Induce macrophage cytotoxic activity. Medical search. Frequent questions

In the presence of accessory cells, IL-10 inhibits mitogen- or anti-CD3 induced proliferation of T lymphocytes. (bdbiosciences.com)
Cytotoxic T lymphocytes were determined as the cellular effectors of GVHD, and the key role of antigen-presenting cells (APCs) in T-lymphocyte activation was established during the following years [ 11 , 12 ]. (hindawi.com)
The current understanding of aGVHD pathogenesis can be summarized as (1) initial tissue damage induced by the conditioning regimen followed by the denudation of auto- and alloantigens accompanied by massive inflammatory cytokine secretion ("cytokine storm") activating APCs, (2) auto- and alloantigen presentation mediated by APCs together with the costimulatory signaling prime donor's cytotoxic T lymphocytes and their proliferation, and (3) the migration of activated cellular effectors toward GVHD target tissues. (hindawi.com)
IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and natural killer (NK) cells. (rndsystems.com)
G ) CD4 + T lymphocytes cells differentiate into Th1, which activates phagocytosis through NK cells and macrophages, promoting pathogen killing. (news-medical.net)
Th1 cytokines (IL-2, tumor necrosis factor, IL-12, and IFN-γ) and Th2 cytokines (IL-4, IL-5, IL-6, and IL-10) along with IL-8 and IL-17 induce antitumor activity mediated by cytotoxic T lymphocytes, natural killer cells (NK), neutrophils, and macrophages. (biomedcentral.com)
CH25H manifestation was interferon-dependent and induced by SIV disease in monkey-derived PBMC and macrophages cells, and 25-HC inhibited SIV disease both in permissive cell lines and major monkey lymphocytes. (iassist2012.org)
Furthermore, Aclacinomycin A 25-HC got no significant immunosuppressive results on cytotoxic Compact disc8+ T lymphocytes or antibody-producing B lymphocytes. (iassist2012.org)
Mouse spleen lymphocytes became cytotoxic to tumor cells after culture with AG and FU at concentrations of 10-100 μg/mL. (elsevierpure.com)
Also, AG and FU were mitogenic in spleen lymphocytes and peripheral macrophages. (elsevierpure.com)
These data suggest that AG and FU are activators of lymphocytes and macrophages. (elsevierpure.com)
Cytotoxic T lymphocytes (CTLs) recognize antigens on target cells and lyse these cells. (msdmanuals.com)

Besides the secretion of pro-inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6), the increased expression of receptor repertoire (pattern recognition receptors, PRR) on APCs, mostly macrophages and dendritic cells, occurs as a result of the release of endogenous and exogenous antigens (damage-associated molecular patterns, DAMPs, and pathogen-associated molecular patterns, PAMPs). (hindawi.com)
E ) Upon virus attack in epithelial cells, probiotics mediate their antiviral effects by eliciting immune responses by activating macrophages and dendritic cells. (news-medical.net)
These features may be responsible for the recruitment and activation of T cells, macrophages and dendritic cells, characterizing the stromal component of this lymphoma, and may point towards innate immunity and a tumor tolerogenic immune response in T-cell/histiocyte-rich large B-cell lymphoma. (haematologica.org)

The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. (origene.com)
Measured by its ability to neutralize IL‑12-induced proliferation in PHA-activated human peripheral blood mononuclear cells (PBMC) [Yokota, T. et al . (rndsystems.com)
Cell Proliferation Induced by IL‑12 and Neutralization by Human IL‑12 Antibody. (rndsystems.com)
This interaction induces IFN-gamma gene expression, enhancing the cytotoxic activity of resting NK and T cells, inducing and synergizing with IL-2 in the generation of lymphokine-activated killer (LAK) cells, acting as a co-mitogen to stimulate proliferation of resting T cells, and inducing proliferation of activated T and NK cells. (rndsystems.com)
Current evidence indicates that IL-12, produced by macrophages in response to infectious agents, is a central mediator of the cell-mediated immune response by its actions on the development, proliferation, and activities of TH1 cells. (rndsystems.com)
H ) CD4 + cells differentiate into Th2 cells, which induce B-cells' proliferation that produces antibodies like IgA, IgG, and IgM. (news-medical.net)
For example, opioid receptor activation can promote the proliferation of microglia and macrophages [ 18 ]. (biomedcentral.com)
These results demonstrate differential sensitivity of standard cytotoxicity assessments on the PPP, thus (1) decoupling 'mitochondrial activity' as an interpretation of cellular formazan and Alamar Blue metabolism, and (2) demonstrating the implicit requirement for investigators to sufficiently verify interaction of these methods in routine cytotoxicity and proliferation characterization. (cdc.gov)
In parallel, an increase of infiltrating T cells, macrophages, and macrophage pro-inflammatory cytokine formation as well as improved proliferation and apoptosis in kidneys of anti-Tim3Ctreated mice was recognized. (engineering-gdfsuez.com)
Recent evidence, however, supports a dual role for macrophages in the regulation of tumour proliferation and immune control 10 , 16 , and indicates that the local tissue microenvironment plays a critical role in determining cell phenotypes. (ersjournals.com)

