DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceHealth Care
Acute Radiation SyndromeRadioactive Hazard ReleaseRadiation Injuries, ExperimentalRadiation InjuriesWhole-Body IrradiationRadiation-Protective AgentsRadiation DosageLethal Dose 50Dose-Response Relationship, RadiationRadiodermatitisSyndromeRadiation PneumonitisTerrorismDisaster PlanningMass Casualty IncidentsSeptember 11 Terrorist AttacksTerminology as TopicHazardous Substances
Lymphoblastic leukemiaRespiratory distressHematopoieticMyeloidRisk of acute myelogenMyelodysplastic SyndromeNuclear Countermeasures Program2023SymptomsEmergenciesSepsisNplateClinical indicationsAntibody Radiation-ConjugatesLeukemiaExposure to ionizingDoseIllnessNeutronsOccurChemotherapy or radiationTherapyCancerTherapeuticGeneticVaccinesBoneInfectious DiseasesDiagnosisTherapiesDoses of radiationSicknessInfectionsIonizing RadiationElectromagnetic radiationSevereTreatmentTreatmentsImmatureOrgansAssessesPhase-IIIDiagnosticSignificantSegmentTreatIntervention
Lymphoblastic leukemia1
  • This phase II trial studies the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell acute lymphoblastic leukemia (B-ALL) that has come back (relapsed). (sncrf.org)
Respiratory distress3
  • Acute respiratory distress syndrome (ARDS): Evaluate patients who develop fever, lung infiltrates, or respiratory distress. (drugs.com)
  • Opaganib is a novel oral pill with a five-year shelf-life that is being developed for multiple indications, including COVID-19, acute respiratory distress syndrome (ARDS), oncology, and more. (stocktitan.net)
  • Acute Respiratory Distress Syndrome (ARDS). (drugs.com)
Hematopoietic6
  • Increase survival in patients acutely exposed to myelosuppressive doses of radiation (Hematopoietic Subsyndrome of Acute Radiation Syndrome). (drugs.com)
  • Patients with Hematopoietic Syndrome of Acute Radiation Syndrome (HS-ARS): Nplate is indicated to increase survival in adults and pediatric patients (including term neonates) acutely exposed to myelosuppressive doses of radiation. (orau.gov)
  • With the January 28, 2021 approval of Nplate® for hematopoietic acute radiation syndrome (H-ARS), the FDA has now granted approvals for four products to treat H-ARS, three of which relied on NIAID-supported preclinical data. (orau.gov)
  • Amgen has a target action date of January 28 for its Nplate for Hematopoietic Syndrome of Acute Radiation Syndrome (H-ARS). (pharmalive.com)
  • AREAS COVERED: We reviewed pharmaceutical products approved to treat Hematopoietic Acute Radiation Syndrome (H-ARS) and to treat or prevent pulmonary infections following Bacillus anthracis (anthrax) exposure. (bvsalud.org)
  • This includes any patient requiring urgent radiation to any sites of extramedullary disease prior to enrollment (e.g. retinal/optic nerve involvement) * Hematopoietic stem cell transplant (HSCT): Patients must not have had a prior hematopoietic stem cell transplant * A single intrathecal chemotherapy at the time of relapse will be allowed. (sncrf.org)
Myeloid2
  • Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML): Monitor patients with breast and lung cancer using UDENYCA in conjunction with chemotherapy and/or radiotherapy for signs and symptoms of MDS/AML. (drugs.com)
  • Researchers believe that up to 20% of acute myeloid leukemias may be caused by smoking. (bloodhealthadvice.com)
Risk of acute myelogen1
  • Exposure to the chemical benzene is known to increase the risk of certain leukemia and smoking can increase risk of acute myelogenous leukemia. (dayspringcancerclinic.com)
Myelodysplastic Syndrome2
  • Iodine i 131 apamistamab is under clinical development by Actinium Pharmaceuticals and currently in Phase II for Myelodysplastic Syndrome. (pharmaceutical-technology.com)
  • According to GlobalData, Phase II drugs for Myelodysplastic Syndrome have a 30% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. (pharmaceutical-technology.com)
Nuclear Countermeasures Program1
  • This funding is in addition to the multimillion-dollar U.S. Government Radiation and Nuclear Countermeasures Program (RNCP) contract awarded to opaganib. (stocktitan.net)
20231
  • ROCKVILLE, Md , Nov. 20, 2023 /PRNewswire/ -- NeoImmuneTech, Inc. (NIT or "NeoImmuneTech"), a clinical-stage T cell-focused biopharmaceutical company, today announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation (ODD) for their investigational drug NT-I7 (efineptakin alfa) (rhIL-7-hyFc) for the treatment of Acute Radiation Syndrome (ARS). (nwahomepage.com)
