Induce cellular immune. Medical search. Frequent questions

Our study indicates that co-expression of GP and VP40 antigens based on the SFV replicon vector generates EBOV VLPs in vitro , and vaccination with recombinant DREP vectors containing GP and VP40 antigens induces Ebola antigen-specific humoral and cellular immune responses in mice. (frontiersin.org)
Scientists from Australia and the USA have developed a lymph node-targeted multi-epitope subunit vaccine that induces strong humoral and cellular immune responses against Epstein-Barr virus (EBV) in mice. (news-medical.net)
This induces humoral and cellular immune responses against the encoded antigens. (bvsalud.org)

Notably, vaccination with DREP-GP and DREP-VP40, which produces both GP and VP40 antigens, induced a significantly higher level of anti-GP IgG2a antibody and increased IFN-γ secreting CD8 + T-cell responses relative to vaccination with DREP-GP or DREP-VP40 vector alone. (frontiersin.org)
In phase 2, as the parasites mature and reproduce with the production of eggs, the Th1 response is reduced and a strong Th2 response develops, induced mostly by egg antigens. (hindawi.com)
Molecular Components of the Immune System The immune system consists of cellular components and molecular components that work together to destroy antigens (Ags). (msdmanuals.com)
Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)
After the process of deciduous root resorption, dentin proteins that have not been yet been presented to the immune system become sequestered antigens that can induce autoimmune responses and play a role in etiopathogenesis of dental resorption. (bvsalud.org)
By using direct reprogramming strategies, I could induce the expression of tumor antigens on the surface of cancer cells, making them visible to the immune system again. (lu.se)
when it comes to cancer they are critical as they present tumor antigens to the killer cells of the immune system and orchestrate the anti-tumor immune response. (lu.se)

In conclusion, the mRNA BNT162b2 vaccine induces complex functional reprogramming of innate immune responses, which should be considered in the development and use of this new class of vaccines. (ssrn.com)

T-cell vaccines are designed to induce cellular immunity. (wikipedia.org)
and finally, presentation of neoantigens to dendritic and T cells induce cellular immunity. (cancernetwork.com)
The past three decades have seen a tremendous increase of knowledge on plant innate immunity systems at the molecular and cellular levels. (usda.gov)
Here we confirmed that BNT162b2 vaccination of healthy individuals induced effective humoral and cellular immunity against several SARS-CoV-2 variants. (ssrn.com)
Th1 cells that produce IL-2, IFN- γ , TNF- α, and TNF- β evoke cell-mediated immunity and phagocyte-dependent inflammation while Th2 cells that produce IL-5, IL-4, IL-6, IL-10, and IL-13 induce a strong antibody response that comprises the IgE class and eosinophil accumulation, but it inhibits several functions of phagocytic cells [ 7 ]. (hindawi.com)
The objective was to determine the cellular immune response early in the course of treatment in order to examine whether cell mediated immunity could be responsible for imiquimod mediated regression of BCC. (nih.gov)

The emergence of immunotherapy has recently disrupted the paradigm of traditional cancer treatment (including the three traditional treatments RT, chemotherapy, and surgery), and immunotherapy functions by activating the body's immune system to fight cancer. (nature.com)
Immunotherapy mainly includes immune checkpoint inhibitors (ICIs), such as inhibitors of PD-1 (programmed cell death 1)/programmed cell death ligand 1 (PD-L1). (nature.com)
Immune-inflamed tumors are called hot tumors, while the latter two are collectively referred to as cold tumors, and they respond poorly to immunotherapy. (nature.com)
One study reported an increased survival benefit with simultaneous RT compared with sequential administration, 8 while another study found no significant difference between the two strategies, 9 possibly because simultaneous RT plus immunotherapy and the administration of an ICI before RT may kill cancer cells as well a substantial number of immune cells, leading to poor systemic response and toxic side effects. (nature.com)
Ye is a Professor of Autoimmune liver diseases and Translational Hepatology at the Institute of Immunology and Immunotherapy, University of Birmingham and Consultant Hepatologist at the Queen Elizabeth Hospital where he specialises in the management of autoimmune liver diseases, immune mediated liver injury and liver transplantation. (birmingham.ac.uk)
Immunotherapy can fail in patients with cancer when certain cancer cells can hide from the immune system. (lu.se)

