Induce full tissue regeneration. Medical search. Frequent questions

Human induced pluripotent stem cells (hiPSCs) can form any tissue found in the body, making them attractive for regenerative medicine applications. (biomedcentral.com)
Pluripotent stem cells can differentiate into any cell type found in an organism, making them a valuable tool for tissue engineering [ 1 - 3 ]. (biomedcentral.com)
These cells were termed induced pluripotent stem cells (iPSCs). (biomedcentral.com)
Therefore, mMSCs were reprogrammed into induced pluripotent stem cells (iPSCs) by non-integrative chromosomal technologies and differentiated into corresponding iP-MSCs. (uni-muenchen.de)
MSCs have limited pluripotency and capacity for cell differentiation compared to embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). (biomedcentral.com)
Our lab has focused on harvesting the full potential of patient specific induced pluripotent stem cells (iPSCs) to use to attempt to regenerate the damaged tissue. (ca.gov)
The human induced pluripotent stem cells provide a great platform to study and treatment of human diseases because these can differentiate into many functional and specialized adult cells of body. (fortunepublish.com)
Thus, induced pluripotent stem cells represent a promising combination of adult and embryonic stem cell characteristics. (prnewswire.com)
Induced pluripotent stem cells represent one of the most promising research advances within the past decade, making this a valuable report for both executives and investors to use to optimally position themselves to sell iPSC products. (prnewswire.com)
A distinctive feature of this report is an end-user survey of 273 researchers (131 U.S. / 143 International) that identify as having induced pluripotent stem cells as a research focus. (prnewswire.com)

However, when employing MSC transplantation to treat tissue defects, the research found that: less than one percent of MSCs could home and colonize in the tissue defect area, continuously promoting tissue regeneration, and the paracrine mechanism of MSCs plays a more important role than the replacement of damaged cells by differentiation [ 13 ]. (biomedcentral.com)
Seeding hiPSC aggregates into biomaterial scaffolds can control their differentiation into specific tissue types. (biomedcentral.com)
Controlling the differentiation of human iPSCs into functional tissues remains difficult because complicated cell signaling networks regulate this process [ 5 - 9 ]. (biomedcentral.com)
In addition to stiffness, porosity affects stem cell differentiation and proliferation because contact induces these processes, but excessive contact inhibits aggregate growth. (biomedcentral.com)
Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)
Mesenchymal stem cells (MSCs) exhibit a promising therapeutic potential in the field of cell-based tissue engineering and regenerative medicine due to their immunomodulatory properties and differentiation capacity. (uni-muenchen.de)
Previously, we have shown that maintaining WJMSCs seeded onto DWJM in osteogenic media induces ectodermal differentiation evident by generating CK 19 positive cells. (ku.edu)
Human mesenchymal stem cells (MSCs) are therapeutic for clinical applications because of their excellent immunomodulatory and multiple lineage differentiation abilities at tissue injury sites. (biomedcentral.com)
Moreover, disrupted F-actin dynamics inhibited osteogenic differentiation, proliferation, YAP nuclear translocation, and YAP activation in mechanically induced PDLSCs. (biomedcentral.com)
Introduction: Connective tissue growth factor (CTGF)/CCN2 is a unique growth factor that stimulates the proliferation and differentiation, but not hypertrophy, of articular chondrocytes in vitro. (elsevierpure.com)
The principal aim of this thesis was to investigate the ability of surface topography in inducing bone cell differentiation for biomedical purposes. (gla.ac.uk)
dimethyl labelling, implicated the possibility of sub-population differentiation, i.e. the formation of multiple cell types that could be advantageous in tissue engineering of complex organs. (gla.ac.uk)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)

The present study results indicated that compared with the same number of 2D-cultured cells, microtissue could secrete more nerve regeneration related cytokines to promote SCs proliferation and axons growth. (biomedcentral.com)
WJMSCs are easily accessible non-controversial source of MSCs with self-renewal ability and extended proliferation potential, making them excellent candidates for tissue engineering. (ku.edu)
Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture. (springer.com)

