Induce adenovirus vaccines. Medical search. Frequent questions

These data indicate that an adenoviral vector strategy can induce sustained T cell responses of a magnitude and quality associated with protective immunity and open the way for studies of prophylactic and therapeutic vaccines for HCV. (ox.ac.uk)
Many vaccines that stimulate both cell-mediated immunity and neutralizing antibodies (e.g., live, attenuated virus vaccines) can usually induce prolonged immunity, even if antibody titers decline over time ( 3 ). (cdc.gov)
Since the start of the COVID-19 outbreak, the race for testing new platforms designed to confer immunity against SARS-CoV-2, has been rampant and unprecedented, leading to conditional emergency authorization of various vaccines. (researchgate.net)
To circumvent the negative effect of preexisting immunity to common human serotypes of adenoviruses on the efficacy of adenovirus vaccine carriers, we developed vectors based on chimpanzee-derived adenoviruses C68, C6, and C1 ( 8 ). (cdc.gov)
Thus, monocyte depletion by gemcitabine administration reduced the generation of these DC and increased vaccine-induced immunity, which rejected about 20% of LLC-OVA and B16-OVA tumors, which are non-responders to anti-PD-1. (unav.edu)
In addition, the investigational vaccine appeared to induce strong, long-lasting immunity to the MARV glycoprotein: 95% of participants in the trial exhibited a robust antibody response after vaccination, and 70% maintained that response for more than 48 weeks. (sflorg.com)
Indeed, the use of peptides for eliciting specific antitumor adaptive immunity is hindered by two main limitations: the efficient selection of the most optimal candidate peptides and the use of a highly immunogenic platform to combine with the peptides to induce effective tumor-specific adaptive immune responses. (elifesciences.org)
Lokon's oncolytic adenovirus platform encodes human immunostimulatory genes to induce anti-tumor immunity in cancer patients. (nordiclifescience.org)
The laboratory developed an adenovirus-based vaccine against rabies virus that can provide rapid immunity following a single administration. (wistar.org)
Recombinant adenovirus vaccines should therefore aim at replicating the naturally occurring PPRV immunity. (biomedcentral.com)
It's possible that some people develop a strong T cell immunity independent from antibody immunity, and there is published data indicating that the Johnson & Johnson vaccine elicits a strong T cell response. (cedars-sinai.edu)
Currently available commercial vaccines for leptospirosis are quite effective by providing serovar specific immunity and are used in many developed countries (Wang et al. (biocoreopen.org)
We developed a mathematical model that considers both subpopulations and immunity parameters including vaccination rates, vaccine effectiveness, and a gradual loss of protection. (cdc.gov)
Our results show that a combination of strengthening vaccine-induced immunity and preventative behavioral measures will likely be required to deaccelerate the rise of infectious SARS-CoV-2 variants. (cdc.gov)

Recommendations for the age at which vaccines are administered are influenced by age-specific risks for disease, age-specific risks for complications, age-specific responses to vaccination, and potential interference with the immune response by passively transferred maternal antibodies. (cdc.gov)
Approximately 90%-95% of recipients of a single dose of certain live vaccines administered by injection at the recommended age (i.e., measles, rubella, and yellow fever vaccines) develop protective antibodies, generally within 14 days of the dose. (cdc.gov)
But a disadvantage is that those who have been exposed to natural forms of the adenovirus have antibodies to the virus that will likely block the synthesis of the spike protein, and therefore not afford protection against SARS-CoV-2. (theepochtimes.com)
There is also the risk that the vaccines will accelerate the emergence of new strains of the virus that are no longer sensitive to the antibodies produced by the vaccines. (theepochtimes.com)
Studies have shown that mRNA vaccines are effective in COVID-19 mitigation, and induce anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) antibodies. (news-medical.net)
Human sera from the United States, Thailand, and sub-Saharan Africa and chimpanzee sera were tested for neutralizing antibodies to 3 chimpanzee adenoviruses. (cdc.gov)
However, immune responses induced by AdHu5 vectors are reduced by preexisting AdHu5-neutralizing antibodies found in humans in the United States ( 4 - 7 ). (cdc.gov)
We previously showed that neutralizing antibodies to chimpanzee adenoviruses are rarely found in US residents ( 6 ). (cdc.gov)
Because vaccines to HIV-1 are most urgently needed in sub-Saharan Africa, we evaluated the prevalence of neutralizing antibodies to chimpanzee adenoviruses in sera from humans residing in 3 sub-Saharan countries with natural habitats for chimpanzees: Nigeria, Cameroon, and Côte d'Ivoire. (cdc.gov)
None of the samples from 50 US zoo workers, including those who reported regular contact with primates, had detectable antibodies to chimpanzee adenoviruses. (cdc.gov)
In contrast, serum samples from sub-Saharan African cohorts had higher prevalences of neutralizing antibodies to chimpanzee adenoviruses ( Figure , Table 1 ). (cdc.gov)
The vaccine, which used an adenovirus to smuggle instructions into human cells to make antibodies against the novel coronavirus, saved countless lives. (allafrica.com)
Next-generation vaccines that utilize T cells could potentially overcome the limitations of current influenza vaccines that rely on antibodies to provide narrow subtype-specific protection and are prone to antigenic mismatch with circulating strains. (mdpi.com)
CONCLUSION: These results demonstrate that, while the transmembrane bacterial proteins expressed by the viral vector induced strong and persistent antigen-specific antibodies, this platform failed to induce bactericidal antibodies. (ox.ac.uk)
More than 90% of IBD patients in the study produced antibodies in response to COVID-19 vaccines, regardless of vaccine type and whether they were taking immune-modifying medications, a result that Melmed called reassuring. (cedars-sinai.edu)
The Johnson & Johnson vaccine relies on modified adenovirus-a common virus that causes cold and flu symptoms-to deliver genetic code for the SARS-CoV-2 signature spike protein to cells, causing the immune system to produce antibodies that protect against it. (cedars-sinai.edu)
Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies. (ox.ac.uk)
Vaccines for other coronaviruses have never been approved for humans, and data generated in the development of coronavirus vaccines designed to elicit neutralizing antibodies show that they may worsen COVID-19 disease via antibody-dependent enhancement (ADE) and Th2 immunopathology, regardless of the vaccine platform and delivery method [9-11]. (virutron.com)

