IDO1EnzymeKynurenineIndolamine-2,3-dioxygenaseTumorCatabolismEffectorProteinImmune2019InhibitionCytokine2020MechanismsNucleusClinicalInfectionActivityDataHostDiseaseTryptophan 2,3-dioxygenaseInhibitorKynurenine pathwaySerumSpecificityPrognosisInhibitsSignificanceELISAGeneProfilesDescriptorMechanism2023TermExpressionInflammationMinor topicPatientsDateFunction
IDO17
- The antitumor activity is the result of intratumoral administration of IMO-2125 in combination with an inhibitor of the immunosuppressive enzyme, indoleamine-pyrrole 2,3-dioxygenase (IDO1). (drugdiscoverynews.com)
- Therefore, induction of the host tryptophan catabolizing enzyme, indoleamine-2,3-dioxgenase-1 (IDO1), by interferon gamma (IFNγ) is one of the primary protective responses against chlamydial infection. (duke.edu)
- One mechanism by which this is accomplished is through immune suppression effected by up-regulation of indoleamine 2,3-dioxygenase (IDO1), a heme enzyme that catalyzes the oxidation of tryptophan to N-formylkynurenine. (princeton.edu)
- Background: Indoleamine 2,3-dioxygenase 1 (IDO1), an important intracellular rate-limiting enzyme in the development of Hepatic fibrosis (HF), and has been proposed as a hallmark of HF. (edu.hk)
- However, this effect was accompanied by strong immunosuppression mediated by dendritic cells via the induction of Indoleamine 2,3-Dioxygenase 1(IDO1) and Lymphocyte Activation Gene 3 (LAG3). (ox.ac.uk)
- Indoleamine 2,3-dioxygenase (IDO1) and tryptophane 2,3-dioxygenase (TDO) are two heme-containing enzymes which catalyze the conversion of tryptophan to N-formylkynurenine. (ox.ac.uk)
- Furthermore, while indoleamine 2,3-dioxygenase (IDO1) drives AhR activation in other settings, MHV infection induced equal expression of downstream genes in wild-type (WT) and IDO1-/- macrophages, suggesting an alternative pathway of AhR activation. (bvsalud.org)
Enzyme9
- Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO EC 1.13.11.52) is a heme-containing enzyme physiologically expressed in a number of tissues and cells, such as the small intestine, lungs, female genital tract or placenta. (wikipedia.org)
- Indoleamine 2,3-dioxygenase is the first and rate-limiting enzyme of tryptophan catabolism through the kynurenine pathway. (wikipedia.org)
- Epacadostat (INCB24360), navoximod (GDC-0919), and linrodostat (BMS-986205) are potent inhibitors of the indoleamine 2,3-dioxygenase enzyme and are in clinical trials for various cancers. (wikipedia.org)
- In particular, interferon-gamma (IFN-gamma) induces an enzyme of tryptophan catabolism, indoleamine 2,3-dioxygenase (IDO), which is responsible for conversion of tryptophan and other indole derivatives to kynurenine. (nih.gov)
- Indoleamine 2,3-dioxygenase is the first and rate limiting enzyme of the kynurenine pathway of tryptophan metabolism, has potent effects on cell proliferation and mediates antimicrobial, antitumorogenic, and immunosuppressive effects. (edu.au)
- Some enzyme activity could be recovered in the presence of thioredoxin, indicating that the inhibitory effect of H 2 O 2 is at least partially reversible in vitro. (edu.au)
- Human mesenchymal stem cells (MSC) strongly repress activated T-cell proliferation through the production of a complex set of soluble factors, including the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO), which is induced by IFN-gamma. (hal.science)
- Influenza infection stimulates protective host immune responses but paradoxically enhances lung indoleamine 2,3 dioxygenase (IDO) activity, an enzyme that suppresses helper/effector T cells and activates Foxp3-lineage regulatory CD4 T cells (Tregs). (elsevierpure.com)
- OBJECTIVE: Indoleamine 2,3 dioxygenase (IDO) is a catabolic enzyme that initiates the kynurenine pathway of tryptophan degradation and has immunomodulatory properties. (ox.ac.uk)
Kynurenine2
- It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway, the O2-dependent oxidation of L-tryptophan to N-formylkynurenine, the others being indolamine-2,3-dioxygenase 2 (IDO2) and tryptophan 2,3-dioxygenase (TDO). (wikipedia.org)
- COX-2 inhibitors down-regulate indoleamine 2,3-dioxygenase, leading to a reduction in kynurenine levels as well as reducing proinflammatory cytokine activity. (wikipedia.org)
Indolamine-2,3-dioxygenase1
- The limiting step for its initiation is activation of two oxidoreductases-indolamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO). (encyclopedia.pub)
Tumor1
- One of the main players responsible for the reemergence of tumor defenses is the protein indoleamine-pyrrole 2,3-dioxygenase (IDO). (thecurestartsnow.org)
Catabolism1