Challenges in organ transplantation such as high organ demand and biocompatibility issues have led scientists in the field of tissue engineering and regenerative medicine to work on the use of scaffolds as an alternative to transplantation. (mdpi.com)
The development of tissue engineering and regenerative medicine has a history of more than three decades. (biomedcentral.com)
It covers a range of topics such as regenerative medicine, stem cell therapy, tissue engineering, wound healing, and tissue repair. (oap-journals.info)

An alcohol-induced increase of tumor necrosis factor (TNF) α, a pro-inflammatory cytokine, in the mouse brain is closely linked to neurodegeneration[ 4 ]. (wjgnet.com)
They tend to dampen inflammation and promote tissue remodeling and tumor progression, for example through pro-angiogenic properties [ 4 ], immunosuppression (e.g. (biorxiv.org)
These findings confirm that the proteins in a urine-based diagnostic signature are aberrantly expressed in bladder tumor tissues, and support the potential additional utility of selected biomarkers for the clinicopathological evaluation of excised tissue or biopsy material. (biomedcentral.com)
In this study, we investigated the expression pattern of the urine-based signature proteins in solid bladder tumor tissue as a means to further substantiate our previously validated urine-based signature for the detection of BCa. (biomedcentral.com)
Digital immunohistochemistry confirmed the aberrant expression of nine of the ten the biomarkers in bladder tumor tissues and revealed that selected proteins in the set had associations with stage and grade and clinical outcome. (biomedcentral.com)
2011. Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. . (ucsf.edu)

In periodontitis, EVs play a pivotal role in regulating the biological functions of both periodontal tissue cells and immune cells, as well as the local microenvironment, thereby promoting periodontal injury repair and tissue regeneration. (biomedcentral.com)
Herein, we gave a brief introduction to MSC-EVs and focused on their mechanisms and clinical application in periodontal regeneration. (biomedcentral.com)
Periodontitis is a dental plaque-caused chronic inflammatory disease invading periodontal tissue. (biomedcentral.com)
By performing local transplants, other non-periodontal-derived MSCs such as dental pulp stem cells (DPSCs), bone marrow stem cells (BMSCs), and adipose tissue-derived stem cells (ADSCs) also aid in the regeneration of periodontal tissue [ 12 ]. (biomedcentral.com)
Guided tissue regeneration, periodontal. (bvsalud.org)

Regeneration in humans is the regrowth of lost tissues or organs in response to injury. (wikipedia.org)
Some tissues such as skin, the vas deferens, and large organs including the liver can regrow quite readily, while others have been thought to have little or no capacity for regeneration following an injury. (wikipedia.org)
Numerous tissues and organs have been induced to regenerate. (wikipedia.org)
Other organs and body parts that have been procured to regenerate include: penis, fats, vagina, brain tissue, thymus, and a scaled down human heart. (wikipedia.org)
One goal of scientists is to induce full regeneration in more human organs. (wikipedia.org)
Some human organs and tissues regenerate rather than simply scar, as a result of injury. (wikipedia.org)
Advances in research have enabled the induced regeneration of many more tissues and organs than previously thought possible. (wikipedia.org)
The immune system is constituted by a very complex network of cells, tissues, and organs that through soluble factors and direct cell-to-cell contacts interact among themselves and with cells belonging to other (organ) systems. (frontiersin.org)
She develops experiments and techniques to understand the physics that allow biological systems to build nano-scale molecules into cells, organs, tissues, and organisms. (libsyn.com)
This pathological end stage of tissue repair is characterised by excess extracellular matrix (ECM) deposition due to increased production and/or an imbalance in turnover often resulting in functional damage in tissues and organs [ 3 , 4 ]. (biomedcentral.com)
Thus, a comprehensive understanding of how organs develop in the embryo is necessary to effectively interrogate maladaptive processes and understand regeneration. (nih.gov)

