Induce proapoptotic. Medical search. Frequent questions

Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53. (ox.ac.uk)
These results demonstrate that 53BP2 is a DNA damage-inducible protein that promotes DNA damage-induced apoptosis. (ox.ac.uk)
PINK1 protein levels progressively decrease after treatment, inducing this switch. (lih.lu)
Consistently, knockdown of Bid protein using small interfering RNA (siRNA) technique suppressed Andro-induced Bax conformational change and apoptosis. (elsevierpure.com)
The majority of PUMA induced apoptosis occurs through activation of the tumor suppressor protein p53. (wikipedia.org)
LCN2 protein induced upregulation of glial fibrillary acidic protein (GFAP), cell migration, and morphological changes similar to characteristic phenotypic changes termed reactive astrocytosis. (jneurosci.org)
Chronic ER stress promotes apoptosis, at least in part through the UPR-induced transcription factor C/EBP homologous protein (CHOP). (jci.org)
Tumor protein 53-induced nuclear protein 1 (TP53INP1) is a proapoptotic protein involved in cell stress response. (urotoday.com)
Moreover, treatment of LNCaP cells with a TP53INP1 ASO down-regulates TP53INP1 protein level, inhibits proliferation, and induces apoptosis. (urotoday.com)
ATF4 induces expression of the proapoptotic transcription factor CCAAT/enhancer-binding protein homologous protein (CHOP), which mediates PERK-induced apoptosis ( 16 ). (spandidos-publications.com)
Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)
Subcellular fractionation and Western blot disclose that stimulation with LL-37 (8 μM) for 2 h triggers release of the mitochondrial protein apoptosis-inducing factor (AIF) to the cytosol, whereas LL-37 causes no release of cytochrome C oxidase subunit IV of the inner mitochondrial membrane, suggesting that LL-37 affects mitochondrial membrane. (lu.se)

When the inhibition of these is lifted, they result in the translocation of Bax and activation of mitochondrial dysfunction resulting in release of mitochondrial apoptogenic proteins cytochrome c, SMAC, and apoptosis-inducing factor (AIF) leading to caspase activation and cell death. (wikipedia.org)
Other cancers, which exhibit overexpression of antiapoptotic Bcl-2 family proteins, counteract and overpower PUMA-induced apoptosis. (wikipedia.org)
The key regulator of this process, hypoxia inducible factor 1 (HIF-1), can initiate apoptosis by inducing high concentrations of proapoptotic proteins, such as BNIP3, and can cause stabilisation of p53. (bmj.com)
Our studies have demonstrated apoptosis in muscles following critical illness and/or immobilization alone, with upregulation of certain death-inducing molecules and downregulation of some anti-apoptotic genes and/or their proteins. (massgeneral.org)
These conditions include but are not limited to artery or vein occlusion in diabetic retinopathy, hypoxic retina in retinopathy of prematurity, aging in age-related macular degeneration, expression of mutant proteins in inherited retinal degeneration, traumatic injury leading to retinal detachment, and light sensitivity in the case of light-induced retinal degeneration. (molvis.org)
This is based on the concept that aberrant proteasomal degradation of key regulatory proteins induced by viral infection/transformation will generate novel epitopes. (cardiff.ac.uk)
Several types of cellular stress, including hypoxia ( 8 ), infection ( 9 ), nutrient deprivation ( 10 ), oxidative stress ( 11 ) and dysfunctional calcium homeostasis ( 12 ), may induce accumulation of unfolded proteins in the ER lumen. (spandidos-publications.com)
2013). Apoptosis is induced intrinsically by the release of pro-apoptotic proteins from the inter-membrane space of the mitochondrion (eg. (uni-muenchen.de)
Our results indicate that several dozens of proteins for each cell type, are PE-lipoxidated in HT-22, MLE, and H9c2 cells and M2 macrophages after they were induced to undergo ferroptosis. (cdc.gov)

Recent evidence suggests that the early calcium wave elicited by an axonal injury induces epigenetic changes in the nucleus, thereby priming the system for subsequent transcriptional events. (nature.com)
ICB's findings showed that assays established by the Group, aiming has coordinated the HPV-AHEAD several oncogenic viruses have the to characterize the natural history of consortium, which included a multi- ability to induce epigenetic changes and several viruses at different anatomical disciplinary team in Europe and deregulate cel ular gene expression. (who.int)

