• We show here that expression of EBF3 resulted in cell cycle arrest and apoptosis. (aacrjournals.org)
  • SETD2 loss synergizes with pharmacologic inhibition of the H3K79 methyltransferase DOT1L to induce DNA damage, growth arrest, differentiation, and apoptosis. (nature.com)
  • induces growth arrest or apoptosis depending on the physiological circumstances and cell type. (lsbio.com)
  • Exogenous TGF-β 1 suppresses gene amplification in the null keratinocytes at concentrations that do not cause a G 1 growth arrest and in human tumor cell lines that are insensitive to TGF-β 1 - mediated growth inhibition. (psu.edu)
  • Exogenous TGF-β1 suppresses gene amplification in the null keratinocytes at concentrations that do not cause a G1 growth arrest and in human tumor cell lines that are insensitive to TGF-β1- mediated growth inhibition. (psu.edu)
  • The novel PLK1 inhibitor, onvansertib, is the first available for oral administration and has shown tumor growth inhibition in hematologic tumors, osteosarcoma, ovarian carcinoma, breast cancer and colon adenocarcinoma cells. (childrenscolorado.org)
  • In the new series, SCAA will continue to drive awareness for sudden cardiac arrest and give listeners a broader level of expertise as we join forces with our medical partners, survivors and industry specialists to build an unparalleled advocacy ecosystem to increase survivor rates for the world's leading cause of death. (associationdatabase.com)
  • We explore what an SCA is versus a heart attack, ways we can all respond to save lives, a rapid response checklist and the ongoing vision for the Sudden Cardiac Arrest Association as we look to 2020 and beyond. (associationdatabase.com)
  • However, if someone collapses from a sudden cardiac arrest, why can't I use the same technology to find the closest AED? (associationdatabase.com)
  • When his wife Julie had a cardiac arrest, it took 45 seconds to get CPR started. (associationdatabase.com)
  • SCAA is partnering with the Children's Cardiomyopathy Foundation this September to raise awareness of pediatric cardiomyopathy, the number one cause of sudden cardiac arrest and heart transplants among young people. (associationdatabase.com)
  • The development of preantral and antral follicles is gonadotropin independent and gonadotropin dependent, respectively. (glowm.com)
  • The second category, referred to as precocious pseudopuberty or peripheral precocious puberty (PPP), is gonadotropin-independent, and the presence of sex steroids is independent of pituitary gonadotropin release. (medscape.com)
  • In gonadotropin-independent precocious puberty, the presence of testosterone in boys or estrogen in girls is not secondary to activation of the HPG axis. (medscape.com)
  • But Beninoise coastal guards arrested the suspects at Zone de Ambassad/Leobelle located off the coast line of Cotonou, according to Canal 3, the Beninoise state television station. (mmsplusng.com)
  • Once on aboard the ship, the naval guards arrested the four suspects, and on interrogation, they reportedly failed to provide satisfactory explanations concerning the crude oil consignment they were carrying and the destination they were heading. (mmsplusng.com)
  • Following the arrest of the four suspects, the Benin Republic authorities has since mobilized the deployment of about 26 trucks to transfer the crude oil from the stranded ship, which has been floating on the seas for days. (mmsplusng.com)
  • By the following year, however, several key suspects had been arrested or tried for war crimes, and the government had adopted a strong anticorruption strategy. (britannica.com)
  • Together, these findings provided a foundation for estimation of growth rates, juvenile stage durations, and mean age at maturation for Kemps ridleys stranded in the mid-Atlantic region of the U.S. east coast during the mid- to late 1990s (Snover et al. (noaa.gov)
  • Puberty is the process of physical maturation manifested by an increase in growth rate and the appearance of secondary sexual characteristics. (medscape.com)
  • Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. (lsbio.com)
  • These studies reveal a novel TGF-β-mediated pathway regulating genomic stability and suggest that defects in TGF-β signaling may have profound effects on tumor progression independent of cell proliferation. (psu.edu)
