• Dr Alejandra Tomas , Senior Lecturer at the Department of Metabolism, Digestion and Reproduction , explores new and emerging incretin-based therapies for managing diabetes. (imperial.ac.uk)
  • Incretin-based therapies work through modulation of gut-derived hormones that play a role in maintaining euglycemia and regulating hormones. (medscape.com)
  • Amongst the current treatments for diabetes are incretin therapies which are based on hormones called 'incretins', released from the gut after we eat. (imperial.ac.uk)
  • Key metabolic actions of the incretin hormones GLP-1 and GIP. (imperial.ac.uk)
  • Incretins are a group of metabolic hormones that stimulate a decrease in blood glucose levels. (wikipedia.org)
  • The observation that glucose taken orally results in a more pronounced insulin secretion than intravenously given glucose is the so-called incretin effect. (touchendocrinology.com)
  • The mechanism of action of these incretin drugs that impacts beta cells (glucose-dependent insulin secretion) and alpha cells (glucagon suppression) provides a plausible explanation for the development of pancreatic inflammation or possible neoplasm. (patientcareonline.com)
  • Incretins are released after eating and augment the secretion of insulin released from pancreatic beta cells of the islets of Langerhans by a blood-glucose-dependent mechanism. (wikipedia.org)
  • Glucagon-like peptide-1 (GLP-1) is an important endogenous incretin hormone, which stimulates glucose-dependent insulin secretion from the pancreatic islet cells and supports glucose homeostasis [ 7 ], as well as stimulating β -cell proliferation and inhibiting β -cell apoptosis, increasing insulin sensitivity, and inhibiting glucagon secretion and gastrointestinal motility [ 7 - 10 ]. (hindawi.com)
  • The metabolic endotoxemia, modifications in the secretion of incretins and butyrate production might explain the influence of the microbiota in these diseases. (frontiersin.org)
  • In 2005 , the first incretin-based agent was introduced into the type 2 diabetes treatment landscape to address postprandial glucose control. (medscape.com)
  • Incretin-based therapy plays a major role in managing patients with type 2 diabetes and has become a popular choice for controlling blood glucose levels because of its glycemic efficacy, ease of use, and low risk for hypoglycemia. (medscape.com)
  • On July 26, 2013 the European Medicines Agency (EMA), in a press release, stated that it sees no reason for concern about pancreatitis and pancreatic neoplasm in incretin-treated patients with type 2 diabetes. (patientcareonline.com)
  • The US Food and Drug Administration and the American Diabetes Association (US FDA/ADA) have empanelled a similar committee to consider the safety of incretins. (patientcareonline.com)
  • So far, most incretin therapies have been directed at the GLP-1 receptor because the GIP receptor does not work well in people with diabetes. (imperial.ac.uk)
  • Medications based on incretins are used in the treatment of diabetes mellitus type 2. (wikipedia.org)
  • He also proposed that such incretins could be used as a treatment for diabetes mellitus. (wikipedia.org)
  • Aim: To examine the effects of glibenclamide and repaglinide on glucose stimulated insulin release, incretins, oxidative stress and cell adhesion molecules in patients with type 2 diabetes suboptimally treated with metformin. (ku.dk)
  • Their study showed that incretin treatments are prescribed to T2D patients whose diabetes is caused by undiagnosed pancreatic cancer. (ajmc.com)
  • Some researchers suspect that this may prompt physicians to back away from prescribing the class at all, moving toward newer therapies, particularly the incretins, when metformin alone is no longer working for type 2 diabetes patients. (medpagetoday.com)
  • A new study published in @DiabetologiaJnl finds that people with type 2 #diabetes who are socioeconomically disadvantaged are less likely to be prescribed incretin-based therapies, even though they may have more to gain from such treatments. (diabetologia-journal.org)
