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  • insulin secretion
  • Factors which increase insulin secretion include the incretin hormones Glucose-dependent insulinotropic polypeptide (GIP and glucagon-like peptide-1 (GLP-1), acetylcholine, and fatty acids. (reactome.org)
  • Although several studies have addressed changes in gastrointestinal hormones the incretin effect on insulin secretion after gastric bypass has been estimated in only a few studies. (clinicaltrials.gov)
  • To the best of our knowledge the incretin effect on insulin secretion after sleeve gastrectomy remains unexplored.We are aware of four ongoing randomised controlled trials comparing the effect of gastric bypass and sleeve gastrectomy on several endpoints including weight and comorbidities (ClinicalTrial.gov identifiers: NCT00722995, NCT00356213, NCT00793143, and NCT00667706). (clinicaltrials.gov)
  • Therapies
  • Nearly all published randomized trials of incretin therapies have compared them with a placebo or a reference glucose-lowering agent, wrote André J. Scheen, MD, and Régis P. Radermecker, MD, both of the University of Liège in Belgium. (medpagetoday.com)
  • In the point narrative below, Dr. Butler and colleagues provide their opinion and review of the data to date and that we need to reconsider the use of incretin-based therapies because of the growing concern of potential risk and based on a clearer understanding of the mechanism of action. (diabetesjournals.org)
  • In the counterpoint narrative following the contribution by Dr. Butler and colleagues, Dr. Nauck provides a defense of incretin-based therapies and that the benefits clearly outweigh any concern of risk. (diabetesjournals.org)
  • diabetes
  • Incretin based treatment for type 2 diabetes improves hyperglycaemia without causing weight gain and is increasingly being used worldwide. (bmj.com)
  • However, Dr Renehan, who also chairs the EASD's Diabetes and Cancer Study Group, pointed out, "It's not definitive yet….The use of incretins is still relatively young. (medscape.com)