Induce immune system responses. Medical search. Frequent questions

1990. The effect of mild stress on DMH-induced colorectal cancer. (cdc.gov)
In this review, we will discuss the mechanisms according to which T2D induces cellular senescence and the role of type 2 diabetes-induced cellular senescence in the pathogenesis and progression of colorectal cancer. (frontiersin.org)
MSCs were preconditioned with lipopolysaccharide (LPS) to induce apoptosis in colorectal cancer cells. (bvsalud.org)

Overall, 85% of patients had either a T-cell response or an antibody response against survivin," said Locke. (medicalxpress.com)
Recently, we demonstrated that recombinant Cry1Ac protoxin (pCry1Ac) administered to mice by the intraperitoneal ( ip ) or intragastric ( ig ) route induces systemic and mucosal antibody responses similar to those obtained with cholera toxin (6). (scielo.br)
One of the immunotherapies is an antibody that binds to and blocks an immune checkpoint molecule on T cells called CTLA-4, allowing the T-cells to infiltrate and fight tumor cells. (hopkinsmedicine.org)
Antibody responses targeting the M protein have been shown to favor the conserved C region. (lu.se)
To evaluate the incidence of formation of antibody against adalimumab and the association with serum adalimumab concentrations and clinical response. (bmj.com)
Not surprisingly, blood type A individuals have the least aggressive antibody immune response against the T and probably Tn antigens. (dadamo.com)
So the hypothesis goes that because of the lower level of antibody against T and Tn antigens or stumps, and because of this tendency for the immune system of A's to be a bit confused or disinclined to attack Tn antigens, blood type A is at an immunologic disadvantage in attacking any cell bearing these T and Tn antigenic markers. (dadamo.com)
The adaptive immune system involves two types of responses: antibody-mediated or cell-mediated. (nutrichem.com)
We hypothesized that glucose and/or glutamine significantly alter rates of spontaneous and anti-Fas antibody-induced apoptosis of human neutrophils cultured ex vivo . (portlandpress.com)

The main cells of the immune system are lymphocytes known as B cells and T cells . (khanacademy.org)
Figure 1: CD3/CD46 stimulation induces IL-10 production in human peripheral blood CD4 + T lymphocytes. (nature.com)
Van Parijs, A. & Abbas, A. K. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. (nature.com)
Lymphocytes of the adaptive immune system can eradicate tumor cells. (lu.se)

Here we show that co-engagement of CD3 and the complement regulator CD46 in the presence of IL-2 induces a Tr1-specific cytokine phenotype in human CD4 + T cells. (nature.com)
The cytokine response during chronic stress appears to play a key role in exacerbating the acute CNS infection and the development of subsequent autoimmune responses. (naturalnews.com)
Today, that once-pioneering research in psychoneuroimmunology (PNI) has burgeoned into sophisticated clinical studies that look at, for example, how caregiving can affect the immune system, how stress may delay wound healing and how pretreatment with an antidepressant prevents cytokine-induced depression in therapy for cancer. (psychiatrictimes.com)
We have previously shown that the sialic acid-containing (Sia + ) fraction of intravenous immune globulin (IVIG) influences cell surface marker expression and cytokine/ chemokine secretion during the differentiation and maturation of human dendritic cells (DC). (scirp.org)
Our data indicate that the Sia + fraction of IVIG possesses the ability to influence inflammatory processes in multiple immune cell types and induces novel signatures in cell surface marker expression and cytokine/chemokine production. (scirp.org)
Intubation may be required during an acute respiratory syndrome induced by a cytokine storm cascade . (psychiatrist.com)

Specific immune responses are triggered by antigens . (khanacademy.org)
The immune system responds to antigens by producing cells that directly attack the pathogen, or by producing special proteins called antibodies . (khanacademy.org)
The immune system must distinguish not only between self and non-self, but also between innocuous and pathological foreign antigens to prevent unnecessary or self-destructive immune responses. (nature.com)
In fact, the T and Tn antigens, and blood type A antigens are actually immunologically considered to be quite similar because of their shared terminal sugar (N-acetylgalactosamine), and so might be readily confused by the immune system of blood type A individuals. (dadamo.com)
The surface of each pathogen's cell membrane has a unique structure comprised of antigens , which are large, foreign signalling molecules that are the key to a full and effective immune response. (nutrichem.com)
This induces humoral and cellular immune responses against the encoded antigens. (bvsalud.org)

