Independent endometrial carcinoma. Medical search. Frequent questions

LENVIMA plus KEYTRUDA is now approved by the European Commission for two different types of cancer: for advanced or recurrent endometrial carcinoma in adults who have disease progression on or following prior treatment with a platinum containing therapy in any setting and who are not candidates for curative surgery or radiation and for the first-line treatment of adult patients with advanced renal cell carcinoma. (eisai.com.cn)
Cabometyx (cabozantinib) developed for the treatment of patients with advanced renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC). (pharmaceutical-technology.com)
KEYTRUDA plus LENVIMA is approved in the U.S., the EU, Japan and other countries for the treatment of advanced renal cell carcinoma (RCC) and certain types of advanced endometrial carcinoma. (streetinsider.com)
This phase II trial studies how well Ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor AZD6738 works alone or in combination with olaparib or durvalumab in treating participants with renal cell carcinoma (RCC), urothelial carcinoma, all pancreatic cancers, endometrial cancer, and other solid tumors excluding clear cell ovarian cancer that have spread to nearby tissue or lymph nodes or other parts of the body. (ucbraid.org)
In the past decade, the use of immune checkpoint inhibitors (ICIs) has revolutionized the treatment of a variety of tumors, including lung cancer, melanoma, colorectal cancer, and renal cell carcinoma [ 1 , 2 ]. (biomedcentral.com)
E6 and Metabolic syndrome and risks of colon and rectal renal cell carcinoma. (who.int)
The relationship between blood pressure and risk of renal cell carcinoma. (who.int)
Epidemiology of Renal Cell Carcinoma: 2022 Update. (who.int)
Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort. (who.int)
Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. (who.int)

KEYNOTE-158 (ClinicalTrials.gov, NCT02628067 ) is an ongoing global, open-label, non-randomized, multi-cohort, multi-center, Phase 2 study evaluating KEYTRUDA in patients with multiple types of advanced solid tumors - including endometrial carcinoma - that have progressed on standard of care therapy. (businesswire.com)
The first (Type I) pathway leads to borderline tumors, which can develop into low-grade serous, mucinous, endometrioid, and clear cell carcinomas. (hindawi.com)
Type II tumors include high-grade serous carcinoma, malignant mixed mesodermal tumors, and undifferentiated carcinomas. (hindawi.com)
This type of EC mainly occurs in background of endometrial hyperplasia and it usually responds to hormone therapy, whereas type II EC is not related to hyperestrogenic state and usually occurs in older age groups in the setting of atrophic endometrium or sometimes endometrial polyp, and typically presents as high-grade tumors with poor prognosis (1-6). (iranpath.org)
High-grade ECs are composed of grade 3 endometrioid endometrial carcinoma (EEC3) and mainly non-endometrioid endometrial carcinomas including papillary serous carcinoma (PSC), clear cell carcinoma (CCC), undifferentiated carcinomas, and malignant mixed mullerian tumors (MMMT) (7). (iranpath.org)
Endometrial carcinoma (EC) is the most frequently diagnosed malignancy of the female genital tract, ranking fourth among all invasive tumors affecting women. (biomedcentral.com)
Endometrial carcinoma (EC) is the predominant sub type, ranking fourth among all invasive tumors that affect women. (biomedcentral.com)
BACKGROUND: Individuals with Lynch syndrome are at increased hereditary risk of colorectal and endometrial carcinomas with microsatellite instability (MSI-H) and mismatch repair-deficiency (dMMR), which make these tumors vulnerable to therapy with immune checkpoint inhibitors. (bvsalud.org)
The Lynch-spectrum tumors should be expanded to breast carcinomas with medullary features. (bvsalud.org)
The primary study hypotheses are that pembrolizumab is superior to the combination of carboplatin and paclitaxel with respect to Progression Free Survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) as assessed by Blinded Independent Central Review (BICR) and Overall Survival (OS). (msdoncologyclinicaltrials.com)
The lack of claudin-4 expression in ovarian small cell carcinomas of hypercalcemic type suggests that these tumors may be better regarded as sarcomas rather than carcinomas. (cusabio.cn)
INTRODUCTION: We aimed to determine the possible clinicopathological factors that might affect recurrence and survival in synchronous malignancy of the endometrium and ovary without discriminating the presence of two independent primary tumors or metastasis. (hnhtipdergisi.com)
Endometrial cancer (EC) is one of the three most common malignant tumors of the female reproductive system, and its incidence has been increasing globally, as described by Global Disease Burden (GDB) statistics. (spandidos-publications.com)
Nomograms are graphic calculation tools that visualize and individualize prediction in different situations, and they have been used for several types of cancer, including endometrial stromal sarcoma and metastatic tumors ( 3 , 4 ). (spandidos-publications.com)