Symptoms4
  • the full syndrome will usually occur with a dose greater than approximately 0.7 Gy (70 rads) although mild symptoms may occur as low as 0.3 Gy or 30 rads. (cdc.gov)
  • The DelveInsight's Acute Radiation Syndrome market report gives a thorough understanding of the Acute Radiation Syndrome by including details such as disease definition, symptoms, causes, pathophysiology, diagnosis, and Acute Radiation Syndrome treatment. (delveinsight.com)
  • Acute Radiation Syndrome-- The signs and symptoms which, taken together, characterize a person suffering from the effects of intense radiation. (cdc.gov)
  • As a result, this type of leukemia can go undiagnosed with little indications of symptoms. (dayspringcancerclinic.com)
Emergencies1
  • Five agents authorized for anthrax emergencies only have FDA approval for this indication, five antibiotics have FDA approvals as antibiotics for common infections and for bacillus anthrax, and four agents have regulatory approvals for supportive care for cancer and for radiological incidents. (bvsalud.org)
Sepsis3
  • The "magic bullet"-like properties of RRx-001 interact with several therapeutic targets, including NLRP3, to treat a range of indications such as cancer, acute radiation syndrome, NASH, sickle cell disease, sepsis, Parkinson's and Alzheimer's Diseases, inflammatory bowel, and cardiopulmonary disorders. (epicentrx.com)
  • Abiraterone was associated with greater increase in rates of acute heart failure, atrial fibrillation, acute kidney injury, urinary tract infections, sepsis, and pneumonia. (bvsalud.org)
  • Sepsis and Septic Shock Sepsis is a clinical syndrome of life-threatening organ dysfunction caused by a dysregulated response to infection. (msdmanuals.com)
Nplate3
  • NIAID -sponsored studies demonstrated that administration of Nplate®, originally licensed in 2008 for treatment of immune thrombocytopenia, increased platelet counts and improved survival in preclinical models of lethal radiation exposure. (orau.gov)
  • Nplate® represents a new class of molecules to target radiation-induced hemorrhage by increasing platelet counts. (orau.gov)
  • Wednesday, the U.S. Department of Health and Human Services (HHS) said it's throwing down $290 million to lock up an undisclosed amount of Amgen's blood disorder med Nplate, which is approved to treat blood cell injuries linked to acute radiation syndrome (ARS) in kids and adults. (robertscottbell.com)
Clinical indications1
  • In addition, clinical indications involving the roots of teeth are mostly endodontic or related and require single dental X-ray as the best imaging modality with minimal radiation dose. (bvsalud.org)
Antibody Radiation-Conjugates1
  • Actinium Pharmaceuticals (Actinium) develops antibody radiation conjugates (ARC), which combine the targeting ability of antibodies with the cell killing ability of radiation. (pharmaceutical-technology.com)
Leukemia6
  • 1. Acute leukemia deals with immature blood cells called blasts. (dayspringcancerclinic.com)
  • People who've undergone certain types of cancer treatments like chemotherapy or radiation are at a great risk for certain types of leukemia. (dayspringcancerclinic.com)
  • Genetic abnormalities like Down syndrome and a family history of leukemia add to risk factors. (dayspringcancerclinic.com)
  • Surgery, radiation, and chemotherapy are common conventional treatments for leukemia which can be very aggressive on the body. (dayspringcancerclinic.com)
  • People with Down syndrome and certain other genetic conditions get leukemia more frequently. (bloodhealthadvice.com)
  • Exposure to high doses of ionizing radiation has been associated with the development of all types of leukemia except CLL. (bloodhealthadvice.com)
Exposure to ionizing2
  • The purpose of this draft guidance is to provide information and recommendations to assist sponsors and other interested parties in the development of drugs to prevent or treat acute radiation syndrome ( ARS ) caused by exposure to ionizing radiation from accidental or deliberate events. (govdelivery.com)
  • Acute Exposure-- An exposure to ionizing radiation for a duration of less than 15 days. (cdc.gov)
Dose12
