ProliferationPathwayXenograftOxidativeInductionCytotoxicityToxicityVitroApoptoticArrestMigrationImmunohistochemistryHepatocellular CarcinomaTumorCaspasesAccumulationInhibitionExtracellularAssayReactiveProteinsAttenuatesPhysiologicalImportant roleCancerModelFoundPotentialIncreasesExpressionGrowthIncludeDevelopmentTypesStudiesTreatmentFeaturesSurfaceYears
Proliferation7
- Exhibiting high consistence in sequence and structure, S100 family members are interchangeable in function and they show a wide spectrum of biological processes, including proliferation, apoptosis, migration, inflammation and differentiation and the like. (cancerindex.org)
- ACNVs were found to possess specific antitumor cell proliferation activity associated with an apoptosis-inducing pathway. (dovepress.com)
- First, we found that GS-002 significantly inhibited cell proliferation and induced cell apoptosis in dose-dependent manners. (hindawi.com)
- ATF-3 induces DNA synthesis and expression of cyclin D1 in hepatocytes [ 21 ] and is involved in serum-induced cell proliferation as a target gene of c-myc [ 10 ]. (hindawi.com)
- TYRO3 or AXL gene knockdown reduced cell proliferation/colony formation. (nature.com)
- To investigate the effects of silibinin on the growth of oral cancer cells, cell proliferation and anchorage-independent colony formation tests were conducted on YD10B and Ca9-22 oral cancer cells. (jcancer.org)
- Silibinin effectively suppressed YD10B and Ca9-22 cell proliferation and colony formation in a dose-dependent manner. (jcancer.org)
Pathway5
- These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. (mdpi.com)
- Although the dosages of Ab cannot decrease the blood sugar in db/db mice, our results indicate that Ab alleviates glucolipotoxicity-induced DN by inhibiting kidney fibrosis-related proteins through the Ras/ERK pathway. (bvsalud.org)
- In breast cancer, ATF-3 enhances cancer cell-initiating features [ 22 ] and is associated with activation of the canonical Wnt/ β -catenin pathway [ 23 ]. (hindawi.com)
- Western blotting revealed that silibinin downregulated SOD1 and SOD2 and triggered the JNK/c-Jun pathway in oral cancer cells. (jcancer.org)
- Silibinin considerably reduced the development of oral cancer cells by inducing apoptosis, G 0 /G 1 arrest, ROS generation, and activation of the JNK/c-Jun pathway. (jcancer.org)
Xenograft1
- In vivo antitumor activity and toxicity were evaluated in Hep G2 cell xenograft model. (dovepress.com)
Oxidative1
- Chih-Ching Chien Ssu-Ching Chen (2021, Aug). Propolis alleviates 4-aminobiphenyl-induced oxidative DNA damage by inhibition of CYP2E1 expression in human liver cells. (ncu.edu.tw)
Induction8
- Annexin-V assay has been used to detect the induction of apoptosis. (phcogj.com)
- An early apoptosis induction in HepG2 cells was observed by annexin V assay, which clearly exhibited significantly increased early and late apoptosis phases both at 24 and 48 h. (phcogj.com)
- A significantly increasing pattern of hypodiploid phases of cells also been observed, which confirm the apoptosis induction again. (phcogj.com)
- The induction of ATF-3 expression was mediated by mitogen-activated protein kinase (MAPK) signaling pathways in GS-002-treated cells. (hindawi.com)
- These results suggest that the induction of apoptosis by the propolis derivative, GS-002, is partially mediated through ER stress and ATF-3-dependent pathways, and GS-002 has the potential for development as an antitumor drug. (hindawi.com)
- In the past decade, induction of apoptosis has become the major strategy to combat cancer. (hindawi.com)
- Therefore, a search for innovative strategies other than induction of apoptosis is urgently needed. (hindawi.com)
- Receptor-interacting protein (RIP) kinases promote the induction of necrotic cell death pathways. (colinsbraincancer.com)
Cytotoxicity2
- Cytotoxicity, antiproliferative and apoptosis-inducing capacity of ACNVs against hepatoma carcinoma cell were assessed. (dovepress.com)
- The cytotoxicity and genotoxicity of single and combined fenthion and terbufos treatments in human liver cells and zebrafish embryos. (ncu.edu.tw)
Toxicity4
- The current study found that ST has the capacity to induce cell toxicity in human liver cells. (phcogj.com)
- Collectively, results presented in this study demonstrated that the ST, which is used as a euphoritic substance of abuse also, has significant level of toxicity in human cells. (phcogj.com)
- 1998. Protection by extracellular glutathione against sulfur mustard induced toxicity in vitro. (cdc.gov)