Endometrial carcinoma begins in the inner lining of the uterus, which is known as the endometrium, and is the most common type of cancer in the uterus. (businesswire.com)
more than 90% of uterine body cancers occur in the endometrium, so the actual numbers for endometrial carcinoma cases and deaths are slightly lower than these estimates). (businesswire.com)
Endometrial cancer (also referred to as corpus uterine cancer or corpus cancer) is the most common female genital cancer in the developed world, with adenocarcinoma of the endometrium the most common type. (medscape.com)
Approximately 95% of these malignancies are carcinomas of the endometrium . (medscape.com)
Endometrial biopsy is the removal of a small piece of tissue from the lining of the uterus (endometrium) for examination. (medlineplus.gov)
In contrast, type 2 serous endometrial carcinoma is estrogen-independent, associated with atrophic endometrium and does not follow the hyperplasia-dysplasia-carcinoma sequence. (surgpath4u.com)

For the 25% of endometrial cancers in patients who are perimenopausal or premenopausal, the symptoms suggestive of cancer may be subtler. (medscape.com)
Amplification and overexpression of HER2/neu have been shown to have a significant role in the pathogenesis of cancers in various organs, including carcinomas of breast, ovary, stomach, and esophagus (10). (iranpath.org)
A review of the cases of endometrial carcinoma in HRT users from Sweden resulted in a down-grading of 40% of the cancers to atypical hyperplasia ( 3 ) . (studd.co.uk)
Several female malignancies including breast, ovarian, and endometrial cancers can be characterized based on known somatic and germline mutations. (hindawi.com)
Inherited mutations in a small number of genes account for about five to ten percent of women's cancers.These inherited variations, identified in breast, ovarian, and endometrial cancer susceptibility, can be characterized in the general population by their frequency and the magnitude of their impact upon a patient (Table 1 ).Some inherited variants occur rarely in the general population, but confer large risks to the individual. (hindawi.com)
Endometrial carcinoma is one of the most common gynecological cancers. (diclemedj.org)
KSR1 is normally overexpressed in endometrial carcinoma and is necessary for both proliferation and NS13001 anchorage-independent development of endometrial cancers cells (8). (researchatlanta.org)
While endometrial cancer affects reproductive age as well as postmenopausal women, 75% of endometrial cancers occur in postmenopausal women, with the mean age of diagnosis at 61 years. (medscape.com)
These mutations lead to microsatellite instability in 90% of colon cancers and 75% of endometrial cancers. (medscape.com)
Approximately 25.0% of endometrial cancers are MSI-H or dMMR. (onclive.com)

Abnormal expression of ABCD3 is an independent prognostic factor for colorectal cancer. (cdc.gov)
Another group of women at increased risk of premenopausal endometrial cancer are those with Lynch II syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC). (medscape.com)
It is known that over-expression of RHAMM correlates with an increase in the mitogen activated protein (MAP) kinase and progression of breast cancer (4), with the histological grade, invasion and metastasis of endometrial carcinoma (5), with adverse prognostic factors in colorectal cancer (6), and with gastric tumor progression (7). (jri.ir)

