AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceNamed GroupsHealth Care
Cord Blood Stem Cell TransplantationTransplantation, HomologousHematopoietic Stem Cell TransplantationGraft vs Host DiseaseTransplantation ConditioningFetal BloodHematologic NeoplasmsGraft vs Leukemia EffectGraft vs Tumor EffectLeukemiaTransplantation, AutologousBone Marrow TransplantationSpinal CordTreatment OutcomeRetrospective StudiesRecurrenceAcute DiseaseSpinal Cord InjuriesTime FactorsTransplantation ChimeraSurvival RateIsoantigensGraft SurvivalT-LymphocytesLymphocyte Culture Test, MixedFollow-Up StudiesHistocompatibility TestingTissue DonorsUmbilical CordBlood BanksStem Cell TransplantationHistocompatibilityRisk FactorsWhole-Body IrradiationProspective StudiesAntigens, CD34Infant, NewbornTransplantation, IsogeneicHematopoietic Stem CellsBusulfanLymphocyte ActivationMyeloablative AgonistsSkin TransplantationTransplantation ImmunologyGraft RejectionGraft vs Host Reaction
Umbilical-cordTransplantationGraft versusAutologousTransplantTransplantsDonorHuman leukocyHematopoietic stemGVHDPediatric patientsBoneMortalityUnderwentMalignantAutoimmuneChronicTransfusionRegistriesEfficacyClinical trialsMalignanciesEngraftmentApplicabilityRegenerative medicineComplicationsDisordersTreatment2018Total nucleatedHSCsTherapiesProgenitor cellsYearsAffectsPlacentalGloballyStableRemains
Umbilical-cord11
  • Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood in order to replicate inside of a patient and to produce additional normal blood cells. (wikipedia.org)
  • The three sources of stem cells include bone marrow, umbilical cord blood, and peripheral blood. (oncologynurseadvisor.com)
  • Kilbride P, Meneghel J, Lamb S, Morris J, Pouzet J, Jurgielewicz M, Leonforte C, Gibson D, Madrigal A. Recovery and Post-Thaw Assessment of Human Umbilical Cord Blood Cryopreserved as Quality Control Segments and Bulk Samples. (anthonynolan.org)
  • Many people look at umbilical cord blood as medical waste after a baby's birth. (cellculturedish.com)
  • Researchers are using umbilical cord blood to develop NK cells, NK-CAR and other types of T cells. (cellculturedish.com)
  • In addition, the isolation and storage of umbilical cord blood hematopoietic stem cells have been used to rebuild the immune system for the treatment of hematological malignancies and might be promising for the dynamic equilibrium expansion of functional T cells [ 12 ]. (hindawi.com)
  • 1987). Umbilical cord blood was recognized as an alternative source of hematopoietic stem cells (Gluckman et al. (revistadehematologia.org.mx)
  • 1999). First identified and isolated from the bone marrow (BM), MSCs can now be expanded from a variety of other tissues including adipose tissue (AT), umbilical cord blood (UCB), skin, tendon, muscle, and dental pulp (Im et al. (pdffox.com)
  • and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
  • Natural killer (NK) cells derived from donated umbilical cord blood and activated with a novel bispecific antibody known as AFM13 (which targets CD16A and CD30) were shown to be effective in patients with pretreated and refractory CD30-positive lymphoma. (ascopost.com)
  • The use of umbilical cord blood (UCB) has been steadily increasing, and UCB transplantation (UCBT) currently accounts for one-third of all allogeneic HCTs. (apbmt.org)
Transplantation28
  • Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
  • In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
  • In 2006, 50,417 first HSCTs were recorded worldwide, according to a global survey of 1,327 centers in 71 countries conducted by the Worldwide Network for Blood and Marrow Transplantation. (wikipedia.org)
  • The Worldwide Network for Blood and Marrow Transplantation reported the millionth transplant to have been undertaken in December 2012. (wikipedia.org)
  • In 2014, according to the World Marrow Donor Association, stem-cell products provided for unrelated transplantation worldwide had increased to 20,604 (4,149 bone-marrow donations, 12,506 peripheral blood stem-cell donations, and 3,949 cord-blood units). (wikipedia.org)
  • Allogeneic hematopoietic stem cell transplantation (HSCT) can effectively induce immunological antileukaemic control in patients with ALL by means of the graft-versus-leukaemia effect (GvL), but treatment related mortality (TRM), morbidity and late effects remain serious problems of this treatment modality. (gpoh.de)
