Thalassemia, sickle cell disease and sickle-HbC have been found to be associated with cold agglutinin disease. (ispub.com)
Conceivably, the increased expression of "I" and "I" in sickle cell disorders, thalassemia and HbE and polycythemia vera might render the erythrocytes in these disorders more vulnerable to cold agglutinins and hemolysis. (ispub.com)
The PCR-RFLP technology was used to determine variant of G6PD deficiency and haplotype analysis of sickle cell, while ARMS-PCR and GAP-PCR was used for detecting the mutation pattern in β-thalassaemia and α-thalassaemia respectively. (biomedcentral.com)
The present study reveals wide spread prevalence of sickle cell anaemia, α-thalassaemia, G6PD deficiency and malaria in the studied population. (biomedcentral.com)
Hematologic1
Teardrop cells may be seen in the setting of marrow infiltration (by fibrosis, granulomatous inflammation, hematologic or metastatic malignancy), splenic abnormalities, megaloblastic anemia, and thalassemia. (askhematologist.com)
Hemoglobin4
''Thalassemias are inherited blood disorders characterized by decreased hemoglobin production. (drpareshmajumder.com)
thus normal hemoglobin levels and red cell indices do not necessarily exclude the condition. (findzebra.com)
Thalassemia is an entity involving a collection of inherited diseases caused by defective or absent hemoglobin chain synthesis leading to anemia due to ineffective erythropoiesis. (hindawi.com)
The primary forms of NTDT include β -thalassemia intermedia, hemoglobin E (HbE) β -thalassemia, and hemoglobin H disease [ 9 ]. (hindawi.com)
Abnormalities1
1981), with mental retardation and alpha-thalassemia without molecular abnormalities of the alpha-globin gene complex on chromosome 16p. (findzebra.com)
Microcytic1
A hemoglobinopathy work up was done due to the microcytic hypochromic indices. (ispub.com)
Diagnosis4
As a result, compound heterozygosity for hemochromatosis may be more common than diagnosis based on pathology would suggest. (wikipedia.org)
We present the difficulties we encountered in treating his resistant psychosis, the process of diagnosing his co-morbidities (beta-thalassemia and latent Toxoplasma gondii infection), a differential diagnosis of the intense positive symptoms the patient presented and the implications of toxoplasmosis in the evolution and treatment of a paranoid schizophrenic patient. (romjpsychiat.ro)
This comprehensive review aims to assess the significance of the Mentzer, Shine& Lal, and other red cell indices in the diagnosis of IDA and their utility in clinical practice. (journalahrj.com)
When used in conjunction with a comprehensive clinical evaluation, these indices can aid in the diagnosis of IDA and guide appropriate management strategies. (journalahrj.com)
Genetic2
Thalassemias are genetic disorders inherited from a person's parents. (drpareshmajumder.com)
This prospective study was planned to evaluate the role of genetic polymorphisms in QTL genes as determinant of HbF levels in beta thalassemia major patients. (mdpi.com)
Alpha globin2
[7] The severity of alpha and beta thalassemia depends on how many of the four genes for alpha globin or two genes for beta globin are missing. (drpareshmajumder.com)
The authors suggested that the responsible locus encoded a trans-acting factor involved in the normal regulation of alpha-globin expression. (findzebra.com)
Complications4
ABSTRACT In the present study, the aim was to explore the quality of life of thalassaemia major (TM) patients according to age, sex, school performance, severity and complications of the disease. (who.int)
RÉSUMÉ La présente étude vise à examiner la qualité de vie de patients atteints de thalassémie majeure en fonction de l'âge, du sexe, des résultats scolaires, et de la gravité et des complications de la maladie. (who.int)
Patients who carry the trait are often asymptomatic and continue to live a normal life, while β -thalassemia major patients suffer from many complications that may be ameliorated due to lifelong transfusions. (hindawi.com)
These 3 clinical entities are the ones suggested such that reactive oxygen species are an integral player in the development of disease specific complications. (hindawi.com)
Differential1
All recently resettled refugees, regardless of age and ethnicity, should have a complete blood count (CBC) with red blood cell indices, white blood cell differential, and platelet count. (cdc.gov)
Molecular1
Molecular characterization of β S revealed the presence of Arab-Indian haplotype in all HbS cases and IVS 1-5 G → C mutation in all β-thalassaemia cases. (biomedcentral.com)
Mutation1
A number sign (#) is used with this entry because X-linked alpha-thalassemia/mental retardation syndrome is caused by mutation in the ATRX gene (300032) on Xq21. (findzebra.com)