Several investigations have demonstrated HER2/neu expression and amplification in type II EC, especially papillary serous carcinoma (PSC). (iranpath.org)
Other histologic subtypes include adenosquamous, clear cell, and papillary serous carcinomas. (medscape.com)
Serous EIC is characterized by marked nuclear atypia, similar to that found in invasive papillary serous endometrial carcinoma. (surgpath4u.com)
Serous endometrial intraepithelial carcinoma (serous EIC) is the in situ correlate of invasive papillary serous-type (type 2) endometrial adenocarcinoma. (surgpath4u.com)
It is thought that serous EIC accompanies, rather than precedes, invasive papillary serous endometrial adenocarcinoma. (surgpath4u.com)

Cabometyx is indicated as monotherapy for the treatment of adult patients with locally advanced or metastatic differentiated thyroid carcinoma (DTC), refractory or not eligible to radioactive iodine (RAI) who have progressed during or after prior systemic therapy. (pharmaceutical-technology.com)
Limited treatment options are available to patients with recurrent or metastatic endometrial cancer. (onclive.com)
2011 Mar 31;22(1):18-24 *25 Soto E, Soto C, Nezhat F, Gretz H, Chuang L. Chylous ascites following robotic lymph node dissection on a patient with metastatic cervical carcinoma. (stamfordhealth.org)
CHICAGO, June 5, 2023 - The Janssen Pharmaceutical Companies of Johnson & Johnson today announced results from an interim analysis of Cohort 1 of the Phase 3 THOR study, evaluating treatment with BALVERSA ® (erdafitinib) versus chemotherapy in patients with metastatic or unresectable urothelial carcinoma (UC) and selected fibroblast growth factor receptor (FGFR) gene alterations who had received prior treatment with an anti-programmed death ligand 1 (PD-[L]1) agent. (janssen.com)
Although pulmonary carcinoids show relatively good prognosis in comparison to carcinomas, metastatic disease and relapse do occur. (who.int)

This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with ultralow dose gemcitabine in participants with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma, and urothelial carcinoma based on Acrivon's OncoSignature® test status. (ucbraid.org)
These results represent the first data from a randomized, controlled trial evaluating BALVERSA ® for the treatment of patients with FGFR-altered urothelial carcinoma, who often experience poor disease outcomes," said Yohann Loriot*, M.D., Ph.D., Institut Gustave Roussy and University of Paris-Saclay, France, and principal study investigator. (janssen.com)

In this cross-sectional study, we performed HER2/neu immunohistochemical (IHC) staining in 37 high-grade EC cases with histological diagnostic categories of PSC (n=23), clear cell carcinoma (CCC) (n=9), and carcinosarcoma with high-grade carcinomatous component (PSC, CCC, grade 3 endometrioid carcinoma, or unclassified high-grade adenocarcinoma) (n=5). (iranpath.org)

CONCLUSIONS: In individuals with Lynch syndrome, MSI-H/dMMR occurs in more than one-half of the malignancies other than colorectal and endometrial carcinomas, including tumor types without increased incidence. (bvsalud.org)
The agent demonstrated acceptable tolerability and durable clinical activity in patients with multiple advanced tumor types, including in those with pretreated endometrial cancer. (onclive.com)
Merck and Eisai are studying the KEYTRUDA plus LENVIMA combination through the LEAP (LEnvatinib And Pembrolizumab) clinical program in various tumor types, including but not limited to endometrial carcinoma, hepatocellular carcinoma, RCC, head and neck cancer, gastric cancer and esophageal cancer across multiple clinical trials. (streetinsider.com)

