• Certain indole derivatives were important dyestuffs until the end of the 19th century. (wikipedia.org)
  • A number of indole derivatives have important cellular functions, including neurotransmitters such as serotonin. (wikipedia.org)
  • Indole and its derivatives can also be synthesized by a variety of methods. (wikipedia.org)
  • One of the simplest and yet widespread indole derivatives are the biogenic amines tryptamine and 5-hydroxytryptamine (serotonin). (wikipedia.org)
  • Furthermore, fluoro -containing indole derivatives have received wide attention from either synthetic or pharmaceutical view for a long time due to their wide potential bioactivities [7- (thefreedictionary.com)
  • Given the importance of heterocycle indole derivatives, much effort has been directed toward the development of methods for functionalization of the indole nucleus at N1 and C3 sites. (mdpi.com)
  • Natural derivatives of aplysinopsin differ in the bromination pattern of the indole moiety ( Figure 1 ), variation in the structure of the C ring, including its oxidation state ( Figure 3 ) and number and position of N -methylation ( Figure 1 ), the presence and absence of the C-8-C-1′ double bond ( Figure 2 ), and the stereochemistry. (mdpi.com)
  • We identified four cannabimimetic indazole and indole derivatives in new illegal psychoactive substances seized from a clandestine laboratory in China. (springer.com)
  • A tiny amount of indole is all it takes to infuse life into a composition of floral notes, to make an abstract, vague petally form to appear as a lush, nectar suffused flower. (typepad.com)
  • The first indole alkaloid, strychnine, was isolated by Pierre Joseph Pelletier and Joseph Bienaimé Caventou in 1818 from the plants of the Strychnos genus. (wikipedia.org)
  • Camalexin is a simple indole alkaloid produced by the plant Arabidopsis thaliana, often used as a model for plant biology. (wikipedia.org)
  • Angewandte Chemie DOI: 10.1002/ange.201005296 Indole Chemistry Lewis Acid Catalyzed Intramolecular Direct Ene Reaction of Indoles** Bo Han, You-Cai Xiao, Yuan Yao, and Ying-Chun Chen* Synthetic modifications on indole skeletons have provoked increasing interest because the related heterocyclic systems are present in numerous alkaloid products, pharmaceuticals, and agrochemicals. (docme.ru)
  • 3. The compound as defined in claim 2 which is 1-methyl-5-(propyl-4-pyridinylamino)-1H-indole. (google.com)
  • 6. The compound as defined in claim 2 which is N-(1-methyl-1H-indol-5-yl)-N-(4-pyridinyl)-2-(carbamic acid, phenylmethyl ester)acetamide hydrochloride. (google.com)
  • Indole-3-carbinol (I3C), a naturally occurring compound found in vegetables of the Brassica genus, such as broccoli and cabbage, is a promising anticancer agent previously shown to induce a G(1) cell-cycle arrest in the cells of human lymph node carcinoma of prostate (LNCaP) through regulation of specific G(1)-acting cell-cycle components. (wellnessresources.com)
  • The title compound, C 27 H 22 N 2 O 2 , was synthesized by the reaction of indole-3-carb-aldehyde with 4-methoxyaceto-phenone and ammonium acetate in glycol under microwave irradiation. (ingentaconnect.com)
  • The title compound, C 34 H 30 N 4 O 2 , lies on an inversion center and consists of two 3-substituted-1 H -indole units linked by a 1,2-dimethyl-enehydrazine bridge. (iucr.org)
  • 2. The compound as defined in claim 1, which is 3-hydroxyimino-4-methyl-1,2,3,4-tetrahydrocyclopent[b]indol-7-ol. (patentgenius.com)
  • Lowering levels of toxic by-products: Harmful bacteria can produce toxins, such as indole , skatole, and methane because of their metabolic reaction to certain foods. (thefreedictionary.com)
  • In this report we disclose the discovery that ScyC (NpR1274), an enzyme encoded by the scytonemin cluster, catalyzes cyclization and decarboxylation of ScyA product 2 to form ketone 5 , thereby constructing the indole-fused cyclopentane moiety of the natural product. (nih.gov)