We believe that these iPSCs can be potentially used in the future to generate sufficient number of cells to be implanted in the damaged heart to regenerate the lost tissue post heart attack. (ca.gov)

Introduction: Many aspects of skeletal muscle regeneration are now considered to be controlled by the innate immune system, specifically macrophages, but the mechanisms for activation and modulation of the innate immune system during injury are not well understood. (cdc.gov)
At the other extreme, M2-like macrophages are induced by the interleukins (IL)-4 and −13, cytokines secreted by activated Th2 cells [ 16 ]. (biorxiv.org)

and stem cell regeneration. (lu.se)

Conclusions: Both receptor types may be potential targets for stimulation of skeletal muscle tissue regeneration and functional restoration after injury. (cdc.gov)
Tissue engineering combines biomaterials and cells, creating functional structures that can replace damaged regions of tissue [ 1 , 2 ]. (biomedcentral.com)
To develop functional genetic tools to study Anopheles gambiae oenocytes, we have trapped an oenocyte enhancer to create a transgenic mosquito Gal4 driver line that mediates tissue-specific expression. (academic-accelerator.com)
There is an urgent need to develop functional foods or specific drugs to protect against bone loss induced by oestrogen deficiency with HLP. (academic-accelerator.com)
In this context, anti-inflammatory and osteoconductive multi-functional nanoparticles have attracted considerable attention for application in improved bone tissue regeneration. (springeropen.com)
We believe that this one-step method for fabrication of multi-functional nanoparticles has considerable potential in tissue engineering approaches that require control of complex microenvironments, as required for tissue regeneration. (springeropen.com)
were the first to assess nanoparticle-like exosomes released from trophoblasts and determine the functional activity of trophoblast exosomes in human uterine spiral artery remodeling by inducing vascular smooth muscle cell migration for successful pregnancy [ 16 ]. (biomedcentral.com)
Murugan and colleagues describe their achievement in a paper titled, " Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis ," in which they concluded, "This provides a proof of principle for kickstarting complex organ regeneration responses in vertebrate models using compound interventions consisting of a drug blend and a wearable bioreactor delivery device. (genengnews.com)
Despite significant technological advances, clinicians still lack tools to facilitate the recovery or reversal of tissue loss, while prosthetics offer only limited functional restoration of the patient's own limbs," the team continued. (genengnews.com)

This study aimed to evaluate the effect of mesenchymal stem cell (MSC)-derived exosomes on an immune-induced liver injury model. (biomedcentral.com)
We aimed to produce highly homogeneous induced pluripotent stem cell-derived mesenchymal stem cells (iP-MSCs) in an autologous manner from initially isolated human mucosa mesenchymal stem cells (mMSCs) of the upper respiratory tract. (uni-muenchen.de)
Examples of projects this cohort include determining the effects of muscle progenitor cells on white blood cells function in mice with diet-induced obesity, evaluating migration of mesenchymal stem cells into biomaterials, and studying whole-body regeneration in a marine invertebrate, among others. (ca.gov)