Three independent case control studies have reported an increased risk of endometrial cancer in postmenopausal women exposed to exogenous estrogens for prolonged periods. (rxlist.com)
The three case control studies reported that the risk of endometrial cancer in estrogen users was about 4.5 to 13.9 times greater than in nonusers. (rxlist.com)
Besides colon cancer, women affected have a 40-60% risk of endometrial cancer by age 70 years, compared to a baseline population risk of 1.5% at the same age. (medscape.com)

Some investigators believe vaginal ultrasonography to evaluate the endometrial stripe should be the first diagnostic procedure, because vaginal ultrasonography is less invasive than endometrial biopsy. (medscape.com)
No evidence suggests that routine endometrial sampling or transvaginal sonography to evaluate the endometrial stripe in asymptomatic women has a role in early detection of uterine cancer, even in women who take tamoxifen after breast cancer or has a cancer syndrome. (medscape.com)

New molecular markers to predict the prognosis of endometrial cancer patients preoperatively should be found for individualization of treatment. (nih.gov)
Type 2 presents as a high-grade aggressive lesion, with a significantly poorer prognosis than type 1 carcinomas. (surgpath4u.com)

Endometrial adenocarcinoma is the most common gynecologic malignancy in the United States. (medscape.com)

Hepatocellular Carcinomas from Iran: Evidence study of lung cancer among European asphalt carcinoma among postmenopausal women in the for Lack of Association between HBV Genotype workers. (who.int)

This approval is welcome news for patients in Europe, and is based on the first Phase 3 study evaluating an immunotherapy and tyrosine kinase inhibitor combination that showed superior overall survival for patients with advanced or recurrent endometrial cancer compared to chemotherapy," said Dr. Gregory Lubiniecki, Vice President, Clinical Research, Merck & Co., Inc., Kenilworth, N.J., U.S.A. Research Laboratories. (eisai.com.cn)
In the analysis featured in the poster, investigators shared the results regarding the safety and clinical activity of retifanlimab in patients with MSI-H or dMMR recurrent endometrial cancer, which was cohort H of the POD1UM-101 study. (onclive.com)
The trial enrolled patients who were at least 18 years of age with histologically proven, unresectable recurrent endometrial cancer that was MSI-H or dMMR based on local testing. (onclive.com)

Retifanlimab demonstrated encouraging antitumor activity with favorable tolerability in patients with recurrent microsatellite instability-high or mismatch repair deficient endometrial cancer, according to data from the phase 1 POD1UM-101 trial. (onclive.com)