However, data on the long-term trajectory of IgG responses to mRNA vaccine doses are limited. (news-medical.net)
Further, sera from another cohort were analyzed to compare the immunogenicity of the heterologous and homologous regimens using the adenoviral vector-based ChAdOx1 vaccine and Comirnaty mRNA vaccine. (news-medical.net)
Dr. Robert Malone, identified in the video as the inventor of mRNA vaccine technology, said he sent "manuscripts" months ago to the U.S. Food and Drug Administration claiming the spike protein posed a health risk. (politifact.com)
Pfizer/BioNTech is a mRNA vaccine. (bizcommunity.com)
A similar mRNA vaccine, made by Moderna, has shown comparable results. (bizcommunity.com)
Efficacy of 95% has been reported for the Pfizer/BioNTech (mRNA) vaccine, far exceeding the expectations. (bizcommunity.com)
If licensed, it will be the first mRNA vaccine approved for human use by the regulatory authorities. (bizcommunity.com)
The company's Phase II trial is investigating its vaccine as a booster dose in people who have previously received an mRNA vaccine in their primary series. (clinicaltrialsarena.com)

Vaccines are generally recommended for members of the youngest age group at risk for experiencing the disease for which vaccine efficacy and safety have been demonstrated. (cdc.gov)
Rapid clearance and reduced cell entry thus lead to decreased amount of oncolytic adenovirus in target cells and decreased efficacy. (helsinki.fi)
This testing helps to demonstrate safety in diverse human populations living in different settings, and to determine vaccine efficacy - the ability to prevent infection and disease. (bizcommunity.com)
This includes phase III trials - the point at which scientists aim to determine how well a vaccine protects (efficacy) trial participants from infection or severe Covid-19 symptoms. (bizcommunity.com)
Vaccines that aim to expand tumor-specific CD8 (+) T cells have yielded disappointing results in cancer patients although they showed efficacy in transplantable tumor mouse models. (wistar.org)
Also, while there are regulatory agencies that are more conservative and would demand such large-scale registrational trials, there may be others who would be open to efficacy endpoints that demonstrate competitive rates of neutralising antibody titers versus an approved vaccine, or even a challenge trial design, he adds. (clinicaltrialsarena.com)
In Phase 3, the vaccine is given to thousands of people and tested for efficacy and again for safety. (bnlpulse.com)
We are currently testing simian adenovirus (ChAd63) and poxvirus (MVA) viral vectored vaccines expressing the transmission-blocking vaccine candidate Pfs25 fused to a multimerisation domain (IMX313) in human clinical trials to assess the it's safety, immunogenicity and ex vivo efficacy. (ox.ac.uk)
A group of 57 leading scientists, doctors and policy experts has released a report calling in to question the safety and efficacy of the current COVID-19 vaccines and are now calling for an immediate end to all vaccine programs. (virutron.com)
There are still far too many questions about the safety, efficacy, and necessity of the Covid-19 vaccines that have not been addressed. (conservativeplaybook.com)
How does the efficacy of the AstraZeneca vaccine compare with the efficacy of other COVID-19 vaccines? (who.int)
Data subsequently reviewed by the WHO SAGE shows that the efficacy of the AZ vaccine is enhanced when the interval between the first and second dose of vaccine is increased. (who.int)
The vaccine efficacy when the two doses were given at an interval of 12 weeks was 81.3% (95% CI 60, 91). (who.int)
As with other COVID-19 vaccines, the efficacy of the AZ vaccine increases with increasing disease severity. (who.int)
GI Involvement May Signal Risk for MIS-C After COVID Dr William Balistreri comments on data linking gastrointestinal symptoms to this life-threatening complication, and COVID vaccines' efficacy at preventing it. (medscape.com)

Two (the Moderna vaccine and the Pfizer/BioNTech vaccine) are based on mRNA technology, whereas the other two (produced by Johnson & Johnson and AstraZeneca) are based on a double-stranded DNA recombinant viral vector. (theepochtimes.com)
Experts say there is no evidence that the spike proteins produced by the Moderna and Pfizer vaccines, or the spike protein created by genetic material in the Johnson & Johnson vaccine, are toxic. (politifact.com)
But the mRNA vaccines, from Moderna and Pfizer-BioNTech, contain neither the virus nor the spike protein - just the genetic instructions for the body to make the spike protein associated with the coronavirus. (politifact.com)
All three - Pfizer/BioNTech , Moderna mRNA-1273 and Oxford ChAdOx1-S vaccines - are in the late stage of phase III clinical trials. (bizcommunity.com)
They are highly effective, cheap, and much easier to store and transport than mRNA vaccines - such as the Pfizer-BioNTech and Moderna jabs. (allafrica.com)
The two-dose mRNA vaccines, produced by Pfizer-BioNTech or Moderna, are preferred rather than the single-dose, adenovirus-vector vaccine from Johnson & Johnson (Janssen). (heart.org)
In fact, two COVID-19 vaccines developed by Pfizer and Moderna, are 95% and 94.1% effective, respectively, at preventing an infection with the novel coronavirus causing COVID-19. (livescience.com)
The MRNA-1273 vaccine developed by Kaiser Permanente Washington Health Research Institute, Washington and taken up for production by the US-based Moderna pharmaceutical is just a step behind. (netindian.in)
In contrast, the Pfizer-BioNTech and Moderna are mRNA vaccines that deliver SARS-CoV-2 genetic code directly to host cells in the body. (cedars-sinai.edu)

