Independent poor prognostic. Medical search. Frequent questions

Conclusion: VGLL3 is overexpressed in GC tissues and associated with a poor prognosis, indicating its potential as a novel prognosis biomarker and therapeutic target for GC. (researchgate.net)
In conclusion, CEP55 was increased in ccRCC samples, and may be considered a potential diagnostic and prognostic biomarker for ccRCC. (urotoday.com)
Due to the huge heterogeneity of prognosis in CRC patients, a single biomarker was not enough to provide accurate prognostic information for CRC patients. (biomedcentral.com)
Plasma 25OHD level is a prognostic biomarker with low 25OHD associated with poorer survival, particularly in those with rs11568820 GG genotype. (bmj.com)
Based on the similar pathogenesis of squamous and glandular lesions of the cervix, we hypothesized that K17 overexpression could also be a diagnostic and/or prognostic biomarker for endocervical neoplasia. (medscape.com)
Thus, the goal of this study was to determine if K17 expression is a negative prognostic biomarker associated with decreased survival of patients with endocervical adenocarcinoma. (medscape.com)

Prognostic biomarkers can estimate the natural course of the disease and divide the tumor into two groups: good prognosis and poor prognosis [ 3 , 4 ]. (hindawi.com)
However, they are also important for summarising other evidence, such as the accuracy of screening and diagnostic tests, 1 the causal association of risk factors for disease onset, and the prognostic ability of bespoke factors and biomarkers. (bmj.com)
[ 16-20 ] There remains a critically important, unmet clinical need, however, to identify prognostic (as opposed to diagnostic) biomarkers of endocervical adenocarcinoma. (medscape.com)

In addition, the prognostic risk model nomogram showed that VGLL3 was the most important indicator, with an area under the receiver operating characteristic (ROC) curve (AUC) of 0.613 for 3-year survival and 0.706 for 5-year survival. (researchgate.net)
Zhang W, Zhang Y, Liu Q, Nie Y, Zhu X. Development and validation of a prognostic nomogram for decompensated liver cirrhosis. (wjgnet.com)
A prognostic nomogram was developed based on the previous immune genes. (biomedcentral.com)
This study aimed to establish a prognostic nomogram for predicting overall survival (OS) and cancer-specific survival (CSS) of patients with early-onset endometrial cancer (EOEC). (preprints.org)
Univariate and multivariate Cox regression analyses were performed to ascertain the independent factors impacting the prognosis of EOEC patients, while a prognostic nomogram was established. (preprints.org)

Various studies have shown that ALDH1 is one of the markers of CSC that can be used as a prognosis indicator because it can be a biological marker for poor prognostic factors in TNBC. (hindawi.com)
Various studies showed that ALDH1 is one of the CSC markers that can be used as an independent prognostic indicator in node-positive breast cancer [ 6 ]. (hindawi.com)
For instance, anemia alone is an established prognostic indicator in a variety of clinical circumstances. (ispub.com)
Tumoural HMGA1 expression was found to be an independent prognostic indicator in patients who underwent resection. (bl.uk)
K ep is an important indicator of altered blood-brain barrier permeability in patients with decreased blood flow, as K ep is flow-independent. (ajnr.org)
However, baseline phosphate is known to be an important prognostic indicator and was not well balanced between the two groups. (preprints.org)
[ 15 ] Other studies have shown K17 to be a negative prognostic indicator in gastric adenocarcinoma, bladder carcinoma, epithelial ovarian carcinoma, and triple-negative breast carcinoma. (medscape.com)

The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer. (springermedizin.at)
GPS: Glasgow Prognostic Score. (isciii.es)

Multivariate analysis indicated that stromal PD-L2 was an independent and favorable prognostic factor. (jcancer.org)
This prognostic model could discriminate high risk patients with poor prognosis from low risk patients with favorable prognosis. (biomedcentral.com)
Is lung involvement a favorable prognostic factor for pancreatic ductal adenocarcinoma with synchronous liver metastases? (lu.se)