The virus infects resting B cells in the oropharynx and induces transcriptional programming of these cells to establish life-long viral latency. (news-medical.net)
The inclusion of both latent and lytic antigenic epitopes is intended to induce robust T-cell response targeting different phases of the viral life cycle. (news-medical.net)
The findings revealed that vaccination with Amphiphile-CpG adjuvant induces significantly higher viral antigen-specific cytokine-producing CD8+ T cells compared to vaccination with soluble CpG. (news-medical.net)
The persistence of HIV in treated patients results from the establishment of a viral reservoir insensitive to ART and poorly visible to the immune system. (europa.eu)
An immune receptor normally known for identifying viral RNA is also capable of binding to cellular RNA to induce immune defenses. (pasteur.fr)
The researchers further showed that VP24 disrupts signaling pathways that are meant to activate the immune system's defenses against viral invaders like Ebola. (sciencedaily.com)
Interestingly, however, the BNT162b2 vaccine also modulated the production of inflammatory cytokines by innate immune cells upon stimulation with both specific (SARS-CoV-2) and non-specific (viral, fungal and bacterial) stimuli. (ssrn.com)

This vaccination regimen also led to the generation of both Th1 and Th2 cellular immune responses in mice. (frontiersin.org)
Moreover, vaccination with Amphiphile-CpG induced three times more gp350-specific cytokine-producing CD4+ T cells than soluble CpG. (news-medical.net)
Our results showed that ME49Δ cdpk3 vaccination triggered a strong immune response marked by significantly elevated proinflammatory cytokine levels, such as IFN-γ, IL-12, and TNF-α, and increased the percentage of CD4 + and CD8 + T-lymphocytes. (nature.com)
In February 2010, induced Warts after a 12-year history of slowly progressing cutaneous warts, the patient sought medical care for numerous, after HPV flat, erythematous warts that were coalescing into large plaques on her forearms, backs of hands, and fingers (on- Vaccination line Technical Appendix Figure, panel A, wwwnc.cdc. (cdc.gov)
The response of innate immune cells to TLR4 and TLR7/8 ligands was lower after BNT162b2 vaccination, while fungi-induced cytokine responses were stronger. (ssrn.com)

In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)
Also our study indicated that WSC induced an increase in the transcriptional expression of matrix metalloproteinases, MMP-2 and MMP-9 and an immune response regulator, Toll Like Receptor-4. (who.int)

RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy. (nature.com)
To observe the effect of H2O2 induced oxidative stress on autophagy and apoptosis of human bone marrow mesenchymal stem cells (hBMSCs). (researchsquare.com)
In addition, cell death analysis indicated that PF treatment markedly reduced UV‑B‑radiation‑induced apoptosis in keratinocytes, which was accompanied by increased procaspase 3 expression and decreased cleaved caspase 3 expression. (spandidos-publications.com)
UV-B-induced DNA damage can trigger cell signaling pathways to activate defense systems, leading to DNA repair and/or apoptosis ( 6 ). (spandidos-publications.com)

Strategies to induce anti-tumor immune responses could complement standard-of-care therapies for these patients. (oncotarget.com)

The testing of the polyepitope vaccine immunogen using peripheral mononuclear cells isolated from EBV seropositive donors revealed that the immunogen can be effectively processed by antigen-presenting cells to generate epitopes that can be presented on HLA class I molecules and subsequently recognized by human CD8+ T cells to promote an immune response. (news-medical.net)
Moreover, the immunization route influenced which antigen-specific T-cells (CD4+ or CD8+) were induced. (druglib.com)
The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. (bvsalud.org)
We focused particularly on harnessing reprogramming, or direct cellular reprogramming, to induce antigen presentation in cancer cells. (lu.se)
Direct reprogramming strategies with cDC1-specific factors can induce antigen-presentation in cancer cells, making cancer cells visible to the immune system and easier to fight. (lu.se)

Our group found that complement C3 is expressed in beta cells where it plays a prosurvival role, partly by inducing autophagy, a mechanism by which cells recycle cellular components. (lu.se)