  • As a pediatric endocrinologist, I can tell you we're seeing more and more Type 2 diabetes in kids and adolescents, and it seems to be a more aggressive form than adult onset diabetes, so we do need better therapies to achieve even greater efficacy and degree of weight loss," said Andrea Haqq , a professor in the University of Alberta's Faculty of Medicine & Dentistry . (eurekalert.org)
  • In 1932, Belgian physiologist Jean La Barre used the word "incretin" for a gut hormone, which stimulates the endocrine pancreas including insulin release. (wikipedia.org)
  • Incretin-based T2DM therapy is not a direct cause of pancreatitis or pancreatic cancer asserts the European Medicines Agency. (patientcareonline.com)
  • These ads tout the risk of pancreatitis and pancreatic cancer associated with the use of incretin therapies. (patientcareonline.com)
  • Our study also shows that the reverse causation observed for incretin drugs is also observed for other anti-diabetic therapies, in particular for insulin therapy," Koechlin added. (ajmc.com)
  • This group of patients had been prescribed injectable treatments (incretins or insulin) for better control of their T2D. (ajmc.com)
  • In this short review we evaluate incretin-based therapies with respect to the risk of hypoglycaemia. (touchendocrinology.com)
  • Instead, many clinicians may move directly to incretin therapy if metformin no longer does the trick. (medpagetoday.com)
  • However, we now know that when blood sugar levels get under control, the GIP receptor starts to work more effectively again, and as this is a very strong receptor, there is a good case for developing therapies that target the GLP-1 receptor and the GIP receptor simultaneously. (imperial.ac.uk)
  • The researchers recently published a paper that examines the potential of several drugs that control incretins. (eurekalert.org)
  • Therefore, hypoglycaemia is a typical side effect of sulfonylurea therapy. (touchendocrinology.com)
  • The incretin effect describes the phenomenon whereby oral glucose intake elicits a higher insulin response compared to intravenously introduced glucose that produces the same levels of serum glucose levels. (wikipedia.org)
  • Post-marketing studies have shown incretin treated patients experiencing non-fatal and fatal pancreatitis, but the numbers of people experiencing these complications are miniscule compared with millions of patient years of exposure to incretins. (patientcareonline.com)
  • Most importantly, the EMA pointed out differences in the age, gender, disease duration, and other therapies used in patients, all of which confound interpretation. (patientcareonline.com)
  • Under the FDA's restrictions last fall, rosiglitazone is to be used only in patients who have failed therapy with pioglitazone. (medpagetoday.com)
  • The way that incretin receptors work together in the pancreas is not yet very clear. (imperial.ac.uk)
  • Understand these changes is important to predict diseases and develop therapies. (frontiersin.org)
  • Incretins also activate receptors in the brain that promote feelings of fullness and reduce appetite - an added benefit for individuals who need to lose weight. (imperial.ac.uk)
  • The agency said therapy longer than a year was associated with 27.5 excess cases of bladder cancer per 100,000 person-years of follow-up, compared with never using the drug. (medpagetoday.com)
  • In conclusion, longer-term administration of apelin-13 analogues, induced similar and in some respects more effective metabolic improvements than incretin mimetics in db/db mice, providing a viable alternative approach for counteracting metabolic dysfunction for mild and more degenerative forms of the disease. (ulster.ac.uk)
  • His thesis research was focused on 1) repurposing FDA approved diabetes medications (incretins mimetics) for treating neurodegenerative disease/injury and 2) investigating novel proteins involved in brain disease/injury associated neuroinflammation. (nih.gov)
  • Results Overall, incretin-based therapies have shown beneficial effects on CVD risk factors, and glucagon-like peptide 1 (GLP-1) receptor agonists appear to have a more pronounced effect compared with dipeptidyl peptidase-4 inhibitors. (medscape.com)
  • Incretin-based therapies, including the injectable glucagon-like peptide 1 (GLP-1) receptor agonists and oral dipeptidyl peptidase 4 (DPP-4) inhibitors, offer another treatment option for patients with type 2 diabetes. (medscape.com)