Skin tissue can be regenerated in vivo or in vitro. (wikipedia.org)
regeneration by drugs and regeneration by in vitro 3D printing. (wikipedia.org)
Whilst by 2016, regeneration by 3d printing had been generally operationalised by in vitro (inside the lab) in order to be built and prepare tissue for transplantation. (wikipedia.org)
In vitro analysis using human adipose derived stem cells (hADSCs) showed that mTNs effectively scavenged reactive oxygen species (ROS) and enhanced osteogenesis of hADSCs by inducing secretion of alkaline phosphatase. (springeropen.com)
Mice with full thickness wounds when transplanted with in vitro differentiated/undifferentiated WJMSCs on DWJM demonstrated no skin regeneration. (ku.edu)
However, mice transplanted with in vitro differentiated WJMSCs on DG demonstrated complete skin regeneration along with skin appendages like hair follicles and sebaceous glands. (ku.edu)
Further, the combination of DWJM and DG with in vitro differentiated WJMSCs also showed complete skin regeneration but skin appendages were not as developed. (ku.edu)
The population of MSC in human tissues is insufficient, and obtaining a high cellular yield and maintaining biological capacity during in vitro expansion remains challenging [ 4 ]. (biomedcentral.com)
Soft tissue engineering for both clinical use and as novel 3D in vitro models for improved laboratory studies. (sheffield.ac.uk)
Consistent with these in vivo effects, rCTGF/CCN2 enhanced type II collagen and aggrecan mRNA expression in mouse bone marrow-derived stromal cells and induced chondrogenesis in vitro. (elsevierpure.com)
In orthopedic research, regeneration of bone defects can be performed in vitro using biomaterials. (gla.ac.uk)

To test whether complete removal of skeletal muscle tissue affects the spatiotemporal relationship between myogenesis and angiogenesis during regeneration, subthreshold volumetric muscle loss was created with a biopsy punch (diameter, 2 mm) through the center of the gluteus maximus (GM) in adult mice. (biomedcentral.com)

Cytochalasin D was used to determine the effects of F-actin on osteogenic commitment and YAP switch behavior in mechanically induced PDLSCs. (biomedcentral.com)

By 2016, regeneration of tissue had been induced and operationalized by science. (wikipedia.org)
Whereas 3rd degree burns heal slowly by scarring, in 2016 it was known that full thickness fractional photothermolysis holes heal without scarring. (wikipedia.org)
By 2016, regeneration by instrument, regeneration by materials and by regeneration drugs had been generally operationalised in vivo (inside living tissues). (wikipedia.org)
In 2016 this fractional pattern technique was also proven in human tissue. (wikipedia.org)

Generally, humans can regenerate injured tissues in vivo for limited distances of up to 2mm. (wikipedia.org)
In order to study stem cells, Schmidtea mediterranea (planaria) is used as a model organism because of their unique ability to completely regenerate lost tissues through the use of stem cells. (snc.edu)

Nowadays, the immune system is thought to be activated by "danger signals" which are relevant not only to the induction of inflammation and immune responses but also to the activation of counter regulatory (anti-inflammatory/modulatory) mechanisms required to shutdown inflammation and allow tissue healing. (frontiersin.org)

NYSE American: AGE), a biotechnology company developing therapeutics for human aging and cell regeneration, and LyGenesis, Inc. ("LyGenesis"), a privately held biotechnology company developing cell therapies that enable organ regeneration, announced today that they will proceed to negotiate an agreement for a merger of the two companies. (businesswire.com)
Many bone tissue engineering therapies involve the use full-length proteins as bioactive agents. (confex.com)
Despite the best medical therapies, none address the issue of irreversible myocardial tissue loss after a heart attack and thus there has been a great interest to develop approaches to induce regeneration. (ca.gov)

The combination of interproximal tunneling and customized connective tissue grafts (CTGs) has shown promise in papilla augmentation. (bvsalud.org)
Interestingly, bundles of aligned and uniformly spaced collagen fibrils were more prevalent in keratocytes in Y-27632-treated corneas, which is reminiscent of fibripositor-like structures that have been proposed as a mechanism of matrix deposition in embryonic connective tissues. (molvis.org)

Immunohistochemistry: LS-B495 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. (lsbio.com)

