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  • Notably
  • Notably, sprouts of many broccoli cultivars contain negligible quantities of indole glucosinolates, which predominate in the mature vegetable and may give rise to degradation products (e. (thefreedictionary.com)
  • Fischer
  • Selv om syntesen av indol selv er problematisk med bruk av Fischer indolsyntese, blir den ofte brukt til å generere indolsubstitutter i 2- og/eller 3-posisjonene. (wikipedia.org)
  • naturally
  • In the current study, we will test the central hypothesis that treatment with these naturally- occurring indoles is effective against induction and progression of EAE through a central pathway of activation of AhR, leading to suppression of proinflammatory Th1/Th17cells and induction of T regs/Th2 cells via epigenetic regulatory mechanisms such as DNA methylation and miRNA dysregulation that block neuroinflammation. (labome.org)
  • pharmaceutical
  • This method is especially popular in the pharmaceutical industry , where many pharmaceutical drugs are made up of specifically substituted indoles. (lycaeum.org)
  • nitrogen
  • Deltakelsen av et enslig elektronpar av nitrogen i den aromatiske ringen medfører at indol ikke er en base , og det oppfører seg ikke som et usammensatt amin . (wikipedia.org)
  • novel
  • These studies should provide novel insights into the basic mechanisms through which plant indoles exhibit anti- inflammatory properties so that they can be used against a wide range of autoimmune and inflammatory diseases. (labome.org)
  • broccoli
  • Add fresh steamed spinach with almonds or a mixture of cauliflower and broccoli or glazed carrots with lemon slices -- all of which not only add color to the table, but antioxidants such as beta-carotenoids, Vitamins A and C, indole bi-carbinols, tannins and fiber. (thefreedictionary.com)
  • Indole-3-carbinol (I3C), a chemical found in vegetables of the broccoli family, is thought to possess cancer preventive properties. (portsmouthhospital.com)
  • dietary
  • The current study investigates the mechanism of action of plant-derived indoles used as dietary supplements, specifically addressing the role of AhR activation in the regulation of inflammation. (labome.org)
  • research
  • The indole subunit is a near-ubiquitous component of biologically active natural products, and its study has been a major focus of research for generations. (sigmaaldrich.com)
  • treatment
  • To this end, we will test the following aims: In aim 1, we will examine whether treatment with indoles such as I3C or DIM leads to decreased neuroinflammation by downregulation of Th1 and Th17 cell responses against myelin antigens and upregulation of Th2 and FoxP3+ Tregs. (labome.org)
  • Immunoblot and quantitative RT-PCR assays revealed that I3C inhibited the expression of AR protein and mRNA levels within 12 h of indole treatment. (wellnessresources.com)
  • activity
  • In aim 2, we will test the central hypothesis that indoles facilitate Th17 to Treg switch in EAE mice by DNA hypomethylation of Foxp3 gene promoter while silencing the Th17 activity by hypermethylation of IL-17 promoters. (labome.org)
  • Antiangiogenic activity of indole-3-carbi. (mendeley.com)
  • structures
  • Substituted indoles have frequently been referred to as privileged structures since they are capable of binding to multiple receptors with high affinity, and thus have applications across a wide range of therapeutic areas. (sigmaaldrich.com)
  • structure
  • Indeed, their studies showed, chemicals that posses a structure known as an indole ring -- including the essential amino acids L-tryptophan and L-proline -- provide "a more specific means of lowering the formation of mutagens" than had the antioxidants. (thefreedictionary.com)
  • test
  • It is the only system that allows a simultaneous test for both MUG positive and indole positive E. (thefreedictionary.com)
  • We will test whether activation of AhR by these indoles leads to dysregulation in the Th/Treg cell responses using AhR knock out (KO) mice. (labome.org)
  • Lastly, in aim 3, we will test the hypothesis that administration of these indoles triggers dysregulation in the expression of microRNA-466i and microRNA-325 that leads to increased polarization of Tregs and decreased differentiation of T17 cells. (labome.org)
  • known
  • In female rats, they discovered that a specific indole , known as indole -3-carbinol, significantly boosted the rate at which an enzyme converted a form of estrogen to 2-hydroxyestrone, an inactive version that doesn't trigger mammary tumor growth. (thefreedictionary.com)
  • studies
  • Laboratory and animal studies suggest that indole-3-carbinol may prevent a variety of cancers, including estrogen-dependent cancers, but only one clinical trial has been performed. (mskcc.org)
  • Michael
  • It condenses with serine via Michael addition of indole to PLP-aminoacrylate . (lycaeum.org)
  • Cyanuric chloride is an inexpensive, efficient, and mild catalyst for the Michael addition of indoles to nitroolefins at 70°C under solvent-free conditions. (hindawi.com)
  • major
  • Indole is a major constituent of coal-tar , and the 220-260 °C distillation fraction is the main industrial source of the material. (lycaeum.org)
  • cancer
  • Indole 3-carbinol has cancer-preventive effects, but it has not been shown to treat cancer in humans. (mskcc.org)
  • Indole-3-carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells. (wellnessresources.com)