able to be activated to proliferate without inducing the expression of the integrated provirus or, alternatelively, may be able to proliferate without cellular activation. (frontiersin.org)
Fifteen micromoles of purvalanol induced a reduction in cell viability by 20 and 35% within 24 and 48 h, respectively. (spandidos-publications.com)
Because of the eminent role of receptors for mediating the biological effects of steroid hormones, changes in receptor expression could alter responsiveness of the target cells and determine the physiological circumstances in which gonadal steroids become important regulators of cell function. (jneurosci.org)
MMC induces DNA damage to quiescent corneal keratocytes, which remains unrepaired, resulting in abnormal cell replication and gene transcription that leads to long-term effects on corneal repair. (molvis.org)
These data indicate that the effect of MMC on corneal scarring and haze is related to the generation of DNA ICLs leading to defective cell replication and gene expression. (molvis.org)
In non-small cell lung cancer, the FLI1 expression score is associated with the stage of SCLC. (biomedcentral.com)

As discussed below, the mechanism underlying the beneficial effects of carbohydrate ingestion for exercise that lasts about 1 h and perhaps for intermittent exercise (sometimes lasting longer than 1 h) appears to be different than that for more prolonged continuous exercise and is associated with effects on the central nervous system. (gssiweb.org)
Notably, FECR1 utilizes a positive feedback mechanism to activate FLI1 by inducing DNA hypomethylation in CpG islands of the promoter. (biomedcentral.com)

Scope includes mutations and abnormal protein expression. (cancerindex.org)

Lacking proteosomal function on aggregates of unfolded proteins, ER stress may induce autophagic machinery. (spandidos-publications.com)

The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. (genome.jp)
Mitomycin C (MMC) belongs to a family of anti-tumor quinolone antibiotics derived from Streptomyces caespitosus , and functions as a powerful bifunctional alkylating agent that induces DNA interstrand crosslinks (ICL). (molvis.org)
Tumor-infiltrated macrophages were isolated from human GC tissues using magnetic beads, gene transcription was determined by real-time PCR, protein expression was monitored using western blots, metabolites were determined using HPLC, and transcriptional regulation was analyzed by the luciferase-based reporter gene system. (cancerindex.org)
To determine the role of FLI1 in breast cancer, we first examined its expression in tumor samples collected from patients with breast cancer. (biomedcentral.com)

Cells will adapt by activating the expression of genes involved in metabolic adaptation, such as those involved in glycolysis. (bmj.com)
Using models of cAMP- and glucocorticoid-induced transcription in human bronchial epithelial BEAS-2B cells, we show that combining inhibitors of phosphodiesterase (PDE) 3 and PDE4 provides greater benefits compared with inhibiting either PDE alone. (aspetjournals.org)
The vasopressin (VP) magnocellular neurosecretory cells (MNCs) in the supraoptic and paraventricular (PVN) nuclei are regulated by estrogen and exhibit robust expression of estrogen receptor (ER)-β. (jneurosci.org)
Our results indicate that traumatic stress exaggerated chronic SNP-induced nociceptive hypersensitivity, and that N/OFQ and activated satellite glia cells may play an important role in the interaction between both conditions. (iasp-pain.org)

Most levodopa-induced dyskinesia occurs when antiparkinsonian effects of levodopa are maximal, hence the term peak dose dyskinesia . (bcmj.org)

We employed the HEK expression system and a biosensor allowing us to simultaneously detect the changes in intracellular diacylglycerol (DAG) and Ca 2+ concentrations. (mdpi.com)
During prolonged exercise, the performance benefits of carbohydrate ingestion are likely achieved by maintaining or raising plasma glucose concentrations and sustaining high rates of carbohydrate oxidation, whereas during intense exercise, carbohydrate intake seems to positively affect the central nervous system. (gssiweb.org)

Epileptic seizure was induced by injection of. (koreamed.org)

The osmotically induced decrease in ER-β expression was selective for MNCs because ER-β-IR remained unaltered in PVN parvocellular neurons. (jneurosci.org)
2012 ) Intermittent social defeat stress enhances mesocorticolimbic Î"FosB/BDNF co-expression and persistently activates corticotegmental neurons: implication for vulnerability to psychostimulants. (neurotree.org)
Following kainate (KA)-induced epilepsy, rat hippocampal neurons strongly ex-press immediate early gene (IEG) products, i.e., c-FOS and c-JUN, and neural stress protein, HSP72. (koreamed.org)

Collectively, these data provide a rationale for the use of PDE3 and PDE4 inhibitors in the treatment of COPD and asthma where they may enhance, sensitize, and prolong the effects of LABA/ICS combination therapies. (aspetjournals.org)

Importantly, the combination of siguazodan plus rolipram prolonged the duration of gene expression induced by formoterol, dexamethasone, or dexamethasone plus formoterol. (aspetjournals.org)
Treatment of human alveolar macrophages (AMs) with the synthetic GC dexamethasone (Dex) did not alter the expression of TLRs -1, -4, and -6. (bsz-bw.de)

In contrast, catabolic markers and IL-8 expression were upregulated by 41.5-EVi1. (bvsalud.org)

In wild-type (WT) mouse chondrocytes, baseline receptor expression levels and gp130 cytokine-induced JAK/STAT signaling were determined by flow cytometry, and expression of SOCS-3 was assessed by quantitative polymerase chain reaction. (nih.gov)

Beclin-1 and Atg-5 expression levels were upregulated and LC3 was cleaved after a 6 h purvalanol treatment. (spandidos-publications.com)
Furthermore, methane significantly increased SOD levels, decreased MDA levels, and decreased testicular expression of PK2 and PKR1. (hindawi.com)
The appearance of levodopa-induced dyskinesia is closely related to plasma levels of levodopa. (bcmj.org)
Meanwhile, macrophage inflammatory protein 2 (MIP-2) expression levels were upregulated in nontumoral liver tissue from the end of Week 13 of CDAA-HF-T(-) feeding to the end of Week 63. (bvsalud.org)

As with prolonged exercise, there is a potential for gastrointestinal distress if an athlete ingests too much carbohydrate during high-intensity exercise. (gssiweb.org)

Chemicals and Drugs5

Phenomena and Processes1

Information Science1

Apoptosis12

Shown to induce3

Diet-induced obesity1

Acute7

Oxidative stress2

Reactive oxygen2

Proliferative2

Inflammation5

Cytokines1

Inhibitor2

Apoptotic3

Cytokine secretion1

Inhibition2

Differentiation4

Neuronal3

TLR25

Vivo3

Alterations4

Mechanisms6

Obesity3

Anti-inflammatory1

Phosphorylation4

Vitro3

Topoisomerase1

0.052

Ventral1

Hypoxic1

Upregulation2

Starvation2

MRNA and protein expression1

Hypoxia5

Pharmacological1

Phenotype1

Mitochondrial1

Amphetamine1

Genetic1

Exposure1

Survival2

Inflammatory conditions1

Proliferation1

Adult2

Cell6

Mechanism2

Mutations1

Proteins1

Tumor4

Cells4

Occurs1

Concentrations2

Injection1

Neurons3

Asthma1

Dexamethasone2

Contrast1

Receptor expression1

Levels4

Gastrointestinal1