  • DPP-4 inhibitors enhance circulating levels of GLP-1 and the incretin hormone, glucose-dependent insulinotropic peptide (GIP). (medscape.com)
  • [ 1 , 3 ] The American Diabetes Association (ADA), the European Association for the Study of Diabetes (EASD), and the American Association of Clinical Endocrinologists (AACE) recommend addition of GLP-1 receptor agonists or DPP-4 inhibitors to metformin as components of dual or triple therapy. (medscape.com)
  • Incretin-based drugs, such as glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase 4 inhibitors, are now routinely used to treat type 2 diabetes mellitus. (nih.gov)
  • The concerns about pancreatitis and pancreatic cancer relate to some relatively new type 2 diabetes drugs, the glucagonlike peptide-1 (GLP-1) agonists and dipeptidyl peptidase (DPP-4) inhibitors, collectively known as GLP-1-based drugs, or "incretins. (medscape.com)
  • The observation that the insulinotropic actions of GLP-1 are reduced in type 2 diabetes mellitus (T2DM) led to the development of incretin-based therapies - GLP-1 receptor agonists and dipeptidyl peptidase 4 (DPP-4) inhibitors - for the treatment of hyperglycaemia in these patients. (nih.gov)
  • Here, we review the role of GLP-1 and the actions of associated therapies on glucose metabolism, the gut-renal axis, classical renal risk factors, and renal end points in randomized controlled trials of GLP-1 receptor agonists and DPP-4 inhibitors in patients with T2DM. (nih.gov)
  • EVOO's Effects on Incretin Production: Is There a Rationale for a Combination in T2DM Therapy? (unipa.it)
  • The management of T2DM, before starting specific therapies, includes cornerstones such as healthy eating, regular exercise and weight loss. (unipa.it)
  • In this review, we explore observations regarding the pathophysiological basis of the existence of an enhanced effect between the action of EVOO and incretins and, consequently, try to understand whether there is a rationale for their use in combination for T2DM therapy. (unipa.it)
  • In patients with T2DM, the incretin effect is diminished. (uspharmacist.com)
  • In 1932, Belgian physiologist Jean La Barre used the word "incretin" for a gut hormone , which stimulates the endocrine pancreas including insulin release. (wikipedia.org)
  • The gut-derived incretin hormone glucagon-like peptide 1 (GLP-1) is secreted upon meal ingestion and controls glucose metabolism by modulating pancreatic islet cell function, food intake and gastrointestinal motility, amongst other effects. (nih.gov)
  • The incretin effect describes the phenomenon whereby oral glucose intake elicits a higher insulin response compared to intravenously introduced glucose that produces the same levels of serum glucose levels. (wikipedia.org)
  • incretin effect in type 2 (non-insulin-dependent) diabetes. (ui.ac.id)
  • 3,4 Referred to as the incretin effect , they exert their effects by binding to their respective receptors of the pancreas' beta cells to ultimately release insulin. (uspharmacist.com)
  • It shall be used before commencing insulin therapy. (myhealth.gov.my)
  • The success of exenatide and sitagliptin, the first therapies in their respective drug classes to be based on incretins, has fostered the development of multiple new agents that are currently in late stages of clinical development or awaiting approval. (nih.gov)
  • Aim To review the effi cacy and safety data on incretin-based therapies currently available (exenatide, liraglutide, sitagliptin, vildagliptin) for the treatment of type 2 diabetes mellitus in Asian population. (ui.ac.id)
  • It was shown that incretin-based therapies improved HbA1c at higher extent (up to -1.42% in exenatide 10 mcg bid, -1.85% for liraglutide 0.9 mg qd, -1.4% for sitagliptin 100 mg and -1.4% for vildagliptin 50 mg bid) compared to the effects observed in studies with Caucasian population, with comparable safety profile. (ui.ac.id)
  • SAN FRANCISCO - The Endocrine Society is the latest organization to issue a statement indicating that more research is needed before any conclusion can be reached about a possible link between incretin-based type 2 diabetes therapies and pancreatic cancer. (medscape.com)