Strain susceptibility and resistance to 1,2-dimethylhydrazine-induced enteric tumors in germfree rats (40146). (cdc.gov)
None of the treatments are new, but were used by the Johns Hopkins team to demonstrate the value of combining treatments that augment the immune response against glioblastomas, the most common brain tumors in human adults. (hopkinsmedicine.org)
WASHINGTON-(Jan. 16, 2018)-Tumors have come up with ingenious strategies that enable them to evade detection and destruction by the immune system. (medicalxpress.com)
It is clear however, that tumors skew the immune system towards a "tolerogenic" faith, leading to immune-paralysis. (lu.se)

Antigen-specific cellular and humoral responses were assessed in a subset of subjects. (nih.gov)
Esto induce una respuesta inmunitaria, de tipo humoral y celular, contra los antígenos codificados. (bvsalud.org)

Research interests focus on: the study of the interface of the pathogen and host at the level of the host's immune response, the nature of the protective immune response and how the pathogen modulates the host response to ensure its success, the detection, treatment and prevalence of parasites of veterinary importance (including those of zoonotic concern), and the disinfection of wastewater and sewage. (cornell.edu)
Several lines of evidence suggest that dynamic interactions between the host's enteric microbiota and innate immune system modulate the intestinal response to radiation. (uclahealth.org)
HPV infection may induce changes to the immune system and limit the host's immune response. (techscience.com)

These hormones typically terminate an inflammatory response following infection or injury. (naturalnews.com)
Damaged mitochondria trigger an immune response much like an infection. (holtorfmed.com)
This study is focused on finding a way to re-educate the body's immune system to better fight HIV infection," says co-senior study author David Margolis of the University of North Carolina (UNC) at Chapel Hill. (sciencedaily.com)
However, the existing HIV-specific immune response in ART-treated individuals is insufficient to clear persistent infection, even in the presence of latency-reversal agents that induce HIV expression. (sciencedaily.com)
Infection of other cell types possessing ACE2 receptors has been described including the epithelial cells of the lung, intestine, kidney, heart, and blood vessels inducing cardiotropic damage [ 4 , 5 ]. (springer.com)
Once SARS-CoV-2 enters the body it can elicit a hyper inflammatory response characterized by high levels of interleukin-6 (IL-6), interleukin-1 (IL-1), tumor necrosis factor-alpha (TNFα) that can damage the myocardium or through direct infection of cardiomyocytes which can damage the heart. (springer.com)
This form of classical inflammation is typically a short-term response to infection and injury, aimed at removing the infective stimulus and allowing repair of the damaged tissue, ultimately resulting in healing and a return to homeostasis. (cdc.gov)
The American Society of Hematology defines it as an isolated thrombocytopenia with clinically no apparent associated conditions or no other cause of thrombocytopenia, such as HIV infection, systemic lupus erythematosus, lymphoproliferative disorders, myelodysplasia, agammaglobulinaemia or hypogammaglobulinaemia, drug-induced thrombocytopenia, alloimmune thrombocytopenia or congenital/hereditary non-immune thrombocytopenia [7]. (who.int)
The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. (bvsalud.org)
Interferons control the activity of genes that help block the viruses from replicating themselves and stimulate the activity of certain immune system cells to fight infection. (medlineplus.gov)