The immune mechanism against this disease is extremely complex and involves a combination of humoral and cellular factors. (kenyon.edu)
His group basic science research aims to dissect the pathogenesis mechanism of autoimmune liver diseases, immune mediated and drug induced/check point inhibitors liver injury with TransOMICS approach, deep immune profiling and develop personalised and stratified therapies. (birmingham.ac.uk)

The role of the innate immune system in ASNHL. (nih.gov)
The investigation will reveal how calcium signal and signaling contribute to plant innate immune response. (usda.gov)
Ozone exposure induces airway neutrophilia and modifies innate immune monocytic cell-surface phenotypes in healthy individuals. (nih.gov)
High-dose inhaled corticosteroids can reduce O(3)-induced airway inflammation, but their effect on innate immune activation is unknown. (nih.gov)
We used a human O(3) inhalation challenge model to examine the effectiveness of clinically relevant doses of inhaled corticosteroids on airway inflammation and markers of innate immune activation in healthy volunteers. (nih.gov)
The normal process of fracture repair begins with an immediate inflammatory response as the innate immune system (macrophages, monocytes, neutrophils, and NK cells) responds with a variety of cytokines that recruit and activate several cell types, including osteoprogenitor mesenchymal stem cells (MSCs), to the site of injury [ 1 , 2 ]. (hindawi.com)
The present results suggest that the CNS innate immune system can respond to an acute stressor as if it were cellular damage, thereby releasing the danger signal HMGB-1 in the brain to prime microglia by acting on the NLRP3 inflammasome, in preparation for a later immune challenge. (jneurosci.org)
The concept has developed that innate immune receptors discriminate between danger and non-danger rather than self and non-self ( Matzinger, 2002 ). (jneurosci.org)
Title : Effect of Elevated Carbon Dioxide on Bronchial Epithelial Innate Immune Receptor Response to Organic Dust from Swine Confinement Barns Personal Author(s) : Schneberger, D.;Cloonan, D.;DeVasure, J. M.;Bailey, K. L.;Romberger, D. J.;Wyatt, T. A. (cdc.gov)

They are also referred to as cell-mediated immune (CMI) vaccines. (wikipedia.org)
Little is known about the broad effects of the new class of mRNA vaccines, especially whether they have combined effects on innate and adaptive immune responses. (ssrn.com)
Killed Y. pestis vaccines induce some measure of host protection, although it is less effective. (kenyon.edu)

Cellular factors which play role in host defense mechanisms against HIV were identified and their role in HIV induced inflammation was established. (europa.eu)
This study confirmed and extended data demonstrating the protective effect of FP against O(3)-induced airway inflammation and immune cell activation. (nih.gov)
CONCLUSION: The data reported here represent the first in vitro demonstration of the effect of waterpipe smoke on cellular parameters providing evidence of the potential involvement of WPS in the pathogenesis of COPD through impairing cellular growth and inducing inflammation. (who.int)
Partial body cryotherapy (PBC) is proposed to alleviate symptoms of exercise-induced muscle damage (EIMD) by reducing associated inflammation. (researchgate.net)

