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Indole AlkaloidsSecologanin Tryptamine AlkaloidsCatharanthusAlkaloidsTerpenesRauwolfiaAspidospermaVinca AlkaloidsIndolesRubiaceaeMonoterpenesPlant ExtractsAlstoniaCarbon-Nitrogen LyasesSea BreamPrenylationLyngbya ToxinsTabernaemontanaUncariaIridoid GlucosidesIbogaineMolecular StructureApocynaceaePlant BarkPyrrolizidine AlkaloidsPsychotriaIridoidsTryptaminesPlants, MedicinalPlant LeavesGelsemiumSalvia officinalisMitragynaAlocasiaCinchona AlkaloidsDiterpenesErythritolGlucosidasesResins, PlantStereoisomerismAmphibian VenomsSesquiterpenesOils, VolatileOxylipinsCyclopentanesMagnetic Resonance SpectroscopyBerberine AlkaloidsHepatophytaCurcumaVolatile Organic CompoundsBiological ProductsRhizomeGingerAlkyl and Aryl TransferasesLimoninsTriterpenesAngiospermsAmaryllidaceae AlkaloidsAzadirachtaXyluloseAspergillusAconitumGas Chromatography-Mass SpectrometryPiceaPlant RootsAporphinesClavicepsOleanolic AcidMolecular ConformationMolecular Sequence DataCarbolinesPhytotherapyBenzylisoquinolinesGene Expression Regulation, PlantHarmineDelphiniumTryptophanMevalonic AcidPlant ProteinsSolanaceous AlkaloidsCyclizationPlantsBerberineAcetatesNeotyphodiumCoptisRutaceaeTryptophanasePlant PoisoningSkatoleFlavonoidsFruitErgotismLycopodiumErgotamine
BiosynthesisCatharanthusTerpene indole alkaloidsMonoterpenoid indole alkaloidsRauvolfiaSecondary metabolitesStrictosidineRauwolfia AlkaloidsBenzylisoquinoline alkaloidsAccumulateBiosyntheticCompoundsAccumulationAmorphousPathwayTryptophan decarboxylaseYieldHeterocyclicBerberineVinblastineYieldsPrecursorPlantSecologaninBiochemistryHyoscyamineSyntheticProductionImportantMajorActiveApplicationsCellsCondition
Biosynthesis9
  • Two moieties are involved in the biosynthesis of ajmalicine, the terpenoid moiety and the indole moiety. (wikipedia.org)
  • Since the terpenoid indole alkaloids (TIAS) biosynthesis pathway is adjustable, modification of underlying substrate and enzymes concentration by biotic and abiotic elicitors are important approaches for overproduction of these metabolites. (jmp.ir)
  • 9. Hedhili S, Courdavault V, Giglioli-Guivarc'h N, Gantet P. Regulation of the terpene moiety biosynthesis of Catharanthus roseus terpene indole alkaloids. (jmp.ir)
  • Assessing the limitations to terpenoid indole alkaloid biosynthesis in Catheranthus roseus hairy root cultures through gene expression profiling and precursor feeding. (northeastern.edu)
  • Secologanin, a secoiridoid glucoside, is a pivotal terpenoid intermediate in the biosynthesis of biologically active monoterpenoid indole alkaloids such as reserpine, ajmaline, and vinblastine which are biosynthesized via strictosidine, an alkaloidal glucoside, formed from secologanin and tryptamine. (go.jp)
  • shoots) in terms of alkaloid accumulation and transcript abundance of strictosidine beta-d-glucosidase (SGD) and acetyl-CoA: 4-O-deacetylvindoline 4-O-acetyl-transferase (DAT) genes, representing intermediate and late steps, respectively, of terpenoid indole alkaloid biosynthesis. (braf-signal.com)
  • Published in Nature Chemical Biology, this collaborative work demonstrates a scalable de novo manufacturing platform for bioactive monoterpenoid indole alkaloids (MIAs, plant metabolites that possess various medicinal properties) in yeast and provides a foundation for further pathway refactoring toward microbial biosynthesis of both native and new-to-nature MIAs. (univ-tours.fr)
  • Our new spotlight published in Trends in Plant Science, on a report by Li et al on single-cell multi-omics approach used to elucidate the architecture and regulation of anticancer alkaloid biosynthesis in medicinal plants. (univ-tours.fr)
  • In this highlight published in ChemBioChem, we discuss how tropane alkaloid biosynthesis evolved via the recruitment of two distinct and convergent pathways in Erythroxylaceae and Solanaceae. (univ-tours.fr)
Catharanthus3