  • The most common adverse event following allogeneic hematopoietic stem cell transplantation (HSCT) is graft-versus-host disease (GVHD), which can increase morbidity and mortality in HSCT patients. (oncologynurseadvisor.com)
  • Forlanini F, Zinter MS, Dvorak CC, Bailey-Olson M, Winestone LE, Shimano KA, Higham CS, Melton A, Chu J, Kharbanda S. Hematopoietic Cell Transplantation-Comorbidity Index Score Is Correlated with Treatment-Related Mortality and Overall Survival following Second Allogeneic Hematopoietic Cell Transplantation in Children. (ucsf.edu)
  • Mild Acute Graft-Versus-Host Disease Improves Outcomes After HLA-Haploidentical-Related Donor Transplantation Using Posttransplant Cyclophosphamide and Cord Blood Transplantation. (kyoto-u.ac.jp)
  • There is a paucity of information to guide selection of the most suitable stem cell donor in haploidentical (Haplo) hematopoietic stem cell transplantation (HSCT). (bvsalud.org)
  • In the majority of patients, this disorder is typically characterized by infantile-onset hemophagocytic lymphohistiocytosis (HLH), which is lethal unless allogeneic transplantation is performed. (biomedcentral.com)
  • Patients with an absence of cytotoxic T lymphocyte (CTL) function have a high risk for developing HLH, and could therefore benefit the most from early hematopoietic stem cell transplantation (HSCT). (biomedcentral.com)
  • This was the first report of a hematopoietic stem cell transplantation (HSCT) conducted in Mexico, only 4 years after the pioneer work by E. Donnall Thomas in Cooperstown, New York, USA (Ruiz-Argüelles et al. (revistadehematologia.org.mx)
  • Body iron disorders have been reported after myeloablative conditioning in patients undergoing hematopoietic stem cell transplantation (HSCT). (karger.com)
  • The Allogeneic bone-marrow transplantation represents the only curative treatment and requires a compatible donor HLA. (longdom.org)
  • Since then, allogeneic hematopoietic stem cell transplantation (HSCT) has evolved to become a frequently used and effective therapy for many hematologic malignancies. (longdom.org)
  • Allogeneic bone marrow transplantation, as we understood it, allows saving lives, but cannot take place without donors. (longdom.org)
  • If one of the brothers and sisters is compatible, we speak about geno-identical allogeneic transplantation having the advantage of reducing the complications post-transplantation. (longdom.org)
  • In this case we will speak about pheno-identical allogeneic transplantation. (longdom.org)
  • Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
  • Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
  • Long-term efficacy of haploidentical hematopoietic stem cell transplantation in the treatment of pediatric acute leukemia[J]. Blood&Genomics. (blood-genomics.com)
  • Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the optimal treatment for pediatric patients with high-risk or intermediate-acute myeloid leukemia. (blood-genomics.com)
  • There was no difference in transplantation-related toxicity (TRT) in terms of infection, hepatic dysfunction, oral mucositis, and engraftment syndrome between the haploidentical HSCT and HLA-matched HSCT groups. (blood-genomics.com)
  • Major increases were observed in allogeneic, haploidentical HSCT and, to a lesser extent, in cord blood transplantation. (unisg.ch)
  • Figure 1 shows the trend in the annual number of allogeneic and autologous HCTs in adults with AML reported in the Japanese transplantation registry. (apbmt.org)
  • His research focus is on haematopoietic stem cell transplantation (HSCT) and translational research of normal and malignant stem cells. (edu.au)
  • Professor Ma holds leadership or scientific membership positions in a number of national and international scientific communities including the World Network for Blood & Marrow Transplantation (a WHO affiliated NGO), the AsiaPacific BM Transplant and the Royal College of Pathology of Australasian Quality Assurance Programme. (edu.au)
Graft versus5
  • Infection and graft-versus-host disease are major complications of allogeneic HSCT. (wikipedia.org)
