• Therapeutic Candidate or Device OSSM007: cryopreserved, interferon-gamma-primed bone marrow mesenchymal stem cells (BM-MSC) Indication acute Graft versus host disease (aGVHD) resulting from hematopoietic cell transplantation Therapeutic Mechanism Immunomodulation of host-reactive T cells to induce operational tolerance of donor HSC-derived lymphocytes through direct cell-to-cell contact and secreted paracrine factors. (ca.gov)
  • This phase II trial studies how well total marrow and lymphoid irradiation works as a conditioning regimen before hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute leukemia. (survivornet.com)
  • TRANSPLANT: Patients undergo hematopoietic cell transplantation on day 0. (survivornet.com)
  • BACKGROUND: This study aimed to assess the outcome of stem cell transplantation (SCT), including overall survival (OS), failure-free survival (FFS) and graft-versus-host disease (GvHD)-free/failure-free survival (GFFS), and to analyze prognostic. (koreamed.org)
  • If living cells from mouse strain CBA were injected into an adult mouse of strain A, some immunologic process destroyed the CBA cells, and the A-line mouse that received the CBA cells quickly destroyed any subsequent graft from the same donor strain. (medscape.com)
  • While bone marrow transplants (BMTs) are sometimes the only hope for patients with diseases like leukemia and other blood disorders, they come with the significant risk of the patient developing graft-vs-host disease (GVHD). (genengnews.com)
  • Conventional methods for preventing the disease include removing T cells from the donor graft and treating the patient with global immunosuppressive drugs. (genengnews.com)
  • Along with giving the patient standard antirejection drugs, Dr. Lengele reports, 'We made an infusion of stem cells (from the donor's bone marrow) because it was observed in hand transplantation that the donor marrow that had been transplanted in the bones of the forearm gave rise to lymphocytes in the circulation of the recipient, inducing a microchimerism believed to favor the immune tolerance of the graft. (dermatologytimes.com)
  • A recent study reported that quantitation of cytomegalovirus (CMV)-specific CD8+ T lymphocytes in the graft and monitoring of these T cells might identify hematopoietic stem cell transplantation-recipients at the risk for progressive CMV infection. (ox.ac.uk)
  • The frequency of CMV-specific CD8+ T cells of the donor in the graft was 3.7% of CD8+ T-cells. (ox.ac.uk)
  • These finding suggested that active transferred immunity from the graft with a high frequency of CMV-specific CTL could induce a rapid reconstitution of CMV-specific T-cell mediated immunity in pediatric HLA-identical allogenetic bone marrow transplantation. (ox.ac.uk)
  • Total body irradiation can lower the relapse rate but has some fatal side effects such as irreversible damage to normal internal organs and graft-versus-host disease (a complication after transplantation in which donor's immune cells recognize the host as foreign and attack the recipient's tissues). (survivornet.com)
  • Once the graft has escaped the initial acute phase rejection reactions, a cumulative unresponsiveness to the graft develops as the recipient is continually exposed to donor MHC, a stable state that sometimes depends on the development of antigen-specific T-suppressor cells [ 371 , 5349 - 5354 ]. (nanomedicine.com)
  • In due course, the stem cells in the bone marrow reconstitute the peripheral lymphoid system but the newly formed T cells seem to accept the graft as self [ 403 ]. (nanomedicine.com)
  • Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
  • VM), showed that the recovery of motor functions induced implanted either (1) as a solid piece in the lateral ven- by the grafted fetal dopamine neurons was well cor- tricle6 or a cortical cavity8 adjacent to the denervated related with the extent of graft-derived reinnervation caudate-putamen, or (2) as a crude cell suspension of the host caudate-putamen. (lu.se)
  • Later, Arnold Caplan's group described mesenchymal stem/stromal cells (MSCs) as multipotent mesenchymal cell populations which can differentiate into several tissue types, and demonstrated roles for MSCs in the regeneration of bone, cartilage or ligaments in animal and clinical studies [2-4]. (issca.us)
  • This concept started from the observation that bone marrow transplantation can provide stromal cells able to synthesize intact collagen type I, replacing deficient patient cell function and ameliorating disease symptoms [5]. (issca.us)
  • Mesenchymal stromal cells in renal transplantation: opportunities and challenges. (genescells.ru)
  • Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. (nature.com)
  • Accordingly, investigations on cellular therapies have therefore moved to progenitor cell populations such as bone marrow derived mesenchymal stem cells (BMSCs), which have the ability to differentiate into cartilage cells 4 . (nature.com)
  • The second obstacle was the availability of transplant donors. (nih.gov)
  • Using mice models, Dr. Fitzhugh et al showed for the first time that sirolimus and post-transplant cyclophosphamide work synergistically to induce tolerance (Fitzhugh CD et al. (nih.gov)
  • Transplant tolerance is defined as a state of donor-specific unresponsiveness without a need for ongoing pharmacologic immunosuppression. (medscape.com)
  • Growing evidence demonstrates that various cancer treatment modalities, including chemotherapy, radiation therapy, targeted therapy, immunotherapy, hormone therapy, stem cell or bone marrow transplant, and surgery [ 3 - 5 ] , cause premature senescence, as reviewed elsewhere [ 6 - 8 ] . (oaepublish.com)
  • This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. (nih.gov)
  • This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. (nih.gov)
  • Total marrow and lymphoid irradiation may allow a greater dose of radiation to be delivered to the bone marrow as a preparative regimen before hematopoietic cell transplant while causing less side effects to normal organs than standard total body irradiation. (survivornet.com)
  • Immune cells from the patient or a transplant donor are used to attack residual leukemia, lymphoma or myeloma cells that remain after chemotherapy. (tlls.org)
  • This review presents analysis of the modern state of transplant tolerance forming problem in recipient organism by using stem/ progenitory cells of bone marrow (BM) and differentiated immunoregulatory (tolerogenic) subsets of blood cells-regulatory B- and T-lymphocytes (Treg), and regulatory dendritic cells (DCreg). (genescells.ru)
  • Combined application of BM cells and Treg permits to increase the terms for maintaining of donor chimerism into all cell lines (incuding Tcells) and transplant tolerance in recipient organism. (genescells.ru)
  • Among the topics covered are age-related issues with regard to gene expression patterns in kidney transplant recipients and selection of donor-recipient combinations in liver transplantation. (tts.org)
  • Stem cells from a donor (also called an allogeneic transplant). (cdc.gov)
  • A transplant using stem cells from a donor increases your risk for fungal infection more than a transplant that uses stem cells from your own body. (cdc.gov)
  • Five weeks after the donor's death, frozen spleen/lymph node homogenate from the donor that had been used for human leukocyte antigen testing was sent from the transplant center to CDC, and initial WNV PCR testing was performed as part of the transplant-transmission investigation ( 7 ). (cdc.gov)
  • Immunologic tolerance is a state of immune unresponsiveness specific to a particular antigen or set of antigens induced by previous exposure to that antigen or set. (medscape.com)
  • Pretransplant exposure to donor antigen is known to modulate recipient alloimmunity, and frequently results in sensitization. (usuhs.edu)
  • It may thus be a preferable method for donor antigen administration. (usuhs.edu)
  • A human leukocyte antigen (HLA)-identical sibling donor is ideal, followed by an HLA-matched sibling donor. (msdmanuals.com)
  • We evaluated tissues collected from a deceased donor who was associated with transmission of WNV through solid organ transplantation to determine if WNV RNA, viral antigen, or infectious viral particles could be detected in postmortem tissues. (cdc.gov)
  • 106 MSCs from a transgenic GFP-expressing mouse and found a median of only one 1.8% donor-derived osteopoiesis (range 0 = 5) in keeping with. (morainetownshipdems.org)
  • Osteoprogenitor MSCs not only differentiate into bone, but they also exert modulatory effects on immune cells via a variety of mechanisms. (hindawi.com)
  • Insight into this paradigm can provide valuable clues in identifying cellular and noncellular targets that can potentially be modulated to enhance both natural bone healing and bone repair augmented by the exogenous addition of MSCs. (hindawi.com)
  • Coupled with reports that allogeneic MSCs have immunoprivileged status and immunomodulatory properties, there has been considerable interest in exploring the use of these cells as a therapeutic option for bone repair. (hindawi.com)
  • MSCs were initially isolated from bone marrow but are now known to exist in a wide range of tissues in the human adult, including brain, thymus, lung, liver, spleen, kidney, and dental pulp [ 11 , 12 ]. (hindawi.com)