Dendritic cell vaccines have the potential to harness the patients ' own immune system to get them into remission and potentially keep the cancer from coming back. (medicalxpress.com)
ASCT is typically preceded by induction therapy with chemotherapy to kill as many cancer cells as possible and induce a remission. (medicalxpress.com)
Therefore, we hypothesized that by targeting this protein, we could induce an immune response in patients who have the most aggressive disease and potentially keep them in remission for a longer period of time. (medicalxpress.com)
PHILADELPHIA, PENNSYLVANIA, October 9, 2018 - The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new data showing treatment with a single intravenous (IV) dose of STELARA ® (ustekinumab) induces clinical remission and response in adults with moderate to severe ulcerative colitis (UC) who previously experienced an inadequate response or were intolerant to conventional or biologic therapies. (jnj.com)
Results from the induction phase of the Phase 3 UNIFI study show that treatment with a single IV dose of STELARA induced clinical remission in a significantly greater proportion of UC patients at week 8, compared with placebo, at both doses studied. (jnj.com)
Ulcerative colitis is a complex immune disease, and more than half of UC patients have not experienced remission with currently available conventional or biologic treatment options," said lead investigator Bruce E. Sands, MD, Dr. Burrill B. Crohn Professor of Medicine and Chief of the Dr. Henry D. Janowitz Division of Gastroenterology at the Icahn School of Medicine at Mount Sinai. (jnj.com)
The significant rates of remission observed through the 8-week induction, coupled with a safety profile that is well-documented through years of research and use in other immune diseases, demonstrate the potential for ustekinumab as an effective treatment for UC. (jnj.com)
At week 8, patients (n=961) were evaluated for clinical remission, endoscopic healing, clinical response, change from baseline in the IBDQ score, and mucosal healing (an endpoint that includes both endoscopic healing and histologic healing). (jnj.com)
The goals of pharmacotherapy for prostate cancer are to induce remission, reduce morbidity, and prevent complications. (medscape.com)

They take up foreign proteins, break them down, and present the fragments (peptides) to other immune cells to stimulate an immune response, Locke explained. (medicalxpress.com)
The data obtained in the present study confirm that the Cry1Ac protoxin is a potent immunogen able to induce a specific immune response in the mucosal tissue, which has not been observed in response to most other proteins. (scielo.br)
In previous reports, Prasad and Shethna (4,5) suggested that these proteins have antitumoral activity against Yoshida ascites sarcoma in rats (4) and enhance the immune response to sheep red blood cells (5). (scielo.br)
The researchers speculate that when radiation destroys tumor cells, the dead tumor cells may release proteins that help train immune cells to recognize and attack the cancer, said Michael Lim , M.D., an associate professor of neurosurgery, oncology at the Johns Hopkins University School of Medicine and member of Johns Hopkins' Institute of NanoBiotechnology. (hopkinsmedicine.org)
Here, we show that human Abs can induce increased Fn-binding affinity in M proteins, likely by enhancing the weak A-B domain binding. (lu.se)
The human immune system is a remarkable network of organs, glands, defense cells, proteins and chemicals that work in concert to protect and heal your body when it is exposed to a pathogen (bacteria, viruses, fungi) or a toxin (heavy metals and pesticides). (nutrichem.com)
There was also no decrease in the size of the latent reservoir, most likely because of the absence of therapies such as latency-reversal agents, which are designed to perturb the reservoir and induce recognizable expression of HIV proteins that trigger immune responses. (sciencedaily.com)
Filament formation stimulates signals that turn on the production of immune system proteins called interferons. (medlineplus.gov)

When pathogens are able to bypass innate immune defenses, the adaptive immune system is activated. (khanacademy.org)
After an encounter with a new pathogen, the adaptive immune system often 'remembers' the pathogen, allowing for a faster response if the pathogen ever attacks again. (khanacademy.org)
The results of the current study indicate that Tr14 seems to limit exercise-induced muscle damage most likely via attenuation of both innate and adaptive immune responses. (hindawi.com)
An acute bout of physical exercise depending on duration and intensity is known to induce changes of the immune response of both the innate and the adaptive immune system. (hindawi.com)
This shows that the innate immune system upregulates, but the adaptive response lowers when the body is exposed to chronic stress. (naturalnews.com)
It is divided into two parts: the innate and adaptive immune system. (nutrichem.com)
There are two main parts of the immune system: innate (nonspecific) immunity and adaptive (specific) immunity. (nutrichem.com)