TP53INP1 overexpression in PC seems to be a worse prognostic factor, particularly predictive of biological cancer relapse. (urotoday.com)
Adding CRP to the well-established prognostic models such as the R-IPI score might improve their predictive ability. (nih.gov)
Low TS expression was predictive of improved OS of patients with negative EGFR-mutated advanced AC-NSCLC, whereas high ERCC1 expression resulted in poor OS in patients with positive EGFR-mutated advanced AC-NSCLC. (medsci.org)

Multivariate analysis showed that VGLL3 expression status was an independent risk factor for prognosis. (researchgate.net)
Therefore, it may be a valuable prognostic factor for poor survival in CRC patients. (hindawi.com)
Using human colon adenocarcinoma tissues (hereinafter referred to as colon cancer) and their corresponding non-diseased colon from 114 patients' biopsies, the expression of SPARC and vascular endothelial growth factor (VEGF) were investigated by immunohistochemistry staining to assessment the relationship between SPARC and VEGF, as well as their prognostic significance in patients. (nih.gov)
Cox Regression Analysis, SPARC emerged as an overall survival and disease-free survival independent prognostic factor for colon cancer. (nih.gov)
The low expression or absence of stromal SPARC was an independent prognostic factor for poor prognosis of colon cancer. (nih.gov)
The conclusion of this study is that ALDH1 can be used as a poor prognostic factor in TNBC patients although it cannot be an independent prognostic factor. (hindawi.com)
In PC, TP53INP1 overexpression correlates with high Gleason grade, unfavorable D'Amico score and lymph node invasion, and is an independent factor of biological cancer relapse. (urotoday.com)
In the present study, we demonstrated high CRP levels at diagnosis of DLBCL as an independent poor prognostic factor for clinical outcome. (nih.gov)
Univariate and multivariate Cox proportional hazards analyses demonstrated that CEP55 expression was an independent risk factor for poor prognosis. (urotoday.com)
Young age is considered an independent poor prognostic factor in patients with breast cancer. (oncolink.org)
Finally, the risk score of prognostic signatures was indicated as an independent risk factor of survival. (frontiersin.org)
Our discovery of a novel independent prognostic factor in breast cancer highlights a correlation between tumor phenotype and immune contexture. (lu.se)
MPUC was an independent prognostic factor for PFS in multivariable analysis. (bmj.com)
Although thousands of prognostic factor studies are published each year, often they are of variable quality and the findings are inconsistent. (bmj.com)
A prognostic factor is any variable that is associated with the risk of a subsequent health outcome among people with a particular health condition. (bmj.com)
Different values or categories of a prognostic factor are associated with a better or worse prognosis of future health outcomes. (bmj.com)
For example, in many cancers, tumour grade at the time of histological examination is a prognostic factor because it is associated with time to disease recurrence or death. (bmj.com)
And PRDM5 expression was found to be an independent prognostic factor for GC. (jcancer.org)
This study aimed to evaluate the role of PD-L2 as a prognostic factor for NPC patients as well as its role in immune regulation. (jcancer.org)
The present study evaluated the prognostic value of the epidermal growth factor receptor (EGFR) mutation status, and excision repair cross-complementation group 1 (ERCC1) and thymidylate synthase (TS) expression following intercalated tyrosine kinase inhibitor (TKI) therapy and platinum- and pemetrexed-based chemotherapies (subsequent second-line treatment) for patients with adenocarcinoma non-small-cell lung cancer (AC-NSCLC). (medsci.org)
Increased CD68 + TAMs were a good prognostic factor in some cases and could be used as an independent prognostic factor in male T3 stage GC. (researchsquare.com)
Cox regression analysis suggested that our signature was an independent prognostic factor. (aging-us.com)
Age was one prognostic factor that demonstrated a consistent association with outcome in three studies, however cautious interpretation is advised. (biomedcentral.com)
At present, there is insufficient evidence to recommend any factor as an independent predictor of outcome. (biomedcentral.com)
this may be in part because they have a higher rate of triple-negative breast cancer (negative for estrogen and progesterone receptors and human epidermal growth factor receptor [HER2] oncogene), which has a poorer prognosis than other types. (msdmanuals.com)
[ 5 ] It has been shown that histologic type is an independent prognostic factor in cervical cancer, with adenocarcinoma subtypes being associated with a poorer prognosis compared with SCC. (medscape.com)