  • Pivotal studies by the group of Horwitz in children with osteogenesis imperfecta, an inherited enzyme deficiency of collagen synthesis by mesenchymal cells in bone, opened the field for intravenous use of MSCs. (issca.us)
  • Therefore, the authors concluded that transplantation of isolated healthy allogeneic MSCs might cure the disease. (issca.us)
  • This implies homing of transplanted MSCs to sites in bone marrow and/or bone. (issca.us)
  • In a second study [6], these authors showed that autologous, enzyme-deficient MSCs transduced with a copy of the intact gene resulted in normal collagen production in bone cavities. (issca.us)
  • To induce in vitro chondrogenesis, MSCs were seeded into MC solution retained within a porous polyurethane (PU) matrix. (nature.com)
  • Mechanical stimulation led to a significant increase in chondrogenic gene expression, while histological analysis detected sulphated glycosaminoglycans and collagen II only in loaded specimens, confirming MC hydrogel suitability to support load induced MSCs chondrogenesis. (nature.com)
  • However, in GVHD, the donor T cells also recognize the recipient's normal tissues as foreign and begin to attack organs like the intestine, liver, lungs, and skin. (genengnews.com)
  • Transplantation is the transfer of living cells, tissues, or organs from one person, the donor, to another, the recipient (e.g., a blood transfusion), or from one part of the body to another (e.g., skin grafts) with the goal of restoring a missing function [ 361 ]. (nanomedicine.com)
  • These agents also damage all tissues (e.g., gut epithelium, bone marrow) where rapid cell division is occurring, creating other undesirable side effects, thus often may not be suitable for use in medical nanorobotics. (nanomedicine.com)
  • WNV transmission through tissue transplantation (i.e., skin, muscle, or connective tissues) has not been identified, and the risk for transmission by this route is not known. (cdc.gov)
  • none of the donor tissues were transplanted. (cdc.gov)
  • Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
  • Stem cells derived from dental tissues are isolated from specialized tissues and have a strong ability to give rise to other cell lines, but with a different potential of bone marrow stem cells 16 . (bvsalud.org)
  • Induction of immunologic tolerance has been achieved and studied in numerous laboratory animal models, but it remains an elusive goal in clinical organ transplantation and in the management of autoimmune disease in humans. (medscape.com)
  • Immune suppression may be deliberately induced with drugs, as in preparation for bone marrow or other organ transplantation, to prevent rejection of the donor tissue. (cancer.gov)
  • The conference will bring together international and national faculties who will share their knowledge and expertise in the field of organ transplantation. (tts.org)
  • We identified West Nile virus (WNV) RNA in skin, fat, muscle, tendon, and bone marrow from a deceased donor associated with WNV transmission through solid organ transplantation. (cdc.gov)
  • However, the virus can also be transmitted by transfusion of infected blood products or by solid organ transplantation ( 3 , 4 ). (cdc.gov)
  • In 2011, the Centers for Disease Control and Prevention (CDC) assisted state and local health departments in an investigation of a cluster of WNV disease transmitted through solid organ transplantation ( 6 ). (cdc.gov)
  • Subsequently, all 4 organ donor recipients were tested and had positive results for WNV RNA. (cdc.gov)
  • Children who received transplants showed improved growth rates and started to synthesize intact bone. (issca.us)
  • Moreover, children who received transplants approached growth curves similar to the children transplanted with allogeneic complete bone marrow [6]. (issca.us)
  • GvHD is commonly associated with bone marrow transplants and stem cell transplants . (wikipedia.org)
  • the ATO dosage is 0.15 mg/kg/day IV until bone marrow remission occurs (maximum induction, 60 doses). (medscape.com)
  • Most patients up to the age of approximately 75 years should be considered for intensive combination chemotherapy with the aim to induce complete remission. (cancercentrum.se)
  • Our findings may therefore have profound implications on the performance of clinical BMT while also potentially helping to develop new strategies for using a NIMA-mismatched donor in the absence of an HLA-identical donor. (elsevierpure.com)
  • Mn stimulates macrophages via Dectin-2 to induce donor Th17 differentiation after allogeneic bone marrow transplantation. (ashpublications.org)