  • The highly tumorigenic cell line HCT116 up-regulates TGFα mRNA expression during growth arrest, whereas the poorly tumorigenic growth factor-dependent FET cell line down- regulates TGFα mRNA expression as it becomes quiescent. (elsevierpure.com)
  • The emergence of these findings, suggesting a direct control of cellular metabolism by tumorigenic pathways, has helped fuel explosive growth in this area of cancer research. (aacrjournals.org)
  • Here, we show that the phosphoprotein phosphatase SppA has strong effects on polar growth and cell shape and that it reverses the AfsK-mediated phosphorylation of DivIVA. (lu.se)
  • Strains with a nonphosphorylatable mutant DivIVA confirm that the effect of afsK on hyphal branching during normal growth is mediated by DivIVA phosphorylation. (lu.se)
  • However, the phenotypic effects of sppA deletion are independent of DivIVA phosphorylation and must be mediated via other substrates. (lu.se)
  • With domestic production continuing to stagnate and the transport sector expected to register a compound annual growth rate (CAGR) of 9.5 per cent during the 2019-2024 period 4 , India's thirst for oil is unlikely to abate in the near future. (idsa.in)
  • Organisations like the International Energy Agency (IEA) have been cutting their estimates for oil demand growth through 2019, citing the impact of trade issues between the US and China on the global economy, as well as growing concerns over the impact of hydrocarbons, particularly oil and coal, on climate change, which it says have led to a fall in the demand for oil. (idsa.in)
  • The province appointed an independent, two-person panel in 2019 to review old-growth policies and is also consulting with the public. (cheknews.ca)
  • This same sequence confers TGFα promoter responsiveness to exogenous growth factor or autocrine TGFα. (elsevierpure.com)
  • DDIT4 acts as a negative regulator of mTOR, a serine/threonine kinase that regulates a variety of cellular functions such as growth, proliferation and autophagy. (wikipedia.org)
  • Streptomyces coelicolor modulates polar growth via the Ser/Thr protein kinase AfsK, which phosphorylates DivIVA. (lu.se)
  • This study adds a PPP-family protein phosphatase to the proteins involved in the control of polar growth and cell shape determination in S. coelicolor. (lu.se)
  • Autocrine transforming growth factor α (TGFα) is an important positive growth effector in maligant cells and plays a significant role in generating the growth factor-independent phenotype associated with malignant progression. (elsevierpure.com)
  • However, the molecular mechanisms by which TGFα confers a growth advantage in progression is poorly understood. (elsevierpure.com)
  • The pathway of TGF-β 1 suppression is independent of the p53 and Rb genes, but requires an intact TGF-β type II receptor. (psu.edu)
  • Here, we show that nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the NAD + salvage pathway, governs the proinflammatory SASP independent of senescence-associated growth arrest. (nature.com)
  • In the 1920s, Otto Heinrich Warburg discovered that cancer cells, unlike normal cells, use the glycolytic pathway to obtain energy for growth even in the presence of oxygen, which is a phenomenon known as 'aerobic glycolysis' or the Warburg effect ( 9 ), and aerobic glycolysis is a common metabolic phenotype in NSCLC ( 11 ). (spandidos-publications.com)
  • Reprimo (RPRM), a downstream effector of p53-induced cell cycle arrest at G2/M, has been proposed as a putative tumor suppressor gene (TSG) and as a potential biomarker for non-invasive detection of gastric cancer (GC). (pucv.cl)
  • They were arrested after a rally against DeSantis. (yahoo.com)
  • Alterations in expression of or responsiveness to transforming growth factor β (TGF-β) are frequently found in human and animal epithelial cancers and are thought to be important for loss of growth control in the neoplastic cell. (psu.edu)
  • SAN FRANCISCO (Reuters) - Growth in global smartphone shipments will fall sharply this year and keep slowing through 2018, with average prices dropping significantly as demand shifts to China and other developing countries, according to market research firm IDC. (yahoo.com)