Many aspects of IMPC have previously been studied, including clinicopathological features, analysis of prognostic factors, and relative special markers [ 6 - 16 ]. (jcancer.org)

The T test, Chi square test, Kaplan-Meier survival analysis model, and Multivariate Cox proportional hazards regression model were applied to assess the prognostic significance of SLA, LDH, and serum ALB on the patients with mCRC. (hindawi.com)
The objective of this retrospective study was to clarify the potential prognostic significance of pre-therapeutic fibrinogen levels in head and neck squamous cell carcinoma (HNSCC) patients treated with curative intent by primary radiotherapy (RT) or with postoperative radiotherapy (PORT). (springermedizin.at)
However, whether they have prognostic significance in acute myeloid leukemia (AML) is unknown. (nature.com)

High HDGF expression is associated with poor overall survival in patients with HCC. (biomedcentral.com)
To identify the population of patients with high risk of distant metastasis and the poor prognosis before treatment, so as to provide early intervention and better treatment decision. (hindawi.com)
69 patients with nonmetastatic colorectal cancer (non-mCRC) and 57 with metastatic CRC (mCRC) were enrolled to evaluate the prognostic value of serum albumin (ALB), serum lactate (SLA), and lactate dehydrogenase (LDH) in patients with metastatic CRC. (hindawi.com)
Multivariable analysis showed the elevated LDH combined with elevated SLA (HR=2.922, 95%CI=0.971-8.793, P=0.056), the reduced ALB (HR=0.417, 95%CI=0.230-0.754, P=0.004), and the elevated CA199 (HR=2.072, 95%CI=1.125-3.816, P=0.019) were independent prognostic factors for PFS of patients with mCRC. (hindawi.com)
Taken together, our results implicate that the elevated LDH combined with elevated SLA and the reduced ALB are prognostic indicators for patients with mCRC. (hindawi.com)
Therefore, the elevated levels of SLA and LDH indicate the aggravated tumor burden, tumor angiogenesis, tumor progression, and poor prognosis of patients [ 14 ]. (hindawi.com)
This study assessed the prognostic survival rate with a retrospective cohort method in TNBC patients. (hindawi.com)
Both epigenetic classifiers identified poor prognosis patients that partially overlapped. (eur.nl)
The aim of this study was to evaluate the prognostic impact of pretreatment CRP levels on overall survival (OS) and disease-free survival (DFS) in a large bicentre study of DLBCL patients. (nih.gov)
PTC therefore represents an independent and easy to determine prognostic parameter for patients' oncological outcome. (uni-muenchen.de)
In patients with MM who never received ASCT (n=319), PARP1 and POLD2 were not associated with OS, suggesting that the prognostic effect of these genes may be treatment-dependent. (haematologica.org)
meanwhile, most patients treated with conventional therapies, including chemotherapy and radiotherapy, show recurrence after a short period of time, which results in poor patient prognosis ( 3 ). (spandidos-publications.com)
Using a cohort of 386 colon cancer patients we demonstrate that high MGL binding to stage III tumors is associated with poor disease-free survival, independent of microsatellite instability or adjuvant chemotherapy. (oncotarget.com)
The prognostic value of PRDM5 in GC patients was evaluated using Kaplan-Meier plotter. (jcancer.org)
For pNETs 1 to 4 cm, LNM predicts poor OS and DSS, which supports lymphadenectomy in these patients. (lww.com)
PD-L2 expressed on stromal cells might play a role in the regulation of NPC progression, and involve in immune activation in the tissue microenvironment and have an independent good prognosis for NPC patients. (jcancer.org)
The current study identified twenty prognostic immune genes for CRC patients and constructed an immune-related regulatory network. (biomedcentral.com)
To evaluate the prognostic capacity of the Inflammatory-Nutritional Index (INI) in gastrointestinal and lung cancer patients. (isciii.es)
The INI showed prognostic capacity in this sample and may be a useful tool, based on routinely available blood tests, to assess cancer patients. (isciii.es)
Elevated MCSF is correlated with invasion, metastasis and poor survival of tumour patients. (researchsquare.com)
Survival analysis revealed that IL8, IL2Ra (CD25) and PF4 were independent determinants of a more negative prognosis in mesothelioma patients, independent of other known prognostic factors. (iospress.com)
These patients have a poor prognosis, with unselected large series revealing median survivals between 7 and 11 months [ 3 , 4 ]. (iospress.com)
Patients with high-risk BC had poorer survival than those with low-risk BC. (aging-us.com)
The association between being diagnosed with a cardiometabolic disease before cancer and survival in patients with breast cancer and in patients with colorectal cancer was independent of body mass index (BMI). (who.int)
Having a higher BMI at ages 20-50 years was associated with poorer survival in patients with breast cancer and in patients with colorectal cancer. (who.int)
This finding may contribute to improved prognostic stratification in patients with cancer who are affected by cardiometabolic comorbidities. (who.int)