Clinical2
The term Nontransfusion dependent thalassaemia (NTDT) was suggested to describe patients who had clinical manifestations that are too severe to be termed minor yet too mild to be termed major. (hindawi.com)
Nontransfusion-dependent thalassemia (NTDT), as its name implies, is a term coined to describe those patients that do not require lifelong transfusions who instead may need emergent transfusions for specific clinical settings [ 8 ]. (hindawi.com)
Manifestations1
Hereditary spherocytosis or hereditary elliptocytosis is suspected in patients with unexplained hemolysis (as suggested by the presence of anemia and reticulocytosis), particularly if splenomegaly, a family history of similar manifestations, or suggestive RBC indices are present. (msdmanuals.com)
Infection1
He had a fever and splenomegaly, suggesting an underlying infection or lymphoma. (ispub.com)
The degree of red blood cell hypochromia and Hb H levels, which varied from 0.7 to 6.7%, were milder than usually found in alpha-thalassemia. (findzebra.com)
Red Blood Cell (RBC) indices and HbF levels were assessed. (mdpi.com)
Oxidative damage by reactive oxygen species (generated by free globin chains and labile plasma iron) is believed to be one of the main contributors to cell injury, tissue damage, and hypercoagulability in patients with thalassemia. (hindawi.com)
Various red cell indices, including the Mentzer, Shine& Lal, and other emerging indices, have been proposed as practical tools for distinguishing IDA from other types of anemia (7,16,18). (journalahrj.com)
In conclusion, the Mentzer, Shine& Lal, and other emerging red cell indices offer valuable tools for screening and differentiating IDA from other forms of anemia. (journalahrj.com)
Clear indices of cell death-myocyte disruption, coagulative necrosis, elevation of cardiac proteins in serum-are present by 24 hours. (spiritsong.org)
Patients5
see alpha-thalassemias, 141800) and mental retardation in 3 unrelated patients of northern European descent. (findzebra.com)
As opposed to thalassemia major, where transfusional induced iron overload is targeted towards the reticuloendothelial system and parenchyma, iron is amassed in patients with NTDT that differ, primarily occurs in hepatocytes [ 10 - 13 ]. (hindawi.com)
The objective of this study is to test and validate on our population a score established from the parameters of SYSMEX XN analyzers, to differentiate patients with monocytic dysplasia - which may suggest a hematological malignancy, in particular CMML -, from patients with reactive monocytosis, and reduce the number of unnecessary BS. (journalahrj.com)
justifiant de ce fait une meilleure prise en charge de ces patients. (bvsalud.org)
La présente étude détermine la prévalence de l'infection par le virus de l'hépatite C en en determinant les génotypes ainsi que les facteurs y associés dans ce groupe de patients. (bvsalud.org)
Blood2
Cold agglutinin disease was suggested by the agglutination of RBC in cold and the absence of clumping when blood was incubated at 37º. (ispub.com)
In spite of normal blood count figures, careful observation of blood morphology suggested previously unsuspected disorders. (askhematologist.com)
Study1
Beta-thalassaemia major (TM) is a Study design distant relatives due to TM. (who.int)
Iron2
The rate of iron loading is significantly different in thalassemia major ranging between 0.30 and 0.60 mg/kg/day versus 0.01 mg/kg/day in NTDT [ 14 ]. (hindawi.com)
The pattern of iron accumulation and the predilection of iron to target organs in NTDT is markedly different from transfusion-dependent thalassemia (TDT). (hindawi.com)
Case2
Porteous and Burn (1990) described a 6-year-old boy who had a maternal uncle with an X-linked mental retardation syndrome, and suggested that their case resembled 2 brothers previously thought to have an atypical form of the Coffin-Lowry syndrome (303600) (illustrated in Smith's Recognizable Patterns of Human Malformation, Jones, 1988). (findzebra.com)
Prices nationally rose 15.8% over July 2021, and while that is a wide gain, it was well below the 18.1% gain in the previous month, according to the S&P CoreLogic Case-Shiller Indices. (eoption.com)
Disease1
It was also suggested that the incidence of individuals born with the severe form of the disease is 60,000 per year. (hindawi.com)
Male1
1990) described the syndrome in a 21-year-old male and his brother who had died earlier, suggesting X-linked inheritance. (findzebra.com)
Studies1
A systematic search was conducted to identify relevant studies and publications that evaluated the diagnostic accuracy of these indices in different patient populations. (journalahrj.com)