To further increase vaccine-induced immune response, an Amphiphile-modified CpG DNA adjuvant was incorporated into the vaccine. (news-medical.net)
The testing of lymph node accumulation of vaccine immunogens revealed that the Amphiphile-modified CpG DNA adjuvant is highly capable of increasing lymph node drainage and retention of immunogens, in addition to persistently inducing an acute inflammatory response in local and distal lymph nodes. (news-medical.net)
The analysis of gp350-specific B cell response in immunized mice revealed that both Amphiphile-CpG and soluble CpG induce comparable numbers of antibody-secreting B cells in splenocytes. (news-medical.net)
Five different immunization schedules were considered to evaluate the feasibility of eliciting an immune response. (oncotarget.com)
The criteria should not include a specific immune test or a response to therapy. (nih.gov)
Adaptive immune response in the ear over time. (nih.gov)
Specific features of calcium ion in the cell, such as its level, shape, amplitude, and frequency, in response to environment may carry stimulus information and induce distinct responses. (usda.gov)
H2O2 can induce hMSCs to produce oxidative stress response. (researchsquare.com)
Pretreatment of cells with N-acetyl-L-cysteine (NAC), an agent known to counteract oxidative stress, attenuates the cellular p53 response to UV ( 4 ). (spandidos-publications.com)
In this manuscript, we report the in vitro mutagenicity of waterpipe smoke condensate (WSC), the alteration in cellular parameters of lung alveolar cells in response to WSC exposure and discuss the implication of cellular responses in the pathophysiology of chronic obstructive pulmonary disease (COPD). (who.int)
The adaptive immune response, primarily comprised of T and B lymphocytes, has important implications in the fracture healing process as well [ 3 , 4 ]. (hindawi.com)
Although the expression of MHC class I and II molecules can be upregulated by MSC exposure to inflammatory cytokines interferon-gamma (IFN- γ ) and tumor necrosis factor-alpha (TNF- α ), they are still unable to induce an immunological response [ 18 ]. (hindawi.com)
The cellular response pattern is associated with both the acute and chronic phases of the disease, in which cytokines play a critical role. (hindawi.com)
Therefore, cytokine response is directly related with the influence of treatment in the variation of the immune response. (hindawi.com)
Both T helper 1 (Th1) and T helper 2 (Th2) responses are induced in response to the infection [ 3 ]. (hindawi.com)
Th1 and Th2 responses are crucial in understanding the role of cytokines in the immune response to infectious agents [ 4 , 5 ]. (hindawi.com)
8 ] speculated that IL-10 is important in regulating the human immune response to Schistosoma mansoni infection and that it is the main cytokine that plays part in the control of morbidity. (hindawi.com)
However, human studies have shown that, during infection, the immune response advances through at least three phases. (hindawi.com)
Schistosomes are known to downregulate host immune responses and to induce a modified Th2 response [ 13 ]. (hindawi.com)
H7N9 virus infection induced strong immune response, however cellular repair mechanisms were inhibited at the same time. (aacc.org)
Protein changes were also related to pathways involved in cell damage, immune response, and cancer. (cdc.gov)
The results are consistent with a cell mediated immune response being responsible for the clearance of the BCC. (nih.gov)
Exposure to acute and chronic stressors sensitizes the proinflammatory response of microglia to a subsequent immune challenge. (jneurosci.org)
When their protective barriers are missing, hormones and cells that are present during inflammatory processes induce activation of clasts which, when unbalanced, no longer perform physiological bone remodeling and begin to provoke an immunopathological response that causes dental resorption. (bvsalud.org)
it is a common the chemical allergen sufficient to induce a cutaneous occupational and environmental health issue and immune response of the necessary vigor. (cdc.gov)
International Immunopharmacology 2 (2002) 201-211 immune response will be provoked at the point of 2.2. (cdc.gov)

Researchers have uncovered the complex cellular mechanisms of Ebola virus, which could help explain its severe toll on humans and identify potential pathways to treatment and prevention. (sciencedaily.com)
Indeed, that research will hopefully identify even more precisely the molecular mechanisms by which viruses like Ebola invade the body and find ways to cleverly avoid its immune defenses. (sciencedaily.com)
We next investigated underlying cellular and molecular mechanisms. (biorxiv.org)
Osteoprogenitor MSCs not only differentiate into bone, but they also exert modulatory effects on immune cells via a variety of mechanisms. (hindawi.com)
Several immune-mediated tumour destruction mechanisms are likely to be involved. (nih.gov)
Some of the more interesting cellular and molecular mechanisms are reviewed briefly in this article. (cdc.gov)

For the purposes of this workshop, immune mediated ear disease was defined to include both primary autoimmune sensorineural hearing loss (ASNHL) originating in the inner ear and secondary immune mediated ear disease/hearing loss (IMED) from systemic immune/autoimmune disease originating outside the inner ear. (nih.gov)
His research group focus on basic discovery science in autoimmune liver diseases, develop translational cellular therapy and practice precision medicine. (birmingham.ac.uk)
Ye and his team explore the underlying immune balance in the early and late stage of autoimmune liver diseases. (birmingham.ac.uk)