Interestingly, WC-Co particles also induced Bcl-2, an anti-apoptotic factor, up-regulation. (cdc.gov)
While it is well understood that doxorubicin activates p53 and induces cell-cycle arrest, we observed that cell-cycle arrest disabled inactivation of anti-apoptotic Bcl-2-family members by vincristine. (uni-muenchen.de)

ATZ also induces morphological changes similar to apoptosis and initiates mitochondria-dependent cell death in several experimental models. (frontiersin.org)
Our results suggest that lcn2 acts in an autocrine manner to induce cell death sensitization and morphological changes in astrocytes under inflammatory conditions and that these phenotypic changes may be the basis of reactive astrocytosis in vivo . (jneurosci.org)

Netherton, CL, Parsley, JC & Wileman, TE 2004, ' African swine fever virus inhibits induction of the stress-induced proapoptotic transcription factor CHOP/GADD153 ', Journal of Virology , vol. 78, no. 19, pp. 10825-10828. (uea.ac.uk)
Mechanistically, we showed that kenpaullone directly inhibits CDK2 kinase activity and reduces cisplatin-induced mitochondrial production of reactive oxygen species, thereby enhancing cell survival. (nih.gov)
By using Jurkat T cells, we now show how diphenhydramine inhibits Hv1 mediated currents, inducing a drop in intracellular pH and cellular viability. (unlp.edu.ar)

Cells adapt to this environmental stress, so that after repeated periods of hypoxia, selection for resistance to hypoxia induced apoptosis occurs. (bmj.com)

By treatment with PGE 2 , the chondrocytes apoptosis was significantly increased, the proapoptotic CHOP and JNK were upregulated, the prosurvival GRP78 and XBP1 were downregulated, and GSK-3 β was also upregulated. (hindawi.com)
In both genetic and diet-induced models of insulin resistance, CHOP deficiency improved β cell ultrastructure and promoted cell survival. (jci.org)
In addition, GSK2606414 treatment inhibited eIF2α phosphorylation and reduced CHOP and VEGF mRNA expression levels in RPE cells under TG‑induced ER stress. (spandidos-publications.com)

Common anticancer chemotherapeutic agents causing drug-induced thrombotic microangiopathy via immune-mediated mechanism or dose-dependent toxicity or both [ 4 , 7 ]. (hindawi.com)
Most chemotherapeutic agents induce apoptosis. (uni-muenchen.de)

3- 5 Therefore, during severe hypoxia or anoxia, the cell initiates a cascade of events that leads to apoptotic cell death, thereby preventing the accumulation of cells with hypoxia induced mutations. (bmj.com)
Disruption of PERK activity has been demonstrated to reduce hydroquinone-induced apoptosis and hypoxia-induced VEGF expression in human RPE cells in vitro ( 5 , 21 ). (spandidos-publications.com)

In this study, Andro induced apoptosis in human cancer cells via activation of caspase 8 in the extrinsic death receptor pathway and subsequently with the participation of mitochondria. (elsevierpure.com)
Apoptosis is induced through the mitochondrial pathway resulting in caspase-9 activation and downstream caspase-3 activation. (cdc.gov)
In addition, my experiments showed that the active form of p38 associates with caspase 8 and caspase 3, which is necessary for p38-induced phosphorylation of serine-362 and serine-150 on these caspases. (lu.se)
These biochemical modifications impair the activities, and possibly also the stability, of caspase 8 and 3 and thereby weaken the capacity of these enzymes to induce apoptosis. (lu.se)

PUMA is involved in p53-dependent and -independent apoptosis induced by a variety of signals, and is regulated by transcription factors, not by post-translational modifications. (wikipedia.org)
Other agents that induce p53 dependent apoptosis are neurotoxins, proteasome inhibitors, microtubule poisons, and transcription inhibitors. (wikipedia.org)

Catalase inhibit WC-Co-induced ROS as well as mitochondrial membrane permeability damage, indicating that H2O2 may play an important role in the cytotoxicity induced by WC-Co. Further studies indicated that WC-Co nanoparticle s elicited a higher cytotoxicity and apoptotic induction than fine particles. (cdc.gov)
The human antimicrobial peptide LL-37 permeabilizes the plasma membrane of host cells, but LL-37-induced direct effects on mitochondrial membrane permeability and function has not been reported. (lu.se)