Chronic stress creates chronic inflammation which damages cellular receptors for the same stress hormones that would turn off the inflammatory response. (naturalnews.com)
The skin's microbiome can induce inflammation, further aggravating acne, especially in cases of P. acnes overgrowth. (skininc.com)
This loss of diversity can activate the skin microbiome's immune system, resulting in inflammation and excess sebum production. (skininc.com)
In general, this induces inflammation that if left untreated can further damage mitochondria. (holtorfmed.com)
And the immune system is what is actually causing the chronic inflammation that's present in the intestine that we prescribe medications to treat. (mayoclinic.org)
2 The book explains that there is one unique feature that distinguishes autistic children from other children-chronic brain inflammation and immune activation. (coconutresearchcenter.org)
Frequent exposure to harmful agents can keep the brain's immune system continually activated, stoking the flames of inflammation and promoting tissue damage. (coconutresearchcenter.org)
Medical investigators at Johns Hopkins University were among the first to identify chronic inflammation and immune over-activation in autistic children. (coconutresearchcenter.org)
In each case, they found extensive immune activation and widespread elevated inflammation. (coconutresearchcenter.org)
Interferons also help regulate inflammation, which is another part of the body's innate immune response. (medlineplus.gov)
As a result of these changes, interferon production is abnormally turned on, leading to excessive immune system activity and inflammation. (medlineplus.gov)
As in Aicardi-Goutières syndrome, the IFIH1 gene mutations involved in Singleton-Merten syndrome are described as "gain-of-function" and lead to excessive immune system activity and inflammation, disrupting calcium handling in the body. (medlineplus.gov)

A dendritic cell vaccine administered before and after autologous stem cell transplant (ASCT) was safe and immunogenic and was associated with durable clinical responses in patients with high-risk multiple myeloma, according to research published in Clinical Cancer Research . (medicalxpress.com)
Sia + IgG induced increased expression of CD80 and dendritic cell immunoreceptor (DCIR) on monocytes, whereas the expression of HLA-DR was decreased. (scirp.org)

To produce the vaccine, the researchers engineered the patients' own dendritic cells to express survivin and induce an immune response against the protein. (medicalxpress.com)
To increase the number of survivin peptides presented to the immune system, and therefore the likelihood of triggering a survivin-specific response, Locke and team engineered the dendritic cells to express a version of the entire protein, with a mutation to increase safety without compromising immunogenicity. (medicalxpress.com)
B1 receptors are G-protein coupled receptors that are induced by injured tissue. (wikipedia.org)
The present paper describes important features of the immune response induced by the Cry1Ac protein from Bacillus thuringiensis in mice. (scielo.br)
GAS' M protein constitutes a primary target of the immune system due to its spatial configuration and dominance on the bacterial surface. (lu.se)
A critical protein, interleukin-1, which signals other immune cells, was found to be more than 60% lower during exam week than during the students summer break. (naturalnews.com)
Approaches using pharmacological HIV-latency-reversal agents to induce latent virus to express viral protein could make this reservoir vulnerable to T cells. (sciencedaily.com)
The IFIH1 gene provides instructions for making the MDA5 protein, which plays an important role in innate immunity, the body's early, nonspecific response to foreign invaders (pathogens) such as viruses and bacteria. (medlineplus.gov)
Alternatively, filaments containing the altered protein may not be broken down when immune signaling is no longer needed. (medlineplus.gov)

Inflammatory response. (khanacademy.org)
An inflammatory response begins when a pathogen stimulates an increase in blood flow to the infected area. (khanacademy.org)
The area often becomes red, swollen, and painful during an inflammatory response. (khanacademy.org)
Eccentric exercise like downhill running is a special exercise mode which is known to cause substantial muscle damage followed by a pronounced inflammatory response. (hindawi.com)
The heart can become damaged in COVID-19 by three distinct mechanisms: (i) the acute hyper-inflammatory response increases blood coagulability, which can cause blood clots that obstruct arteries and indirectly affect the heart. (springer.com)
Once they have performed their function, neutrophils die by apoptosis, which is important for the effective resolution of the inflammatory response. (portlandpress.com)