  • Administer the first dose as soon as possible after suspected or confirmed exposure to myelosuppressive doses of radiation, and a second dose one week after. (drugs.com)
  • Acute Radiation Syndrome (ARS) (sometimes known as radiation toxicity or radiation sickness) is an acute illness caused by irradiation of the entire body (or most of the body) by a high dose of penetrating radiation in a very short period of time (usually a matter of minutes). (cdc.gov)
  • The dose usually must be external (i.e., the source of radiation is outside of the patient's body). (cdc.gov)
  • The entire body (or a significant portion of it) must have received the dose.3 o Most radiation injuries are local, frequently involving the hands, and these local injuries seldom cause classical signs of ARS. (cdc.gov)
  • 4 o The survival rate of patients with this syndrome decreases with increasing dose. (cdc.gov)
  • 2 The referenced absorbed dose levels in this document are assumed to be from beta, gamma, or x radiation. (cdc.gov)
  • Neutron or proton radiation produces many of the health effects described herein at lower absorbed dose levels. (cdc.gov)
  • ARS is an illness that occurs following a high dose of radiation exposure, leading to severe damage to the bone marrow and the immune system. (nwahomepage.com)
  • Absorbed Dose-- The energy imparted by ionizing radiation per unit mass of irradiated material. (cdc.gov)
  • This term refers to the practice of making every reasonable effort to keep exposure to radiation as far below the dose limit as possible while still achieving the purpose for which radiation is licensed to be used. (cdc.gov)
  • In a comparison of prospectively gated 64- and 256-slice CT scanning, the 256-slice scan provided better and more stable image quality, at equivalent effective radiation dose. (medscape.com)
  • ARS, also known as radiation sickness, occurs when a person's body is exposed to a high dose of penetrating radiation, which is capable of "reaching internal organs in a matter of seconds," HHS explained in a release. (robertscottbell.com)
Illness4
  • The influence of background (natural) radiation during the spectrum replacement of the illness spectrum in the organism is accounted for to enhance the oppression and destruction of the illness spectrum. (kalinka-store.com)
  • The CEM Tech device analyzes and blocks pathological electromagnetic radiation which always accompanies illness. (kalinka-store.com)
  • Somatropin should not be used to treat patients with acute critical illness due to complications following open heart surgery, abdominal surgery or multiple accidental trauma, or those with acute respiratory failure. (nutropin.com)
  • Increased mortality in patients with acute critical illness due to complications following open heart surgery, abdominal surgery or multiple accidental trauma, or those with acute respiratory failure has been reported after treatment with pharmacologic doses of somatropin. (nutropin.com)
Neutrons1
  • o High energy X-rays, gamma rays, and neutrons are penetrating radiations. (cdc.gov)
Occur3
  • External exposure to radiation may occur from natural or man-made sources. (cdc.gov)
  • it can also occur secondary to radiation therapy and certain medications. (medscape.com)
  • Takotsubo syndrome or broken heart syndrome, can occur when a person experiences sudden acute stress that can rapidly weaken the heart muscle and often mimic or cause cardiomyopathy. (sentaraproviderresources.com)
Chemotherapy or radiation1
  • IVIG therapy is a vital treatment option for individuals with immunodeficiency disorders such as primary immunodeficiency diseases, Acquired Immunodeficiency Syndrome (AIDS), and secondary immunodeficiency disorders resulting from chemotherapy or radiation therapy. (reportsanddata.com)
Therapy9
  • o Fractionated doses are often used in radiation therapy. (cdc.gov)
  • Given the poor prognosis of all patients with DIPG, patients may enroll at any point in their disease course provided they have received standard radiation therapy (also defined below) and meet all other eligibility requirements. (childrenshospital.org)
  • Standard radiation therapy is defined, for this study, as 54-60 Gy standard focal (photon or proton) radiation therapy, administered over 6 weeks (+/- 10 days). (childrenshospital.org)