We identified Eiger, the Drosophila tumor necrosis factor (TNF) homolog, as the signal responsible for apoptosis-induced apoptosis (AiA). (elifesciences.org)
TRAIL, Tumor necrosis factor Related Apoptosis Inducing Ligand). (uni-muenchen.de)
2013). Cell cycle arrest was induced in tumor cell lines and patient samples in G0, G1 or G2 with cytostatic drugs, phase-specific inhibitors or RNA interference against cyclinB and E. Molecular or biochemical arrest at any point of the cell cycle augmented the rate of apoptosis by TRAIL. (uni-muenchen.de)

Additionally, many human tumors contain p53 mutations, which results in no induction of PUMA, even after DNA damage induced through irradiation or chemotherapy drugs. (wikipedia.org)
2 In addition, hypoxia induces genetic instability by the induction of fragile sites causing gene amplification. (bmj.com)
The results demonstrate that apoptosis induced by WC-Co involve both 'extrinsic' and 'intrinsic' apoptotic pathways and nanoparticle s exhibit higher cytotoxicity and apoptotic induction than fine particles. (cdc.gov)
The p38 survival signal was transiently lost during both spontaneous and Fas-induced apoptosis, favoured induction of the apoptotic process. (lu.se)

We have discovered that Smac mimetics can induce long-term changes in the breast cancer cell phenotype which includes inflammatory signaling. (lu.se)

The results demonstrated that propofol-induced impairment in spatial learning and memory of rats and promoted oxidative stress, neuronal injury and apoptosis in rat hippocampal tissues. (degruyter.com)

Khz cytotoxicity was measured using an MTT assay and the mitochondrial membrane potential (MMP)-related, calcium-induced generation of reactive oxygen species (ROS) in A549 cells was measured by flow cytometry. (springer.com)
Khz ( fusion of Ganoderma lucidum and Polyporus umbellatus mycelia ) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen species. (springer.com)
Miyajima, A, Nakashima J, Yoshioka K. Role of reactive oxygen species in cis-dichlorodiammineplatium-induced cytotoxicity on bladder cancer cells. (springer.com)

PUMA apoptosis may also be induced independently of p53 activation by other stimuli, such as oncogenic stress growth factor and/or cytokine withdrawal and kinase inhibition, ER stress, altered redox status, ischemia, immune modulation, and infection. (wikipedia.org)
Whether 5,7,3′,4′-tetramethoxyflavone (TMF) plays the chondroprotective role in inhibition of PGE 2 -induced chondrocytes apoptosis associating with ERS has not been reported. (hindawi.com)
Inhibition of apoptosis may decrease critical illness-induced skeletal muscle wasting and weakness. (massgeneral.org)
Moreover, knocking down BDNF partially reversed esketamine-mediated activation of the mBDNF/TrkB/PI3K signaling pathway and inhibition of neuronal apoptosis in propofol-induced rats. (degruyter.com)

We now demonstrate that endogenous 53BP2 levels increase following UV irradiation induced DNA damage in a p53-independent manner. (ox.ac.uk)

Many cancers do exhibit p53 gene mutations, making gene therapies that target this gene[clarification needed] impossible, but an alternate pathway may be to focus on therapeutic to target PUMA and induce apoptosis in cancer cells. (wikipedia.org)
TMA caused by drugs is called drug-induced TMA (DTMA) [ 4 ], and cancer therapeutic agents are among the most common medications reported to cause DTMA. (hindawi.com)

31] Biochemical studies have shown that PUMA interacts with antiapoptotic Bcl-2 family members such as Bcl-xL, Bcl-2, Mcl-1, Bcl-w, and A1, inhibiting their interaction with the proapoptotic molecules, Bax and Bak. (wikipedia.org)

Interestingly, pro-apoptotic signaling from the PERK UPR pathway was also not induced. (nih.gov)
The lcn2-induced phenotypic changes of astrocytes occurred through a Rho-ROCK (Rho kinase)-GFAP pathway, which was positively regulated by nitric oxide and cGMP. (jneurosci.org)

PIs prevent degradation of proapoptotic factors and permit activation of programmed cell death in myeloma cells [ 10 ]. (hindawi.com)