  • 5. Alam MM, Naeem M, Khan MMA and Uddin M. Vincristine and vinblastine anticancer catharanthus alkaloids: pharmacological applications and strategies for yield improvement. (jmp.ir)
  • The invaluable antineoplastic bisindole alkaloids of Catharanthus roseus and their precursor, vindoline, are not produced in cell cultures. (braf-signal.com)
  • Transient studies of nutrient uptake, growth, and indole alkaloid accumulation in heterotrophic cultures of hairy roots of Catharanthus roseus. (ac.ir)
Terpene indole alkaloids1
  • Extracts containing these terpene indole alkaloids (TIAs) can inhibit the formation and destabilize preformed fibrils of amyloid β protein (a pathological marker of Alzheimer's disease), and have been shown to improve the cognitive function of mice with Alzheimer-like symptoms. (biomedcentral.com)
Monoterpenoid indole alkaloids1
Rauvolfia1
Secondary metabolites2
  • Terpenoids comprise another large family of secondary metabolites, consisting of over 40,000 different compounds 4 . (scialert.net)
  • Alkaloids are naturally occurring secondary metabolites, low molecular weight, and nitrogen containing compounds that are found in more than 20% of plant species [ 1 ]. (biomedcentral.com)
Strictosidine1
Rauwolfia Alkaloids2
Benzylisoquinoline alkaloids7
  • Kalra, A. Endophytes of opium poppy differentially modulate host plant productivity and genes for the biosynthetic pathway of benzylisoquinoline alkaloids. (thelondonbridged.com)
  • Many benzylisoquinoline alkaloids have been reported to show therapeutic properties and to act as novel medicines. (biomedcentral.com)
  • Thus it is important to collect and compile benzylisoquinoline alkaloids in order to explore their usage in medicine. (biomedcentral.com)
  • We extract information about benzylisoquinoline alkaloids from various sources like PubChem, KEGG, KNApSAcK and manual curation from literature. (biomedcentral.com)
  • This information was processed and compiled in order to create a comprehensive database of benzylisoquinoline alkaloids, called BIAdb. (biomedcentral.com)
  • The current version of BIAdb contains information about 846 unique benzylisoquinoline alkaloids, with multiple entries in term of source, function leads to total number of 2504 records. (biomedcentral.com)
  • A database of benzylisoquinoline compounds has been created, which provides comprehensive information about benzylisoquinoline alkaloids. (biomedcentral.com)
Accumulate2
Biosynthetic1
  • Alkaloids can be classified on the basis of biological activities, chemical structure and biosynthetic pathways. (biomedcentral.com)
Compounds2
  • Chemically, these compounds are either nitrogen-containing (alkaloids) or nitrogen-deficient (terpenoids and phenolics) 2 . (scialert.net)
  • alkaloid is applied to nitrogen containing molecules belonging to one of the largest and most diverse families of naturally occurring compounds. (slideshare.net)
Accumulation1
  • cultures caused transcriptional upregulation of SGD and enhanced the accumulation of total alkaloids but did not produce vindoline as DAT transcripts were always found to be absent in suspension-cultured cells. (braf-signal.com)
Amorphous2
Pathway3
  • The terpenoid moiety is synthesized by the MEP pathway. (wikipedia.org)
  • The indole moiety is brought about by the indole pathway, where tryptophan decarboxylase (TDC) catalyzes the formation of tryptamine from tryptophan. (wikipedia.org)
  • the enzyme is involved in the 2-C-methyl-D-erythritol-4-phosphate/terpenoid metabolic pathway part of the iridoid pathway, overview. (brenda-enzymes.info)
Tryptophan decarboxylase1
  • Artemisinic acid was studied as a novel elicitor to enhance the yield of terpenoid indole alkaloids, artemisinic acid can up-regulate the transcriptions of tryptophan decarboxylase, geraniol 10-hydroxylase, tabersonine 16-hydroxylase and deacetoxyvindoline 4-hydroxylase. (biopurify.com)
Yield3
  • Breeding techniques have produced more than 100 varieties, with improved floral traits, increase tolerance to disease and alkaloid yield. (stuartxchange.org)