  • Patients who receive standard radiation therapy with concurrent chemotherapy may be eligible as long as other criteria are met. (childrenshospital.org)
  • Patients must have received their last fraction of radiation therapy at least 2 weeks prior to treatment initiation. (childrenshospital.org)
  • The acute infections segment is also expected to witness significant revenue growth during the forecast period, owing to the growing incidence of infectious diseases and the increasing use of IVIG therapy for their treatment. (reportsanddata.com)
  • The increasing incidence of infectious diseases, particularly in emerging economies, is expected to drive demand for IVIG therapy and hence revenue growth in the acute infections segment. (reportsanddata.com)
  • splenic ablation by splenectomy or radiation therapy may be indicated. (msdmanuals.com)
  • The data will come from a study design that calls for the enrollment of approximately 190 patients in a randomized, multinational, double-blind, placebo-controlled study to evaluate SGX942 for the treatment of severe oral mucositis in patients with squamous cell carcinoma of the oral cavity that are undergoing chemo-radiation therapy. (thenewsuniverse.com)
Cancer3
  • On the death toll of the accident, the report states that 28 emergency workers died from acute radiation syndrome and 15 patients died from thyroid cancer. (wikipedia.org)
  • Also different from the other inhibitors in the review, RRx-001 is in a Phase 3 clinical trial for the treatment of small cell lung cancer (SCLC) and a soon-to-start trial in first line head and neck cancer for protection against the radiation- and chemotherapy-driven development of severe oral mucositis (blistering in the mouth). (epicentrx.com)
  • In childhood cancer survivors who were treated with radiation to the brain/head for their first neoplasm and who developed subsequent GHD and were treated with somatropin, an increased risk of a second neoplasm has been reported. (nutropin.com)
Therapeutic1
  • And, at least two products are developing quickly from the company's late-stage bio-defense vaccine program, one that has successfully demonstrated compelling vaccine protection with its heat stable ricin toxin vaccine technology, and the other showing promising treatments that offer therapeutic benefit to specialized markets including acute radiation syndrome, and antibiotic-resistant infectious disease. (thenewsuniverse.com)
Genetic1
Vaccines1
  • Report all clinically significant post-vaccination reactions to the Vaccine Adverse Event Reporting indications for which licensed vaccines are recommended. (cdc.gov)
Bone1
  • Myelosuppression happens when radiation damages internal organs, including bone marrow. (pharmalive.com)
Infectious Diseases1
Diagnosis1
  • The 2021 American Heart Association/American College of Cardiology guidelines for the evaluation and diagnosis of chest pain represent the first ever guidelines for the evaluation of patients with acute chest pain. (uscjournal.com)
Therapies3
Doses of radiation1
  • Patients receiving high doses of radiation can't produce enough new white blood cells, red blood cells, and platelets, which is called myelosuppression. (pharmalive.com)
Sickness1
  • In what could be a troubling sign of the times, the United States is stocking up on radiation sickness drugs. (robertscottbell.com)
Infections2
  • Based on application, the global intravenous immunoglobulin (IVIG) market has been segmented into immunodeficiency diseases, autoimmune diseases, acute infections, and others. (reportsanddata.com)
  • Eleutherococcus is useful in acute kidney infections, chronic fatigue, immune dysfunction syndrome and general exhaustion and weakness. (youarethehealer.org)
Ionizing Radiation3
  • Ionizing radiation can also be in the form of particulate radiation, which includes subatomic l charged or neutral particles traveling near the speed of light and therefore with high very high kinetic energy. (medscape.com)
  • Absorber-- Any material that absorbs or lessens the intensity of ionizing radiation. (cdc.gov)
  • Crystalline cesium iodide and cesium fluoride are used in scintillation counters, which convert energy from ionizing radiation into pulses of visible light for radiation detection and spectroscopy. (cdc.gov)
Electromagnetic radiation2
  • Energy can travel through space in the form of electromagnetic radiation. (medscape.com)