Once the immune system recognizes a pathogen as 'non-self,' it uses cellular and chemical defenses to attack it. (khanacademy.org)
In the setting of cancer, instead of eliciting effector pathways that would lead to tumor elimination, these antibodies might promote down-regulation of the cellular inflammatory responses to the tumor. (scirp.org)
Because age-related cellular senescence and type 2 diabetes (T2D) have been recognised as risk factors for CRC development, the recent finding that type 2 diabetic patients present an elevated circulating volume of senescent cells raises the question whether type 2 diabetes facilitates the process of CRC tumorigenesis by inducing premature cell senescence. (frontiersin.org)
Senescence is a stress-response cellular state characterised by proliferative arrest but active metabolism ( 7 ). (frontiersin.org)
Age-related and metabolic diseases such as type 2 diabetes (T2D) represent a source of cellular stress due to their disruptive effect on normal physiological processes and, therefore, can induce premature senescence ( 10 ). (frontiersin.org)
One safe avenue for harnessing T cell responses to fight HIV is adoptive cellular therapy. (sciencedaily.com)

Group A streptococcus (GAS) is a highly adapted, human-specific pathogen that is known to manipulate the immune system through various mechanisms. (lu.se)
Therefore, the present study identifies uncertainties of mixture effect predictions for complex biological systems calling for studies targeting the underlying processes and mechanisms. (ufz.de)
little attention has been devoted to the mechanisms and other immune cells. (hindawi.com)
To study the mechanisms behind how the innate immune system in late stage cancer patients is suppressed, with consequences and how to restore it. (lu.se)
All these mechanisms are mediated by innate immune cells. (lu.se)
Understanding the immune suppression in breast cancer patients may lead to insights into treatment responses, resistance mechanisms and novel treatment modalities aimed to hinder this phenomenon which would eventually encumber the devastating progression of breast cancer metastasis. (lu.se)

To minimize the potential morbidity and mortality from drug-induced respiratory diseases, healthcare providers should be familiar with the possible adverse effects of the medications they prescribe. (medscape.com)
Drug-induced pulmonary toxicity is a diagnosis of exclusion. (medscape.com)
Radiologic patterns observed in drug-induced pulmonary toxicity are highly variable and depend on the type of adverse reaction the patient is experiencing. (medscape.com)
Most drug-induced pulmonary toxicities involve the parenchyma, thus, interstitial infiltrates may be demonstrated on radiographs. (medscape.com)
If the drug-induced pulmonary toxicity causes airway obstruction, then the FEV 1 /FVC ratio and FEV 1 will be reduced. (medscape.com)
In general, bronchoscopy with transbronchial biopsy is not helpful in establishing the diagnosis of drug-induced pulmonary toxicity. (medscape.com)
Bronchoalveolar lavage (BAL) can contribute to the expected clinicopathologic pattern of a given drug-induced lung disease such as identifying eosinophils in a drug-induced eosinophilic pneumonia. (medscape.com)

Changes of leukocytes are regularly accompanied by an exercise-induced increase of inflammatory cytokines such as IL-6, IL-10, and IL-1ra [ 1 ]. (hindawi.com)
Exercise-induced allergic reactions occur during or after exercise. (msdmanuals.com)
Exercise-induced asthma is more likely to occur when the air is cold and dry. (msdmanuals.com)
The diagnosis of exercise-induced allergic reactions is based on the symptoms and their relationship to exercise. (msdmanuals.com)
For people with exercise-induced asthma, the goal of treatment is to be able to exercise without symptoms. (msdmanuals.com)
People who have had an exercise-induced anaphylactic reaction should avoid the form of exercise that triggered the attack. (msdmanuals.com)

Cry1Ac toxin administration induced a strong immune response in serum but in the small intestinal fluids only anti-Cry1Ac IgA antibodies were detected. (scielo.br)
The first dose primes the immune system while the second dose induces a vigorous immune response and production of antibodies. (motherjones.com)
The bottom line is that you want your immune system to produce a robust enough level of antibodies that if you're exposed to a virus, your body can effectively fight it. (motherjones.com)
One explanation for non-response is that patients develop anti-adalimumab antibodies. (bmj.com)
In a cohort of 121 consecutive patients with RA treated with adalimumab, serum adalimumab concentrations and antibodies against adalimumab were measured together with clinical response variables before and up to 28 weeks after the start of treatment. (bmj.com)
Serum antibodies against adalimumab are associated with lower serum adalimumab concentrations and non-response to adalimumab treatment. (bmj.com)
However, recent data on Crohn's disease indicate that these anti-infliximab antibodies are associated with allergic reactions and a shorter duration of response. (bmj.com)
2 In RA, the development of antibodies against infliximab is associated with a reduced response to infliximab after treatment for an extended period of time. (bmj.com)
Everyone has preexisting anti-T and anti-Tn antibodies, or a built in immune system response against cells with these markers. (dadamo.com)
These anti T and TN-antibodies are primarily induced by intestinal flora. (dadamo.com)

