AntibodiesAutoimmunityPrevalenceReceptorsPemphigusAutoimmune DiseaseSerumPatientsImmunizationHypothyroidismHyperthyroidismAntigenInflammatoryAbnormalitiesLiverAcutePhenotypesProteinsViralTumorsInsulinBody'sClinicalAntibodyDiagnosticDiseasesBloodMembraneIncreasinglyProductionDrugCellsSpecificPositivePanelFeaturesCasesFormation
Antibodies11
- Auto-antibodies induced neurological diseases show various clinical phenotypes (see details in Table 1 ). (springer.com)
- however, rabbit antibodies raised against the recombinant proteins encoded by the gene of mouse bullous pemphigoid antigen 2 (BP180) are capable of inducing blisters in newborn mice in a complement-dependent manner. (medscape.com)
- By injecting the antibodies in a subcutaneous slow-release delivery formulation in the tumor area, we show that an eight-fold lower dose of antibody is as effective in inducing tumor eradication as systemic delivery. (aacrjournals.org)
- Autoantibodies (AAB) against nuclear and membrane structures as well as neurotransmitter receptors including muscarinic cholinergic receptor M3/M4-antibodies (M3-mAChR/M4-mAChR) and beta-1 and -2-adrenergic receptor (beta1-AR/beta2-AR) have been described in patients with ME/CFS ( 3 , 6 - 8 ). (frontiersin.org)
- The portant risk factor for the development of risk of lithium-induced antibodies increases subclinical hypothyroidism, 95% confi- with the duration of therapy and is more dence intervals (95% CI) were calculated. (who.int)
- There are lots of reviews that cross-linking antibodies (Abs) certain to the floor of B-lymphoma cells can induce apoptosis and/or cell dying, particularly with anti-CD20 Abs. (ncbcs.org)
- Self-reactive antibodies (autoantibodies) are usually weeded out at "tolerance checkpoints" as the B cell matures, but these self-defense tactics are far from perfect. (databasefootball.com)
- Our laboratory researches a rare and debilitating autoantibody-mediated disease called pemphigus vulgaris, in which the immune system generates antibodies against desmogleins, which are proteins responsible for holding skin cells together. (databasefootball.com)
- The focus of our laboratory's research program over the last decade has been to determine the pathways by which autoantibodies arise and to identify what features of the antibody gene or protein sequence separate disease-causing autoantibodies from the normal antibodies that protect from infection. (databasefootball.com)
- Normal serum contains IgG, IgM, and IgA antibodies, which are referred to as natural antibodies because they are induced without deliberate immunization and are independent of antigenic exposure. (medscape.com)
- Most people with PLAID have abnormal antibodies called autoantibodies in their blood. (medlineplus.gov)
Autoimmunity3
- Therefore, it was groups, hypothyroidism, hyperthyroidism, concluded that iodine may induce thyroid simple goitre, and a healthy control group autoimmunity in patients with endemic (no goitre and normal thyroid function). (who.int)
- Autoantibodies in Covid19 - A model for viral induced autoimmunity. (cdc.gov)
- Humoral and cellular studies are conducted first to detect a trigger that will induce beta cell autoimmunity in children at increased genetic risk. (lu.se)
Prevalence3
- Although estimates of the prevalence of opioid-induced constipation (OIC) vary widely, most experts agree that it occurs in up to half of patients treated with opioids. (medscape.com)
- ABSTRACT To compare the prevalence of positive autoantibodies in patients with thyroid disorders and healthy subjects in an iodine-replete area of the Islamic Republic of Iran, we studied 930 women in a clinic-based study: 698 patients (286 hypothyroid, 140 hyperthyroid, 272 with simple goitre) and 232 healthy women. (who.int)
- RBC autoantibody prevalence was 3.1% (7/228). (bvsalud.org)
Receptors2
- In patients with infection-triggered onset, the associations of low sCD26 with elevated autoantibodies (AAB) against alpha1 adrenergic (AR) and M3 muscarinic acetylcholine receptors (mAChR) point to a pathomechanism of infection-triggered autoimmune-mediated vascular and immunological dysregulation. (frontiersin.org)
- Blockade of macrophage Fc receptors is considered the primary mechanism of action of immune globulin in persons with ITP and other autoantibody-mediated cytopenias. (medscape.com)
Pemphigus6
- Whereas the pemphigus subset of diseases is mediated by autoantibodies that target the extracellular skin components that link one epidermal cell to another, the pemphigoid subset is mediated by autoantibodies that target the extracellular skin components that link the skin basement membrane components either to the lowermost layer of epidermal cells or to the dermal components. (medscape.com)