Previous studies indicate that low circulating 25-hydroxyvitamin D (25OHD) is associated with poor colorectal cancer (CRC) survival yet sample timing and inflammatory response to cancer or surgery may confound these findings. (bmj.com)

Prognostic Value and Clinical Predictors of Lymph Node Metas. (lww.com)
INI risk and severe malnutrition were independent predictors for poor survival. (isciii.es)
We tested for the ability of febrile illness and elevated cytokine levels to predict developmental outcomes, independent of known predictors of stunting, family income, and maternal education. (cdc.gov)

Diagnostic and prognostic value of CEP55 in clear cell renal cell carcinoma as determined by bioinformatics analysis. (urotoday.com)
An optimal prognostic model based on gene expression for clear cell renal cell carcinoma. (cdc.gov)

0.001, P = 0.001) and grade ( P = 0.011, P = 0.048) were independent prognostic factors of OS and DSS. (lww.com)
El grupo con INI de riesgo llevó 0.78 año para decaer 50%, en cuanto el grupo con INI normal llevó 2.78 año (p = 0.001). (isciii.es)

Here we aimed to evaluate whether MGL ligand expression has prognostic value and whether this was correlated to BRAF V600E mutation status. (oncotarget.com)
Concordance indexes, calibration curves, and Brier scores were used to evaluate the performance of prognostic model. (biomedcentral.com)

Conclusions We have observed that upper tract MPUC is associated with poor oncological outcomes in terms of PFS and CSS. (bmj.com)

Data from the TCGA-BRCA cohort were analyzed using univariate Cox regression analysis, and least absolute shrinkage and selection operator (LASSO) analysis was performed to build a stable prognostic model. (aging-us.com)

TERT Promoter Mutation as an Independent Prognostic Marker for Poor Prognosis MAPK Inhibitors-Treated Melanoma. (cdc.gov)
K17 is highly expressed in most cases of both invasive adenocarcinoma and in AIS and is a powerful, negative prognostic marker for patient survival. (medscape.com)

A growing body of evidence suggests that anemia reflects poor health and increases risks of adverse outcomes. (ispub.com)
Prognostic factors are associated with the risk of future health outcomes in individuals with a particular health condition or some clinical start point (eg, a particular diagnosis). (bmj.com)
Prognostic evidence arises from prognosis studies, which aim to examine and predict future outcomes (such as death, disease progression, side effects or medical complications like pre-eclampsia) in people with a particular health condition or start point (such as those developing a certain disease, undergoing surgery, or women who are pregnant). (bmj.com)
Clinical and biological markers of inflammation in the first year of life were significantly associated with poor neurodevelopmental outcomes. (cdc.gov)