E histolytica is a pseudopod-forming, nonflagellated protozoal parasite that causes proteolysis and tissue lysis (hence the species name) and can induce host-cell apoptosis. (medscape.com)
Treatment with the AMPK inhibitor dorsomorphin reversed ebastine-induced apoptosis and autophagy. (ijbs.com)
The results showed that chrysin inhibited cancer cell growth at a dose-dependent manner by inducing apoptosis and cell cycle arrest at G2/M phase. (propolisscience.org)
PKC isozymes are LR-dependent molecules that link psychosine-induced LR disruption to reduced PKC function and altered cell signaling activity, possibly driving demyelination and apoptosis in oligodendrocytes and Schwann cells. (medscape.com)

Our results revealed that nSP exerted higher cytotoxicity in macrophage cells compared with submicron-sized silica particles. (springer.com)
However, tartrate-resistant acid phosphatase (TRAP) activity and the number of osteoclast cells (TRAP-positive multinucleated cells) were not changed by nSP treatment in the presence of receptor activator of nuclear factor κB ligand (RANKL) at doses that did not induce cytotoxicity by silica particles. (springer.com)
RESULTS: Starting from the concentration of 0.31 mg/ml, Hemidesmus indicus induced cytotoxicity and altered cell-cycle progression, through a block in the G0/G1 phase. (unibo.it)
NSAID) as positive control were screened for their cytotoxicity and anti-inflammatory properties by evaluating the cell cytotoxicity and the nitric oxide (NO) inhibitory activities upon activated fibroblast synoviocytes (HIG-82) and macrophage (RAW 264.7) cell lines with phorbol-12- myristate acetate (PMA) and lipopolysaccharide (LPS), respectively. (upm.edu.my)
Results showed exposure of NHBEs to ABS emissions did not significantly affect epithelium integrity, ciliation, mucus production, nor induce cytotoxicity. (cdc.gov)
In nanotoxicology, the capacity of nanoparticles of the same composition but different shape to induce cytotoxicity and genotoxicity is largely unknown. (birmingham.ac.uk)
Proliferative activity, cytotoxicity and apoptotic markers showed a significant trend in the two cell types. (birmingham.ac.uk)

It has been shown that this induces greater cell migration in vivo and in vitro, possibly by promoting degradation of the ECM. (wikipedia.org)
RESULTS: In silico and in vitro assays showed that all of the green tea compounds have antileishmanial activity. (bvsalud.org)
CONCLUSION: In this study, in silico and docking results were in accordance with the in vitro activity of the compounds. (bvsalud.org)
Further, in vivo study using completed Freund's adjuvant (CFA)-induced arthritis animal model was conducted to evaluate the therapeutic and toxicity effects of selected thiopurine compounds (6-MP and 6-MP riboside) selected based on in vitro study with different dosages (3, 6 and 10 mg/kg). (upm.edu.my)
Different groups have established several protocols to induce the differentiation of MSCs into HLCs in vitro . (springer.com)
A series of cytotoxic and genotoxic responses following in vitro exposure to differently shaped CuO nanoparticles (CuO NPs, mass concentrations from 0.1 to 100 μg/ml) were assessed in murine macrophages RAW 264.7 and in peripheral whole blood from healthy volunteers. (birmingham.ac.uk)
Major Findings: The in vitro growth inhibition assays demonstrated additive activity when AHCC is co-administered with PLD. (researchgate.net)