The recently identified role of SARS-CoV-2 Spike glycoprotein for inducing endothelial damage characteristic of COVID-19, even in absence of infection, is extremely relevant given that most of the authorized vaccines induce endogenous production of Spike. (researchgate.net)
These vaccines have been developed "at warp speed," given the urgency of the situation with the COVID-19 pandemic. (theepochtimes.com)
Thus far, there are four different vaccines that have been approved for emergency use for protection against COVID-19 in the US and/or Europe. (theepochtimes.com)
In addition, IgG4 responses were not induced post-heterologous or homologous doses of the COVID-19 adenovirus-vectored vaccines. (news-medical.net)
The COVID-19 vaccines' "spike protein is very dangerous, it's cytotoxic. (politifact.com)
Vials of Johnson & Johnson COVID-19 vaccine sit in the pharmacy of National Jewish Hospital for distribution on March 6, 2021, in east Denver. (politifact.com)
The headline on a YouTube video and a person who speaks in it make a troubling claim about the way the COVID-19 vaccines work. (politifact.com)
We rated False Bridle's claim that the COVID-19 vaccines' spike protein means people are being inoculated "with a toxin. (politifact.com)
COVID-19 vaccines work by triggering the human body's natural immune response, without introducing a form of the COVID-19 virus itself. (politifact.com)
Rise in U.S. infant mortality rate connected to COVID-19 vaccines. (politifact.com)
The Johnson & Johnson vaccine contains a modified adenovirus - not the COVID-19 virus - with a gene that induces cells to produce the spike protein, said vaccine expert Dr. Walter Orenstein at Emory University. (politifact.com)
We are not aware of any published cases of initial MS manifestation after vaccination with Pfizer-BioNTech COVID-19 vaccine. (springer.com)
Scientists are working around the clock to develop and test vaccines against SARS-CoV-2, the causative agent of Covid-19. (bizcommunity.com)
Experts agree that widespread use of safe and effective vaccines will rapidly contain the Covid-19 pandemic , preventing transmission and disease. (bizcommunity.com)
Globally, Covid-19 vaccine trials are being conducted in all continents, representing all diverse human populations in the world. (bizcommunity.com)
To date there are 260 Covid-19 vaccine candidates at different stages of development. (bizcommunity.com)
Resources will be urgently needed to procure and distribute Covid-19 vaccines at a rapid pace. (bizcommunity.com)
This is overseeing the pooling of procurement and equitable distribution of eventual Covid-19 vaccines. (bizcommunity.com)
This mRNA-based Covid-19 vaccine induces T-cell and strong neutralising antibody immune responses. (bizcommunity.com)
The U.S. recommended a "pause" in use of the single-dose Johnson & Johnson COVID-19 vaccine on Tuesday to investigate reports of rare, but potentially dangerous blood clots, setting off a chain reaction and dealing a setback to the vaccination campaign. (medpagetoday.com)
The Oxford AstraZeneca Covid-19 vaccine. (allafrica.com)
AstraZeneca in partnership with the University of Oxford developed one of the first vaccines against COVID. (allafrica.com)
Ertl's research centers on developing vaccines for an array of diseases and conditions-including AIDS , chronic viral infections, COVID -19 and some forms of cancer-not typically considered to be treated using this approach. (wistar.org)
Oral Covid vaccine: can Vaxart overcome clinical trial obstacles? (clinicaltrialsarena.com)
Vaxart oral Covid-19 vaccine: could trial execution obstacles delay market entry? (clinicaltrialsarena.com)
Vaxart's Covid-19 vaccine tablet has a coating that allows it to withstand the low pH in the stomach. (clinicaltrialsarena.com)
Vaxart is aiming to be a vital player in boosting vaccination rates with its oral Covid-19 vaccine. (clinicaltrialsarena.com)
There is still unmet need, with only 53% of the world's population receiving at least one dose of a Covid-19 vaccine. (clinicaltrialsarena.com)
The California-based company's Covid-19 vaccine tablet (VXA-CoV2-1.1-S) has the obvious convenience advantage of not needing a cold chain protocol, as well as doing away with needles, syringes and vials. (clinicaltrialsarena.com)
At this point of the pandemic, it will be "incredibly difficult" for companies with unvalidated Covid-19 vaccine mechanisms that are still in early-phase clinical trials to gain regulatory support, Petrovsky says. (clinicaltrialsarena.com)
The American Heart Association continues to align with expert guidance from the U.S. Centers for Disease Control and Prevention (CDC) , the nation's infectious disease experts, regarding COVID-19 vaccines and boosters. (heart.org)
Last Thursday, the CDC recommended the mRNA COVID-19 vaccines as the preferred vaccines for most adults. (heart.org)
also known as vaccine induced thrombocytopenia with thrombosis, or VITT) after receiving the Johnson & Johnson COVID-19 vaccine. (heart.org)
Cases of TTS occurred several days after being vaccinated with the one-dose Johnson & Johnson COVID-19 vaccine. (heart.org)
The CDC's latest data indicate that TTS is a rare, yet serious, possible side effect after receiving the Johnson & Johnson COVID-19 vaccine. (heart.org)
Individuals who receive the Johnson & Johnson COVID-19 vaccine should be monitored for symptoms of TTS and seek immediate treatment," said American Heart Association volunteer expert and co-author of the Association's April 2021 special report on TTS, Mary Cushman, M.D., M.Sc. (heart.org)
The American Heart Association/American Stroke Association, a global force for longer, healthier lives for all, affirms the CDC's guidance on COVID-19 vaccines and boosters. (heart.org)
The Association continues to recommend all adults and children ages 5 and older in the U.S. to receive the COVID-19 vaccine as soon as they are eligible, as recommended by the CDC and fully approved or authorized for emergency use by the FDA. (heart.org)
The COVID-19 pandemic served as an unexpected proof of concept for mRNA vaccines. (livescience.com)
Days before her 91st birthday, Margaret Keenan became the first person in the world to receive the Pfizer-BioNTech COVID-19 vaccine outside of clinical trials. (livescience.com)
But the COVID-19 pandemic served as an unexpected proof of concept for mRNA vaccines, which, experts told Live Science, have the potential to dramatically reshape vaccine production in the future. (livescience.com)
Margaret Keenan, 90, is applauded by staff as she returns to her ward after becoming the first person in the U.K. to receive the Pfizer/BioNtech COVID-19 vaccine on Dec. 8, 2020. (livescience.com)
COVID-19 has really "laid the foundation" for rapid production of new vaccines, such as mRNA vaccines, to fight future pathogens, said Maitreyi Shivkumar, a virologist and senior lecturer in molecular biology at De Montfort University in Leicester, England. (livescience.com)
Both these firms have already inked an agreement with Indian manufacturers for production of the COVID vaccines. (netindian.in)
With the primary scientific inputs coming from institutions like Pune-based ICMR institution National Institute of Virology and Hyderabad-based CSIR institution Centre for Cellular and Molecular Biology, six Indian companies are working on a vaccine for COVID-19. (netindian.in)
Cedars-Sinai investigators recently looked into whether IBD patients are likely to experience side effects from the COVID-19 vaccines. (cedars-sinai.edu)
Because immune system malfunction is one possible cause of IBD, and patients are often treated with immune-modifying medications, there has been concern that vaccines might not produce a sufficient immune response in these patients to protect them against COVID-19. (cedars-sinai.edu)
It's also not clear how well the vaccine would perform in older people who are more at risk of severe disease from Covid-19. (bnlpulse.com)
Participants received the Covid-19 vaccine or a meningitis vaccine. (bnlpulse.com)
The responses measured in the blood and the absence of serious harms indicate there is a possibility of an effective vaccine against Covid-19. (bnlpulse.com)
There are two certainties regarding the global distribution of Covid-19 vaccines. (virutron.com)
It has been prepared by nearly five dozen highly respected doctors, scientists, and public policy experts from across the globe to be urgently sent to world leaders as well as all who are associated with the production and distribution of the various Covid-19 vaccines in circulation today. (virutron.com)
This may be the most important document ever written about the Covid-19 vaccines. (conservativeplaybook.com)
There are two certainties about the Covid-19 vaccines being mass-distributed around the world. (conservativeplaybook.com)
I'd like to welcome you to today's COCA Call: Johnson and Johnson Janssen COVID-19 Vaccine and Cerebral Venous Sinus Thrombosis with Thrombocytopenia -- Update for Clinicians on Early Detection and Treatment. (cdc.gov)
Shimabukuro, a medical officer and the Vaccine Safety Team lead as part of CDC's COVID-19 response. (cdc.gov)
Practices COVID-19 Vaccines Workgroup as part of CDC's COVID-19 response. (cdc.gov)
Today I'll be discussing some background on the CVST situation and then move into a description of the reports of cerebral venous sinus thrombosis with thrombocytopenia following the Janssen COVID-19 vaccine. (cdc.gov)
So, the discussion around this issue or awareness of this issue originated from reports of a rare but serious condition following AstraZeneca's COVID-19 vaccine, and this condition initially recognized was CVST in the presence of thrombocytopenia, so, blood clots in the brain with low platelets. (cdc.gov)
The Europeans have looked into this and have issued several guidance documents both broadly, you know, the European Medicines Agency and also, individual countries have issued documents stating their findings about a possible link between this rare condition and vaccination with AstraZeneca's COVID-19 vaccine. (cdc.gov)
The Astra Zeneca COVID-19 vaccine (also named generical y ChAdOx1 vaccine) was approved by WHO under Emergency Use Listing (EUL) on 15 February 2021. (who.int)
The WHO's GACVS wil continue to review the safety data from all COVID-19 vaccines and update any advice as necessary and supports the EMA's plans to further investigate and monitor for any adverse events. (who.int)
Prior receipt of any vaccines administered =30 days before enrolment and/or planned receipt of a vaccine =30 days after enrolment EXCEPT for protein, RNA (or other non-adenovirus based) COVID-19 vaccinations which may be given within 14 days of the trial vaccine. (who.int)