In turn, the immune system is known to influence nervous system function by cytokines and other peptides secreted by immune cells. (psychiatrictimes.com)
In macrophage-colony stimulating factor (MCSF) generated macrophages, Sia + IgG induced increased production of numerous cytokines/ chemokines including IL-6, TNFα, CXCL1, and IL-10, and the expression of the macrophage surface marker CD163. (scirp.org)
D. Bruder, E. , O. Richards, J. , M. Michel, K. and Oaks, M. (2016) Differential Effects of Alternative Glycoforms of IgG on Human Monocytes and Macrophages: Sialylated IgG Induces Novel Expression Signatures of Cell Surface Markers, Cytokines, and Chemokines. (scirp.org)

Increased body temperature may slow or stop pathogens from growing and helps speed up the immune response. (khanacademy.org)
There was also an increase of Proteobacteria and Firmicutes, harmful opportunis.c pathogens that trigger immune responses. (skininc.com)
The human immune system works to not only heal your body when it is exposed to a pathogen, but also protect it from pathogens you have already been exposed to. (nutrichem.com)

The combination treatment consists of highly focused radiation therapy targeted specifically to the tumor and strategies that lift the brakes and activate the body's immune system, allowing anti-cancer drugs to attack the tumor. (hopkinsmedicine.org)
The combination treatment described in the July 11 issue of PLOS One consists of highly focused radiation therapy targeted specifically to the tumor and strategies that lift the brakes and activate the body's immune system, allowing anti-cancer drugs to attack the tumor. (hopkinsmedicine.org)
Singleton-Merten syndrome and Aicardi-Goutières syndrome both have autoimmune features, which occur when the immune system malfunctions and damages the body's own tissues and organs. (medlineplus.gov)

Since in classic chemotherapies it is observed a decrease in immune response, methotrexate (MTX) was used only to compare the PnV effects on innate immune cells with a highly immunosuppressive antineoplastic drug. (nature.com)

In this state the immune response is suppressed by the tumor and even induces a wound healing processes stimulating tumor progression. (lu.se)

A CD4 + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. (nature.com)
Antigen-specific immune responses were observed in 78.8 % of monitored subjects and their presence correlated with OS (P = 0.003). (nih.gov)
These data indicate antigen-specific immune activation as a mechanism by which sipuleucel-T prolongs OS. (nih.gov)

However, bacteria that are present in the respiratory tract of most pigs may interfere with the induction of a protective immune response by LAIV vaccination since it is delivered into the nose. (usda.gov)
Or, the bacteria may interfere with the ability of the immune system to provide protection that was induced by the vaccine. (usda.gov)
The bacteria Bordetella bronchiseptica has been shown to alter immune responses in the pig, therefore, we completed a study to determine if B. bronchiseptica interfered with LAIV vaccination or the protection vaccination provides to pigs against IAV challenge. (usda.gov)
Severe pneumococcal infections result from dissemination of bacteria to the bloodstream and the central nervous system. (cdc.gov)
Whenever the brain is exposed to potentially harmful substances, such as bacteria or toxins, its immune system is kicked into heightened state activity. (coconutresearchcenter.org)