Studies have shown strong associations between schistosoma infection and schistosoma-induced cytokine profiles [ 6 ]. (hindawi.com)

4 According to the number of tumor-infiltrating lymphocytes, tumors can be divided into three phenotypes: immune-inflamed, immune-excluded, and immune-desert types. (nature.com)
An increase in circulating leukocyte subsets such as CD8⁺ T cells and CD56loCD16⁺ natural killer cells suggests that PBC may induce a transient mobilisation of lymphocytes. (researchgate.net)

They have complementary skills in the fields of molecular and cellular virology, immunology, and physiopathology of infectious diseases. (europa.eu)
He also leads the UK drug induced liver injury immunology work stream with his team and AIH Immunology work. (birmingham.ac.uk)

The use of artificial mRNAs provides a real opportunity to make any protein of interest, or even multiple proteins, which may induce therapeutic immune reaction. (cancernetwork.com)
Human papillomaviruses (HPVs), small, double-strand- ed DNA viruses with a circular genome of 8,000 bp, are assigned to different genera and species on the basis of their major capsid protein gene (L1) nucleotide sequence, which reflects their tropism (cutaneous or mucosal) and potential to induce tumors. (cdc.gov)
The Ebola virus is extremely skilled at dodging the body's immune defenses, and in our study we characterize an important way in which that evasion occurs through disruption of the nuclear envelope, mediated by the VP24 protein," says co-senior author Adolfo García-Sastre, PhD, Professor of Microbiology, and Director of the Global Health and Emerging Pathogens Institute of the Icahn School of Medicine at Mount Sinai. (sciencedaily.com)
Here, high mobility group box-1 (HMGB-1) protein was explored as a potential mediator of stress-induced microglial priming and whether HMGB-1 does so via the nucleotide-binding domain, leucine-rich repeat, pyrin domain containing protein 3 (NLRP3) inflammasome. (jneurosci.org)
We also found that CD59, a protein present on the surface of almost all cells which protects cells from being attacked by the immune system, can also be found inside cells, where it regulates insulin secretion. (lu.se)

In addition, UV induces the generation of reactive oxygen species (ROS), which overwhelm the antioxidant defense system, resulting in oxidative stress and damage to cell structure, DNA, proteins and lipids ( 5 ). (spandidos-publications.com)
In addition, oxidative stress is associated with UV-induced activation of p53 ( 4 ). (spandidos-publications.com)
p38 acts as a stress-activated MAPK that is preferentially activated by diverse cellular stressors, including UV-B-induced oxidative stress ( 9 ). (spandidos-publications.com)

Exposure to UV induces extensive generation of reactive oxygen species (ROS), and results in photoaging and skin cancer development. (spandidos-publications.com)

UV can be directly absorbed by cellular macromolecules, thus leading to photochemical modification of DNA and proteins ( 4 ). (spandidos-publications.com)
Among these cell-signaling proteins, activation of p53 is important in cells with UV radiation-induced DNA damage ( 4 , 7 ). (spandidos-publications.com)

The precise spatial and temporal impact of immune cells and their cytokines on fracture healing remains obscure. (hindawi.com)
At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)
In recent years, much has been learned of the characteristics of immune responses to skin sensitizing chemicals and of the roles played by dendritic cells, cytokines and chemokines. (cdc.gov)

Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. (biorxiv.org)
SUMMARY BLURB Essential oil derived from the camphor tree acts by stimulating immune cell-dependent regression of skin tumors in a mouse model of cutaneous squamous cell carcinoma. (biorxiv.org)

CMV infection has been shown to induce transient abnormalities of in vitro cellular-immune function in otherwise healthy human hosts (2,3). (cdc.gov)
The present study evaluated the protective effects of PF on UV‑induced skin damage in vitro, and demonstrated that the effects were mediated via the ROS‑p38‑p53 pathway. (spandidos-publications.com)
In this paper, we review the current literature on both in vitro and in vivo studies on the role of the immune system in fracture repair, the use of MSCs in the enhancement of fracture healing, and interactions between MSCs and immune cells. (hindawi.com)