- Passive transfer experiments have demonstrated that purified autoantibodies from patients with the pemphigus group of diseases can induce blister formation when delivered to newborn mice. (medscape.com)
- Patients with pemphigus vulgaris are known to have autoantibodies of the IgA1, IgA2, IgG1, and IgG4 subclasses, with IgG4, in particular, being a marker of active disease. (databasefootball.com)
- Pemphigus foliaceus has the following 6 subtypes: pemphigus erythematosus (PE), pemphigus herpetiformis (PH), endemic pemphigus foliaceus, endemic pemphigus foliaceus with antigenic reactivity characteristic of paraneoplastic pemphigus (but with no neoplasm), immunoglobulin A (IgA) pemphigus foliaceus, and drug-induced pemphigus foliaceus. (medscape.com)
- Drug-induced pemphigus foliaceus is mostly associated with penicillamine, nifedipine, or captopril, medications with a cysteinelike chemical structure. (medscape.com)
- Superficial blisters in pemphigus foliaceus are induced by immunoglobulin G (IgG) (mainly IgG4 subclass) autoantibodies directed against a cell adhesion molecule, desmoglein 1 (160 kd), expressed mainly in the granular layer of the epidermis. (medscape.com)
Autoimmune Disease5
- Animal models of autoimmune diseases have shown lence of autoimmune disease in monozygotic twins show that infections can induce autoimmune disease. (cdc.gov)
- Genetic factors are important in the development of be induced by injecting mice with heart proteins mixed with autoimmune disease, since such diseases develop in cer- adjuvant(s), which indicates that an active infection is not tain strains of mice (e.g., systemic lupus erythematosus or necessary for the development of autoimmune disease. (cdc.gov)
- In several instances, such as rheumatoid arthritis, multiple sclerosis, and myocarditis, the autoimmune disease can be induced experimentally by administering self-antigen in the presence of adjuvant (col- lagen, myelin basic protein, and cardiac myosin, respec- tively) (3). (cdc.gov)
- Moreover, we showed that antigen specific Tregs are of much greater potency than polyclonal expanded Tregs, suppress autoimmune disease in an antigen specific manner, and, importantly, block the expansion of antigen specific T follicular helper cells, the key T cell subset for the development of autoantibodies. (lupusresearch.org)
- Autoimmune disease can attack almost any organ in the body including the skin, thyroid, brain, kidney, muscle, liver, and more, all due to autoantibodies wreaking havoc on the body's normal functions. (databasefootball.com)
Serum6
- This administration method is associated with very low serum levels of antibody, which decreases the risk of treatment-induced side effects. (aacrjournals.org)
- The median serum PRL was 98 (37-470) ng/mL in patients with positive thyroid autoantibodies, and 92 (40-470) ng/mL in patients who were negative (P = 0.975). (scielo.br)
- Serum autoantibodies to nervous system proteins develop in hens poisoned with neuropathic insecticides and also have not been studied after human poisoning. (cdc.gov)
- The profiles of serum autoantibodies to neurofilament triplet proteins, myelin basic protein, and glial fibrillary acidic protein were measured in order to characterize changes occurring as a result of OPIDP. (cdc.gov)
- Marked increases in serum immunoglobulin G (IgG) autoantibodies to glial fibrillary acidic protein and to neurofilament 200 were observed after the development of OPIDP. (cdc.gov)
- Serum autoantibody titers to nervous system proteins may be useful markers of neuropathy. (cdc.gov)
Patients13
- We hypothesized that the presence of autoantibodies may predict the risk of developing immune-related adverse events (irAEs) in patients with cancer receiving immune checkpoint inhibitors (ICIs). (mendeley.com)
- We aimed to assess the diagnostic performance of a battery of autoantibodies to predict irAEs in patients with cancer receiving ICIs. (mendeley.com)
- However, hIgG from patients with detectable TRAb (TRAb-hIgG) (n = 13) induced a doserelated increase in extracellular cAMP (maximum effect at 0.1 mg/ml) and a 3-fold increase in human thyroid cell growth over a 4-day period (maximum effect at 1.5 mg/ml). (elsevierpure.com)
- Furthermore, anti-BP180 autoantibodies from patients affected with BP are capable of inducing dermal-epidermal separation in cryosections of normal human skin, further supporting the pathogenic role of BP180. (medscape.com)
- It has been reported that patients experiencing side effects of amiodarone (AM) therapy, such as amiodarone-induced thyrotoxoco. (nel.edu)
- Patients with chronic hepatitis type C and interferon-alpha-induced hyperthyroidism in two-years clinical follow-up. (nel.edu)