  • A knowledge from the systems that regulate this differentiation potential can lead to book remedies for disorders of bone tissue aswell as options for conserving the integrity of endosteal hematopoietic niches. (morainetownshipdems.org)
  • CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. (thermofisher.com)
  • Using these reporter lines to monitor the induction of HSC "stemless' program, we are making progress in optimizing differentiation conditions toward generating functional HSCs for transplantation. (ca.gov)
  • A previous study has shown that 4 Gy irradiation induced the apoptosis of spermatocytes and revealed autophagosomes in cells exposed to radiation. (bvsalud.org)
  • Therefore, the present study generated gefitinib-resistant PC-9 (PC-9G) cells, which were revealed to be more resistant to gefitinib-induced reductions in proliferation, migration and invasion, and increases in apoptosis, and had no detectable EGFR mutations compared with the control PC-9 cell line. (bvsalud.org)
  • In vitro PUVA treatment preferentially induces apoptosis in alloactivated T cells. (genescells.ru)
  • Transplanting their own (autologous) bone marrow-derived stem cells into 48 patients with end-stage liver disease resulted in therapeutic benefit to a high number of the patients, report researchers publishing in the current issue of Cell Transplantation (19:11). (medicaldaily.com)
  • Therapeutic Candidate or Device The therapeutic candidate is a patient specific (autologous) induced pluripotent stem cell derived retinal pigment epithelium (AiPSC-RPE) product. (ca.gov)
  • Therapeutic Candidate or Device Autologous hematopoietic stem cells transduced with a HexA/HexB expressing lentiviral vector Indication Tay-Sachs disease Therapeutic Mechanism The transplanted gene modified autologous hematopoietic stem cells will engraft in the bone marrow and start producing HexA/HexB expressing immune progeny. (ca.gov)
  • Before transplantation, the frequency of CMV specific CD8+ T cells of the recipient was 0.1% in the peripheral blood. (ox.ac.uk)
  • Although the phenotypic pattern of the CMV-specific T cells of the recipient was different from those of the donor before transplantation, the phenotype of the donor-derived cells retained their original phenotype in the recipient after transplantation. (ox.ac.uk)
  • While all secondary recipient mice succumbed to an aggressive leukemia in the absence of Dox, Dox-induced down-regulation of NUP98-FP expression efficiently prevented the outbreak of lethal leukemia (Figure 1B ). (lbg.ac.at)
  • At all times, the level of HDL in ABC1 -/- recipient mice remained low relative to WT recipient mice irrespective of the genotype of the donor macrophage ABCA1 or high-fat feeding. (jci.org)
  • Because only one fourth of patients have such a sibling donor, mismatched related or matched unrelated donors (identified through international registries) are often used. (msdmanuals.com)
  • Tetramer assay showed that the frequency of CMV-specific CD8+ T cells of the donor in the peripheral blood was 5.3%, higher than average amongst young children. (ox.ac.uk)
  • The screening of peripheral blood using HLA-peptide tetramer staining might be beneficial to select donors. (ox.ac.uk)
  • Nature communications 2022 - Prdm1 attenuates its effects on tumor growth inhibition through PD-L1-induced tumor immune evasion in immune-competent mice. (thermofisher.com)
  • a Representative subcutaneous tumors (left)/orthotopic transplantation tumors (right) collected from Hepa1-6-bearing C57BL/6 mice. (thermofisher.com)
  • For example, mice genetically deficient for adaptive immunity displayed accelerated bone healing. (hindawi.com)
  • Immuno-phenotypic characterization of bone marrow from leukemic mice revealed excessive accumulation of Mac-1/GR-1-positive donor-derived cells in the bone marrow and spleen of affected animals. (lbg.ac.at)
  • We generated mice expressing ABCA1 in macrophages and mice with selected inactivation of ABCA1 in macrophages by bone marrow transplantation in ABCA1-deficient ( ABC1 -/- ) and wild-type (WT) mice. (jci.org)
  • Expression of WT macrophage ABCA1 in ABC1 -/- mice resulted in a small but significant increase in apoA-I levels starting 2 weeks after transplantation. (jci.org)
  • Adult stem cells were firstly isolated from bone marrow in mice (Spangrude, Heimfeld, and Weissman, 1988) and later in humans. (bmrat.org)
  • Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). (thermofisher.com)
  • Bone marrow transplantation from a pediatric donor with a high frequency of cytomegalovirus-specific T-cells. (ox.ac.uk)