OBJECTIVE: The objective was to compare the safety and cellular immunogenicity of intradermal versus intramuscular immunization with an HIV-lipopeptide candidate vaccine (LIPO-4) in healthy volunteers. (druglib.com)

These data demonstrated that ME49Δ cdpk3 inoculation induced effective cellular and humoral immune responses against acute and chronic Toxoplasma infections with various strains and was a potential candidate to develop a vaccine against toxoplasmosis. (nature.com)
The infection induces both cellular and humoral responses that correlate with the acute and chronic form of the disease. (hindawi.com)

The Amphiphile-CpG vaccine-induced T cells exhibited robust polyfunctional effector phenotype. (news-medical.net)
RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. (nature.com)
However, some immune cells are immunosuppressive or transform into immunosuppressive phenotypes under specific conditions, leading to the development of radioresistance. (nature.com)
In this review, we discuss the changes in irradiated cancer cells and immune cells in the TME under different RT regimens and describe existing and potential molecules that could be targeted to improve the therapeutic effects of RT. (nature.com)
Furthermore, inflammatory mediators released by irradiated dying cells can attract and regulate immune cells in the tumor microenvironment (TME), further killing cancer cells. (nature.com)
A T-cell vaccine is a vaccine designed to induce protective T-cells. (wikipedia.org)
HIV persistence may arise from ongoing residual virus replication and/or from latently-infected cells defined as the cellular reservoir in which long-lived resting memory CD4+ T cells harbouring an integrated but transcriptionally silent provirus represent the largest pool in the blood (Chomont et al. (europa.eu)
To determine the effect of FP on cellular function, we assessed sputum cells from seven subjects by flow cytometry for cell-surface marker activation. (nih.gov)
There is strong evidence suggesting that regulatory T cells are crucial in restoring immune tolerance. (birmingham.ac.uk)
His team dissect intrahepatic immune cells cross talk in the context of microenvironment and develop novel assay. (birmingham.ac.uk)
This provides the first evidence for the effect of PBC exposure on redistribution of immune cells. (researchgate.net)
PBC may thus enable a more efficient trafficking of these cells from the circulation to the site of initial cellular insult from exercise, potentially accelerating the process of cellular recovery. (researchgate.net)
One promising cellular therapy is the use of regulatory T cells to induce a state of donor-specific tolerance to the transplant. (lu.se)
Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)
Her research involves direct reprogramming approaches, which function like a Trojan horse, enabling cancer cells to be targeted by the immune system. (lu.se)

During RT, alterations in signaling pathways result in changes in the local immune microenvironment. (nature.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
These previous results indicated that the ROS-p38-p53 pathways are involved in UV-induced cell damage. (spandidos-publications.com)
Our evaluation identified biological pathways that require a future evaluation and also demonstrates that exposure assessment of CIPP worksites should examine multiple chemical components beyond styrene , as many cellular responses were styrene -independent. (cdc.gov)

effectively, these individuals would be immune to infection and not reported as cases. (wattsupwiththat.com)
It is commonly believed that exposure to cold environmental temperatures depresses immune function and increases the risk for infection. (researchgate.net)

Extracts of peony root have previously been shown to exert protective effects against UV-induced DNA damage and facial wrinkles in human skin ( 16 ). (spandidos-publications.com)

In conclusion, intradermal LIPO-4 immunization was well tolerated, required one-fifth of the intramuscular dose, and induced similar HIV-specific CD8+ T-cell responses. (druglib.com)

Treatment with PF markedly reduced the production of ROS, and inhibited the activation of p38 and p53 in human keratinocytes, thus suggesting that the ROS‑p38‑p53 pathway has a role in UV‑B‑induced skin damage. (spandidos-publications.com)
However, WSC induced cell cycle arrest and cellular senescence mediated by the p53-p21 pathway. (who.int)
Pathway analysis of exposure-induced proteomic alterations identified MYC and p53 to be regulators of cellular responses. (cdc.gov)

CD8+ T-cell immune responses to HIV epitopes (ELISpot interferon-gamma assay) and tetanus toxin-specific CD4+ T-cell responses (lymphoproliferation) were assessed at baseline, two weeks after each injection, and at week 24. (druglib.com)

