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  • Ki67
  • The following grading scheme is currently recommended for all gastroenteropancreatic neuroendocrine neoplasms by the World Health Organisation: If mitotic count and ki67 are discordant, the figure which gives the highest grade is used. (wikipedia.org)
  • necrosis
  • The Trojani system scores the sample, depending on tumour differentiation, mitotic index, and tumour necrosis, between 0 and 6 and then converts this into a grade of between 1 and 3, with 1 representing a less aggressive tumour. (wikipedia.org)
  • frac
  • Therapeutic Index = L D 50 E D 50 {\displaystyle {\mbox{Therapeutic Index}}={\frac {\mathrm {LD} _{50}}{\mathrm {ED} _{50}}}} in animal studies, or for humans, Therapeutic Index = T D 50 E D 50 {\displaystyle {\mbox{Therapeutic Index}}={\frac {\mathrm {TD} _{50}}{\mathrm {ED} _{50}}}} For many drugs, there are severe toxicities that occur at sublethal doses in humans, and these toxicities often limit the maximum dose of a drug. (wikipedia.org)
  • arrest
  • Here, we show that Notch inhibition in KS tumor cells using γ-secretase inhibitors or Notch-1 small interfering RNA resulted in G 2 -M cell cycle arrest and mitotic catastrophe characterized by the presence of micronucleated cells and an increased mitotic index. (aacrjournals.org)
  • Further experiments revealed that the type B cells exhibited a biphasic dose-response curve, with mitotic arrest at low drug concentrations (100 nM nocodazole or 6 nM vincristine) that failed to depolymerize microtubules and a p53-independent p21 waf1/cip1 -associated G 1 and G 2 arrest at higher concentrations (1 μM nocodazole or 100 nM vincristine) that depolymerized microtubules. (pubmedcentralcanada.ca)
  • Our results indicate that HMEC and breast cancer cell lines can be divided into two groups, those that respond with the expected mitotic arrest and those that do not. (pubmedcentralcanada.ca)
  • tumor
  • Mitotic index in the regenerating liver of tumor-bearing mice. (jax.org)
  • Theologides, A and Zaki, G F., "Mitotic index in the regenerating liver of tumor-bearing mice. (jax.org)
  • Fibrovascular stroma confined to the neuronal component, perivascular lymphocytic infiltrates, and small foci of calcification are common, as is immunopositivity for synaptophysin, neuron-specific enolase, and chromogranin A. Elevated Ki-67 and p53 labeling index is associated with more aggressive tumor behavior in both children and adults with gangliogliomas. (wikipedia.org)
  • ratio
  • The therapeutic index (TI) (also referred to as therapeutic ratio) is a comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes toxicity. (wikipedia.org)
  • dose
  • A higher therapeutic index is preferable to a lower one: a patient would have to take a much higher dose of such a drug to reach the toxic threshold than the dose taken to elicit the therapeutic effect. (wikipedia.org)
  • example
  • For example, a market capitalization weighted index is more influenced by price changes in the stock of its largest companies than by price changes in the stock of its smaller companies. (thefreedictionary.com)
  • 1) A statistical indicator that measures changes in the economy in general or in particular areas.An example is the cost-of-living index. (thefreedictionary.com)
  • important
  • One of the most prominent examples of an index is the Dow Jones Industrial Average , which is weighted for price and tracks 30 stocks important in American markets. (thefreedictionary.com)
  • changes
  • An index reports changes up or down, usually expressed as points and as a percentage, in a specific financial market, in a number of related markets, or in an economy as a whole. (thefreedictionary.com)
  • among
  • For instance, among the opioid painkillers, remifentanil is the most forgiving, offering a therapeutic index of 33,000:1, while morphine is less so with a therapeutic index of 70:1. (wikipedia.org)