Dendritic cells are an essential component of the immune system. (medicalxpress.com)
NK cells, among other cells, are key effector cells of the innate immune system and play a crucial role in the antiviral response. (cdc.gov)
Cells that belong in the body carry specific markers that identify them as 'self' and tell the immune system not to attack them. (khanacademy.org)
In these instances, the immune system uses cell-mediated immunity to destroy infected body cells. (khanacademy.org)
1991. Control of 1,2-dimethylhydrazine-induced crypt hyperplasia by naturalkiller cells and its relevance to carcinogenics. (cdc.gov)
When brain tumor cells were re-introduced under the skin of the animals, their immune systems appeared to protect them against the development of a new brain tumor. (hopkinsmedicine.org)
Drake said since the immune system usually doesn't generate a memory when foreign (tumor) cells are still present in the body. (hopkinsmedicine.org)
The major form of communication is chemical messengers, whether they are secreted by nerve cells, endocrine organs or immune cells,' Dunn said. (psychiatrictimes.com)
In fact, several studies have shown that T2D induces senescence in multiple types of cells, including fibroblasts and endothelial cells ( 11 , 12 ). (frontiersin.org)
Using 304 relevant samples from TCGA, we assessed immune cell function in CESC patients to better understand the status of both tumor micro-environment cells and immune cells in CESC. (techscience.com)
We further focused on CCL5 as a hub gene in CESC, as it had significant correlations with increased numbers of several types of immune cells. (techscience.com)
The latter involves an array of cell-to-cell communication between immune cells and direct or indirect death of infected cells. (nutrichem.com)
We found that this approach of re-educating the immune cells and reinfusing them was safe, which was the primary goal of the study. (sciencedaily.com)
This procedure involves collecting T cells from a patient, growing them in the laboratory to increase their numbers, and then giving them back to the patient to help the immune system fight disease. (sciencedaily.com)
Activated T-cells are one of the immune cells involved in the antiviral response. (springer.com)
Neutrophils are phagocytic cells of the innate immune system that use a combination of reactive oxygen species and anti-microbial toxins to kill and destroy ingested micro-organisms. (portlandpress.com)
For this they need to be activated by cells of the innate immune system. (lu.se)

Furthermore, the vaccine induced survivin-specific immune responses. (medicalxpress.com)
Our study showed that we can target survivin with a vaccine-based approach and induce immune responses, and it suggested that this strategy could ultimately help improve patient outcomes," added Locke. (medicalxpress.com)
Our results show that B. bronchiseptica does not interfere with the induction of the immune response to the LAIV vaccine, but our results indicate that the Bordetella in the lung may make it difficult for the immune system to provide protection. (usda.gov)
Outbreak response as an essential component of vaccine development. (cdc.gov)

Before we can combine this approach with treatments meant to bring HIV out from hiding so the improved immune response can clear it from the body, we need to first establish that this immunotherapy approach is safe on its own," says co-senior study author Catherine Bollard of the Children's National Health System. (sciencedaily.com)

Overview of Allergic Reactions Allergic reactions (hypersensitivity reactions) are inappropriate responses of the immune system to a normally harmless substance. (msdmanuals.com)

1988. Species-specific response to the rodent carcinogens 1,2-dimethylhydrazine and 1,2-dibromo-3-chloropropane in rodent bone-marrow micronucleus assays. (cdc.gov)
Re-evaluation of 1,2-dimethylhydrazine in the mouse bone marrow micronucleus assay: Observation of a positive response. (cdc.gov)

The human body has a series of nonspecific defenses that make up the innate immune system . (khanacademy.org)

At least four genetic changes in the IFIH1 gene have been found to cause MDA5 deficiency, an immune system disorder (immunodeficiency) that leads to recurrent, severe viral infections in the lungs and airways (respiratory tract). (medlineplus.gov)

These physiological responses were probably driven by CIP-induced alterations in the gut microbiome or immune system of gammarids. (ufz.de)

A large study done by Texas A&M University demonstrated this relationship between chronic stress and immune dysfunction. (naturalnews.com)
People exposed to chronic social conflict experience high levels of stress and consequent dysregulation of the immune system , thereby increasing vulnerability to infectious and autoimmune disease," said lead author Mary Meagher. (naturalnews.com)
Chronic stress induced GCR is associated with higher levels of neutrophils and lower levels of leukocytes. (naturalnews.com)
This vicious cycle continually worsens mitochondrial and immune system function, which promotes the occurrence of chronic conditions and severe disease. (holtorfmed.com)
However, it takes a high percentage of heavily damaged mitochondria to induce chronic disease. (holtorfmed.com)

The venom was effective at impairing tumor development in murine xenogeneic model, activating the innate immune response and increasing tumor infiltrating macrophages. (nature.com)