This is in contrast to wound healing, or partial regeneration, which involves closing up the injury site with some gradation of scar tissue. (wikipedia.org)
In 2008, in full thickness wounds over 3mm, it was found that a wound needed a material inserted in order to induce full tissue regeneration. (wikipedia.org)
The further the wound distance is from 2mm the more the wound regeneration will need inducement. (wikipedia.org)
Importantly, the impact to coral microbiomes by fish feces under higher temperatures appeared to inhibit wound healing in corals, as percentages of tissue recovery at the site of feces deposition were lower at 30°C compared to 26°C. Lower percentages of tissue recovery were associated with greater relative abundance of several bacterial lineages, with some of them found in surgeonfish feces (i.e. (frontiersin.org)
Tissue regeneration and wound healing is promoted by the survival and regenerative capacities of tissue-resident or invading stem cells. (uni-muenchen.de)
Thus, the most promising approach for the repair of full thickness wound is using a tissue-engineered skin graft with the primary goal is to restore lost barrier function. (ku.edu)
Confocal imaging and histological analyses of whole-mount GM preparations and tissue cross-sections assessed the growth of microvessels and myofibers into the wound. (biomedcentral.com)
Following punch biopsy of adult skeletal muscle, regenerating microvessels span the wound and become perfused with blood prior to myofiber regeneration. (biomedcentral.com)
Introduction: the latex biomembrane BiomembranaTM has been used in several medical specialties with promising results in promoting wound healing, including surgical, traumatic, isquemic and pressure-induced, as well as ulceration of varied etiology. (bvsalud.org)

There are no commercialized off-the-shelf alternatives to current esophageal reconstruction and regeneration methods. (nature.com)
Materials and Methods: The effects of recombinant CTGF/CCN2 (rCTGF/CCN2) on repair of damaged cartilage were evaluated by using both the monoiodoacetic acid (MIA)-induced experimental rat osteoarthritis (OA) model and full-thickness defects of rat articular cartilage in vivo. (elsevierpure.com)

Bone tissue engineering is the study of how the intersection of cells, biomaterials, and bioactive factors can restore normal bone function after surgical, degenerative, or traumatic bone loss. (confex.com)
It is one of a number of analysis and characterisation facilities within the Department, and is predominantly used by members of the Biomaterials and Tissue Engineering theme . (sheffield.ac.uk)
Third generation biomaterials aim not only to support tissue (first generation) and not only to be 'bioactive' (second generation), but to stimulate specific, known and desirable responses at the molecular level. (gla.ac.uk)

This structure can be applied to full-thickness circumferential esophageal defects and esophageal regeneration. (nature.com)
The repair and management of full-thickness skin defects such as those resulting from burns and chronic wounds remains a significant challenge. (ku.edu)
CTGF/CCN2, a hypertrophic chondrocyte-specific gene product, possessed the ability to repair damaged articular cartilage in two animal models, which were experimental osteoarthritis and full-thickness defects of articular cartilage. (elsevierpure.com)

Among different types of scaffolds, polymeric hydrogel scaffolds have received considerable attention because of their biocompatibility and structural similarity to native tissues. (mdpi.com)
Tissue engineering performs the culture of cells on scaffolds, aiming at the restoration of damaged tissue. (springer.com)

However, calcium-releasing materials have been shown as effective at inducing osteogenesis. (confex.com)

Furthermore, it can prove useful in cases of inflammatory alterations and tissue recession around implants caused by a taut fraenulum insertion, i.e., the general health of the soft tissues surrounding an implant 4 . (bvsalud.org)

Therefore, effective autologous nerve replacement is critical in the field of peripheral nerve regeneration. (biomedcentral.com)
[ 4 ] An important quality of the peripheral nervous system, as compared to the central nervous system, is its remarkable ability to recover after an injury through remyelination and regeneration of the axon. (medscape.com)
Differentiating between a peripheral nerve problem and an injury involving the spinal cord, brain, bone, or soft tissue is crucial. (medscape.com)
Cunha C, Panseri S, Antonini S. Emerging nanotechnology approaches in tissue engineering for peripheral nerve regeneration. (springer.com)

While most studies on limb regeneration have focused on animals such as the axolotle, which demonstrates natural regrowth capabilities, the newly reported study in frogs could help direct future research towards limb regeneration in mammals, including humans. (genengnews.com)