IL-10 has also been shown to costimulate the development of thymocytes, B cell differentiation and the generation of cytotoxic T cells. (bdbiosciences.com)
Collectively, the results suggested that nanosilica exerts no effect on RANKL-induced osteoclast differentiation of RAW264.7 cells, although a detailed mechanistic examination of the nSP70-mediated cytotoxic effect is needed. (springer.com)
Our studies revealed that nSP induced high ROS and pro-inflammatory cytokine production, and these cellular responses may induce excess osteoclast differentiation. (springer.com)
Therefore, we consider that it is necessary to estimate nSP-induced effects on osteoclast differentiation. (springer.com)
Furthermore, because we indicated previously that nSP induced different cellular responses from submicron-sized silica particles, such as those described above, it was of interest to analyse the effects of particle size on osteoclast differentiation. (springer.com)
The analysis of cell differentiation by nitroblue tetrazolium (NBT) reducing activity, adherence to the plastic substrate, alpha-napthyl acetate esterase activity and morphological analysis was performed through light microscopy (LM) and transmission electron microscopy (TEM). (unibo.it)
The decoction caused differentiation of HL-60 cells as shown by NBT reducing activity, adherence to the plastic substrate, alpha-naphtyl acetate esterase activity, and increasing expression of CD14 and CD15. (unibo.it)
Thus, a careful characterization and understanding of this macrophage differentiation state is needed in order to efficiently tailor cancer therapy. (nutriforce.cn)

In addition, Maca polysaccharides have good immune-regulatory activity on macrophages by regulating the polarization and increasing the phagocytosis [ 16 ]. (hindawi.com)
Macrophages treated with AG and FU (10-100 μg/mL) exhibited induced tumoricidal activity and increased phagocytosis, lysosomal enzyme activity, and production of nitrite, H 2 O 2 , tumor necrosis factor (TNF)-α, and interleukin (IL)-6. (elsevierpure.com)
Macrophages treated with AG and FU (10-100 μg/mL) exhibited induced tumoricidal activity and increased phagocytosis, lysosomal enzyme activity, and production of nitrite, H2O2, tumor necrosis factor (TNF)-α, and interleukin (IL)-6. (elsevierpure.com)

RAW 264.7 macrophages elicited enhanced phagocytizing activity towards "nitrosylated" HL-60 cells. (cdc.gov)
Inhibitory effect of the compounds on nitric oxide production PMA-stimulated HIG-82 had only a small inhibition effect, however excellent inhibition and suppressive activity were observed on RAW 264.7 cell. (upm.edu.my)
Meanwhile, at the highest concentration (100 μM) 6-TG and diclofenac had a cytotoxic effect to RAW 264.7 and HIG-82 cell respectively. (upm.edu.my)

On macrophages, IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances. (rndsystems.com)
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. (origene.com)
IL-10, TGF-β, chronic infection and cancer induce PD1 expression by different cytokines and is a characteristic of exhausted T cells (Wherry & Kurachi, 2015 ). (biomedcentral.com)
Thus, the tumoricidal effect of AG- and FU-activated macrophages appeared to be mainly mediated by production of free radicals (NO and H 2 O 2 ) and cytokines (TNF-α and IL-6). (elsevierpure.com)

Despite the activity of effector cells, host immunoreactivity may fail to control tumor occurrence and growth. (msdmanuals.com)
Natural killer (NK) cells are another population of effector cells with anti-cancer activity. (msdmanuals.com)