Women with PCOS have higher risk of multiple diseases including Infertility, type 2 diabetes mellitus (DM-2), cardiovascular risk, metabolic syndrome, obesity, impaired glucose tolerance, depression, obstructive sleep apnea (OSA), endometrial cancer, and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH). (wikipedia.org)
1-3 This risk was independent of the other known risk factors for endometrial cancer. (rxlist.com)
These studies are further supported by the finding that incidence rates of endometrial cancer have increased sharply since 1969 in eight different areas of the United States with population-based cancer reporting systems, an increase which may be related to the rapidly expanding use of estrogens during the last decade. (rxlist.com)
Approximately 75% of women with endometrial cancer are postmenopausal. (medscape.com)
Once the diagnosis of endometrial cancer has been made, routine presurgical evaluation is performed to assess operability, including appropriate blood studies, electrocardiography, and chest radiography. (medscape.com)
Diagnostic hysteroscopy for endometrial cancer. (medscape.com)
Treatment of endometrial cancer is dependent on the stage of the disease and the patient's surgical candidacy. (medscape.com)
Among 303 consecutive endometrial cancer patients treated during the period of this study, 55 patients (18.2%), including 44 without peritoneal metastasis (FIGO stage IIIc) and 11 with peritoneal metastasis (FIGO stage IV), were found to have retroperitoneal lymph node metastasis. (nih.gov)
LVSI and number of positive PAN groups were independent prognostic factors for stage IIIc endometrial cancer patients. (nih.gov)
New chemotherapy regimen including taxane needs to be considered as an adjuvant therapy for patients with node-positive endometrial cancer. (nih.gov)
Regardless of mismatch repair status, patients whose endometrial cancer progresses or returns after prior platinum-containing systemic therapies now have a combination treatment option in KEYTRUDA plus LENVIMA that demonstrated a 38% reduction in risk of death compared to chemotherapy alone. (eisai.com.cn)
It was acknowledged that there was probably a small increase in breast cancer but as the mortality rate was less than in untreated women it was possible that the apparent risk was an artefact of precise pathological diagnosis between ductal in situ and invasive cancer as the tissues had not been examined by a second independent reviewer although there had been many requests for this. (studd.co.uk)
These results suggest that, unlike other steroid receptors, glucocorticoid and/or progesterone receptors may play an important role in the reducing migration of endometrial carcinoma and might be used as targets to reduce the metastasis of this type of cancer. (diclemedj.org)
In the present work we used spectral karyotyping (SKY) to identify cancer-related aberrations in a well-characterized experimental model for spontaneous endometrial carcinoma in the BDII rat tumor model. (biomedcentral.com)
This article discusses endometrial cancer and uterine sarcomas. (medscape.com)
This is an autosomally dominant germline mutation in DNA mismatch repair (MMR) genes ( MSH1 , MSH2 , MSH6 ) and accounts for 9% of patients younger than 50 years with endometrial cancer. (medscape.com)
It was also under development for the treatment of relapsed/refractory multiple myeloma, salivary gland, cancer and adenoid cystic carcinoma (ACC). (pharmaceutical-technology.com)
Endometrial Intraepithelial carcinoma (EIC)/Serous (Type 2) Surface Cancer. (surgpath4u.com)
Retifanlimab (INCMGA 0012) demonstrated encouraging antitumor activity with favorable tolerability in patients with recurrent microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) endometrial cancer, according to data from the phase 1 POD1UM-101 trial (NCT03059823), presented during the 2021 SITC Annual Meeting . (onclive.com)
Data from a preplanned interim analysis of the trial showed that the agent had promising activity specifically in patients with recurrent MSI-H or dMMR endometrial cancer. (onclive.com)
This is a Phase IB/II multi-cohort study designed to evaluate the efficacy and safety of targeted agents with or without cancer immune checkpoint therapy with atezolizumab in participant with recurrent and/or persistent endometrial cancer. (ucbraid.org)
This phase II trial studies how well abemaciclib works in treating patients with ovarian or endometrial cancer that has an activation of the CDK4/6 pathway and that has come back (recurrent). (ucbraid.org)
Giving abemaciclib may work better for the treatment of recurrent ovarian and endometrial cancer. (ucbraid.org)
Integration of robotics into two established programs of minimally invasive surgery for endometrial cancer appears to decrease surgical complication. (stamfordhealth.org)
However, it remains unclear whether SETD2 dysfunction is a complementary or independent factor to microsatellite instability-high (MSI-H) and tumor mutational burden-high (TMB-H) for immunocheckpoint inhibitor (ICI) treatment, and little is known regarding whether this type of dysfunction acts differently in various types of cancer. (biomedcentral.com)
METHODS: Patients who were admitted with the diagnosis of synchronous endometrial and ovarian cancer between 2000 and 2015 were reviewed retrospectively. (hnhtipdergisi.com)
There is a significant relationship between presence of lenfovascular invasion), involvement of lymph node, spread to non-ovarian, and non-endometrial pelvic organs or beyond and the increase recurrence risk in the synchronous endometrial and ovarian cancer. (hnhtipdergisi.com)
Transforming mutations in GNAS have been well documented in human thyroid and pituitary tumours, and recent sequencing efforts have shown these mutations to be present in a wide variety of additional tumour types, including colon cancer, hepatocellular carcinoma, and parathyroid, ovarian, endometrial, biliary tract and pancreatic tumours. (nature.com)
The purpose of the present study was to investigate the predictive value of metabolic syndrome in evaluating myometrial invasion (MI) in patients with endometrial cancer (EC). (spandidos-publications.com)
Cancer Lett, 300:215-224.doi:10.1016/j. squamous cell carcinoma in north-eastern Iran. (who.int)
99:209 -215.doi:10.1007/s11060 - 010 - 0129 -5 cell carcinoma-a population-based study in with and without cervical cancer in Tbilisi, Georgia. (who.int)