In contrast, high tumor abundance of PD-L2 correlated with poor disease-free survival, but had no obvious correlation with clinicopathological parameters. (jcancer.org)

The prognostic value of AS events has been demonstrated in several cancer types, such as breast cancer ( 7 - 9 ), hepatocellular carcinoma ( 10 , 11 ), gastric cancer ( 12 , 13 ), and others ( 14 - 23 ). (frontiersin.org)
Teng Jj, Zhao Wj, Zhang Xl, Zhao DK, Qiu XY, Chen Xd, Yang L. Downregulation of promoter methylation gene PRDM5 contributes to the development of tumor proliferation and predicts poor prognosis in gastric cancer. (jcancer.org)

The prognostic influence of CRP and other factors, including age, tumour stage, and revised International Prognostic Index (R-IPI) on 5-year OS and 5-year DFS, were studied by Kaplan-Meier curves as well as univariate and multivariate Cox regression models. (nih.gov)
An independent significant association between high CRP levels and poor clinical outcome in multivariate analysis for 5-year OS (HR=1.51, CI 95%=1.04-2.20, P=0.031) and for DFS (HR=1.91, CI 95%=1.28-2.85, P=0.002) was found. (nih.gov)
The prognostic signatures based on AS events were built by multivariate Cox analysis. (frontiersin.org)

Aside from having a poor prognosis, triple-negative breast cancers also pose a challenge in terms of therapy. (hindawi.com)
We showed that HMGA1 is overexpressed in more than 90% of pancreatic cancers and is associated with poorer postoperative survival. (bl.uk)

General prognostic indicators that have been published include age, sex, histology, and performance status, with refinements accounting for weight loss, haemoglobin and albumin levels also being reported [ 6 ]. (iospress.com)
These findings suggest that markers of inflammation could serve as prognostic indicators and potentially lead to immune-based therapies to prevent developmental delays in at-risk children. (cdc.gov)

We show that circulating 25OHD falls after CRC surgery independent of C-reactive protein (CRP), a measure of systemic inflammatory response. (bmj.com)

Therefore, identification of efficient diagnostic and prognostic molecular markers may improve survival times. (urotoday.com)
Univariate Cox regression was used to screen prognostic markers for CRC. (biomedcentral.com)
Identification of Hepatocellular Carcinoma prognostic markers based on 10-immune gene signature. (cdc.gov)

Additionally, prognostic factors directly related to breast cancer including tumor size, histology, grade, nodal and receptor status, and stage at diagnosis are expressed differentially in the population by age and race/ethnicity [ 19 - 23 ] adding further complexity to any discussion of disparities in cancer care. (cdc.gov)

p=1.4e-12), yet the postoperative fall in 25OHD was independent of CRP. (bmj.com)

Here, we describe immune clusters which improve the prognostic accuracy of immune contexture in breast cancer. (lu.se)
Prognostic immune genes and transcription factors were used to construct an immune-related regulatory network. (biomedcentral.com)

However, the calculation formulas of these exquisite prognostic models are complex, which seriously restricts the popularization and application of clinical practice. (biomedcentral.com)

Prospective studies investigating the association between baseline prognostic factors and recovery over time were included. (biomedcentral.com)
Results are presented for nine studies that presented baseline prognostic factors for recovery after an acute ankle sprain. (biomedcentral.com)

Receiver operating characteristic (ROC) curves displayed that the area under the curve (AUC) of the following prognostic signatures, including exon skip (ES), alternate terminator (AT), alternate acceptor site (AA), alternate promoter (AP), alternate donor site (AD), retained intron (RI), and total events, was greater than 0.8, suggesting that these seven signatures had valuable prognosis prediction capacity. (frontiersin.org)
Two recent articles provided a guide to undertaking reviews and meta-analysis of prognostic (prediction) models. (bmj.com)

This subtype often has a poor prognosis with the 5 y disease survival rate being 40 % versus 88 % for invasive ductal carcinoma no special type (IDC-NST). (jcancer.org)