Here, we show that successful treatment of cervical carcinoma in mouse models with synthetic long peptide (SLP) vaccines induced influx of cytokine-producing CD8 T cells that strongly altered the numbers and phenotype of intratumoral macrophages. (aacrjournals.org)
The primary aim of the present study was to determine the immunological phenotype of NSCLC-associated macrophages. (ersjournals.com)
CD68 + macrophages expressing markers of a cytotoxic M1 phenotype or a noncytotoxic M2 phenotype were identified in the islets and stroma of surgically resected tumours from 20 patients with extended survival (median 92.7 months) and 20 with poor survival (median 7.7 months), using immunohistochemistry. (ersjournals.com)
Macrophages infiltrating the tumour islets in nonsmall cell lung cancer were predominantly of the M1 phenotype in patients with extended survival. (ersjournals.com)
The M1 phenotype (classically activated) macrophages are thought to be induced by interferon-γ, with or without lipopolysaccharide and tumour necrosis factor (TNF)-α, and exert a cytotoxic effect against cancer cells. (ersjournals.com)
Additionally, M2 macrophages have been traditionally thought of as being the predominant macrophage phenotype in solid tumours (tumour-associated macrophages). (ersjournals.com)
We are only beginning to understand the environmental cues that contribute to transient retention of macrophages in a specific phenotype. (nutriforce.cn)

Because protein S-nitrosylation can act as a regulatory redox-sensitive mechanism, we hypothesized that nitrosative stress enhances PS externalization in cells by inhibiting APT activity. (cdc.gov)
This pathway should be particularly important during inflammation whereby oxidative/nitrosative burst generated by macrophages may cause direct nitrosylation or trans-nitrosylation of APT in target cells. (cdc.gov)
To experimentally address this hypothesis we utilized HL-60 cells that express high activity of APT. (cdc.gov)
We speculate that our proposed mechanism of macrophage induced nitrosative stress contributes to effective clearance of apoptotic cells and regulates switching of acute inflammatory response to anti-inflammatory phase as has been observed in the lung and in the brain in in vivo experiments with inhalation of single-walled carbon nanotube s and cortical trauma, respectively. (cdc.gov)
Tumors can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing peripheral immune tolerance, while the immune cells in the microenvironment can affect the growth and evolution of cancerous cells. (wikipedia.org)
In 1960, Klein and colleagues found that in mice, primary methylcholanthrene-induced sarcomas exhibited an antitumor immune response mediated by lymph node cells to cancer cells derived from the primary tumor. (wikipedia.org)
IL-10 has numerous biological activities including the inhibition of cytokine synthesis by activated T cells, NK cells, monocytes, and macrophages. (bdbiosciences.com)
Furthermore, it is possible that nSP circulating in the blood can reach the alveolar bone, which is presented in the submucosal layer, as well as various cells such as macrophages and osteoblasts. (springer.com)
These novel changes induced by WNV may serve as of 173 cellular genes were identified by ArrayTools to be biomarkers and help explain the neuropathologic features differentially expressed in the WNV-infected A172 cells. (cdc.gov)
These effects include inducing production of IFN-gamma and TNF by resting and activated T and NK cells, synergizing with other IFN-gamma inducers at both the transcriptional and post-transcriptional levels. (rndsystems.com)
These changes of the intratumoral myeloid composition coincided with macrophage recruitment by chemokines, including CCL2 and CCL5, and were completely dependent on a vaccine-induced influx of tumor-specific CD8 T cells. (aacrjournals.org)
Incubation of tumor cells with T cell-derived IFNγ and TNFα recapitulated the chemokine profile observed in vivo , confirming the capacity of antitumor CD8 T cells to mediate macrophage infiltration of tumors. (aacrjournals.org)
Moreover, PCNs altered the immune cell profiles within the tumor by increasing cytotoxic T cells and M1-like macrophages with antitumor activity. (biomedcentral.com)
This finding opens new avenues for treating RA during synovial inflammation of RA and the inhibitory effects of 6-MP and 6-MP riboside to suppress inflammatory cells marker such as synovial fibroblast and macrophages by proliferating healthy synoviocytes. (upm.edu.my)
This free radical acts as a cytotoxic agent against exogenous microorganisms, by stimulating macrophage-induced inflammation and death of infected cells. (pdffox.com)
Injection of infectious but not of non‐infections influenza A virus or of infectious or non‐infectious Sendai virus intraperitoneally into mice induces the generation of plastic‐adherent cells that arc able to effect release of 51 Cr from labelled virus‐infected target cells but not from labelled, uninfcctcd cells. (edu.hk)
Similarly, the activity of the cell preparation cannot be explained by contamination with natural killer or 'K' cells. (edu.hk)
Urothelial and bladder tumor cells infected by BCG increases the expression of antigen-presenting molecules, inducing immune response via cytokine release. (biomedcentral.com)
Accordingly, administration of a obstructing anti-Tim3 antibody inside a model of experimental Chlormadinone acetate sensitive encephalomyelitis resulted in activation and development of macrophages in the brain and worsening of the disease.7 This observation could be traced back to direct cell-to-cell-interaction between differentiated TH-1 cells and CD11b+/F4/80+ macrophages,7 which was inhibited by Tim3. (engineering-gdfsuez.com)
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome induced by aberrantly activated macrophages and cytotoxic T cells. (scienceopen.com)
Macrophages can kill specific tumor cells when activated by a combination of factors, including lymphokines (soluble factors produced by T cells) and interferon. (msdmanuals.com)
Under certain circumstances, macrophages may present TAAs to T cells and stimulate tumor-specific immune response. (msdmanuals.com)
This accumulation causes formation of globoid cells (hematogenous often-multinucleated macrophages containing undigested galactosylceramide), which is the histologic hallmark of Krabbe disease. (medscape.com)
A study by White et al found that psychosine's cytotoxic effects on oligodendroglia and Schwann cells was mediated through disruption of the architecture and composition of lipid rafts (cell membrane regions characterized by high cholesterol and sphingolipid concentration), followed by altered protein kinase C (PKC) function. (medscape.com)