  • Oxindole-3-acetic acid (OxIAA), OxIAA conjugated to a hexose moiety via the carboxyl group, and the conjugates indole-3-acetyl aspartic acid (IAAsp) and indole-3-acetyl glutamate (IAGlu) were identified by mass spectrometry as primary products of IAA fed to the plants. (plantphysiol.org)
  • Indole-3-acetic acid (IAA) is a ubiquitous molecule playing regulatory roles in many living organisms. (nih.gov)
  • The molecule occupies a crystallographic inversion center and consists of two 3-substituted 1 H -indole moieties linked by a (1E,2E)-1,2-dimethylenehydrazine bridge, one of numerous examples in which two aromatic ring systems are joined by this 4-atom bridge. (iucr.org)
  • Each technique provides complementary information specific to the photophysical processes in the indole molecule. (osti.gov)
  • Global And China Indole-3-acetic Acid (IAA) Industry 2017 Market. (mynewsdesk.com)
  • The Global And China Indole-3-acetic Acid (IAA) Industry 2017 Market Research Report is a professional and in-depth study on the current state of the Indole-3-acetic Acid (IAA) industry. (mynewsdesk.com)
  • The Indole-3-acetic Acid (IAA) market analysis is provided for the international market including development history, competitive landscape analysis, and major regions' development status. (mynewsdesk.com)
  • What's more, the Indole-3-acetic Acid (IAA) industry development trends and marketing channels are analyzed. (mynewsdesk.com)
  • In examining the presence of indole-3-acetic acid (IAA) in supernatants of pink-pigmented facultativemethylotrophic (PPFMs) bacterial cultures, three out of the 16 isolates tested showed a positive reaction ina colorimetric assay. (springer.com)
  • Production of gibberellins and indole-3-acetic acid by Rhizobium phaseoli in relation to nodulation of Phaseolus vulgaris roots. (springer.com)
  • Production of indole 3-acetic acid and gibberellins A1 and A3 by Acetobacter diazotrophicus and Herbaspirillum seropedicae in chemically-defined culture media. (springer.com)
  • The metabolism of indole-3-acetic acid (IAA) was investigated in 14-d-old Arabidopsis plants grown in liquid culture. (plantphysiol.org)
  • A genome-wide transcriptional profile of Bradyrhizobium japonicum, the nitrogen-fixing endosymbiont of the soybean plant, revealed differential expression of approximately 15% of the genome after a 1 mM treatment with the phytohormone indole-3-acetic acid (IAA). (nih.gov)
  • Indole is widely distributed in the natural environment and can be produced by a variety of bacteria. (wikipedia.org)
  • But when it accompanies 200 ppm of indole (half of that haxane's bacteria-inhibiting dose), a mere 6. (thefreedictionary.com)
  • brasilense cepa SP7 inducen a que la bacteria utilice varias rutas metabolicas para la sintesis de indoles y, en especial, AIA a partir del TRP. (thefreedictionary.com)
  • Methods: The PUBMED database and Google Scholar were searched to identify experimental and clinical studies investigating biological effects of gut bacteria-derived indoles. (eurekaselect.com)
  • Unlike most amines, indole is not basic: just like pyrrole, the aromatic character of the ring means that the lone pair of electrons on the nitrogen atom is not available for protonation. (wikipedia.org)
  • Assembly of the cyclopentyl[b]indole structure in this manner has little precedent in the chemical literature. (nih.gov)
  • Spectrum Chemical offers a high quality inventory of simple indoles which have numerous applications with pharmacologists and chemists. (spectrumchemical.com)
  • Spectrum specializes in providing the top simple indoles but if you do not see the product, grade or form of the ingredient you require, just contact our chemical specialist at 800-772-8786. (spectrumchemical.com)