The associations between prognostic factors and poor recovery after an acute lateral ankle sprain are largely inconclusive. (biomedcentral.com)
There is a need for well-conducted prospective cohort studies with adequate sample size and long-term follow-up to provide robust evidence on prognostic factors of recovery following an acute lateral ankle sprain. (biomedcentral.com)

The identification of early prognostic factors associated with poor recovery may provide an opportunity for early-targeted intervention and improve outcome. (biomedcentral.com)

RÉSUMÉ Le taux de survie à cinq ans chez les femmes atteintes d'un cancer du sein en Jordanie et certains des facteurs ayant eu une influence sur la survie ont été mesurés. (who.int)
Toutes les femmes jordaniennes chez lesquelles un nouveau diagnostic de cancer du sein avait été posé en 1997-1998 ont été incluses. (who.int)
This association was independent of whether the patient had been diagnosed with cardiometabolic diseases, such as stroke, myocardial infarction, and type 2 diabetes, before being diagnosed with cancer. (who.int)
These results suggest that BMI has a direct effect on cancer survival that is independent of pre-diagnostic cardiometabolic disease. (who.int)

In medullary thyroid carcinomas, TP53INP1 overexpression correlates with poor prognosis. (urotoday.com)
Overexpression of HMGA1 promotes PI3-K/Akt-dependent anoikis resistance and anchorage independent proliferation. (bl.uk)

The expression of PRDM5 was downregulated in GC, and that was associated with poor survival and tumor progression. (jcancer.org)
TS and ERCC1 expression levels were effective prognostic factors for negative and positive EGFR-mutated AC-NSCLC, respectively. (medsci.org)

To study whether cells and molecules present in pleural effusions provide prognostic information for mesothelioma. (iospress.com)
This study demonstrates that pleural effusions rich in a range of soluble factors are associated with poor prognosis. (iospress.com)
Two independent assessors performed the study selection, data extraction and quality assessment of the studies. (biomedcentral.com)

Research to identify genuine prognostic factors is important because these factors can help improve risk stratification, treatment, and lifestyle decisions, and the design of randomised trials. (bmj.com)
An estimated one-third of the world's children younger than 5 years fail to meet their full developmental potential, increasing the risk that poor health and poverty will follow these disadvantaged children into adulthood, thereby perpetuating the vicious cycles of poverty and impaired development [ 1 , 2 ]. (cdc.gov)

In the elderly, anemia is an independent predictor of fragility, function, and mortality(4;5). (ispub.com)
In the multivariable model, MPUC still remained a statistically significant independent predictor for PFS (HR (95% CI)=3.85 (1.59-9.32), p=0.003). (bmj.com)

The rapid growth and high rate of recurrence of GBM make surgical resection non-curative and leads to poor prognosis of this disease ( 4 ). (spandidos-publications.com)

Following the successful establishment of stable cells, we examined in vitro cell growth by MTT assay, anchorage-independent growth by soft-agar colony formation assay and cell migration/invasion by transwell and boyden chamber assay. (biomedcentral.com)

Anatomy3

Diseases39

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment46

Phenomena and Processes11

Disciplines and Occupations1

Information Science2

Health Care24

Geographicals1

Biomarker6

Biomarkers3

Nomogram5

Indicator7

Glasgow Prognostic Score2

Favorable3

Predictive3

Factor26

Clinicopathological features1

Significance3

Patients26

Colorectal cancer1

Predictors3

Clear cell renal cell carc2

0.0012

Evaluate2

Conclusions1

Regression analysis1

Marker2

Outcomes4

Disease-free survival1

Gastric cancer2

Multivariate3

Cancers2

Indicators2

Protein1

Markers3

Additionally1

Postoperative1

Immune2

Clinical1

Baseline2

Prediction2

Survival rate1

Acute2

Outcome1

Cancer4

Overexpression2

Expression2

Study3

Risk2

Predictor2

Resection1

Vitro1