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  • acute lymphobl
  • With the approval of immune checkpoint-blocking antibodies for Hodgkin lymphoma and bispecific antibodies for acute lymphoblastic leukemia (ALL), activation of endogenous T cells already plays a role in several lymphoid malignancies. (springer.com)
  • refractory
  • Porter DL et al (2016) Randomized, phase II dose optimization study of chimeric antigen receptor (CAR) modified T cells directed against CD19 in patients (pts) with relapsed, refractory (R/R) CLL. (springer.com)
  • Based on this underlying treatment concept and on promising data taken from preclinical results and a small pilot study, an open-label, non-randomized, uncontrolled, dose-escalating phase I/II-study is conducted to evaluate safety and preliminary efficacy of the investigational antibody FBTA05 in combination with DLI for patients suffering from rituximab- and/or alemtuzumab-refractory, CD20-positive low- or high-grade lymphoma after allogeneic SCT. (biomedcentral.com)
  • multipotent stem
  • In mature adult tissues, we find adult multipotent stem cells, which are generally only able to renew and regenerate tissues from the embryonic layer of which they come. (intechopen.com)
  • therapeutic
  • We also provide insights on the pathogenesis of neonatal lung disease, as modulated by hyperoxia and microbial product-induced changes in exosomal miRNA 876-3p, which could be targeted for future therapeutic development. (jci.org)
  • They are able to generate cell lines derived from any of the three embryonic germ layers (ectoderm, mesoderm and endoderm), giving them great therapeutic potential. (intechopen.com)
  • However, based on the so‐called phenomenon of cellular plasticity, in some instances, they can differentiate into cell populations different to those of their embryonic origin, providing many therapeutic options [ 16 ]. (intechopen.com)
  • A variety of therapeutic options are now available for advanced renal cell cancer, including antiangiogenic and anti-mTOR agents. (jcancer.org)
  • proliferation
  • Furthermore, in the latter, the increased inhibition of T-cell proliferation was positively correlated with IDO gene expression and negatively correlated with SDF1 gene expression. (cognizantcommunication.com)
  • organ
  • Exosomes and exosomal miRNAs may regulate cell differentiation and tissue and organ development. (jci.org)
  • Thymoglobuline is a polyclonal rabbit antiserum specific for human T cells used in organ transplantation for induction of tolerance and rejection prevention and treatment. (clinicaltrials.gov)
  • clinical
  • The transfer of HAdV-specific donor T cells in patients with HAdV viremia has been evaluated in several clinical phase I/II trials and preliminary data suggest that this approach may be feasible and effective. (springer.com)
  • The goal of this clinical research study is to learn if giving donor lymphocyte cells and SGI-110 will help control AML and MDS. (bioportfolio.com)
  • The clinical improvement of this patient was accompanied by a decreased B cell population together with an increased frequency of regulatory B cells (Bregs) and Tregs after MSC treatment. (frontiersin.org)
  • chemotherapy
  • Intensive chemotherapy followed by stem cell support has improved survival of patients with chemotherapy sensitive lymphoma. (biomedcentral.com)
  • In this trial, Bucaneve and colleagues evaluated prophylactic levofloxacin in 675 hospitalized adult patients (46 had nonhematologic cancer) in whom profound and prolonged chemotherapy-induced neutropenia was expected. (acpjc.org)
  • survival
  • Deletion of the Ppl gene in mice improved survival and reduced lung fibrosis development after bleomycin-induced injury. (jci.org)
  • antigen
  • development of hematopoietic stem cells and T-cells activity during aging as well as understanding antigen recognition mechanisms by their receptors and its coupling to cellular response in mast cells as a model. (weizmann.ac.il)
  • Periplakin is strongly expressed by epithelial cells in the lung and is a target antigen for autoimmunity in idiopathic pulmonary fibrosis. (jci.org)
  • Adenovirus-specific CD4+ T cell clones recognizing endogenous antigen inhibit viral replication in vitro through cognate interaction. (springer.com)