  • GvHD can also occur after a blood transfusion , known as Transfusion-associated graft-versus-host disease or TA-GvHD if the blood products used have not been gamma irradiated or treated with an approved leukocyte reduction system. (wikipedia.org)
  • There are medical benefits to using cord-such as less graft-versus-host disease (GvHD) and less relapse-that made it my preferred graft source. (cellculturedish.com)
  • For this reason, we conducted a retrospective analysis in order to evaluate the impact of Haplo family donors characteristics on HSCT outcomes in patients with acute myeloid leukemia (AML) who received graft-versus-host disease prophylaxis with post-transplant cyclophosphamide (PTCy). (bvsalud.org)
  • The 3-year probability of total chronic graft-versus-host disease (GVHD) was 21.4% and 34.1% in the haploidentical and HLA-matched HSCT groups, respectively ( P =0.526). (blood-genomics.com)
Autologous10
  • It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an identical twin). (wikipedia.org)
  • Autologous HSCT requires the extraction (apheresis) of hematopoietic stem cells (HSCs) from the patient and storage of the harvested cells in a freezer. (wikipedia.org)
  • These advantages have established autologous HSCT as one of the standard second-line treatments for such diseases as lymphoma. (wikipedia.org)
  • Use of allogeneic, and to a lesser degree autologous HCT, decreased for lymphoid malignancies likely reflecting availability of new treatment modalities, including small molecules, bispecific antibodies, and CAR-T cells. (bvsalud.org)
  • Pediatric HCT activity remains stable (+0.3%) with differences between allogeneic and autologous HCT. (bvsalud.org)
  • In recent years, especially after the advent of reduced intensity conditioning in the late 1990s, allogeneic HSCT is increasingly used in older patients and as an effective salvage strategy for patients with lymphoma or myeloma not responding to chemotherapy or autologous HSCT. (longdom.org)
  • Data on 68 146 hematopoietic stem cell transplants (HSCTs) (53% autologous and 47% allogeneic) gathered by 1566 teams from 77 countries and reported through their regional transplant organizations were analyzed by main indication, donor type and stem cell source for the year 2012. (unisg.ch)
  • Compared with 2006, an increase of 46% total (57% allogeneic and 38% autologous) was observed. (unisg.ch)
  • 1,000 new AML patients undergoing allogeneic or autologous HCT. (apbmt.org)
  • Allogeneic HCT has been widely used, while autologous HCT, which is still useful, is less prevalent because of concerns around post-transplant relapse, as well as the recently extended application of allogeneic HCT. (apbmt.org)
Transplant11
  • Non-myeloablative, so-called mini transplant (microtransplantation) procedures, have been developed requiring smaller doses of preparative chemotherapy and radiation therapy, allowing HSCT to be conducted in the elderly and other patients who would otherwise be considered too weak to withstand a conventional treatment regimen. (wikipedia.org)
  • This is known as an allogeneic matched sibling transplant. (zhihuiya.com)
  • Allogeneic transplants involve grafts from a genetically nonidentical donor of the same species and are the transplant type most often used in children. (oncologynurseadvisor.com)
  • [11] About one-third to one-half of allogeneic transplant recipients will develop acute GvHD. (wikipedia.org)
  • Donor Killer Cell Immunoglobulin-Like Receptor Genotype Does Not Improve Graft-versus-Leukemia Responses in Chronic Lymphocytic Leukemia after Unrelated Donor Transplant: A Center for International Blood and Marrow Transplant Research Analysis. (anthonynolan.org)
  • Many of these patients needed an allogeneic hematopoietic stem cell transplant (HSCT)-also known as a blood stem cell transplant-to treat their disease. (cellculturedish.com)
  • I used cord blood almost exclusively as the graft source for transplant unless a patient had an HLA-matched sibling. (cellculturedish.com)
  • Method: We aimed to evaluate the temporal trends in HSCT transplant rates in Argentina. (bvsalud.org)
  • In April 1960, Dr. Álvaro Gómez-Leal, presented during the first meeting of the Agrupación Mexicana para el Estudio de la Hematología, A.C., data on a transplant of allogeneic stem cells in a patient with acute leukemia done in Monterrey, Mexico: the patient received high-dose chemotherapy followed by stem cells from the bone marrow of his brother, improving and obtaining remission for months but relapsing and subsequently died. (revistadehematologia.org.mx)