Objectives To assess the effects on relative survival of established and new prognostic factors in stage I-III grade 1-3 endometrioid endometrial carcinoma and in the subgroup of stage I grade 1-2. (bmj.com)
The aim of this study was to determine pathologic variables associated with disease-specific survival of node-positive patients with endometrial carcinoma treated with combination of surgery including pelvic and para-aortic lymphadenectomy and adjuvant chemotherapy. (nih.gov)
Survival of 55 node-positive endometrial carcinoma patients prospectively treated with surgery and adjuvant chemotherapy between 1982 and 2002 at Hokkaido University Hospital was compared to various histopathologic variables. (nih.gov)
Multivariate Cox regression analysis revealed that peritoneal metastasis and lymph-vascular space invasion (LVSI) were independently related to poor survival in node-positive endometrial carcinoma. (nih.gov)
Multivariate analysis including number of positive PAN groups showed that LVSI, number of positive PAN groups were independent prognostic factors for survival. (nih.gov)
The primary objective of this study is to evaluate progression-free survival (PFS) by blinded independent central review (BICR) in patients treated with intermittent regimen of relacorilant in combination with nab-paclitaxel compared with patients treated with nab-paclitaxel monotherapy. (froedtert.com)
Besides, presence of endometrioid type ovarian tumor and absence of endometrial myometrial invasion are related with increased survival. (hnhtipdergisi.com)
DISCUSSION AND CONCLUSION: Variables such as endometrial tumor diameter, myometrial invasion, endo/non endo type of ovarian tumor and presence of bilateral tumor were found to be effective on survival, variables such as lymphovascular invasion, lymph node involvement, and pelvic spread were effective on recurrence. (hnhtipdergisi.com)

There is some difficult in the concept of 'intraepithelial' in type 2 endometrial carcinoma, as this lesion is notorious for extensive metastasis without evidence of myometrial invasion. (surgpath4u.com)

Women with previous endometrial hyperplasia or vaginal bleeding during the first six months of therapy were excluded from the study. (aafp.org)
Among the women who reported vaginal bleeding, 9 percent had simple hyperplasia, 4 percent had endometrial polyp and 4 percent had endometrial carcinoma. (aafp.org)
No cases of atypical hyperplasia, polyp or carcinoma were found in women who did not report vaginal bleeding. (aafp.org)
Malignant diseases of the uterus: endometrial hyperplasia, endometrial carcinoma, sarcoma: diagnosis and management. (medlineplus.gov)
Remember than type 1 endometrioid endometrial carcinoma is associated with prolonged estrogen exposure and a thickened endometrial stripe on ultrasound, and follows a hyperplasia-dysplasia-carcinoma sequence. (surgpath4u.com)

KEYTRUDA was also granted accelerated approval in September 2019, and received full approval in July 2021, in combination with LENVIMA ® (lenvatinib) for the treatment of patients with advanced endometrial carcinoma that is not MSI-H or dMMR, who have disease progression following prior systemic therapy in any setting and are not candidates for curative surgery or radiation. (businesswire.com)
On July 21, 2021, the Food and Drug Administration approved pembrolizumab (Keytruda, Merck) in combination with lenvatinib (Lenvima, Eisai) for patients with advanced endometrial carcinoma that is not microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR), who have disease progression following prior systemic therapy in any setting and are not candidates for curative surgery or radiation. (fda.gov)
FDA granted accelerated approval on September 17, 2019 to pembrolizumab with lenvatinib for advanced endometrial carcinoma. (fda.gov)
The recommended pembrolizumab dose for endometrial carcinoma is 200 mg every 3 weeks or 400 mg every 6 weeks with lenvatinib 20 mg orally once daily. (fda.gov)
The purpose of this study is to compare the efficacy of pembrolizumab + lenvatinib to chemotherapy in female participants with Stage III, IV, or recurrent endometrial carcinoma. (msdoncologyclinicaltrials.com)
A Clinical trial/study Of Atezolizumab With Lenvatinib Or Sorafenib Versus Lenvatinib Or Sorafenib Alone In patients with Hepatocellular Carcinoma. (who.int)