In fact, a single injection of rCTGF/CCN2 incorporated in gelatin hydrogel (rCTGF/CCN2-hydrogel) into the joint cavity of MIA-induced OA model rats repaired their articular cartilage to the extent that it became histologically similar to normal articular cartilage. (elsevierpure.com)
In contrast, only soft tissue repair occurred when the PBS-hydrogel collagen was implanted. (elsevierpure.com)

Journal of Tissue Repair and Regeneration (JTRR) is an open access, peer-reviewed journal that focuses on the study of tissue repair, regeneration, and related emerging topics. (oap-journals.info)
The journal is dedicated to advancing the knowledge and understanding of the biological, chemical and physical aspects of tissue repair and regeneration, as well as emerging research in related fields. (oap-journals.info)
Journal of Tissue Repair and Regeneration is a comprehensive, peer-reviewed journal that helps disseminate original research work, having a unique aspect of covering many areas which contributes to providing an awareness of research studies of scientists around the globe. (oap-journals.info)
However, they are easy to obtain from human adult tissues without ethical issues and play an essential role in tissue repair and organ homeostasis [ 1 , 2 ]. (biomedcentral.com)
Results: In the MIA-induced OA model, quantitative real-time RT-PCR assays showed a significant increase in the level of CTGF/CCN2 mRNA, and immunohistochemical analysis and in situ hybridization revealed that the clustered chondrocytes, in which clustering indicates an attempt to repair the damaged cartilage, produced CTGF/CCN2. (elsevierpure.com)
The application of platelet-rich plasma (PRP) has been hypothesized to enhance tissue repair and regeneration in musculoskeletal injuries. (thieme-connect.de)
This paper reclaims the term "mechanotherapy" and presents the current scientific knowledge underpinning how load may be used therapeutically to stimulate tissue repair and remodelling in tendon, muscle, cartilage and bone. (bmj.com)
1 - 4 But what happens at the tissue level to promote repair and remodelling of tendon, muscle, articular cartilage and bone? (bmj.com)
Animals rely on stem cells to repair tissue damage following disease or injury. (snc.edu)
Micronutrients also maintain tissue repair and cell regeneration. (mybigcommerce.com)

Following the expansion of stem cell therapy using autologous MSC for tissue regeneration [ 3 ]. (biomedcentral.com)
Autologous platelets as a source of proteins for healing and tissue regeneration. (springer.com)

Continued research will give insight about the molecular mechanisms behind regeneration following injury or disease involving specific cell types. (snc.edu)
of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)

In addition, mice in which the receptor gene for TNFα has been knocked out are resistant to alcohol-induced liver injury[ 5 ]. (wjgnet.com)

In full thickness wounds that are under 2mm, regeneration generally occurs before scarring. (wikipedia.org)
Thus, this current dissertation demonstrates the use of differentiated WJMSCs in combination with DWJM and DG as a novel approach for complete skin regeneration of full thickness wounds in a mouse model. (ku.edu)

Results: Expression of nearly all mammalian TLRs was induced at 1 and/ or 3 days postinjury with a common trend for higher expression at day 3. (cdc.gov)

A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. (researchgate.net)

Agarose gels have been widely systems, such as aqueous biopolymer gels, with relaxation used to model the 1H relaxation behavior of biological characteristics similar to those of tissue. (lu.se)

There are many more historical and nuanced understandings about regeneration processes. (wikipedia.org)

Based on this suggested technique, we developed a bioprinted 3D esophageal structure with multi-layered features and converged with biochemical microenvironmental cues of esophageal tissue by using decellularizedbioinks from mucosal and muscular layers of native esophageal tissues. (nature.com)
It is unknown whether the spatiotemporal coupling between myofiber and microvascular regeneration persists when muscle tissue is completely removed and local guidance cues are lost. (biomedcentral.com)
The loss of residual guidance cues with complete tissue removal disrupts the spatiotemporal correspondence between microvascular and myofiber regeneration. (biomedcentral.com)
In contrast to preserving residual guidance cues following myotoxins or physical trauma, volumetric muscle loss (VML) removes all tissue components. (biomedcentral.com)