In conclusion, the present study reported that PF was able to attenuate UV‑B‑induced cell damage in human keratinocytes. (spandidos-publications.com)

[1] It discusses immunological and epidemiological aspects and implications of pre-existing cross-reactive adaptive immune system memory arising from previous exposure to circulating common cold coronaviruses. (wattsupwiththat.com)
UV-B-induced skin damage may be prevented by avoidance of intense sun exposure, as well as topical and systemic administration of antioxidants ( 11 ). (spandidos-publications.com)
Damage to both the humoral and cellular components of the immune system has been known to occur in humans following inhalation exposure. (cdc.gov)
This review paper will 1) present an overview of human physiological responses to cold exposure, 2) present the human studies examining the effects of cold exposure on immune responses, and 3) summarize recent experiments from our laboratories examining the effects of exercise and fatigue on immune responses during subsequent cold exposure. (researchgate.net)
Based on the review of the literature, there is no support for the concept that cold exposure depresses immune function. (researchgate.net)
12] However, the findings concerning the effects of cold exposure on human immune function are inconsistent. (researchgate.net)

In adults, EBV can induce the development of symptomatic infectious mononucleosis, which is a major risk factor for multiple sclerosis and Hodgkin lymphoma. (news-medical.net)

Hippocampal microglia were isolated 24 h later and stimulated with LPS ex vivo to probe for stress-induced sensitization of proinflammatory responses. (jneurosci.org)

Furthermore, FP pretreatment significantly reduced O(3)-induced modification of CD11b, mCD14, CD64, CD16, HLA-DR, and CD86 on sputum monocytes in a dose-dependent manner. (nih.gov)

The transition from innate to adaptive immune responses in IMED. (nih.gov)

A more detailed appreciation of responses induced by chemical allergens has in turn facilitated the design of novel approaches to the toxicological evaluation of skin sensitization. (cdc.gov)

Thus, stressors must induce the release of an endogenous ligand within the CNS that signals via TLR2 and TLR4 to mediate neuroinflammatory sensitization produced by stressors. (jneurosci.org)

11 Laboratory for Mathematical Modeling of the Immune System, RIKEN Research Center for Integrative Medical Sciences (IMS-RCAI), Yokohama, Japan. (jci.org)
MSCs are able to evade the host cell immune system due to their low expression of major histocompatibility complex (MHC) class I molecules and complete lack MHC class II molecules and other costimulatory molecules (CD40, CD40L, CD80, and CD86) required for immune cell stimulation [ 15 - 17 ]. (hindawi.com)
Drugs that suppress the immune system may inhibit clinical activity of sipuleucel-T. (medscape.com)
See also Overview of the Immune System. (msdmanuals.com)
The immune system also has the capacity to recognize and destroy. (msdmanuals.com)
During odontogenesis, dentin is protected from the immune system and later this protection is provided externally by the cementum, cementoblasts and enamel and internally by the odontoblastic layer. (bvsalud.org)
Our group focuses on the complement system, which is part of the immune system. (lu.se)

Results: Cytotoxicity differences were observed between worksite samples, with the CIPP worksite 4 sample inducing the most cell death. (cdc.gov)

Anatomy32

Organisms22

Diseases20

Chemicals and Drugs106

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes43

Technology, Industry, Agriculture1

Information Science3

Health Care2

Humoral and cellular immune3

Antigens7

Vaccine induces1

Immunity6

Immunotherapy6

Viral7

Vaccination5

Transcriptional2

Apoptosis4

Anti-tumor immune1

Antigen5

Autophagy1

Mechanism2

Innate immune9

Vaccines3

Inflammation4

Response26

Mechanisms6

Autoimmune3

Cytokine1

Lymphocytes2

Immunology2

Protein5

Oxidative stress3

Reactive oxygen1

Proteins2

Cytokines3

Tumors2

Vitro3

Immunogenicity1

Acute and chronic2

Cells16

Pathways4

Infection2

Protective1

Immunization1

Pathway3

Interferon-gamma1

Conclusion1

Exposure6

Infectious1

Vivo1

Pretreatment1

Adaptive immune responses1

Allergens1

Stressors1

System7

Cell1