- Though only present in 30-40% of SLE patients, compared to less specific autoantibody targets, Sm represents the best opportunity for antigen-specific immune regulation in SLE. (lupusresearch.org)
- Patients with fenoprofen induced liver injury should avoid other propionic acid derivatives such as flurbiprofen, ibuprofen, ketoprofen and naproxen. (nih.gov)
- In 100 control subjects, matched by age and gender with HPRL patients, thyroid USG, thyroid function tests (TFTs), and autoantibody panel were obtained. (scielo.br)
- Forty-six patients (46%) and 50 (50%) controls had one or more of the features of thyroid disorder, which were goiter, positive thyroid autoantibody, and thyroid function abnormality (P = 0.888). (scielo.br)
- RÉSUMÉ Nous avons examiné la fonction thyroïdienne chez 46 patients (20 femmes et 26 hommes) des consultations psychiatriques externes traités au lithium en évaluant le taux de triiodothyronine, de thyroxine et de thyréostimuline hypophysaire (TSH). (who.int)
- Dharmalingam B, Singh P, Schramm P, Birklein F, Kaps M, Lips KS, Szalay G, Blaes F, Tschernatsch M. Autoantibodies from patients with complex regional pain syndrome (CRPS) induce pro-inflammatory effects and functional disturbances on endothelial cells in vitro. (uni-giessen.de)
- The high content of anti-idiotypes against autoantibodies in IVIG facilitates its ability to neutralize autoantibodies, as is shown in patients with acquired hemophilia due to autoantibodies against factor VIII. (medscape.com)
Immunization2
- Immunization with vesicular stomatitis virus nucleocapsid protein induces autoantibodies to the 60 kD Ro ribonucleoprotein particle. (ouhsc.edu)
- Furthermore, experimentally, immunization with Sm polypeptides induce SLE-like features. (lupusresearch.org)
Hypothyroidism1
- The role of antithyroglobulin, antiperoxidase and anti-TSH receptor autoantibodies in amiodarone-induced thyrotoxicosis and amiodarone-induced hypothyroidism (A two-center study). (nel.edu)
Hyperthyroidism1
- Graves' disease encompasses hyperthyroidism and a diffuse goiter associated with autoantibodies to the TSH receptor (TRAb). (elsevierpure.com)
Antigen3
- We hypothesized that "autoimmune encephalitides" may result from any brain inflammation concurring with the presence of brain antigen-directed autoantibodies, e.g., against N-methyl-D-aspartate-receptor NR1 (NMDAR1-AB), which are not causal of, but may considerably shape the encephalitis phenotype. (nature.com)
- Autoantibodies specific for the Sm antigen are strongly associated with disease severity in SLE. (lupusresearch.org)
- Sm specific T cells play an important role in class switching anti-Sm autoantibodies and participate as disease effectors, and anti-Sm autoreactivity is strongly associated with the human leukocyte antigen (HLA)-DR15. (lupusresearch.org)
Inflammatory3
- NK cell-derived GM-CSF potentiates murine autoantibody-induced inflammatory arthritis and is negatively regulated by CIS. (edu.au)
- Our data indicate that the Sia + fraction of IVIG possesses the ability to influence inflammatory processes in multiple immune cell types and induces novel signatures in cell surface marker expression and cytokine/chemokine production. (scirp.org)
- As mentioned above, IgG4 is typically considered an anti-inflammatory antibody, induced during states of chronic immune stimulation to dampen disease. (databasefootball.com)
Abnormalities1
- A widely unexplored field in humans, though clearly documented in rodents, is genetic brain inflammation, particularly that associated with myelin abnormalities, inducing primary white matter encephalitis. (nature.com)
Liver4
- Laboratory markers of liver function were measured before, during, and after duloxetine-induced liver injury. (psychiatrist.com)
- This case offers an example of acute drug-induced liver injury occurring after a dosage increase of duloxetine. (psychiatrist.com)
- LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. (nih.gov)
- Fenoprofen is not mentioned in large case series on drug induced liver injury or acute liver failure. (nih.gov)
Acute2
- Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is a new syndrome associated with the ChAdOx1 nCoV-19 adenoviral vector vaccine against severe acute respiratory syndrome coronavirus 2. (nih.gov)
- Neuropathy target esterase (NTE), the putative target enzyme for organophosphate induced delayed polyneuropathy (OPIDP), can be measured in lymphocytes but has rarely been assessed in acute human poisoning. (cdc.gov)
Phenotypes1