  • Leaves and stems yield dimeric alkaloids vincristine and vinblastine. (stuartxchange.org)
  • Extraction yield of alkaloids by ultrasound- microwave-assisted extraction reached 16.146 mg∙g -1 , which was significantly higher than that by ultrasound-assisted extraction, microwave-assisted extraction and heating extraction. (chinbullbotany.com)
Heterocyclic1
  • iv) Indole: is an aromatic heterocyclic organic compound (v) Terpenoid: a diverse class of naturally occurring organic chemicals. (biomedcentral.com)
Berberine2
  • Thin-layer chromatography and high-performance liquid chromatography revealed that the alkaloid extract contained magnoflorine, and berberine was not detectable. (chinbullbotany.com)
  • The benzylisoquinoline alkaloid (BIA) is a diverse category of alkaloids including berberine, morphine, sanguinarine, hydrastine and many more. (biomedcentral.com)
Vinblastine1
  • Vinblastine and vincristine alkaloids are dominantly biosynthesized in the aerial parts of periwinkle, broadly applied for cancer treatment. (jmp.ir)
Yields1
  • The transcriptome data from this study provides an important resource for understanding the formation of major bioactive constituents in the capsule extract from Uncaria , and provides information that may aid in metabolic engineering to increase yields of these important alkaloids. (biomedcentral.com)
Precursor1
  • In garlic, the major flavor precursor is sulfur-alk(en)yl cysteine sulfoxide (ACSO, alliin), which is degraded by alliinase enzymes upon tissue disruption to give pyruvate, ammonia, and thiosulfinate. (springeropen.com)
Plant3
  • Mitragynine - Indole based opioid receptor agonist and the most abundant active alkaloid in the plant. (thekratomstore.com)
  • 7-Hydroxymitragynine - A terpenoid indole alkaloid from the plant. (thekratomstore.com)
  • A protocol of ultrasound-microwave-assisted extraction was developed to isolate alkaloids from the medicinal plant Epimedium brevicornum , and the extraction mechanism is discussed. (chinbullbotany.com)
Secologanin3
  • Secologanin Tryptamine Alkaloids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Secologanin Tryptamine Alkaloids" by people in Harvard Catalyst Profiles by year, and whether "Secologanin Tryptamine Alkaloids" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Secologanin Tryptamine Alkaloids" by people in Profiles. (harvard.edu)
Biochemistry1
  • Alkaloids: biochemistry, ecology, and medicinal applications. (wikipedia.org)
Hyoscyamine1
  • Tropane alkaloids (TA) including anisodamine, anisodine, hyoscyamine and scopolamine are a group of important anticholinergic drugs with rapidly increasing market demand, so it is significant to improve TA production by biotechnological approaches. (biomedcentral.com)
Synthetic1
  • This database will also serve researchers working in the field of synthetic biology, as developing medicinally important alkaloids using synthetic process are one of important challenges. (biomedcentral.com)
Production1
  • Therefore, over production of these alkaloids by using the biotechnological approaches is inevitable. (jmp.ir)
Important2
Major3
Active3
  • The active ingredients in this drug are alkaloids and about 50 have been identified through various studies, although the primary psychoactive components appear to be reserpine, rescinnamine, and deserpidine 10 . (drugbank.com)
  • Alkaloids belonging to this class are found to be pharmacologically active and show potential therapeutic properties. (biomedcentral.com)
  • Tetrandrine (TET) is a bis-benzylisoquinoline alkaloid, which is identified as an active ingredient in Radix Stephanae tetrandrae (a Chinese medicinal herb). (biomedcentral.com)
Applications1
Cells2
  • The inhibitory effect of E. brevicornum alkaloids on human cervical cancer HeLa cells was investigated. (chinbullbotany.com)
  • E. brevicornum alkaloids exhibited a significant dose-dependent inhibitory activity against human cervical cancer HeLa cells. (chinbullbotany.com)
Condition1