Intranasal administration with a single dose of a chimpanzee adenovirus-vectored SARS-CoV-2 vaccine induces potent immune responses. (virology.ws)

In this regard, the AstraZeneca (AZ) vaccine has a slight advantage over the Johnson & Johnson (J&J) vaccine because the virus normally infects chimpanzees rather than humans, so fewer people are likely to have been exposed to it. (theepochtimes.com)
Early results of a closely watched Phase 1/2 trial published in The Lancet suggest a coronavirus vaccine developed by the University of Oxford and AstraZeneca is safe and induces an immune response. (bnlpulse.com)
Phase 2/3 trials of the Oxford/AstraZeneca vaccine are currently underway in the UK, Brazil and South Africa, and later-phase trials are expected to start in the United States in August. (bnlpulse.com)
And I just want to -- I should have mentioned on the previous page that the AstraZeneca vaccine is a chimpanzee adenoviral vector vaccine. (cdc.gov)
This includes two vaccines products referred to as AZ/AZD1222 (produced by AstraZeneca-SKBio in the Republic of Korea) and SII/Covishield produced by the Serum Institute of India (SII). (who.int)
How safe is the AstraZeneca vaccine? (who.int)
Data from the clinical trials on the AstraZeneca (AZ) vaccine among 24,244 participants showed that the majority of adverse reactions reported after administration were mild to moderate in severity and usual y resolved within a few days of vaccination. (who.int)

Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man. (ox.ac.uk)
To enhance vaccine potency and improve thus responses to ICI, we analyzed the gene expression profile of an immunosuppressive dendritic cell (DC) population induced during vaccination, with the goal of identifying druggable inhibitory mechanisms. (unav.edu)
This vaccine uses a modified chimpanzee adenovirus called cAd3, which can no longer replicate or infect cells, and displays a glycoprotein found on the surface of MARV to induce immune responses against the virus. (sflorg.com)
Volunteers were monitored for adverse reactions to the investigational vaccine and evaluated at regular intervals for 48 weeks to track their immune responses. (sflorg.com)
If additional data supports the promising results seen in the Phase 1 trial, the cAd3-Marburg virus vaccine could someday be used in emergency responses to MARV outbreaks. (sflorg.com)
The vaccines are being tested for T and B cell responses in mice. (wistar.org)
Using a system that more faithfully mimics a progressing cancer and its immunoinhibitory microenvironment, we show that in transgenic mice, which gradually develop adenocarcinomas due to expression of HPV -16 E7 within their thyroid, a highly immunogenic vaccine expressing E7 only induces low E7 -specific CD8 (+) T-cell responses, which fail to affect the size of the tumors. (wistar.org)
Also, as Vaxart chief scientific officer Sean Tucker points out, the vaccine has the additional potential benefit of sidestepping unwanted antivector responses as expected with other adenovirus-vectored vaccines. (clinicaltrialsarena.com)
At week 4, vaccine antigen-specific T cell responses were detected in 28 (93.3%) and 18 (60%) of 30 vaccine recipients for CD4(+) and CD8(+) T cells, respectively, by intracellular cytokine staining assay and in 22 (73%) of 30 vaccine recipients by enzyme-linked immunospot assay. (emmes.com)
Env-specific antibody responses were detected in 15 (50%) of 30 vaccine recipients by enzyme-linked immunosorbant assay and in 28 (93.3%) of 30 vaccine recipients by immunoprecipitation followed by Western blotting. (emmes.com)
A single injection induced HIV-1 antigen-specific CD4(+) T cell, CD8(+) T cell, and antibody responses in the majority of vaccine recipients. (emmes.com)
Viral Vectors Expressing Group B Meningococcal Outer Membrane Proteins Induce Strong Antibody Responses but Fail to Induce Functional Bactericidal Activity in Mice. (ox.ac.uk)
OBJECTIVE: Adenoviral vectored vaccines, with the appropriate gene insert, induce cellular and antibody responses against viruses, parasites and intracellular pathogens such as Mycobacterium tuberculosis. (ox.ac.uk)
Here we explored their capacity to induce functional antibody responses to meningococcal transmembrane outer membrane proteins. (ox.ac.uk)
We also show that recombinant adenovirus vaccination induced T cell responses to the same epitopes, and led to memory T cell differentiation. (biomedcentral.com)
Research in organ transplant patients, who are also treated with immune-modifying medications, found that those patients produced very low antibody responses to the Johnson & Johnson vaccine,' said Melmed, professor of Medicine. (cedars-sinai.edu)
Results from trials involving three different coronavirus vaccines released Monday, all showing positive results, with evidence the vaccines can produce immune responses that would be expected to protect people against infection. (bnlpulse.com)
In the last few years we have worked on various platforms for generating recombinant protein and virus-like- particle vaccines for the induction of high titre functional antibody responses. (ox.ac.uk)

Given the high rate of occurrence of adverse effects that have been reported to date, as well as the potential for vaccine-driven disease enhancement, Th2-immunopathology, autoimmunity, and immune evasion, there is a need for a better understanding of the benefits and risks of mass vaccination, particularly in groups excluded from clinical trials. (researchgate.net)
If DSMBs and EACs do not exist, then vaccination should be halted immediately, in particular for demographic groups at highest risk of vaccine-associated death or serious adverse effects, during such time as it takes to assemble these boards and commence critical and independent assessments. (researchgate.net)
An FDA spokesperson told PolitiFact: "There is no scientific data to indicate that the spike protein in mRNA vaccines is toxic or that it lingers at any toxic level in the body after vaccination. (politifact.com)
There are a number of alternate vaccination strategies in current development which may circumvent the need for annual re-vaccination, including new platform technologies such as viral-vectored vaccines. (mdpi.com)
Keenan, who was sporting a polka-dot cardigan over a festive shirt, was given the first dose of a two-dose vaccine at the University Hospital Coventry in England, setting off the first mass vaccination effort against a virus that has now infected at least 70 million people worldwide and killed 1.5 million. (livescience.com)
In March 2021, fol owing reports of rare blood coagulation disorders in a few individuals who had received the AZ vaccine in Europe, the WHO's Global Advisory Committee on Vaccine Safety (GACVS) and European Medicines Agency (EMA) reviewed al available information and data on thromboembolic events (blood clots) and thrombocytopenia (low platelets) after vaccination. (who.int)

Most governments have embraced the notion that these vaccines are the only path towards resolution of this pandemic, which is crippling the economies of many countries. (theepochtimes.com)
Vaccines to HIV-1 are needed to stem further spread of the HIV pandemic. (cdc.gov)
We discuss the different vectored vaccines that have been or are currently in clinical trials, with a forward-looking focus on immunogens that may be protective against seasonal and pandemic influenza infection, in the context of viral-vectored vaccines. (mdpi.com)
On Thursday (Dec. 10), a panel of experts voted and recommended that the Food and Drug Administration (FDA) grant emergency approval to Pfizer's vaccine, or permission for it to be distributed prior to full approval under emergency situations like a pandemic . (livescience.com)
Wistar Institute Vaccine Center scientists are creating new vaccines against pandemic influenza, HIV, and other diseases threatening global health. (health.am)
c) increasing access, affordability and effective deployment of vaccines, antiviral agents, diagnostics and other materials for pandemic preparedness and response. (who.int)
New data were generated for pandemic vaccine capacity projections and identification of access barriers. (who.int)

One vaccine modality that has shown promise is based on adenovirus vectors of human serotype 5 (AdHu5) ( 1 - 3 ). (cdc.gov)

Here, we describe for the first time a streamlined pipeline for the generation of personalized cancer vaccines starting from the isolation and selection of the most immunogenic peptide candidates expressed on the tumor cells and ending in the generation of efficient therapeutic oncolytic cancer vaccines. (elifesciences.org)
These peptides were then tested in our previously described oncolytic cancer vaccine platform PeptiCRAd, a vaccine platform that combines an immunogenic oncolytic adenovirus (OAd) coated with tumor antigen peptides. (elifesciences.org)

A simian adenoviral vector termed adenovirus C68 (AdC68) was generated as a molecular clone to express the glycoprotein of rabies virus. (wistar.org)
The Janssen vaccine is a human adenoviral vector vaccine. (cdc.gov)

The Association's special report, Diagnosis and Management of Cerebral Venous Sinus Thrombosis with Vaccine-Induced Immune Thrombotic Thrombocytopenia , provides important guidance about TTS - the signs and symptoms and the best treatment options. (heart.org)

Why is this also looking a little bit like it may have a similar pathophysiology to heparin-induced thrombocytopenia and thrombosis, or HIT? (medpagetoday.com)
People are calling it vaccine-induced thrombocytopenia [and] thrombosis, or VIT. (medpagetoday.com)
This blood clot syndrome is known as vaccine-induced immune thrombotic thrombocytopenia (VITT). (allafrica.com)