However, the role of LRP6 in the mechanotransduction of mechanically induced PDLSCs remains obscure. (biomedcentral.com)
LRP6 was robustly activated in mechanically induced PDLSCs and PDL tissues. (biomedcentral.com)
Identifying mechanosensors that initiate mechano-to-chemo signaling events would provide a broader horizon to map the full-scale mechanical landscape in PDLSCs. (biomedcentral.com)

Firstly, we constructed an in vivo murine model of 25 Gy irradiation-induced salivary gland damage to evaluate the potential of human dental pulp stem cell (hDPSCs)-derived EVs. (lu.se)

Detailed Description of Training Program Coursework: Our core coursework (i.e. courses taken by students from all three majors) is laboratory intensive, and includes Tissue Engineering, Cell Transplantation, Biomedical Imaging, and Molecular Techniques. (ca.gov)

At the same time, we developed a sustainable histology process to reduce xylene utilization in histological processing for salivary gland tissue processing. (lu.se)
My Ph.D. studies have focused on the regeneration of salivary gland, which is an organ that is responsible for the production of saliva in our mouths. (lu.se)
Then, to translate the knowledge from Paper I and III, a new model that could use human samples needed to be found, this is Paper II, in which we developed a bioengineered model for salivary gland disease that can be used to evaluate regeneration and test pharmaceutical trials (like EV therapy). (lu.se)

More information is now known regarding the passive replacement of tissues in the human body, as well as the mechanics of stem cells. (wikipedia.org)
In 2006, Takahashi and Yamanaka discovered that mature cells could be reprogrammed back into a pluripotent state, which introduced the option of using patient derived stem cells as a tool for engineering tissues [ 4 ]. (biomedcentral.com)
The combined company's pipeline would also include thymus, pancreas, and kidney regeneration, in addition to the existing AgeX assets, including UniverCyte™, which uses the HLA-G gene to potentially confer low immune observability to cells to suppress rejection of transplanted cells. (businesswire.com)
Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. (wjgnet.com)
Laser scanning confocal microscopy is a significant advance in the field of optical microscopy, primarily because it permits sample visualization deeper within living and fixed cells, tissues and other samples. (sheffield.ac.uk)
The 4x and 10x objectives can obtain images of cells grown on standard tissue culture well plates. (sheffield.ac.uk)
Due to the self-renewable ability stem cells are used in therapeutics, tissue regeneration, disease modeling, regenerative medicines and to treat cardiovascular diseases, neural disorders such as Parkinson's disease and most importantly to treat carcinomas. (fortunepublish.com)
The possibilities arising from these characteristics have resulted in great commercial interest, with potential applications ranging from the use of stem cells in reversal and treatment of disease, to targeted cell therapy, tissue regeneration, pharmacological testing on cell-specific tissues, and more. (prnewswire.com)
Previous studies have focused on how stem cells proliferate in response to injuries with large tissue losses where many cell types need to be regenerated at once. (snc.edu)
Work up to this point has allowed for destruction of pigment cells via light-induced pigment cell loss. (snc.edu)

Here we report an tissue, and in this connection water-1H MRD profiles from extensive set of water-1H relaxation data from two widely agarose gels have been reported (10,19,20), but without used tissue models: aqueous gels of agarose and gelatin. (lu.se)

This research is undertaken to evaluate the effect of MSC-derived exosome on concanavalin-A (con-A)-induced liver injury. (biomedcentral.com)

These findings suggest that CTGF/CCN2 may be useful in regeneration of articular cartilage. (elsevierpure.com)
Conclusion: These findings suggest the utility of CTGF/CCN2 in the regeneration of articular cartilage. (elsevierpure.com)