CONCLUSIONS: The cytodifferentiating, cytotoxic and cytostatic activities of Hemidesmus indicus offers a scientific basis for its use in traditional medicine. (unibo.it)
Dexamethasone also inhibited GM-CSF-induced NFkB activation by preventing a significant decrease on the IkB-a protein levels, thus blocking NF-kB migration to the nucleus.Conclusions : The corticosteroid dexamethasone inhibits GM-CSF-induced NF-kB activation, iNOS protein expression and NO production. (pdffox.com)
Conclusions: There is potential improvement in PLD activity when co-administered with AHCC and decrease side effects of PLD. (researchgate.net)

Hypoxia also causes the upregulation of hypoxia-inducible factor 1 alpha (HIF1-α), which induces angiogenesis and is associated with poorer prognosis and the activation of genes associated with metastasis, leading, for instance, to increased cell migration and also ECM remodeling. (wikipedia.org)
Tumor-promoting functions of macrophages include angiogenesis, metastasis formation, and suppression of Th1-type immune responses. (aacrjournals.org)
It has also been described that one of the key roles of M2 macrophages is to promote angiogenesis 7 , 10 . (ersjournals.com)
Vascular endothelial growth factor (VEGF), a key component in the process of angiogenesis, is known to be produced by tumour-associated macrophages 17 , 18 , which have been traditionally reported as M2 macrophages. (ersjournals.com)
It has become clear that hypoxia shapes and induces specific macrophage phenotypes that serve tumor malignancy, as hypoxia promotes immune evasion, angiogenesis, tumor cell survival, and metastatic dissemination. (nutriforce.cn)

Besides, further experiments were conducted to investigate the pro-inflammatory, suppressive and antioxidative effects of 6-MP and 6-MP riboside on inflammation arthritis induced rats model. (upm.edu.my)
6-MP and 6-MP riboside have therapeutic activity and potentially useful for treating inflammatory conditions as served as a new promising disease-modifying anti-rheumatic drugs (DMARDS) in treating early inflammation arthritis in the future. (upm.edu.my)
Cellular factors which play role in host defense mechanisms against HIV were identified and their role in HIV induced inflammation was established. (europa.eu)

Abundant macrophage infiltration of solid cancers commonly correlates with poor prognosis. (aacrjournals.org)
Thus, increasing numbers of macrophages within the tumour islets conferred a marked survival advantage, while increased numbers of macrophages in the tumour stroma were associated with worse prognosis. (ersjournals.com)
The association between prognosis and islet macrophage count has been confirmed recently by others in an independent cohort of patients 5 but the stromal macrophage counts in that study were not associated with survival. (ersjournals.com)
The role of tumor-associated macrophages (TAMs) in cancer is often correlated with poor prognosis, even though this statement should be interpreted with care, as the effects of macrophages primarily depend on their localization within the tumor. (nutriforce.cn)