Unconjugated polysaccharide vaccines do not induce T-cell memory, and additional doses (although they elicit the same or a lower antibody concentration) might increase the duration of protection. (cdc.gov)
However, there were no noteworthy phenotypic differences between epitope-specific CD8 T cell populations across vaccine doses or time points. (nih.gov)
Among the key concerns is the availability of sufficient vaccine doses to meet the high demand. (bizcommunity.com)
This type of vaccine can be rapidly manufactured and scaled to capacity to meet the high demand for millions of doses. (bizcommunity.com)
From March 2 through August 31, 2021, there were 54 cases of hospitalized patients with TTS in the U.S., out of 14.1 million doses of the Johnson & Johnson vaccine administered, representing a case rate of 3.8 cases per million doses. (heart.org)
Melmed suggested that the vaccine mechanism and number of doses could account for this result. (cedars-sinai.edu)
And because they are delivered in two doses, rather than one dose like the Johnson & Johnson vaccine, they provide two immunological hits. (cedars-sinai.edu)
Oxford vaccine expert Adrian Hill said the team is looking at trying both one and two doses in Phase 3 participants. (bnlpulse.com)
Hence SAGE recommends that the two doses of this vaccine be given at an interval of 8 to 12 weeks. (who.int)

For varicella and mumps vaccines, 80%-85% of vaccines are protected after a single dose. (cdc.gov)
Of those who do not respond to the first dose of the measles component of MMR or varicella vaccine, 97%-99% respond to a second dose ( 5,6 ). (cdc.gov)
Flow cytometry analysis was performed to measure the serological anti-SARS-CoV-2 spike (S) IgG titers after 10.0 days of each vaccine dose, 210.0 days post-second dose and 180.0 days post-booster dose vaccinations. (news-medical.net)
Additionally, single-cell RNA sequencing (scRNA-seq) analysis was performed for anti-S B lymphocytes obtained from four donor individuals 210.0 days post-second dose and 10.0 days post-third dose of Comirnaty vaccines. (news-medical.net)
Collectively, these data indicate that the functional and phenotypic properties of vaccine-induced CD8 T cell populations are sensitive to dose manipulation, yet constrained by epitope specificity in a clonotype-dependent manner. (nih.gov)
Preliminary data show no major safety concerns are associated with a two-dose administration of the vaccine. (bizcommunity.com)
Avoid live vaccines for at least 1 month when initiating or after high-dose systemic corticosteroid therapy administered for =2 weeks. (medscape.com)
In areas of Africa where a vaccine for Marburg is most needed, a single-dose vaccine that could protect recipients over a long period of time would be a crucial part of quelling outbreaks. (sflorg.com)
They received a single dose of either a low dose of the vaccine (1x1010 particle units) or a higher dose (1x1011 particle units). (sflorg.com)
In mice, this vector induced complete protection to rabies virus challenge after a single dose. (wistar.org)
This vaccine also achieves long-term protection in non-human primates after a single dose. (wistar.org)
There are no reports to-date of TTS after receiving the Johnson & Johnson vaccine as a booster dose. (heart.org)
The vaccine was well tolerated but was associated with more reactogenicity at the highest dose. (emmes.com)

That said, Valneva's vaccine is considered a more traditional vaccine technology, with VLA2001 being an inactivated SARS-CoV-2 vaccine. (clinicaltrialsarena.com)

Conjugation with a protein carrier improves the effectiveness of polysaccharide vaccines by inducing T-lymphocyte-dependent immunologic function ( 2 ). (cdc.gov)
The mRNA vaccines contain only the code for the SARS-CoV-2 envelope spike protein, whereas the DNA-based vaccines both contain an adenovirus viral vector that has been augmented with DNA that codes for the SARS-CoV-2 spike protein. (theepochtimes.com)
The mRNA in these vaccines codes for the spike protein normally synthesized by the SARS-CoV-2 virus. (theepochtimes.com)
U.S. public health authorities and vaccine experts say there is no evidence that the vaccines' spike protein is toxic or "cytotoxic," which means toxic to cells. (politifact.com)
Bret Weinstein, who is identified in the video as an evolutionary biologist , is the one who says the spike protein in the vaccines "is very dangerous, it's cytotoxic. (politifact.com)
As with the mRNA vaccines, this leads the immune system to recognize the spike protein as foreign and make an immune response against it, he said. (politifact.com)
Responding to the claim made in the video, Emory's Orenstein and vaccine expert Dr. Paul Offit of the Children's Hospital of Philadelphia said they are not aware of any major dangers from the spike protein. (politifact.com)
There are three vaccines at phase III stage with a similar choice of an antigen - the SARS-CoV-2 spike protein. (bizcommunity.com)
Such vaccines work by instructing the human cells to make a small part of the virus surface protein and induce the appropriate type of immune response that is thought to confer protection. (bizcommunity.com)
We developed vaccines expressing the SARS -CoV-2 spike or nucleocapsid protein. (wistar.org)
Vaxine recently reported interim Phase III data of its protein subunit vaccine SpikoGen. (clinicaltrialsarena.com)
Five serious adverse events were reported, of which two were in the vaccine group (pyrexia and transverse myelitis) and three were in the control group (autoimmune haemolytic anaemia, increased C- reactive protein and myelitis). (who.int)

We characterized two immunodominant CD8 T cell populations generated in response to immunization of BALB/c mice with a replication-deficient adenovirus serotype 5 vector expressing the HIV-derived Gag and Pol proteins at equivalent levels. (nih.gov)
In the experiments, conducted in mice, the researchers used a typical vaccine regimen, priming the immune system with an experimental AAV vaccine against HIV and following it with a booster immunization using an HIV vaccine construct incorporating another viral vector called adenovirus, or Ad. (health.am)
Immunization strategies against this morbillivirus using recombinant adenoviruses expressing PPRV-F or -H proteins can protect PPRV-challenged animals and permit differentiation of infected from vaccinated animals. (biomedcentral.com)