- 1998. Protection of human upper respiratory tract cell lines against sulphur mustard toxicity by hexamethylenetetramine (HMT). (cdc.gov)
Vitro2
- We applied an in vitro model of HepG2 cells induced by glucolipotoxicity and evaluated the effects of MLE and its major components nCGA, Crp, and CGA. (bvsalud.org)
- In this study, we examined the antitumor effects of GS-002 in human hepatoma Hep3B and HepG2 cells in vitro . (hindawi.com)
Apoptotic2
- Several main apoptotic indicators were found in GS-002-treated cells, such as the cleaved forms of caspase-3, caspase-9, and poly(ADP-ribose) polymerase (PARP). (hindawi.com)
- Up-regulation of Hsp70.1, STRAP, TCTP, Sti1 and PPase, as well as the down-regulation of hnRNP-E1 could be responsible for the apoptotic and G2/M-arresting effects of oridonin observed in this study. (edu.hk)
Arrest6
- The involvement of cell cycle check point arrest has been performed using flow cytometry analysis. (phcogj.com)
- Moreover the ST extract was able to arrest the cell cycle check point at G2/M phase. (phcogj.com)
- GS-002 also induced endoplasmic reticular (ER) stress as evidenced by increases in ER stress-responsive proteins including glucose-regulated protein 78 (GRP78), growth arrest- and DNA damage-inducible gene 153 (GADD153), phosphorylated eukaryotic initiation factor 2 α (eIF2 α ), phosphorylated protein endoplasmic-reticular-resident kinase (PERK), and ATF-3. (hindawi.com)
- Crizotinib and foretinib decreased TYRO3 and AXL phosphorylation, apoptosis, G2/arrest and reduced colony formation. (nature.com)
- Moreover, it induced cell cycle arrest in the G0/G1 phase, apoptosis, and ROS generation in these cells. (jcancer.org)
- Treatment with oridonin at 44 μM for 24 h induced apoptosis and G2/M cell cycle arrest, which were associated with nine differentially expressed proteins identified by proteomic analysis. (edu.hk)
Migration2
- The effects of silibinin on the migration and invasion of oral cancer cells were evaluated using transwell assays. (jcancer.org)
- Furthermore, silibinin inhibited the migration and invasion abilities of YD10B and Ca9-22 cells by regulating the expression of proteins involved in the epithelial-mesenchymal transition. (jcancer.org)
Immunohistochemistry1
- The TAM receptor and ligand expression was evaluated in LMS cell lines and 358 sarcoma samples by either gene expression or immunohistochemistry. (nature.com)
Hepatocellular Carcinoma2
- The minimum inhibitory concentration was 1 mg/ml against multidrug-resistant bacteria, and LC50 was 62.307 μg/ml on the hepatocellular carcinoma cell line. (springeropen.com)
- Hepatocellular carcinoma (HCC) is the most frequent primary malignancy of the liver and accounts for as many as 1 million deaths annually worldwide [ 1 - 4 ]. (hindawi.com)
Tumor1
- ACNVs could be internalized into tumor cells mainly via phagocytosis, but they were quickly cleared once entering the blood. (dovepress.com)
Caspases1
- To conclude, noise-induced OHC apoptosis and necrosis are modulated by caspases and RIP kinases, respectively. (colinsbraincancer.com)
Accumulation3
- In addition, diabetes-induced glomerular hypertrophy, the saccharide accumulation, and formation of collagen fiber were reduced in diabetic mice receiving Ab. (bvsalud.org)
- The results showed that MLE and nCGA reduced liver fat accumulation by inhibiting SREBP-1/FASN, SREBP-2/HMG-CoAR, and activating PPARα/CPT-1. (bvsalud.org)
- Flow cytometry was used to examine apoptosis, cell cycle distribution, and accumulation of reactive oxygen species (ROS). (jcancer.org)
Inhibition1
- The inhibition of cell wall β-glucan synthase leads to changes in the cell wall integrity and further cell damage [ 9 ] [ 10 ] . (encyclopedia.pub)
Extracellular2
- Extracellular vesicles (EVs) are a group of cell-derived membranous structures, which play an important role in intercellular communication and functional transduction. (dovepress.com)
- 1 , 2 In recent years, mammalian cell-derived exosomes (a type of extracellular vesicle) have been widely used in the field of biomedicine, including diagnosis, regulation of disease progression and drug delivery. (dovepress.com)
Assay1
- Cell viability assay showed that oridonin dose-dependently inhibited cell growth with an IC 50 of 41.77 μM. (edu.hk)
Reactive1
- Reactive oxygen species play a vital role in hyperglycemia-induced renal injury. (bvsalud.org)
Proteins2
- S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)