The two types of esophageal tissue derived-decellularized extracellular matrix bioinks can mimic the inherent components and composition of original tissues with layer specificity. (nature.com)
Periodontitis-caused tissue destruction is unique given the specificity of the local inflammatory microenvironment and oral environment. (biomedcentral.com)

Suppression of con-A-induced liver injury by injection of exosomes was observed as same extent as MSC. (biomedcentral.com)
In this study, we investigated the suppressive effect of exosomes on an immune-induced liver injury model. (biomedcentral.com)
The liver injury was induced by injection of concanavalin A (con-A), a lectin derived from jack beans. (biomedcentral.com)

In particular, nanoparticles that promote suppression of inflammatory response after injury and direction of desirable tissue regeneration events are of immense interest to researchers. (springeropen.com)
Established models of injury have used myotoxins and physical trauma to demonstrate the concurrence of myogenesis and angiogenesis during regeneration. (biomedcentral.com)
Regeneration into the void was evaluated through 21 days post-injury (dpi). (biomedcentral.com)
Whether microvascular regeneration and myofiber regeneration following injury may proceed sequentially has not been resolved. (biomedcentral.com)
Therefore, as an alternative approach to test the interdependence of microvascular and myofiber regeneration following acute injury, a punch biopsy (diameter, 2 mm) was performed through the mouse gluteus maximus (GM) muscle. (biomedcentral.com)

Humans are capable of closing wounds with new tissue growth, and our livers have a remarkable, almost flatworm-like capability of regenerating to full size after a 50% loss. (genengnews.com)

Necrotizing fasciitis is a rapidly progressive inflammatory infection of the fascia, with secondary necrosis of the subcutaneous tissues. (medscape.com)

The extraction, characterization and use of DWJM in skin tissue engineering as a bioactive, biocompatible and biodegradable scaffold were demonstrated. (ku.edu)

To simplify this for patients, these same elements can be thought of as (1) the mechanical trigger or catalyst, (2) the communication throughout a tissue to distribute the loading message and (3) the response at the cellular level to effect the response-that is, the tissue "factory" that produces and assembles the necessary materials in the correct alignment. (bmj.com)
In these models, efferocytosis removes cellular debris while basal laminae persist to provide guidance during myofiber and microvessel regeneration. (biomedcentral.com)

This Funding Opportunity Announcement requests applications for a Human Tissue Core for the GenitoUrinary Development Molecular Anatomy Project (GUDMAP) consortium. (nih.gov)
Whereas the phenomenology of water-1H tions of bulk water (14), and similar ideas regarding long- relaxation in tissue is well documented (1-3), the under- range ordering and slowing down of water motions have lying molecular mechanism remains controversial (4 -9). (lu.se)

Anatomy65

Organisms25

Diseases13

Chemicals and Drugs52

Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Phenomena and Processes51

Disciplines and Occupations4

Technology, Industry, Agriculture19

Information Science3

Pluripotent stem10

Differentiation13

Proliferation3

Regenerative medicine3

Tumor6

Periodontal5

Organs11

IPSCs1

Macrophages2

Stem Cell Regeneration1

Functional9

Mesenchymal3

Vitro11

Skeletal muscle tissue1

Osteogenic1

20164

Regenerate2

Inflammation1

Therapies3

Connective2

Human tissues1

Wound9

Methods2

Biomaterials3

Defects3

Scaffolds2

Osteogenesis1

Soft tissues1

Peripheral4

Regrowth1

Hydrogel2

Repair10

Autologous2

Mechanisms2

Mice1

Thickness wounds2

Mammalian1

Abstract1

Behavior1

Processes1

Cues4

PDLSCs3

Vivo1

Transplantation1

Salivary gland3

Cells10

Gelatin1

Evaluate1

Findings2

Specificity2

Liver injury3

Injury5

Wounds1

Inflammatory1

Bioactive1

Cellular2

Molecular2