It is thought that vaccine-induced protection from infection by far outweighs the risk of autoimmune exacerbation. (springer.com)
Immunosuppressives may diminish therapeutic effects of vaccines and increase risk of adverse effects (increased risk of infection). (medscape.com)
They are applying this platform to develop HIV vaccines and creating new therapeutic vaccines against human papillomavirus (HPV), a leading cause of cervical cancer, and chronic hepatitis B virus infection, a major cause of hepatocellular carcinoma. (wistar.org)
Follow-up assays of the immune response showed that, in all cases, HIV-specific T cells induced by the AAV-vector only poorly protected from infection in a challenge model, failed to secrete adequate levels of important immune-system activating chemicals called cytokines, and most importantly were severely impaired in their ability to proliferate upon re-encounter with their antigen. (health.am)
However, we need more research before we can confirm the vaccine effectively protects against SARS-CoV-2 infection, and for how long any protection lasts. (bnlpulse.com)
The vaccine trial included 1,077 people age 18 to 55 with no history of coronavirus infection and took place in five UK hospitals from late April to late May. (bnlpulse.com)
Technically, the urgent requirement of the newer and effective vaccines may help to control the infection in animals in husbandry, pet animals and cattles to control the spread of infections to humans. (biocoreopen.org)
A good and effective observation was made towards the usage of formalin inactivated multi-serovar preparations with adjuvants and acetic acid heat extracted vaccines provide significant high titres lead to successful resistance towards infection (Kaminski et al. (biocoreopen.org)
Some studies highlighted the usage of bivalent vaccine leads to the protection of animals form the infection and reduction in shedding of leptospires in the urine. (biocoreopen.org)

or fractional vaccines such as recombinant vaccines, produced through genetic technologies. (cdc.gov)
Little is known of the T cell repertoire these recombinant vaccines induce. (biomedcentral.com)

Traditional live attenuated vaccine can also produce immunosuppression, albeit to a lower extent than natural infections [ 10 ]. (biomedcentral.com)

Also included under the category of non-live vaccines are toxoids, which generate an antibody response to toxins produced by a microbe rather than to the microbe itself. (cdc.gov)
The mRNA vaccines may have a more potent mechanism for inducing antibody response,' Melmed said. (cedars-sinai.edu)
The Oxford vaccine prompted an antibody response within 28 days and a T-cell response within 14 days, according to the results published Monday. (bnlpulse.com)

After investigations of an initial safety concern in phase III trial, the Oxford ChAdOx1-S vaccine testing has proceeded well . (bizcommunity.com)
Oxford ChAdOx1-S is a non-replicating viral vector vaccine. (bizcommunity.com)
A Phase I Study to Determine the Safety and Immunogenicity of the Candidate Zika Virus (ZIKV) Vaccine ChAdOx1 Zika in Healthy Adult Volunteers. (who.int)

Optimal response to a vaccine depends on multiple factors, including the type of vaccine, age of the recipient, and immune status of the recipient. (cdc.gov)

Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 candidate vaccine delivered by a replication-defective recombinant adenovirus vector. (emmes.com)
Here, we report the safety, tolerability, and immunogenicity of a replication-defective recombinant adenovirus serotype 5 (rAd5) vector HIV-1 candidate vaccine. (emmes.com)

In the present study, researchers reported assessed IgG titers induced by mRNA vaccinations in the long term. (news-medical.net)
Prevalence of neutralizing antibody titers to chimpanzee adenoviruses. (cdc.gov)
One serum sample from Cameroon neutralized all 3 chimpanzee adenoviruses and had titers of 20 to AdC68 and 160 to AdC6 and AdC1. (cdc.gov)

This multiclade rAd5 HIV-1 vaccine is now being evaluated in combination with a multiclade HIV-1 DNA plasmid vaccine. (emmes.com)
Two among the various possibilities produced in India are inactivated virus vaccine and DNA plasmid vaccine. (netindian.in)

Receipt of recombinant simian adenoviral vaccine prior to enrolment. (who.int)

However, IBD patients receiving the Johnson & Johnson vaccine had significantly lower levels than those receiving the two other vaccines. (cedars-sinai.edu)
Although only about 3% of IBD patients participating in the registry had received the Johnson & Johnson vaccine, Melmed said the study's findings were consistent with research in other types of immune-compromised patients and were highly statistically significant, sending 'a strong signal that vaccine type matters. (cedars-sinai.edu)

These therapeutic methods, including but not limited to oncolytic virus therapies, T-cell therapies and cancer vaccines, are based on the body's ability to recognize mutated antigen peptides presented on the cell surface by MCH-receptors (also known as HLA-receptors in humans) and the disposal of the malignant cells by cytotoxic T-cells. (helsinki.fi)
One relatively new approach is to use oncolytic adenoviruses, which selectively infect and kill cancerous cells leaving healthy cells unharmed. (helsinki.fi)
Another challenge is the cell entry of oncolytic adenovirus, which is mainly mediated by the Coxsackie-Adenovirus receptor and this receptor is downregulated in various cancer cells. (helsinki.fi)
In order to overcome these limitations, this study explored the possibility to use cancer cell derived extracellular vesicles (EVs) as drug delivery system for oncolytic adenovirus. (helsinki.fi)
Since oncolytic adenoviruses have shown to be effective especially in combination with chemotherapeutics, the ability of EVs to deliver both oncolytic adenoviruses and chemotherapeutic drug paclitaxel was studied. (helsinki.fi)
These results confirmed the feasibility of applying the described pipeline for the selection of peptide candidates and generation of therapeutic oncolytic cancer vaccine, filling a gap in the field of cancer immunotherapy, and paving the way to translate our pipeline into human therapeutic approach. (elifesciences.org)
As an emerging cancer immunotherapy, oncolytic virotherapies (OVTs) can not only selectively lyse cancer cells, but also induce a systemic antitumor immune response. (frontiersin.org)

Besides the isolation and identification of major histocompatibility complex I-restricted peptides from the surface of cancer cells, one of the challenges is eliciting an effective antitumor CD8+ T-cell-mediated response as part of therapeutic cancer vaccine. (elifesciences.org)