However, limitations to using the endometrial stripe as a criterion for further diagnostic tests (eg, endometrial biopsy) include false readings in the presence of several conditions (eg, endometrial polyp, obesity, diabetes, receiving tamoxifen). (medscape.com)

Study 309/KEYNOTE-775 enrolled 827 patients with advanced endometrial carcinoma previously treated with at least one prior platinum-based chemotherapy regimen in any setting, including neoadjuvant and adjuvant treatments. (fda.gov)
The purpose of this study is to assess the safety and efficacy of treatment with pembrolizumab (MK-3475) compared to a combination of carboplatin and paclitaxel in women with mismatch repair deficient (dMMR) advanced or recurrent endometrial carcinoma who have not previously been treated with prior systemic chemotherapy. (msdoncologyclinicaltrials.com)

We are pleased to share the activity observed in clinical studies of the LENVIMA plus KEYTRUDA combination, as well as rationale for the combination in advanced endometrial carcinoma through translational research. (eisai.com)

We look forward to sharing the latest results from KEYNOTE-158, including updated data for KEYTRUDA in certain types of MSI-H/dMMR advanced endometrial carcinoma, at the ESMO Congress in September. (businesswire.com)
It is estimated that approximately 30% of endometrial carcinomas are MSI-H or dMMR. (businesswire.com)
Almost all breast carcinomas had medullary features, and most of them were MSI-H/dMMR. (bvsalud.org)
All malignancies in patients with Lynch syndrome, independent of subtype, should be tested for MSI-H/dMMR in case therapy with immune checkpoint inhibitors is considered. (bvsalud.org)
Moreover, Lynch syndrome should be considered an underlying cause of all MSI-H/dMMR malignancies other than colorectal and endometrial carcinomas. (bvsalud.org)

The intraepithelial carcinomas have been referred to as serous intraepithelial carcinomas (STICs) but our own findings (unpublished data) and recent reports have drawn attention to a spectrum of changes that fall short of STICs that we have designated serous tubal intraepithelial lesions (STILs). (hindawi.com)
Glandular involvement by serous intraepithelial carcinoma. (surgpath4u.com)

The authors conclude that an endometrial thickness of 9 mm and a report of vaginal bleeding are independent predictors of endometrial pathology and could be used to select women for hysteroscopy and biopsy during tamoxifen therapy. (aafp.org)

Independent prognostic factors were determined by multivariate Cox regression analysis using a forward stepwise selection. (nih.gov)

Mismatch Repair Deficiency in Ovarian Carcinoma: Frequency, Causes, and Consequences. (cdc.gov)

The present study aimed to screen and explore the key circRNA/microRNA (miRNA or miR)/mRNA interactions in head and neck squamous cell carcinoma (HNSCC) using bioinformatics. (spandidos-publications.com)
Head and neck squamous cell carcinoma (HNSCC) is a common malignancy with ~600,000 cases new each year worldwide. (spandidos-publications.com)
For example, circCORO1C promotes laryngeal squamous cell carcinoma progression by modulating the let-7c-5p/PBX3 axis ( 9 ). (spandidos-publications.com)