The role of macrophage phenotypes in tumour progression has been extensively reviewed 6 - 10 . (ersjournals.com)

Cancer treatment targeting the tumor vasculature by inducing antitumor immune responses and enhancing the delivery of a chemotherapeutic agent with PCNs resulted in tumor regression and may provide an effective therapeutic strategy. (biomedcentral.com)

The conditioning-induced damage of recipients' tissues leads to danger signal secretion [ 13 ]. (hindawi.com)

The present study demonstrates that APS attenuate the immunosuppressive activity of MDSC in melanoma-bearing mice by remodeling the gut microbiota and fecal metabolites. (bvsalud.org)

The cytoprotective and anti-inflammatory activity of APC is mediated through binding to its receptor, endothelial cell protein C receptor (EPCR). (biomedcentral.com)
While the antithrombotic activity of APC is based on its ability to inactivate clotting factors Va and VIIIa, leading to adverse bleeding, the cytoprotective effect is based on its anti-inflammatory, antiapoptotic, and endothelial barrier stabilization activities [ 12 , 14 ]. (biomedcentral.com)
2011 ). In addition to antitumor activities, CDK inhibitors (CDKi) show prominent anti-inflammatory effects (Leitch et al. (researchsquare.com)

EcN was armed with HlyE, a small cytotoxic protein, under the control of the araBAD promoter (P BAD ). (nature.com)
Thioredoxin-interacting protein (Txnip) inhibits the activity of thioredoxin (Trx) to modulate inflammatory responses. (frontiersin.org)
Enables protein serine/threonine kinase activity. (nih.gov)
Myeloid related protein (MRP) 8/14 expression by macrophages is associated with the release of TNF-α 12 . (ersjournals.com)

Their tumoricidal activity is termed natural because it is not induced by a specific antigen. (msdmanuals.com)

Accordingly, there is a compelling need to clarify the biological and cellular responses induced by different particle sizes. (springer.com)

NADPH oxidase-regulated NF-κB activation and pro-inflammatory activation were induced and accompanied by Txnip degradation during GAS infection. (frontiersin.org)
It is well known that opioids can modulate microglia and macrophages by activating surface receptors, thus establishing a plausible mechanism through which morphine can affect the development of the inflammatory response. (biomedcentral.com)
Epidemiological evidence indicates that regular physical activity and/or frequent structured exercise reduces the incidence of many chronic diseases in older age, including communicable diseases such as viral and bacterial infections, as well as non-communicable diseases such as cancer and chronic inflammatory disorders. (frontiersin.org)
Lifelong physical activity 1 is a potent means of reducing the risk of non-communicable diseases including cancer, cardiovascular disease, and other chronic inflammatory disorders ( 1 ). (frontiersin.org)
Finally, in the third part of this article, we summarize recent data suggesting that regular physical activity and frequent exercise, which reduces systemic inflammatory activity and improves aspects of immune function, also leads to alterations in classical biomarkers of an aging immune system. (frontiersin.org)

The survival advantage conferred by islet macrophage infiltration may be related to their cytotoxic antitumour activity. (ersjournals.com)

Moreover, we discuss the deleterious effect of interferon-γ activity in influenza infection and how this observation contrasts with findings in severe COVID-19. (ersjournals.com)

Acute liver failure (ALF) is a life-threatening clinical syndrome characterized by rapid hepatocellular necrosis due to various acute injuries induced by hepatotoxic drugs, immune-mediated attack, or viral infections. (springer.com)
The coronavirus disease 2019 (COVID-19) pandemic has elicited a swift response by the scientific community to elucidate the pathogenesis of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-induced lung injury and develop effective therapeutics. (ersjournals.com)
Clinical data indicate that severe COVID-19 most commonly manifests as viral pneumonia-induced acute respiratory distress syndrome (ARDS), a clinical entity mechanistically understood best in the context of influenza A virus-induced pneumonia. (ersjournals.com)
Our review explores influenza A virus-induced acute respiratory distress syndrome (ARDS) as a paradigm for understanding coronavirus disease 2019 (COVID-19)-induced ARDS pathogenesis and ageing as a risk factor for severe disease. (ersjournals.com)