- AuNPs interact with cell wall macromolecules, damaging them and affecting membrane proteins [ 9 ] . (encyclopedia.pub)
Attenuates2
- An herbal formula inhibits STAT3 signalling and attenuates bone erosion in collagen-induced arthritis. (greenmedinfo.com)
- Sound+Nec-1: treatment with Nec-1 via regional delivery attenuates the noise-induced elevation of p-AMPKfluorescence. (colinsbraincancer.com)
Physiological2
- 3 , 4 Similarly, plant cells also secrete exosome-like nanovesicles (ELNVs) that can participate in various physiological processes such as the inheritance of traits and defense response. (dovepress.com)
- 1993. Sulfur mustard inhalation induced respiratory lesions in guinea pigs: Physiological, biochemical and histological study. (cdc.gov)
Important role2
- Activating transcription factor-(ATF-) 3, a stress-inducible transcription factor, is rapidly upregulated under various stress conditions and plays an important role in inducing cancer cell apoptosis. (hindawi.com)
- by inhibiting the production of virulence factors such as exopolysaccharides and metabolic activity such as surface hydrophobicity playing an important role in bacterium-host cell interactions and biofilm architecture in microbes, respectively [ 7 ] . (encyclopedia.pub)
Cancer3
- These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. (mdpi.com)
- Recent research demonstrated that the potential to induce apoptosis through endoplasmic reticular (ER) stresses can be a target for cancer therapy. (hindawi.com)
- These findings shed new insights into the molecular mechanisms underlying the anticancer properties of oridonin in liver cancer cells. (edu.hk)
Model2
- High-fat diet-fed db/db mice were employed as a model for glucolipotoxicity-induced diabetic nephropathy. (bvsalud.org)
- Low concentrations of 4-ABP promote liver carcinogenesis in human liver cells and a zebrafish model. (ncu.edu.tw)
Found1
- The inhibitory capacity of ST in HepG2 and WRL 68 has been found to be 151 ± 2.5 and 305 ± 11.5 μg/ml for 24 h. (phcogj.com)
Potential1
- Although they do not directly affect blood glucose level, MLE and nCGA show significant potential in managing glucolipotoxicity-induced diabetic nephropathy by targeting lipid metabolism and key molecular pathways. (bvsalud.org)
Increases1
- The antimicrobial activity of AgNPs is directly proportional to the surface area of the particles exposed to the interaction, which facilitates the mechanical penetration of the cell membrane and increases the adhesion to the surface of microbial cells better. (springeropen.com)
Expression1
- High expression of TYRO3 and AXL was detected in LMS cell lines. (nature.com)
Growth1
- On the other hand, ATF-3 is rapidly induced in cells treated with growth stimulators such as serum and growth factors [ 20 ]. (hindawi.com)
Include1
- The major risk factors include chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, environmental carcinogens such as aflatoxin B1 (AFB1), alcoholic cirrhosis, and inherited genetic disorder such as hemochromatosis, Wilson's disease, and tyrosinemia. (hindawi.com)
Development1
- Development: For advances in developmental biology and stem cells. (lu.se)
Types1
- However, resistance to apoptosis is considered to be a characteristic of several types of cancers. (hindawi.com)
Studies1
- Previous studies reported that ATF-3 was induced by treating cells with antitumorigenic compounds [ 14 - 18 ] and a phosphoinositide 3-kinase inhibitor [ 19 ]. (hindawi.com)
Treatment3
- Finally, auditory brainstem response practical measurements and morphological evaluation of OHCs demonstrated that ZVAD treatment decreases noise-induced deficits. (colinsbraincancer.com)
- Number 3b, manifestation in sensory locks cells is definitely modulated by Nec-1 treatment. (colinsbraincancer.com)
- Sound+ZVAD: treatment with ZVAD via regional delivery will not alter noise-induced p-AMPKlevels. (colinsbraincancer.com)
Features1
- In addition, a significant point is the belonging of potentially destroyed bacteria to Gram+ or Gram−, according to their cell walls structural features. (encyclopedia.pub)
Surface1
- Although Gram-positive and Gram-negative cell walls are negatively charged with a high-affinity degree to positively charged AuNPs, having a thinner cell wall, Gram-negative bacteria are more simply exposed to AuNPs, while Gram-positive have rigid peptidoglycan layers on their surface, which prevent the AuNPs entry. (encyclopedia.pub)
Years1
- A weblog on the sciences and practices of living healthily very long - perhaps hundreds of years. (anti-agingfirewalls.com)