  • Electromagnetic radiation is composed of massless waves of oscillating electric and magnetic fields. (medscape.com)
Severe3
  • In the case of a radiological or nuclear public health emergency, many thousands of people could experience severe injuries from radiation exposure, resulting in immunosuppression and infection, hemorrhage, major morbidities, and even death. (orau.gov)
  • Acute-onset, severe hypertension that is accurately measured using standard techniques and is persistent for 15 minutes or longer is considered a hypertensive emergency. (medscape.com)
  • Intravenous (IV) labetalol and hydralazine have long been considered first-line medications for the management of acute-onset, severe hypertension in pregnant women and women in the postpartum period. (medscape.com)
Treatment9
  • FDA announced availability of a draft guidance for industry, Acute Radiation Syndrome: Developing Drugs for Prevention and Treatment . (govdelivery.com)
  • Package inserts are available for radiation treatment pharmaceuticals calcium-DTPA, zinc-DTPA and Radiogardase (Prussian Blue). (orau.gov)
  • The Report also covers current Acute Radiation Syndrome treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the Acute Radiation Syndrome market. (delveinsight.com)
  • It also provides Acute Radiation Syndrome treatment algorithms and guidelines in the United States, Europe, and Japan. (delveinsight.com)
  • The FDA's Orphan Drug Designation is aimed at advancing treatments for rare diseases, including Acute Radiation Syndrome (ARS), which currently has limited treatment options. (nwahomepage.com)
  • The drug "Essentiale Forte" prescribed for the treatment of acute and chronic hepatitis, cirrhosis, necrosis of liver cells, hepatic coma and pre-conditions. (kakprosto.ru)
  • In addition, the "Essentiale Forte" is used in the treatment of psoriasis, neurodermatitis, radiation syndrome, and drug intoxication. (kakprosto.ru)
  • The safety of continuing somatropin treatment in patients receiving replacement doses for approved indications who concurrently develop these illnesses has not been established. (nutropin.com)
  • These criteria are intended to guide radiologists, radiation oncologists and referring physicians in making decisions regarding radiologic imaging and treatment. (bvsalud.org)
Treatments1
  • We believe that our state-of-the-art technology platform can be used to create additional cell products from the placenta, tailored to potentially deliver targeted treatments for a variety of new indications," stated Zami Aberman, Chairman and CEO of Pluristem. (israel21c.org)
Immature1
  • The major cause of this syndrome is depletion of immature parenchymal stem cells in specific tissues. (cdc.gov)
Organs3
  • The radiation must be penetrating (i.e., able to reach the internal organs). (cdc.gov)
  • For example, for 131I in the thyroid (source organ), the absorbed fraction could be the fraction of gamma radiation absorbed in the liver (one of the target organs). (cdc.gov)
  • Inventors explain its operation as stemming from the characteristics of semi-conductor structures with a memory effect which prepares "photography" of E-field radiations or frequency from sick organs and/or bacterium. (kalinka-store.com)
Assesses1
  • GlobalData's report assesses how Iodine i 131 apamistamab's drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. (pharmaceutical-technology.com)
Phase-III1
Diagnostic1
Significant1
  • Significant benefit is seen in any indication having delay in healing. (revitalife.co.in)
Segment1
  • The epidemiology segment also provides the Acute Radiation Syndrome epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan. (delveinsight.com)
Treat1
  • Radiation Emergency Assistance Center/Training Site (REAC/TS) professionals maintain a registry of clinical information and provide expertise to practitioners worldwide on the use of calcium-diethylenetriaminepentaacetic acid (DTPA) and zinc-diethylenetriaminepentaacetic acid (DTPA) and Radiogardase Prussian Blue (Radiogardase™) to treat radiation poisoning. (orau.gov)
Intervention1
  • Based on our conservative estimates for the direct cost savings, there are indications that the outreach facilitation intervention program would be cost effective if it can achieve a reduction in the probability of infection on the order of 0.83 (0.77, 1.05) percentage points. (biomedcentral.com)