- Indoleamine 2,3 dioxygenase-mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen-induced arthritis. (ox.ac.uk)
Effector1
- As a potent cytotoxic effector, the mechanisms of indoleamine 2,3-dioxygenase inhibition deserve greater attention. (edu.au)
Protein2
- We discovered that SARS-CoV-2 requires the lysosomal protein TMEM106B to infect human cell lines and primary lung cells. (bvsalud.org)
- PHOSPHORYLATION of IRF-3 causes the protein to be translocated from the CYTOPLASM to CELL NUCLEUS where it binds DNA , and activates transcription. (lookformedical.com)
Immune3
- 2 Psoriasis is a disease with innate and adaptive immune system disorder and dendritic cells, neutrophils, keratinocytes and T cells play major roles in the pathogenesis. (nature.com)
- Immunotherapy is currently considered as a promising next-generation therapeutic strategy for various cancers thanks to its ability to modulate cell-specific immune responses toward tumors [ 1 ], which has gradually remodeled the landscape of clinical anticancer modality [ 2 ]. (thno.org)
- IL-2 and IFN-γ), immune checkpoint blockade (ICB) therapy (e.g., anti-PD-1/PD-L1 antibodies), and adoptive T-cell transfer (e.g., chimeric antigen receptor (CAR) T-cell therapy) [ 3 - 5 ]. (thno.org)
20191
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19) and has had deleterious impacts on cancer patients including a higher risk for severe illness and related mortality. (thecurestartsnow.org)
Inhibition1
- We present evidence that cysteine oxidation represents one mechanism of indoleamine 2,3-dioxygenase inhibition. (edu.au)
Cytokine1
- Functional alteration of the lymphoma stromal cell niche by the cytokine context: role of indoleamine-2,3 dioxygenase. (hal.science)
20201
- 94(3)2020 01 17. (bvsalud.org)
Mechanisms2
- The work presented here represents the first systematic study exploring the mechanisms by which low levels of hydrogen peroxide (10-100 μM) inhibit indoleamine 2,3-dioxygenase in vitro. (edu.au)
- STING controls T cell memory fitness during infection through T cell intrinsic and Indoleamine-pyrrole 2,3-dioxygenase (IDO) dependent mechanisms" was recently published in PNAS. (indiatimes.com)
Nucleus1
- Tryptophan (Trp) is the largest of the three aromatic amino acids, with a benzoic nucleus and a pyrrole ring on the side chain. (encyclopedia.pub)
Clinical1
- Together with the MD Anderson Cancer Center, Idera is currently conducting a Phase 1/2 clinical trial of intra-tumoral IMO-2125 in combination with ipilimumab (CTLA4) for the treatment of pembrolizumab (PD1)-treated refractory metastatic melanoma patients. (drugdiscoverynews.com)
Infection5
- 3 However, patients treated with biologic agents are prone to relapse, and adverse events, such as nasopharyngitis, upper respiratory tract infection and tuberculosis may occur. (nature.com)
- To identify host factors essential for coronavirus infection, we performed genome-wide functional genetic screens with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus 229E. (bvsalud.org)
- TMEM106B overexpression enhanced SARS-CoV-2 infection as well as pseudovirus infection, suggesting a role in viral entry. (bvsalud.org)
- Furthermore, single-cell RNA-sequencing of airway cells from patients with COVID-19 demonstrated that TMEM106B expression correlates with SARS-CoV-2 infection. (bvsalud.org)
- The present study uncovered a collection of coronavirus host factors that may be exploited to develop drugs against SARS-CoV-2 infection or future zoonotic coronavirus outbreaks. (bvsalud.org)
Activity1
- In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES , and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways. (lookformedical.com)
Data1
- With Amendment 3 the external Data Monitoring Committee was discontinued. (uci.edu)
Host2
- Host server : magellan-srch-3-prod-blue:8080/10.253.228.45:8080. (thermofisher.com)
- These screens uncovered virus-specific as well as shared host factors, including TMEM41B and PI3K type 3. (bvsalud.org)
Disease1
- A total of 47.1% (8/17) of the psoriasis patients had at least 40% improvement in the PASI score, and 17.6% (3/17) had no sign of disease or minimal disease based on the PGA score. (nature.com)
Tryptophan 2,3-dioxygenase2
- It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway, the O2-dependent oxidation of L-tryptophan to N-formylkynurenine, the others being indolamine-2,3-dioxygenase 2 (IDO2) and tryptophan 2,3-dioxygenase (TDO). (wikipedia.org)
- 15. Tryptophan 2,3-dioxygenase in tumor cells is associated with resistance to immunotherapy in renal cell carcinoma. (nih.gov)
Inhibitor1