Here, we report the first case of ixazomib-induced DTMA due to cumulative toxicity rather than immune-mediated mechanism. (hindawi.com)
Our group recently has characterized the molecular mechanism inducing this state in critical illness. (massgeneral.org)
It is of great significance to better understand the potential mechanism of propofol-induced neurotoxicity to eliminate the side effects of propofol. (degruyter.com)
However, its effect on propofol-induced neurotoxicity and the underlying mechanism remain unclear. (degruyter.com)
Therefore, a better understanding of the mechanism underlying propofol-induced neurotoxicity is favorable for eliminating the side effects of propofol. (degruyter.com)
Moreover, histamine H1-receptor antagonists were found to induce apoptosis in tumoral cells but the mechanism is still unclear. (unlp.edu.ar)

With great interest we discovered that the replacement of wildtype p53 by mutant p53 did not disturb the extrinsic apoptosis inducing capacity. (uni-muenchen.de)

During hypoxia, an intricate balance exists between factors that induce or counteract apoptosis, or even stimulate proliferation. (bmj.com)
GSK2606414 treatment inhibited RPE cell proliferation in a dose‑dependent manner, however it did not induce apoptosis. (spandidos-publications.com)

It has been reported that RNF4 negatively regulates TNF-α-induced activation of the nuclear factor-κB (NF-κB) through downregulation of transforming growth factor β-activated kinase 1 (TAK1) activity, indicating the possibility that RNF4-mediated TAK1 suppression results in enhanced sensitivity to cell death. (mdpi.com)
We report that the WNV capsid (Cp) by itself induces rapid nuclear condensation and cell death in tissue culture. (cdc.gov)

The resulting aggregate called death-inducing signaling complex (disc) performs CASP8 proteolytic activation. (lu.se)

Low ATP concentrations in hypoxic tumour cells disable the apoptotic cascade and induce cell death by necrosis. (bmj.com)
Capsid gene delivery into the striatum of mouse brain or interskeletal muscle resulted in cell death and inflammation, likely through capsid-induced apoptosis in vivo. (cdc.gov)
Our aims are to identify and understand mechanisms regulating breast cancer cell death and how inflammatory signaling can be induced and influence breast cancer progression. (lu.se)
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1a induced cell death. (lu.se)

This increase in PUMA levels induces apoptosis through mitochondrial dysfunction. (wikipedia.org)
Overall, esketamine mitigates propofol-induced cognitive dysfunction and brain injury in rats by activating mBDNF/TrkB/PI3K signaling. (degruyter.com)

Treatment with 200 mg/kg bodyweight C-PC (Group III) transcriptionally regulated the instability of the expression of these genes, thus ensuring C-PC is a prospective anticataractogenic agent that probably delays the onset and progression of cataractogenesis induced by sodium selenite. (molvis.org)
The inhibitory effects of the doenjang prepared with the grain-type meju using mixed starter cultures were investigated in azoxymethane (AOM) and dextran sulfate sodium (DSS)-induced colon carcinogenesis mice model. (carcinogenesis.com)

We identified a novel mode of communication by which apoptotic cells induce additional apoptosis in the same tissue. (elifesciences.org)
Thus, in addition to its established role in the sensing and clearance of apoptotic cells, C1q may also regulate fatty acid-induced apoptosis. (europa.eu)

Stably introduced into cancer cell lines, the system reports on elevated endogenous ADAR1 editing activity induced by interferon as well as knockdown of ADAR1 and ADAR2. (cancerindex.org)

In this paper, we will discuss whether PGE 2 can induce activation of ERS and GSK-3 β in chondrocytes and the protection role of TMF. (hindawi.com)
As a next step we studied the influence of cell cycle arrest induced by p53 activation on TRAIL apoptosis sensitivity (Ehrhardt/Wachter et al. (uni-muenchen.de)
Additionally, we studied the impact of p53 activation on the rate of apoptosis induced by combinations of cytostatic drugs (Ehrhardt, Schrembs, Moritz, Wachter et al. (uni-muenchen.de)

CDK2-deficient mice displayed enhanced resistance to cisplatin toxicity in cochlear explants and to cisplatin- and noise-induced hearing loss in vivo. (nih.gov)