  • ECIL-6 guidelines recommend quantitative PCR of whole blood, plasma, or serum to screen for EBV DNA in allogeneic hematopoietic stem cell transplant (HSCT) recipients and to monitor EBV DNA-emia. (medscape.com)
  • The 5-year probability of overall survival (OS) after allogeneic HCT was estimated to be 56% (95% confidence interval[CI], 55%- 57%) for patients receiving a transplant while in CR, and 22% (95% CI, 21%-23%) for those who were experiencing active disease. (apbmt.org)
Transplants1
  • Balassa K, Danby R, Rocha V. Haematopoietic stem cell transplants: principles and indications. (anthonynolan.org)
Donor5
  • As Stem cell source has to be used an classical mismatched donor, a haploidentical donor or, cord blood. (gpoh.de)
  • Evseeva I, Foeken L, Madrigal A. The Role of Unrelated Donor Registries in HSCT. (anthonynolan.org)
  • In conclusion, donor-related variables significantly influence AML patient outcomes following Haplo-HSCT with PTCy. (bvsalud.org)
  • The donor must be between 18 and 50 years at the time of the registration which takes place after a medical interview and a blood sample to determine its typing HLA. (longdom.org)
  • The superior clinical outcomes of allogeneic SCT versus chemotherapy alone as post-remission treatment could be related to the graft-versus-leukemia (GVL) effects of recovered donor T cells. (biomedcentral.com)
Human leukocy2
  • In the last decade the short term outcome of 900 children with ALL from more than 60 different study centres who received allogeneic HSCT has improved, due to the use of donors more closely matched by Human leukocyte antigen (HLA) typing, resulting in less severe graft vs host disease (GvHD) and better supportive care. (gpoh.de)
  • This study analyzed the clinical outcomes of 119 pediatric acute leukemia patients who underwent haploidentical HSCT ( n =68) or human leukocyte antigen (HLA)-matched HSCT ( n =51). (blood-genomics.com)
Hematopoietic stem4
  • 1957). This pioneering work laid the foundation for the exploration of hematopoietic stem cells and their role in treating diseases of the blood and immune system. (revistadehematologia.org.mx)
  • 1989). Hematopoietic stem cells could be harvested easier from peripheral blood after mobilization with G-CSF (Sheridan et al. (revistadehematologia.org.mx)
  • 1992). Since then, hematopoietic stem cells, with their unique ability to differentiate into various blood cell types, have proven to be a revolutionary tool in the treatment of numerous hematological disorders. (revistadehematologia.org.mx)
  • HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
GVHD4
  • To date, no standard treatment is established for GVHD and no therapies are FDA approved for this indication in pediatric or adult patients. (oncologynurseadvisor.com)
  • Recent studies are investigating the efficacy of rituximab (Rituxan) for GVHD in pediatric HSCT patients. (oncologynurseadvisor.com)
  • The white blood cells present within the transplanted tissue then attack the recipient's body's cells, which leads to GvHD. (wikipedia.org)
  • GvHD occurs when the donor's immune system's white blood cells reject the recipient. (wikipedia.org)
Pediatric patients1
  • The study suggests that haploidentical HSCT shows comparable OS, LFS, and GRFS to HLA-matched HSCT in pediatric patients with acceptable complications, and can therefore be recommended as an effective alternative for this population. (blood-genomics.com)
Bone6
  • It is most often performed for patients with certain cancers of the blood or bone marrow, such as multiple myeloma or leukemia. (wikipedia.org)
  • The patient is then treated with high-dose chemotherapy with or without radiotherapy with the intention of eradicating the patient's malignant cell population at the cost of partial or complete bone marrow ablation (destruction of patient's bone marrow's ability to grow new blood cells). (wikipedia.org)
  • A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. (curehunter.com)
  • Bone marrow is the place for the production of the hematopoietic cells which differentiate in to three groups: red blood cells, white blood cells and platelets. (longdom.org)