  • NewAmerica) India India tops World Bank's growth outlook for the first time World Bank Group's latest Global Economic Prospects (GEP) report released on June 10 puts India at the top of the growth chart of major economies (LiveMint, Reuters, IBT). (foreignpolicy.com)
  • Sexual behavior aside here, there is something to be said about the improvements to safety that ridesharing has delivered since its explosive growth over the past five years. (iwf.org)
  • The war in Ukraine had magnified the slowdown in the global economy, which was now entering what could become "a protracted period of feeble growth and elevated inflation," the World Bank said in its Global Economic Prospects report, warning that the outlook could still grow worse. (co.zw)
  • Cellular senescence is a stable growth arrest that is implicated in tissue ageing and cancer. (nature.com)
  • The combined treatment of Flavopiriol and Lonafarnib in BG1-cells showed a slightly increased cell cycle arrest in the subG1-fraction in selected concentrations. (uni-marburg.de)
  • The mechanisms regulating follicle growth and development are under the control of changing concentrations of ligands ( i.e. hormones and growth factors). (glowm.com)
  • We previously reported that artemisinin resistance results from the capacity of young intraerythrocytic F32-ART parasites (ring-stage parasites) to arrest their cell cycle and enter a quiescence state ( 9 , 10 ). (cdc.gov)
  • From Blandau RJ: Growth of the ovarian follicle and ovulation. (glowm.com)
  • A 14-year-old suspected gunman was arrested after two people were killed and at least four wounded during a shooting spree at a luxury shopping centre in the heart of Bangkok. (yahoo.com)
  • New markets for growth bring different rules to play by and 'premium' will not be a major factor in the regions driving overall market growth," IDC analyst Ryan Reith said in a report. (yahoo.com)
  • The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)
  • The sex steroids (estrogen or testosterone) come from either the adrenal gland or the gonad, independent of the hypothalamic-pituitary portion of the pubertal axis. (medscape.com)
  • Hyperfunction of the adrenal cortex can be adrenocorticotropic hormone (ACTH)-dependent or ACTH-independent. (msdmanuals.com)
  • Rare causes of ACTH-independent hyperfunction include primary pigmented nodular adrenal dysplasia (usually in adolescents) and bilateral macronodular hyperplasia (in older adults). (msdmanuals.com)
  • Investigators used CRISPR-Cas9 screening to determine which genes were essential for medulloblastoma tumor growth. (childrenscolorado.org)
  • For adequate growth, term infants require 110-120 kcal/kg/d. (medscape.com)
  • The abberant upregulation of TGFα mRNA in quiescent HCT116 cells may allow them to return to the dividing state under more stringent conditions (nutrient replenishment alone) then quiescent FET cells (requires nutrients and growth factors). (elsevierpure.com)
  • The National Association for Business Economics is slashing its forecast for U.S. growth. (marketplace.org)
  • A former American diplomat who served as U.S. ambassador to Bolivia has been arrested in a long-running FBI counterintelligence investigation, accused of secretly serving as an agent of Cuba's government, The Associated Press has learned. (yahoo.com)
  • Manuel Rocha, 73, was arrested in Miami on Friday on a criminal complaint and more details about the case are expected to be made public at a court appearance Monday, said two people who spoke to the AP on condition of anonymity because they were not authorized to discuss an ongoing federal investigation. (yahoo.com)
  • Amnesty International has urged the government of Uttar Pradesh to launch an independent investigation into the incident. (foreignpolicy.com)
  • During the course of folliculogenesis, growth is achieved by cell proliferation and formation of follicular fluid, whereas development involves cytodifferentiation of all the cells and tissues in the follicle. (glowm.com)
  • Kennedy, who is running as an independent, was home at the time of both arrests, the campaign added. (yahoo.com)
  • At the same time, he will argue that the transition away from fossil fuels has the potential to drive growth and deliver jobs in the new green industries of the future, while cutting off funding for Russia's war in Ukraine. (yahoo.com)