- ccD.Ee phenotypes accounted for 82% of the Rhesus phenotypes and all were Kell negative.Conclusion: The numbers of transfusions and the rates of RBC alloantibodies are low and the most important RBC alloantibody-inducing blood group antigens are relatively homogeneously distributed in this population. (bvsalud.org)
Proteins1
- Autoantibodies attach to normal proteins and can trigger an immune attack against the body's own tissues. (medlineplus.gov)
Viral1
- Tests results for viral hepatitis and autoantibodies were negative. (psychiatrist.com)
Tumors1
- Common solid tumors that have been linked to cancer-induced TMA include gastric, breast, lung, and prostate adenocarcinomas, with gastric adenocarcinoma being the most reported. (hindawi.com)
Insulin1
- Major observations suggest that the association between HLA and autoimmune (type 1) diabetes is secondary to the first appearing autoantibody be it against insulin in children with HLA DR4-DQ8 or GAD65 in children with HLA DR3-DQ2. (lu.se)
Body's1
- When ANCAs (the autoantibodies) adhere to neutrophils, they attack the body's tiny arteries. (medicinenet.com)
Clinical1
- Objectives We systematically reviewed the literature to identify evidence-informed recommendations regarding the detection of drug-induced pancreatitis (DIP) and, secondarily, to describe clinical processes for the diagnosis of DIP. (bmj.com)
Antibody1
- This mini-review summarizes the pathophysiological mechanisms and aims to establish the basis of "auto-antibody-induced cerebellar synaptopathies. (springer.com)
Diagnostic1
- Primary studies that may have used a drug-induced pancreatitis (DIP) diagnostic process but that were not indexed in databases using vocabulary related to DIP would not have been captured by our search. (bmj.com)
Diseases1
- As a group, autoimmune blistering skin diseases are recognized as autoantibody-mediated diseases. (medscape.com)
Blood1
- Most people don't have these ANCAs (autoantibodies that attack small blood vessels). (medicinenet.com)
Membrane1
- In persons with dermatomyositis, IVIG induces a decrease in plasma levels of membrane attack complex and a substantial decrease in the amounts of C3b and membrane attack complex deposited in endomysial capillaries. (medscape.com)
Increasingly1
- Drug-induced thrombotic microangiopathies (DTMAs) are increasingly being recognized as an important category of thrombotic microangiopathies (TMAs). (hindawi.com)
Production4
- Consumption of oats does not induce TG2 autoantibody production at mucosal level in children with celiac disease. (greenmedinfo.com)
- Exposure to amphibole asbestos fibers is linked to the production of autoantibodies. (medscape.com)
- Micrographs of newly described membranes vesicles that induce autoantibody production and accelerate rejection are shown. (genengnews.com)
- In macrophage-colony stimulating factor (MCSF) generated macrophages, Sia + IgG induced increased production of numerous cytokines/ chemokines including IL-6, TNFα, CXCL1, and IL-10, and the expression of the macrophage surface marker CD163. (scirp.org)
Drug3
- Drug-induced vasculitis and renal-limited vasculitis are other conditions linked to ANCA. (medicinenet.com)
- TMA caused by drugs is called drug-induced TMA (DTMA) [ 4 ], and cancer therapeutic agents are among the most common medications reported to cause DTMA. (hindawi.com)
- Common anticancer chemotherapeutic agents causing drug-induced thrombotic microangiopathy via immune-mediated mechanism or dose-dependent toxicity or both [ 4 , 7 ]. (hindawi.com)
Cells2
- The tiny vesicles derive from dying cells and produce autoantibodies. (genengnews.com)
- This protocol describes steps for cloning HA- and FLAG-tagged GPCRs, transient transfection of CHO-K1 or HEK293-T cells, and determination of basal and ligand-induced changes in intracellular cAMP levels. (bvsalud.org)
Specific1
- Under basal thyroid cell culture conditions there were detectable, but low, levels of mRNA specific for the protooncogene c-fos, and this was markedly, and rapidly, induced by the addition of TRAb-hlgG but not normal hlgG. (elsevierpure.com)
Positive1
- In addition, there are instances showing mixed features of DI-AIH and IM-DILI, as well as DILI cases with positive autoantibodies. (wjgnet.com)
Panel1
- The commercially available panel of testing for autoantibodies in CSF was negative. (medscape.com)
Features1
- Immunoallergic features are present in some cases (low grade fever, rash), but are generally not prominent, and autoantibody formation is rare. (nih.gov)
Cases1
- A In most cases lithium-induced hypothy- questionnaire was completed for each pa- roidism is subclinical [ 4-6 ]. (who.int)
Formation1
- MuSK mediates the agrin-induced clustering of AChRs during synapse formation, and is also expressed at the mature neuromuscular junction. (nih.gov)