A stepwise model of progression from cystadenomas to low-grade carcinomas has been proposed for these neoplasms. (hindawi.com)
Although the expression of some steroid receptors has been documented in type II endometrial carcinoma, their roles in tumor progression have not been fully elucidated yet. (diclemedj.org)

Hematologic malignancies are most commonly associated with paraneoplastic pemphigus, although it can also be associated with carcinomas, sarcomas, and benign neoplasms. (medscape.com)

KEYTRUDA monotherapy is already playing a role for the treatment of certain patients with advanced endometrial carcinoma through the tumor-agnostic MSI-H indication which received accelerated approval four years ago. (businesswire.com)
Cohort K enrolled 79 patients with MSI-H endometrial carcinoma and Cohort D enrolled 11 patients with MSI-H endometrial carcinoma for a total of 90 pooled patients who received KEYTRUDA as monotherapy (200 mg fixed dose every three weeks). (businesswire.com)
Conclusion We can conclude that S-phase fraction, DNA ploidy, and p53 overexpression did not improve identification of high-risk patients by stage, grade, and age in stage I-III endometrioid endometrial carcinoma. (bmj.com)
This marks the first combination of tyrosine kinase inhibitor with immunotherapy approved in Europe for these patients with advanced or recurrent endometrial carcinoma. (eisai.com.cn)
The clinic pathological correlation of G9a and S SPRY 1 Immuno-histochemical expression was assessed in tumour specimens of paraffin blocks retrieved from 50 colorectal carcinoma patients. (omicsonline.org)

The lack of proven screening tools for early detection and the high mortality of ovarian serous carcinoma (OSC), particularly high grade, have focused attention on identifying putative precursor lesions with distinct morphological and molecular characteristics. (hindawi.com)
Although the pathway of oncogenesis has not yet been clearly established for type 2 endometrial carcinomas, 'precursor' lesions have been identified that exhibit the cytogenetic aberrations characteristic of type 2 carcinomas such as p53 mutation, increase in Ki-67 and LOH at multiple chromosomal loci such as 17p and 1p. (surgpath4u.com)
These precursor lesions include serous endometrial intraepithelial carcinoma and serous endometrial gland dysplasia (serous EmGD), which exhibits a morphology and IHC pattern that lies at the midpoint between normal glands and serous EIC. (surgpath4u.com)

Pulmonary carcinoids are well differentiated low to intermediate grade lung neuroendocrine tumours (LNETs), that belong to the group of lung neuroendocrine neoplasms which also include highly aggressive lung neuroendocrine carcinomas (LNECs). (who.int)

The finding of occult invasive and intraepithelial fallopian tube carcinomas in prophylactically removed specimens from asymptomatic high-risk BRCA 1/2-mutation carriers supports the notion of an origin for OSC in the fallopian tube. (hindawi.com)

Abnormal histologic findings occurred in 60 percent of women with an endometrial thickness of 9 mm or greater compared with only 6 percent of women with lesser endometrial thickness. (aafp.org)

Anatomy12

Organisms2

Diseases84

Chemicals and Drugs66

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Phenomena and Processes40

Disciplines and Occupations1

Information Science5

Health Care18

Renal cell carc10

Tumors14

Endometrium6

Cancers10

Colorectal cancer3

Papillary serous5

Metastatic5

Urothelial carcinoma2

Endometrioid Carcinoma1

Tumor types3

Risk of endometrial cancer3

Evaluate the endometrial stripe2

Prognosis2

Adenocarcinoma1

Hepatocellular carcinomas1

Recurrent endometrial cancer3

Deficient endometrial cancer1

Cancer31

Survival8

Myometrial invasion1

Hyperplasia5

Lenvatinib6

Polyp1

Chemotherapy2

LENVIMA1

DMMR5

Serous intraepithelial2

Pathology1

Prognostic factors1

Mismatch repair-deficiency1

Squamous3

Progression2

Malignancies1

Patients5

Precursor Lesions3

Neoplasms1

Invasive1

Histologic1