  • Alagie Abdoulie Ceesay, the manager of independent radio station, Taranga FM, is, at time of writing, facing charges of sedition and publication of false news, after being detained for 11 days without charge at NIA headquarters and tortured in July 2015. (hrw.org)
  • Chief Economist and Senior Vice President of World Bank Kaushik Basu said: "With an expected growth of 7.5 percent this year, India is, for the first time, leading the World Bank's growth chart of major economies. (foreignpolicy.com)
  • The implications of this finding overshadowed the importance of mitochondria for tumor growth for a long time. (spandidos-publications.com)
  • The arrest of bleeding in a superficial wound, such as the bleeding time wound, almost exclusively results from the primary hemostatic plug. (medscape.com)
  • this may facilitate development of novel biocide-independent strategies to effectively control this pathogen and its disposal-related hazards in aqueous streams. (cdc.gov)
  • Now, after almost seven years as Foreign Minister, I am more convinced than ever that improving health is crucial for achieving growth, development, equity and stability throughout the whole world. (who.int)
  • We will continue to witness a turbulent path of human and economic development, as some States struggle and some States strive, through crises and growth, progress and upheavals. (who.int)
  • Executive flights at Biggin Hill and Farnborough airports have been brought to a standstill by climate activists concerned at the huge growth in the use of private jets by business people. (indymedia.org.uk)
  • 10 people were then arrested. (indymedia.org.uk)
  • By this point the police warned people they would be arrested and it was decided to return to the camp. (indymedia.org.uk)
  • The NIA has been responsible for the arbitrary arrest and detention of countless people, including journalists, civil servants, students, and LGBT people. (hrw.org)
  • Members of Save Old Growth are among the more than 1,000 people who have been arrested in the Fairy Creek watershed northwest of Victoria for allegedly violating an injunction against blockades. (cheknews.ca)
  • A man was arrested after trespassing twice in one day at the Los Angeles home of presidential candidate Robert F. Kennedy Jr. , police confirmed Thursday. (yahoo.com)
  • The man was served an emergency protective order and released, but he returned to the property later that day, prompting police to arrest him for violating the order. (yahoo.com)
  • Although no one was arrested, the police did seize lock-on devices. (indymedia.org.uk)
  • On the other hand a local police official claimed that Singh had "committed suicide" when the police arrived at his house in Shahjahanpur district to "arrest him" in connection with another case. (foreignpolicy.com)
  • In 150 cities, fatal accidents declined after the introduction of Uber, but in Austin, where ridesharing has left, DWI arrests spiked almost 8 percent. (iwf.org)
  • Independent candidates have two weeks left to qualify for the open Alabama House District 10 seat, which represents Madison and southern Madison county. (whnt.com)
  • Rishi Sunak will call for a "global mission for clean growth" as he joined other world leaders at the start of the latest Cop27 international climate change talks in Egypt. (yahoo.com)
  • This is happening while the world is warming rapidly, against the backdrop of continued steep population growth, a rapid process of urbanization and increasing competition for limited resources, in particular for water and energy. (who.int)
  • Four persons, in an oil bunkering ship, were last week arrested by Benin Republic authorities after a failed attempt to illegally export about 35,000 metric tons of crude oil believed smuggled from Nigeria. (mmsplusng.com)
  • Annual growth in 2014 is expected to be 19.3 percent and then decline to 6.2 percent in 2018, IDC said in a report on Wednesday. (yahoo.com)
  • The Bank expects developing countries to witness a rise in growth to 5.2 percent in 2016 and 5.4 percent in 2017. (foreignpolicy.com)
  • Harassment, arrests and physical threats have caused dozens of journalists to flee Gambia in the last two decades according to press freedom organization, Article 19. (hrw.org)
  • In contrast to the control lines, the PALA-mediated G 1 arrest did not occur in the TGF-β 1 null keratinocytes despite the presence of wild- type p53 in both genotypes. (psu.edu)