In this study, we investigated whether DIM could improve insulin-dependent diabetes and nephropathy in streptozotocin (STZ)-induced diabetic mice. (researchgate.net)
The scope of these studies encompassed diabetic retinopathy, retinopathy of prematurity, glaucoma, retinal detachment, light-induced retinal degeneration, age-related macular degeneration, and inherited retinal degeneration. (molvis.org)

Inhibiting PUMA induced apoptosis may be an interesting target for reducing the side effects of cancer treatments, such as chemotherapy, which induce apoptosis in rapidly dividing healthy cells in addition to rapidly dividing cancer cells. (wikipedia.org)
Expression of the p53 target CDIP correlates with sensitivity to TNFα-induced apoptosis in cancer cells. (nih.gov)
Our experiments have revealed the proapoptotic function of CDK2 in postmitotic cochlear cells and have identified promising therapeutics for preventing hearing loss. (nih.gov)
Khz inhibited cell division and induced apoptosis in A549 cells. (springer.com)
Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells. (springer.com)
ARPE‑19 human RPE cells were treated with 0.01‑50 µM GSK2606414, and ER stress was induced by thapsigargin (TG) treatment. (spandidos-publications.com)

In view of these observations, it is tempting to hypothesize that, through its ability to bind fatty acids on E-LDL particles, C1q may prevent or control their proapoptotic effect. (europa.eu)

In this dissertation thesis, I describe and elucidate intracellular signalling mechanisms that are involved in regulation of spontaneous and Fas-induced apoptosis in human neutrophils. (lu.se)

As an intravenous anesthetic, propofol has been indicated to induce neurotoxicity in both animal and human brains. (degruyter.com)

Propofol (2,6-diisopropylphenol) is an intravenous anesthetic widely used in surgery or intensive care units to induce and maintain anesthesia as well as sedation [ 2 ]. (degruyter.com)

Among them, kenpaullone, an inhibitor of multiple kinases, including cyclin-dependent kinase 2 (CDK2), protected zebrafish lateral-line neuromasts from cisplatin toxicity and, when delivered locally, protected adult mice and rats against cisplatin- and noise-induced hearing loss. (nih.gov)

Objective Indole‐3‐carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3′‐diindolylmethane (DIM) reduce body mass and serum glucose levels in high‐fat‐diet‐induced obese mice. (researchgate.net)
AOM and DSS colon carcinogenesis was induced in female C57BL/6 mice, and doenjang was orally administered for 4 weeks. (carcinogenesis.com)

Because PUMA has high affinity for binding to Bcl-2 family members, another hypothesis is that PUMA directly activates Bax and/or Bak and through Bax multimerization triggers mitochondrial translocation and with it induces apoptosis. (wikipedia.org)

These findings indicate that the doenjang attenuated colon carcinogenesis induced by AOM and DSS by ameliorating the symptoms of colon cancer, reducing the occurrence of neoplasia, regulating proinflammatory cytokine levels, and controlling the expressions of inflammation- and apoptosis-related genes in the colonic tissue. (carcinogenesis.com)

Various studies have shown though, that PUMA does not rely on direct interaction with Bax/Bak to induce apoptosis. (wikipedia.org)

TMF exhibits a chondroprotective role in inhibiting PGE 2 -induced ERS and GSK-3 β . (hindawi.com)
Herein, we investigated the role of esketamine in propofol-induced brain injury. (degruyter.com)

A rat model of propofol-induced brain injury was established with or without the treatment of esketamine. (degruyter.com)

Common solid tumors that have been linked to cancer-induced TMA include gastric, breast, lung, and prostate adenocarcinomas, with gastric adenocarcinoma being the most reported. (hindawi.com)

Anatomy28

Organisms10

Diseases7

Chemicals and Drugs135

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes55

Disciplines and Occupations1

Information Science3

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Protein12

Proteins9

Epigenetic changes2

Anti-apoptotic2

Morphological changes2

Inhibits3

Apoptosis occurs1

CHOP3

Chemotherapeutic agents2

Hypoxia induced2

Caspase4

Transcription2

Mitochondrial membrane permeability2

Tumor3

Induction4

SMAC1

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Reactive3

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Therapeutic2

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Extrinsic1

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CASP81

Cell death4

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Sodium2

Apoptotic cells2

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