A lack of the important early immune response stimulated by interferons leads to severe viral infections in infants with MDA5 deficiency. (medlineplus.gov)

Seizures may occur, and the autonomic nervous system may also be affected. (cdc.gov)

Tetanospasmin, also referred to as tetanus toxin, acts at several sites within the central nervous system, including peripheral motor end plates, the spinal cord, and the brain, and in the sympathetic nervous system. (cdc.gov)

Although waterborne toxicity and diet-related effects (i.e., dietary exposure and microorganism-mediated alterations in food quality for shredders) of fungicides and antibiotics on decomposer-detritivore systems have been increasingly documented, their joint effect is unknown. (ufz.de)
Moreover, the selective feeding of gammarids during the food choice assay indicated alterations in food quality induced by the antimicrobial mixture. (ufz.de)

When a pathogen has invaded, the immune system may also release chemicals that increase body temperature, producing a fever . (khanacademy.org)

The present double-blind, randomized, placebo-controlled clinical trial intended to test whether ingestion of a natural combination medicine (Tr14 tablets) affects serum muscle damage and inflammatory immune response after downhill running. (hindawi.com)

Our findings identify an endogenous receptor-mediated event that drives Tr1 differentiation and suggest that the complement system has a previously unappreciated role in T-cell-mediated immunity and tolerance. (nature.com)

Metabolic reprogramming between resistance and tolerance occurs within the immune system in response to sepsis. (metabolon.com)

In: Chemically induced cell proliferation: Implications for risk assessment. (cdc.gov)
Cell-type fractions of M1 macrophages were significantly higher in the high-immune-scores group, which was associated with better overall survival. (techscience.com)
So, in a very simplistic way, a cancer cell clearly looks like a different yard when observed by an outside observed (your immune system in this case). (dadamo.com)

In addition, Maca polysaccharides have good immune-regulatory activity on macrophages by regulating the polarization and increasing the phagocytosis [ 16 ]. (hindawi.com)

Allergic hypersensitivity can be defined as an inappropriate im- response by a chemical allergen. (cdc.gov)

How Does The Human Immune System Work? (nutrichem.com)

Sipuleucel-T broadly engages the immune system by activating APCs ex vivo and inducing long-lived immune responses in vivo. (nih.gov)

We're trying to find that optimal balance between pushing and pulling the immune system to kill cancer," said Charles Drake, M.D., Ph.D., an associate professor of oncology, immunology and urology, and medical oncologist at the Johns Hopkins Kimmel Cancer Center. (hopkinsmedicine.org)
Both systems are influenced by a series of factors that need to be taken into consideration when discussing optimal immune function. (nutrichem.com)
Both parts of the immune system are equally important and work together when fighting off an outside invader like a virus, but they are both influenced by a variety of lifestyle factors that many do not take into consideration when they think about optimal immune function. (nutrichem.com)

The absorption of tricresyl phosphates caused peripheral nervous system damage, leading to neuromuscular problems (Hewstone 1994a). (cdc.gov)

Concomitantly they induce local expression of adhesive molecules. (wikipedia.org)

Anatomy46

Organisms11

Diseases17

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Psychiatry and Psychology3

Phenomena and Processes68

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science5

Health Care2

Colorectal cancer3

Antibody9

Lymphocytes4

Cytokine6

Antigens6

Tumors4

Humoral2

Host's3

Infection10

Remission9

Proteins8

Adaptive7

Inflammation12

Dendritic cell2

Protein9

Inflammatory response6

Cellular6

Mechanisms6

Drug-induced7

Exercise-induced6

Antibodies10

Cytokines3

Pathogens3

Body's3

Innate immune cells1

Processes1

Antigen-specific3

Bacteria5

Cells17

Vaccine4

Children's National Health System1

Allergic reactions1

Bone marrow2

Nonspecific1

Respiratory1

Physiological1

Chronic5

Xenogeneic1

Viral1

Occur1

Toxin1

Alterations2

Pathogen1

Serum1

Immunity1

Tolerance1

Cell3

Macrophages1

Hypersensitivity1

Human1

Vivo1

Optimal3

Peripheral1

Molecules1