  • In contrast to the control lines, the PALA-mediated G1 arrest did not occur in the TGF-β1 null keratinocytes despite the presence of wild- type p53 in both genotypes. (psu.edu)
  • Overton High School principal Jeffery Darryl Hogg, 59, was arrested on Wednesday on an assault charge. (wsaz.com)
  • MATHARIKA's anti-corruption efforts have led to several high-level arrests but no convictions. (travelblog.org)
  • The sppA mutant hyphae also exhibit a high frequency of spontaneous growth arrests, indicating problems with maintenance of tip extension. (lu.se)
  • By honouring the pledges we made in Glasgow, we can turn our struggle against climate change into a global mission for new jobs and clean growth. (yahoo.com)
  • At 7am two independent groups of campaigners from the Camp for Climate Action stopped carbon-intensive private jets fom operating at two airports in the south east. (indymedia.org.uk)
  • Howard Breen said Saturday that he stopped drinking liquids two days earlier in a bid to pressure the province to stop all old-growth logging due to the climate crisis and that he won't end his protest until the forests minister agrees to a public meeting. (cheknews.ca)
  • Breen called the conversation "polite," but said other action taken by Save Old Growth, including recent blockades of bridges and major roads, points to the seriousness of the "climate emergency" linked to logging. (cheknews.ca)
  • Metro Bank has reported record revenue growth after benefiting from higher interest on customer loans so far this year. (yahoo.com)
  • stay strong and independent all year round. (democracynow.org)
  • A 68-year-old activist says "death-watch monitors" were ensuring his safety on the 23rd day of a hunger strike over old-growth logging practices in British Columbia. (cheknews.ca)
  • 1 , 2 , 3 In each menstrual cycle, the dominant follicle that ovulates its egg originates from a primordial follicle that was recruited to initiate growth almost 1 year earlier (Fig. 2). (glowm.com)
  • Increasing corruption, population growth, increasing pressure on agricultural lands, and HIV/AIDS pose major problems for the country. (travelblog.org)
  • SETD2 loss causes growth arrest and differentiation of AML cells, and leads to increased DNA damage. (nature.com)
  • Conroy announced earlier this month that B.C. was working with First Nations to defer logging across more than a million hectares of old-growth forests at risk of permanent loss, an area greater than 4,100 Stanley Parks. (cheknews.ca)
  • A network of individuals, independent and alternative media activists and organisations, offering grassroots, non-corporate, non-commercial coverage of important social and political issues. (indymedia.org.uk)
  • Since taking power in 1994, President Yahya Jammeh has ruled Gambia with often-ruthless repression of dissent, a tight clamp on virtually all independent media, and the use of state security forces and shadowy paramilitary groups to intimidate and silence all deemed critics of the government. (hrw.org)
  • AMH is an independent media house free from political ties or outside influence. (co.zw)
  • Additional calories are needed for growth, with the smallest neonates tending to demonstrate the greatest need, as their growth rate is highest. (medscape.com)
  • Initiatives we have put in place have helped us to improve net interest margin and lending yield, and drive record revenue growth. (yahoo.com)
  • The experimental parameters that supported optimal growth of MI in culture included an alkaline pH (9.4) coupled with ambient temperature (30 degrees C), starter nutrient (OADC 2.028% v/v) and tramp oil (0.4% v/v.) Though OADC seemed to play an important role, tramp oil was found to be crucial for the colonization process. (cdc.gov)
  • I urged them to protect their health as we continue the important work to protect old-growth forests," she said in an emailed statement from the Forests Ministry. (cheknews.ca)
  • Although GnRH, FSH, and LH are critically important in regulating folliculogenesis, hormones and growth factors, which are themselves products of the follicle, can act locally to modulate (amplify or attenuate) FSH and LH action. (glowm.com)
  • Cell cycle and DNA replication are top signaling hubs for medulloblastoma cell growth. (childrenscolorado.org)