The lack of thorough testing in animals prior to clinical trials, and authorization based on safety data generated during trials that lasted less than 3.5 months, raise questions regarding vaccine safety. (researchgate.net)
Researchers at Oxford University report promising results in human trials of a prototype hepatitis C vaccine. (wikipedia.org)
The cAd3 vaccine platform demonstrated a good safety profile in prior clinical trials when used in investigational Ebola virus and Sudan virus vaccines developed by the VRC. (sflorg.com)
Plans are in place to conduct further trials of the cAd3-Marburg vaccine in Ghana, Kenya, Uganda, and the United States. (sflorg.com)
With untested technologies, regulatory authorities will still likely insist on large-scale, Phase III trials, as was done with first-generation vaccines, and these trial designs are getting increasingly harder to run, he adds. (clinicaltrialsarena.com)
Along with the two Indian vaccines, Covain and ZyCov-D, the world over, 11 out of 140 vaccine candidates have entered the human trials. (netindian.in)
Phase 2 results for one vaccine candidate made by Chinese company CanSino Biologics were also published in the medical journal The Lancet and early results from Phase 1/2 trials of the vaccine made by Pfizer and BioNTech were released in a pre-print paper that has not yet been peer-reviewed. (bnlpulse.com)
These Phase 1/2 results were promising, researchers said, but large-scale trials are needed to determine whether the vaccine protects against the coronavirus. (bnlpulse.com)
We now need to move into larger scale real-world trials, but it is good to see more data and more products moving into this very important phase of vaccine discovery," Dr. Mike Ryan, executive director of the World Health Organization Health Emergencies Program, said during a briefing on Monday. (bnlpulse.com)
The projects in the group ranges from vaccine design, generation and pre-clinical testing to GMP manufacture and Phase 1 human clinical trials. (ox.ac.uk)
We are also in the process of GMP manufacturing a nanoparticle vaccine and progressing it to Phase 1 clinical trials. (ox.ac.uk)
In March 2020, vaccine immunologists and coronavirus experts assessed SARS-CoV-2 vaccine risks based on SARS-CoV-vaccine trials in animal models. (virutron.com)
While there is no clear evidence of the occurrence of ADE and vaccine-related immunopathology in volunteers immunized with SARS-CoV-2 vaccines [15], safety trials to date have not specifically addressed these serious adverse effects (SAE). (virutron.com)
vaccine trials for rotavirus are in progress. (cdc.gov)

Unfortunately, influenza vaccine composition needs to be updated annually due to antigenic shift and drift in the viral immunogen hemagglutinin (HA). (mdpi.com)
This has provided hope for the design of a universal vaccine able to prime against diverse influenza virus strains and subtypes. (mdpi.com)
Expanding global influenza vaccine production capacity. (who.int)

So, the Janssen vaccine timeline is as follows. (cdc.gov)
And on April 13th, CDC and FDA recommended a pause in the Janssen vaccine. (cdc.gov)

A Phase 1 study typically studies a small number of people and focuses on whether a vaccine is safe and elicits an immune response. (bnlpulse.com)

Discoveries at Wistar led to the creation of the rubella vaccine that eradicated the disease in the United States, human rabies vaccines used worldwide, and a new rotavirus vaccine approved in 2006. (health.am)
Subsequently, with the discovery of Norwalk virus ( 1 ), rotavirus ( 2 ), astrovirus ( 3,4 ), and enteric adenovirus ( 5 ), researchers began to recognize viruses as causative agents of gastroenteritis. (cdc.gov)

Other recently identified pathogens include the enteric adenoviruses, calicivirus, astrovirus, and the Norwalk family of agents. (cdc.gov)

A key step in the process of any vaccine development is clinical testing, which involves assigning a vaccine or a placebo to human subjects, then evaluating the health effects over a period of time. (bizcommunity.com)
A newly published paper in The Lancet shows that an experimental vaccine against Marburg virus (MARV) was safe and induced an immune response in a small, first-in-human clinical trial. (sflorg.com)
This first-in-human, Phase 1 study tested an experimental MARV vaccine candidate, known as cAd3-Marburg, which was developed at NIAID's Vaccine Research Center (VRC). (sflorg.com)
In this manuscript, we have developed a recombinant human adenovirus as an expression vector that contains the gene for porcine interferon alpha. (usda.gov)
The development of an effective human immunodeficiency virus (HIV) vaccine is a high global priority. (emmes.com)
Now with the nod given by the Drug Controller General of India CDSCO (The Central Drugs Standard Control Organisation) for the conduct of the human trial, it will take anywhere between fifteen to eighteen months before licence are issued for the vaccines. (netindian.in)

Several recently developed non-live vaccines do not contain antigen but employ RNA or DNA to instruct the recipient's own cellular mechanism to generate antigenic material. (cdc.gov)

However, knowledge about how these vaccines work, how the immune system works and how neurodegenerative diseases come about can be brought to bear on the problem in order to predict potential devastating future consequences of the vaccines. (theepochtimes.com)
This relatively new tech, which relies on a synthetic strand of genetic code called messenger RNA (mRNA) to prime the immune system, had not yet been approved for any previous vaccine in the world. (livescience.com)
Recently, however, evidence has emerged that some of these so-called viral vector systems may undermine the immune system and should not be used for vaccine development. (health.am)
We hope this means the immune system will remember the virus, so that our vaccine will protect people for an extended period. (bnlpulse.com)

None of these vaccines is unlikely to be ready for mass use before 2021. (netindian.in)

It also exhaustively introduces the concrete mechanism of invading GC cells and the viral genome composition of adenovirus and herpes simplex virus type 1 (HSV-1). (frontiersin.org)

The vaccines were approved for emergency use based on grossly inadequate studies to evaluate safety and effectiveness. (theepochtimes.com)

Anatomy11

Organisms22

Diseases13

Chemicals and Drugs99

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes27

Technology, Industry, Agriculture1

Information Science3

Health Care5

Immunity14

Antibodies18

MRNA vaccine8

Efficacy15

Moderna9

COVID63

Chimpanzee adenovirus-vectored1

AstraZeneca7

Responses18

Vaccination6

Pandemic7

Vectors1

Immunogenic2

Adenoviral vector2

Cerebral Venous Sin1

Thrombocytopenia3

Doses9

Dose13

Inactivated SARS-CoV-2 vaccine1

Protein12

Immunization3

Infection9

Recombinant vaccines2

Live-attenuated vaccine1

Antibody response3

ChAdOx13

Type of vaccine1

Replication-defective2

Titers3

Plasmid vaccine2

Simian adenoviral1

Johnson2

Oncolytic7

Therapeutic cancer vaccine1

Trials14

Influenza3

Janssen2

Elicits1

Rotavirus2

Enteric1

Human6

Cellular1

Immune system4

20211

Herpes simpl1

Effectiveness1