- Kynurenine involvement may account for the protection afforded to animals with cerebral malaria and trypanosomiasis when they are treated with an inhibitor of kynurenine-3-monoxygenase (KMO). (ox.ac.uk)
Kynurenine pathway1
- This degradation is the first and rate-limiting step of the L-kynurenine pathway (2). (rndsystems.com)
Serum1
- Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A. (ox.ac.uk)
Specificity1
- A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN . (nih.gov)
Prognosis1
- 12. Altered expression of TIM-3, LAG-3, IDO, PD-L1, and CTLA-4 during nimotuzumab therapy correlates with responses and prognosis of oral squamous cell carcinoma patients. (nih.gov)
Inhibits1
- citation needed] 1-Methyltryptophan is a racemic compound that weakly inhibits indoleamine dioxygenase, but is also a very slow substrate. (wikipedia.org)
Significance1
- This study examined the prognostic significance of indoleamine-pyrrole 2,3-dioxygenase (IDO) expression in patients with LARC who received preoperative CRT. (tokushima-u.ac.jp)
ELISA6
- Detects human Indoleamine 2,3-dioxygenase/IDO in direct ELISA. (rndsystems.com)
- system_update_altデータシートsystem_update_alt安全性データシート概要商品名:Human LOXL3 / Lysyl Oxidase Homolog 3 ELISA Kit製品コード:HUFI00677サイズ:96Tエイリアス:LOXL3, Lysyl oxidase homolog 3, LOL3, LOXL, lysyl (assaygenie.jp)
- system_update_altデータシートsystem_update_alt安全性データシート概要商品名:Human JAK3 ELISA Kit製品コード:HUFI00675サイズ:96Tエイリアス:JAK3, JAKL, LJAK, L-JAK, JAK-3, tyrosine-protein kinase JAK3 (assaygenie.jp)
- system_update_altデータシートsystem_update_alt安全性データシート概要商品名:Human CTLA4 / CD152 ELISA Kit製品コード:HUFI00481サイズ:96Tエイリアス:CTLA4, Cytotoxic T Lymphocyte Associated Antigen 4, CD152, CD, CD152 (assaygenie.jp)
- system_update_altデータシートsystem_update_alt安全性データシート概要商品名:Human CD86 / B7-2 ELISA Kit製品コード:HUFI00476サイズ:96Tエイリアス:B7-2, CD86, Activation B7-2 antigen, B70, B7-2 antigen, B-lymphocyte (assaygenie.jp)
- system_update_altデータシートsystem_update_alt安全性データシート概要商品名:Human APOA2 / Apolipoprotein A-II ELISA Kit製品コード:HUFI00458サイズ:96Tエイリアス:APOA2, Apo-AII, ApoA-II, apoAII, Apo-A2, Apolipoprotein (assaygenie.jp)
Gene1
- To investigate the contribution of genomic variations in the indoleamine 2,3-dioxygenase (IDO) gene to the onset of pre-eclampsia. (nih.gov)
Profiles1
- Below are the most recent publications written about "Homogentisate 1,2-Dioxygenase" by people in Profiles. (umassmed.edu)
Descriptor1
- Homogentisate 1,2-Dioxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
Mechanism1
- It was recently shown that maturation of DCs in the presence of PGE2 results in upregulation of indoleamine 2,3-dioxygenase (IDO) providing a potential mechanism for the development of DC-mediated Tcell tolerance. (nih.gov)
20231
- 44(3): 217-230, 2023 03. (bvsalud.org)
Term1
- 2. Expression of indoleamine 2,3-dioxygenase in tumor endothelial cells correlates with long-term survival of patients with renal cell carcinoma. (nih.gov)
Expression3
- 7. Programmed death ligand 1/indoleamine 2,3-dioxygenase 1 expression and tumor-infiltrating lymphocyte status in renal cell carcinoma with sarcomatoid changes and rhabdoid features. (nih.gov)
- 10. High PD-L1/IDO-2 and PD-L2/IDO-1 Co-Expression Levels Are Associated with Worse Overall Survival in Resected Non-Small Cell Lung Cancer Patients. (nih.gov)
- The expression of programmed cell death (PD)-1, PD1-ligand 1 (PD-L1), forkhead box P3 (Foxp3), transforming growth factor (TGF)-β, and indoleamine-pyrrole 2,3-dioxygenase (IDO) were examined using immunohistochemistry and the relationships between sidedness and several prognostic factors were examined. (tokushima-u.ac.jp)
Inflammation1
- In addition, metabolites of kynurenine downstream of KMO, such as anthranilic acid and 3-hydroxy-anthranilic acid can influence inflammation, and the ratio of these compounds is a valuable biomarker of inflammatory status although the underlying molecular mechanisms of the changes require clarification. (ox.ac.uk)
Minor topic1
- This graph shows the total number of publications written about "Homogentisate 1,2-Dioxygenase" by people in this website by year, and whether "Homogentisate 1,2-Dioxygenase" was a major or minor topic of these publications. (umassmed.edu)
Patients2
- Some patients were given one dose of pembrolizumab, and others were given pembrolizumab continuously every 3 weeks. (ascopost.com)
- In two patients who received pembrolizumab every 3 weeks, we see prolonged persistence of CAR T cells. (ascopost.com)
Date1
- 12 months from date of receipt, 2 to 8 °C as supplied. (rndsystems.com)
Function1
- IDO has an antimicrobial function due to its decreasing the availability of the essential amino acid tryptophan in inflammatory environments (3). (rndsystems.com)