  • 3) 5-substituted indoles (9) are formed in the case of the Lewis acid catalyst (Runs 5,6) by the substitution of chlorine (by Zn[Cl. (thefreedictionary.com)
  • The aim of the present study was to examine the ability of various pineal indoles in inhibiting LDL oxidation which is accompanied by an increase in mobility in agarose gel electrophoresis and by an augmented generation of thiobarbituric acid-reactive substance induced by Cu2+. (biomedsearch.com)
  • Lewis Acid Catalyzed Intramolecular Direct Ene Reaction of Indoles. (docme.ru)
  • Organocatalytic asymmetric alkylation and subsequent discovery of Lewis acid catalyzed intramolecular imino-ene reaction of indole. (docme.ru)
  • Indole cell signaling occurs primarily at low temperatures in Escherichia coli. (nih.gov)
  • We have shown that the quorum-sensing signals acylhomoserine lactones, autoinducer-2 (AI-2) and indole influence the biofilm formation of Escherichia coli. (nih.gov)
  • Here, we review the available evidence on metabolism and biological effects of gut microbiota- derived indoles. (eurekaselect.com)
  • Ample evidence suggests that indoles derived from gut microbiota metabolism exert significant biological effects and may contribute to the etiology of cardiovascular, metabolic, and psychiatric diseases. (eurekaselect.com)
  • Investigators previously reported that the heterocyclic aromatic amine 2-amino-9H-pyrido[2,3-b]indole (AαC) -- the most abundant aromatic amine carcinogen formed in tobacco smoke and a rodent GI genotoxicant -- is present in the urine of tobacco smokers in a dose-dependent manner but is absent in the urine of nonsmokers. (fda.gov)
  • Subsequently, the development of efficient methods that allow rapid access to functionalized indoles with different substitution patterns (at C-2, C-3, N-atom and aromatic ring, Figure 1) constitutes an emerging area. (organic-chemistry.org)
  • There is some evidence that the indoles bind to a somewhat different site on the receptor than traditional cannabinoids, and interact with the receptor primarily by aromatic stacking. (eurekaselect.com)
  • New isatin-indole molecular hybrids 5a - n have been synthesized and characterized by various spectroscopic tools. (mdpi.com)
  • Notably, sprouts of many broccoli cultivars contain negligible quantities of indole glucosinolates, which predominate in the mature vegetable and may give rise to degradation products (e. (thefreedictionary.com)
  • En av de eldste og mest pålitelige metoder for å syntetisere substituerte indoler er Fischer indolsyntese som ble utviklet i 1883 av Emil Fischer . (wikipedia.org)
  • Selv om syntesen av indol selv er problematisk med bruk av Fischer indolsyntese, blir den ofte brukt til å generere indolsubstitutter i 2- og/eller 3-posisjonene. (wikipedia.org)
  • Moreover, the authors expanded the reaction scope to obtain 1,2,3-trisubstituted indoles by switching the order of addition of the two boronic acids. (organic-chemistry.org)
  • The reaction order was determined for iodobenzene (zero order), indole (first order), and the catalyst (first order). (biomedsearch.com)
  • Not surprisingly, the majority of studies in this field have been focused on the Friedel-Crafts reaction of indoles with a range of electrophiles. (docme.ru)
  • In addition, C3-substituted indoles also show reactivity at the C2-position, and the most well-established reaction is the Pictet-Spengler reaction. (docme.ru)
  • In the current study, we will test the central hypothesis that treatment with these naturally- occurring indoles is effective against induction and progression of EAE through a central pathway of activation of AhR, leading to suppression of proinflammatory Th1/Th17cells and induction of T regs/Th2 cells via epigenetic regulatory mechanisms such as DNA methylation and miRNA dysregulation that block neuroinflammation. (labome.org)
  • Indoles are naturally present in jasmine and many other floral notes. (typepad.com)