There is a marked survival advantage for patients with nonsmall cell lung cancer (NSCLC) expressing high numbers of macrophages in their tumour islets. (ersjournals.com)
M2 (alternatively activated) macrophages are thought to be modulated by IL-4 and -13 and associated with tumour formation. (ersjournals.com)
In several instances, tumour sites cytotoxic agents. (who.int)

The morphological analysis by LM and TEM clearly showed the presence of granulocytes and macrophages after Hemidesmus indicus treatment. (unibo.it)

No cytotoxic effects were induced by either of the trans-nitrosating agents. (cdc.gov)

In the extended survival group, M1 islet density was significantly increased compared with M2 density, 70% of islet macrophages were positive for M1 markers versus 38% for M2, and the islet:stromal ratio of M1 macrophages was markedly increased compared with M2. (ersjournals.com)

Besides, anti-PkDBPαII-H antibodies were able to exhibit inhibition activity at a lower concentration than anti-PkDBPαII-S antibodies. (afpm.org.my)

In this review we connect the current understanding of the SARS-CoV-2 replication cycle and host response to the clinical presentation of COVID-19, borrowing concepts from influenza A virus-induced ARDS pathogenesis and discussing how these ideas inform our evolving understanding of COVID-19-induced ARDS. (ersjournals.com)

This tissue is not vascularized, which prevents tumors from growing greater than 2mm in diameter without inducing new blood vessels. (wikipedia.org)
Strikingly, complete regressions of large established tumors depended on the tumor-infiltrating macrophages that were induced by this immunotherapy, because a small-molecule drug inhibitor targeting CSF-1R diminished the number of intratumoral macrophages and abrogated the complete remissions. (aacrjournals.org)

MK2 Regulates Macrophage Chemokine Activity and Recruitment to Promote Colon Tumor Growth. (nih.gov)
i) Hypoxia-induced release of chemoattractants results in enhanced TAM recruitment, which further amplifies the protumoral response. (nutriforce.cn)

This protection was attributed to their immunomodulatory activity. (news-medical.net)

OBJECTIVES: Green tea contains a predominant set of polyphenolic compounds with biological activities. (bvsalud.org)
PkDBPα region II (PkDBPαII) from Peninsular Malaysia and Malaysian Borneo has been shown to occur as distinct haplotypes, and the predominant haplotypes from these geographical areas demonstrated differences in binding activity to human erythrocytes in erythrocyte binding assays. (afpm.org.my)

MK2 drives progression of pancreas and colon cancers by suppressing CD8(+) T cell cytotoxic function and is a potential immunotherapy target. (nih.gov)

The objective was to define the mechanism of the growth inhibition of active hexose correlated compound (AHCC) alone and evaluate its activity in combination with pegylated liposomal doxorubicin (PLD). (researchgate.net)
In addition to providing evidence of the efficacy of AHCC, the mechanism of improved activity was also investigated. (researchgate.net)

Dexamethasone inhibited, in a dose-dependent manner, NO production induced by GM-CSF. (pdffox.com)

The activation of Toll-like receptor 2 (TLR2) initiated Txnip degradation, while no further Txnip degradation was observed in TLR2-deficient bone marrow-derived macrophages. (frontiersin.org)
PCNs induced PAR-1/PAR-3 heterodimerization through EPCR occupation and PAR-1 activation, which resulted in Gα13-RhoA-mediated-Tie2 activation and stabilized vascular tight junctions via the Akt-FoxO3a signaling pathway. (biomedcentral.com)
The electrophoretic mobility shift assay was used to evaluate the activation or inhibition of nuclear factor kappa B (NF-kB).Results : GM-CSF induced iNOS expression and NO production, and activated the transcription factor NF-kB. (pdffox.com)
A rescue study showed that the induction of autophagy and activation of the AMPK/ULK1 signaling pathway by ebastine treatment were reversed by IPMK knockdown, indicating that the activity of ebastine was IPMK dependent. (ijbs.com)

Nephrotoxic serum nephritis was induced as explained previously.18 In brief, mice were pre-immunized subcutaneously with 2 mg/ml rabbit IgG (Jackson ImmunoResearch Laboratories Inc., Western Grove, PA) dissolved in incomplete Freund adjuvant (Sigma, St. Louis, MI), and nonviable desiccated H37a (Difco Laboratories, Detroit, MI). (engineering-gdfsuez.com)