  • A bone marrow cancer that is characterized by under production of white blood cells, red blood cells and platelets. (jax.org)
  • The number of related HCTs has remained stable, while the use of peripheral blood stem cells (PBSCs) has now largely replaced that of bone marrow (BM). (apbmt.org)
Mortality1
  • For other cancers such as acute myeloid leukemia, though, the reduced mortality of the autogenous relative to allogeneic HSCT may be outweighed by an increased likelihood of cancer relapse and related mortality, so the allogeneic treatment may be preferred for those conditions. (wikipedia.org)
Underwent1
  • Data were collected between March and September of 2016, through the evaluation of the medical records of 43 patients who underwent HSCT and developed some type of psychological distress. (bvsalud.org)
Malignant1
Autoimmune1
  • He has successfully taken research discoveries to the bedside and has been instrumental in establishing many of the clinicial HSCT procedures and current clinical trials including HSCT for severe autoimmune diseases and HIV. (edu.au)
Chronic4
  • 5 however, it has been used to treat many pediatric hematologic conditions, including chronic immune thrombocytopenic purpura, posttransplant lymphoproliferative disease, juvenile rheumatoid arthritis, and other blood dyscrasias. (oncologynurseadvisor.com)
  • When a patient is diagnosed with a blood cancer or chronic blood condition, it is often the start of a new journey that will be the beginning of great change. (rochester.edu)
  • In chronic myeloid leukemia (CML), HSCT which is once the mainstay for cure is now largely supplemented by molecularly targeted therapy. (longdom.org)
  • In the absence of better evidence, the American Society of Anesthesiologists (ASA) stated in 2001, "[the ASA] does not believe that extremes of age, smoking, stable COPD [chronic obstructive pulmonary disease], stable cardiac disease, or resolved recent upper respiratory infection should be considered unequivocal indications for chest radiography. (blogspot.com)
Transfusion1
  • Treatment of thrombopathy requires, first of all symptomatic measures: haemostatic glues, desmopressin and the blood transfusion which must be only reserved for the difficult gestures or for the high hemorrhagic risk. (longdom.org)
Registries1
  • Currently, more than 266,000 cord blood units are listed on the Be The Match Registry ® and more than 806,000 are listed on US and international registries. (cellculturedish.com)
Efficacy1
Clinical trials1
  • According to ClinicalTrials.gov, there are at least 1,200 clinical trials evaluating the use of cord blood stem and progenitor cells. (bioinformant.com)
Malignancies1
  • However, CAR-T cells can also produce some adverse events after treatment of hematological malignancies, such as cytokine release syndrome (CRS), neurotoxicity, and on-target/off-tumor toxicity, which may cause systemic immune stress inflammation, destruction of the blood-brain barrier, and even normal tissue damage. (hindawi.com)
Engraftment1
  • In order to better understand the LPI kinetics and its determinants and implications, we undertook sequential LPI determinations before and after conditioning until engraftment in 25 auto-HSCT patients. (karger.com)
Applicability2
  • The successful application of HSCT for diseases such as leukemia, lymphoma, myeloma, and inherited blood disorders underscored its broad applicability in clinical practice (Snowden et al. (revistadehematologia.org.mx)
  • Changes in both HSCT and non-HSCT therapy have modified the indications and applicability of HSCT over time. (longdom.org)
Regenerative medicine2
  • At a fundamental level, cord blood banks are both a real estate investment (cryogenic storage facilities) and a regenerative medicine (RM) play. (bioinformant.com)
  • Cord blood has the potential to be an important source of therapeutic cells for a growing range of regenerative medicine applications. (bioinformant.com)
Complications1
  • There is a concern that labile plasma iron (LPI), the redox-active form of iron, can be involved in the occurrence of toxicity and other complications commonly observed in the early post-HSCT period. (karger.com)
Disorders3