  • Total body irradiation is a form of radiotherapy that involves irradiating the patient's entire body in an attempt to suppress the immune system, prevent rejection of the transplanted bone marrow and/or stem cells and to wipe out any remaining cancer cells. (survivornet.com)
  • These particles induce innate and adaptive host immune responses to preexisting tumors in both orthotopic and genetically engineered models of basal-like TNBC. (jci.org)
  • Total marrow and lymphoid irradiation is a method of using IMRT to direct radiation to the bone marrow. (survivornet.com)
  • A series of sublethal doses of radiation is directed at the patient's lymphoid tissue (spleen, thymus, and lymph nodes in the neck, chest, and abdomen), with bone marrow and other vital organs shielded from the exposure [ 387 ]. (nanomedicine.com)
  • In all patients that might become considered for intensive treatment, the AML diagnosis should be based on morphologic and immunophenotypic features of bone marrow aspirates as well as on genetic characteristics of the leukemic blasts. (cancercentrum.se)
  • Storage of bone marrow or blood leukemic cells in biobanks is strongly recommended. (cancercentrum.se)
  • Senescence-associated secretory phenotype (SASP) can be induced by telomere dysfunction. (oaepublish.com)
  • These data show that the retroviral transplantation model established by us recapitulates critical aspects of human NUP98-FP-induced leukemia, including characteristic changes in immuno-phenotype and gene expression profile. (lbg.ac.at)
  • This knowledge will be critical for generating HSCs in culture dish for transplantation therapies to treat leukemias and other life-threatening blood disorders. (ca.gov)
  • thymus from marrow-derived progenitors circulating in the blood. (lu.se)
  • This way of making iPSCs from adult cells circumvents the need to destroy an embryo from living donor. (bmrat.org)
  • The adult male donor had a history of cerebral palsy, seizures, and blindness. (cdc.gov)
  • V. Cellular and molecular assessment of TMLI effect on bone marrow environment and TMLI effect on the engraftment and disease relapse. (survivornet.com)
  • provides an overview of the dynamic in vivo life of NK cells from their development in the bone marrow to their mature cellular responses in the periphery and their ultimate demise, with emphasis on mouse NK cells and viral infections. (scielo.br)
  • These findings indicate that LTR-HSC can give rise to progeny that differentiate to osteoblasts after BMT suggesting a system for prompt repair from the osteoblastic HSC market following BM damage such as for example that induced by medical BMT preparative regimens. (morainetownshipdems.org)
  • We know that innate immune cells are required for blastema progenitor cell formation, but are lacking an understanding of the immune cell processes and functions that are required for inducing and maintaining these progenitors cells. (lu.se)
  • Section 8.5.2.1 ) are closely matched to those of the donor, transplanted organs are usually rejected (beginning within minutes or hours of surgery [ 1832 ]) unless the recipient's immune system is carefully controlled. (nanomedicine.com)
  • and early trials resulted in vector-induced leukemia in 25% of patients due to insertion of the gene-carrying retrovirus near an oncogene. (stjude.org)
  • The infusion's goal is to attack or suppress leukemia cells by inducing an intense immune reaction against the patient's cancer cells. (tlls.org)
  • Successful Salvage Haploidentical Bone Marrow Transplantation in a Child With Hemophagocytic Lymphohistiocytosis, When the Previously Matched Unrelated Donor Tested Positive for SARS-CoV-2 on the Day of Stem Cells Collection. (cdc.gov)
  • Treatment with a new class of drugs, called senolytics, in donors improved the physical fitness of the recipients, a new study has shown. (medicaldaily.com)
  • However, despite the ability of KEL RBCs to induce anti-KEL antibodies in the absence of complement, removal of C3 or complement receptors 1 and 2 (CR1/2) rendered recipients completely reliant on CD4+ T cells for IgG anti-KEL antibody formation. (jci.org)
  • Secondary Genkwanin BMT studies demonstrated that a single marrow cell able to contribute to hematopoietic reconstitution in primary recipients also drives robust osteopoiesis and LT hematopoiesis in secondary recipients. (morainetownshipdems.org)
  • Using supplementary BMT assays we display here a solitary marrow cell in a position to donate to hematopoietic reconstitution in major recipients drives both osteopoiesis and long-term (LT) hematopoiesis in supplementary recipients. (morainetownshipdems.org)
  • Transplantation proceedings 2021 0 0. (cdc.gov)