We hypothesize that morphine activates opioid receptors (ORs) on microglia and macrophages and changes their expression and function, fundamentally altering the innate immune response to SCI. (biomedcentral.com)

To overcome this limitation, we developed nanoparticles with antiseptic activity that target tumor vascular abnormalities. (biomedcentral.com)

They are less effective than T-cell-mediated cytotoxic mechanisms. (msdmanuals.com)

The coadministration of cisplatin with PCNs induced a synergistic suppression of tumor growth by improving drug delivery as evidenced by increased blood prefusion and decreased vascular permeability. (biomedcentral.com)

3-MA pretreatment counteracted the cytokine regulation induced by flavopiridol. (researchsquare.com)
Despite the apparent health benefits achieved by leading an active lifestyle, which imply that regular physical activity and frequent exercise enhance immune competency and regulation, the effect of a single bout of exercise on immune function remains a controversial topic. (frontiersin.org)
In contrast to the widely accepted long-term health benefits that are achieved by regular physical activity, which imply that immune competency and regulation are improved by frequent exercise bouts, the effect of a single bout of exercise on immune function remains hotly disputed. (frontiersin.org)

Interleukin 12, also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine originally identified in the medium of activated human B lymphoblastoid cell lines. (rndsystems.com)
low/absent NK-cell-activity, hyperferritinemia, and high-soluble interleukin-2-receptor levels. (scienceopen.com)
M1 macrophages are associated with the expression of interleukin (IL)-1, -12, TNF-α and inducible nitric oxide synthase (iNOS) 7 . (ersjournals.com)

Indeed, we found that a single dose of intrathecal morphine increases the expression of activated microglia and macrophages at the injury site. (biomedcentral.com)

Most patients carry a missing or damaged p53 gene, a tumor suppressor whose activity is impaired in almost 50% of all cancers. (nature.com)

Industrial Relevance: This study presents an example of the successful integration of a well- known herbal supplement, AHCC, with traditional western medicine cytotoxic agent, pegylated liposomal doxorubicin, for the treatment of recurrent ovarian cancer. (researchgate.net)
The present authors have previously shown that the anatomical microlocalisation of macrophages in NSCLC strongly predicts patient survival, regardless of cancer stage 4 . (ersjournals.com)

Detection of compounds and proteins that enhance Rac1 activity. (cytoskeleton.com)
The preliminary screening results have shown that all the thiopurine compounds did not show any cytotoxic effect on both cell lines at low and medium concentrations. (upm.edu.my)

Absorbance assay, crystal violet staining and adherence assay were used to detect the antifungal activity of flavopiridol. (researchsquare.com)

MRP 8/14 is enhanced by interferon-γ and lipopolysaccharide 13 , 14 , a characteristic of M1 macrophages, and also has bacteriostatic properties 15 . (ersjournals.com)

Integrating established knowledge of influenza A virus-induced ARDS pathophysiology, we discuss how shared clinical findings frame influenza as only an approximate model for COVID-19. (ersjournals.com)

Anatomy41

Organisms21

Diseases9

Chemicals and Drugs93

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes35

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Lymphocytes12

Dendritic cells3

Proliferation10

Apoptosis4

Cytotoxicity7

Vitro7

Differentiation8

Phagocytosis3

264.73

Cytokines4

Effector cells2

Phenotype7

Cells24

CONCLUSIONS3

Angiogenesis5

Inflammation3

Prognosis4

Phenotypes1

Antitumor immune1

Secretion1

Immunosuppressive1

Anti-inflammatory3

Protein4

Tumoricidal activity1

Responses1

Inflammatory5

Infiltration1

Infection1

Acute4

Tumour3

Granulocytes1

Effects1

Stromal1

Antibodies1

Pathogenesis1

Tumors2

Recruitment2

Immunomodulatory1

Predominant2

Immunotherapy1

Mechanism2

Dose-dependent manner1

Activation4

Mice1

Receptors1

Nanoparticles1

Mechanisms1

Suppression1

Regulation3

Interleukin3

Increases the expression1

Cancers1

Cancer2

Compounds2

Assay1

Characteristic1

Findings1