  • Other IEMs treated by HSCT include other mucopolysaccharide disorders such as Maroteaux Lamy syndrome (MPSVI), other lysosomal storage disorders (LSDs), and the peroxisomal disorder X-linked adrenoleukodystrophy (X-ALD). (ashpublications.org)
  • The challenge will address three blood disorders that exact an enormous toll on populations around the globe. (scinfo.org)
  • Sickle cell disease is a group of inherited red blood cell disorders arising from a single genetic mutation that can cause severe pain and potentially lead to premature death. (scinfo.org)
Treatment3
  • Quality of life is an important indication for second-line treatment in children with immune thrombocytopenia. (ucsf.edu)
  • HSCT) has significantly modified the prognosis of when the pathological process involves BM or when patients with hereditary or acquired hematological, hematopoietic toxicity is the limiting factor in the oncological and immunological diseases and it is the aggressive treatment of the disease. (bvsalud.org)
  • Ruxolitinib is the first and only FDA-approved treatment for this indication. (org.in)
20181
  • The WHO age-sex standardized HSCT rates for the entire country were 153.3 HSCT/10 million inhabitants (95% CI 141.7 −165.8) in 2009 and 260.1 HSCT/10 million inhabitants (95% CI 245.5−275.5) in 2018. (bvsalud.org)
Total nucleated2
  • These studies use unmanipulated whole cord blood (total nucleated cells/TNC), mononuclear cells (MNC), or cord blood-derived mesenchymal stem cells (MSCs). (bioinformant.com)
  • That means a cell and gene therapy developer will have a significant amount of information about a cord blood unit that's been selected, such as total nucleated cell count, CD34+ count, HLA type, volume and viability. (cellculturedish.com)
HSCs1
  • HSCs are characterized by their unique ability to self-renew and give rise to the entirety of the blood and immune system throughout the lifetime of an individual. (longdom.org)
Therapies1
  • Accelerated Biosciences discovered and has freedom-to-operate to the Human Trophoblast Stem Cell (hTSCs) platform for allogeneic therapies and bioproduction. (meetingonthemed.com)
Progenitor cells1
  • Most type II PNH cells (total lack of GPI-linked protein) are due to a frame shift mutation occurring in the early hematopoietic progenitor cells, resulting in same mutation in all blood cell lines. (medscape.com)
Years6
  • Although most were apparently well, survivors at 10 years and 15 years after HSCT continued to have an increased risk of death compared with a group of individuals from the healthy population who were age-matched and sex-matched. (medscape.com)
  • For both therapeutic and financial reasons, the cord blood industry has been witnessing record levels of merger and acquisition (M&A) activity in recent years, with market leaders gaining market share at the expense of smaller competitors and investors vying for buy-in opportunities. (bioinformant.com)
  • Substantial cord blood industry consolidation has happened in recent years and investor appetite for cord blood banks has never been stronger. (bioinformant.com)
  • and (5) how other therapeutic modalities, including ERT, gene therapy, and substrate reduction therapy, might complement and compete with HSCT in the coming years. (ashpublications.org)
  • 2021). Twenty years later, in 1980, Ricardo Sosa and his coworkers at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán conducted and published another HSCT (Sosa-Sánchez et al. (revistadehematologia.org.mx)
  • A chest radiograph (CXR) was obtained for the indication of preoperative evaluation in a patient with asthma older than 55 years. (blogspot.com)
Affects1
  • Anemia affects roughly a third of the world's population and occurs when the body makes too few red blood cells, destroys too many red blood cells, or loses blood. (scinfo.org)
Placental1
  • Specifically, cord blood, cord tissue, placental blood and tissue, and amniotic fluid have demonstrated intriguing therapeutic promise, causing storage services for these biomaterials to proliferate. (bioinformant.com)
Globally1
Stable1
Remains1
  • 2 Most subsequent transplantations in IEM have been for Hurler syndrome (MPSIH), and it remains the most common IEM for which HSCT is indicated and performed and about which most is understood in terms of factors determining both graft and disease outcome. (ashpublications.org)