  • the overriding conclusion was that currently there seems to be little evidence for an increased risk for pancreatic cancer associated with use of incretin therapies. (medscape.com)
  • Incretin-based therapies for type 2 diabetes mellitus: a review of direct comparisons of efficacy, safety and patient satisfaction. (nih.gov)
  • Medications based on incretins are used in the treatment of diabetes mellitus type 2 . (wikipedia.org)
  • [9] He also proposed that such incretins could be used as a treatment for diabetes mellitus. (wikipedia.org)
  • Methods We conducted Medline search of all relevant randomized clinical trials of incretin-based therapies for type 2 diabetes mellitus in Asian populations. (ui.ac.id)
  • Results We found 14 randomized controlled trials of incretin based-therapy which included 3567 type 2 diabetes mellitus in Asian population (Japanese, Chinese, Korean, Indian). (ui.ac.id)
  • Conclusion The efficacy of incretin-based therapies in Asian patients improved glycemic parameters in a higher magnitude on some glycemic parameters compared with those in Caucasian population. (ui.ac.id)
  • Background Incretin-based therapies offer another treatment option for patients with type 2 diabetes. (medscape.com)
  • Conclusions Incretin-based therapies are an important treatment option for patients with type 2 diabetes, offering beneficial effects on CVD risk factors without increasing MACE. (medscape.com)
  • Novel therapeutics for type 2 diabetes: Incretin 16. (ui.ac.id)
  • This poster, presented at ENDO 2022, summarizes key findings from an interim analysis of an online educational program, " Incretins Update: A Holistic Approach to Patients With Type 2 Diabetes and Cardiometabolic Comorbidities ," developed by Clinical Care Options in partnership with the Endocrine Society. (clinicaloptions.com)
  • These findings illustrate the need for continued education for healthcare professionals on the use of incretin therapies for type 2 diabetes. (clinicaloptions.com)
  • This is an exciting new therapy in the treatment of type 2 diabetes (T2D), and we have topline results from some of the clinical trials that have been performed. (medscape.com)
  • Artificial GLP-1 is indicated as an additional treatment of type 2 diabetes patients that still do not achieve good glucose control with metformin alone or other combination therapies of metformin with sulphonyurea or thiazolidinedione. (myhealth.gov.my)
  • i.p.) or saline vehicle, apelin amide, apelin FA, or the established incretin therapies, exendin-4(1-39) or liraglutide, all at 25 nmol/kg body weight for 21 days. (ulster.ac.uk)
  • 26: 1770 - 80.Seino Y. Relevance of incretins in the treatment of Asian patients 10. (ui.ac.id)
  • This review will focus on the off-target effects of incretin-based therapies on CVD risk factors [body weight, blood pressure (BP), lipid profile and albuminuria], major adverse cardiovascular events (MACE), heart failure (HF) and beta-cell preservation. (medscape.com)
  • Clinicians should discuss the potential side effects of incretin-based therapy and the symptoms of pancreatitis with patients, especially those with other risk factors for the condition, and balance the risks and benefits, it states. (medscape.com)
  • Some incretins (GLP-1) also inhibit glucagon release from the alpha cells of the islets of Langerhans . (wikipedia.org)
  • The two main candidate peptides that fulfill criteria for an incretin are the intestinal peptides glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP, also known as: glucose-dependent insulinotropic polypeptide). (wikipedia.org)
  • This Review highlights our current understanding of the mechanisms of action of incretin-based drugs, with an emphasis on the emerging clinical profile of new agents. (nih.gov)
  • application of incretin-based therapy: Therapeutic potential, patient selection and clinical use. (ui.ac.id)
  • In addition, incretin-based therapies have shown positive effects on measures of beta-cell function supporting their durability in the management of diabetes. (medscape.com)
  • Holst JJ, Vilsboll T, Deacon CF. The incretin system and its 13. (ui.ac.id)
  • Possible benefit of starting this therapy earlier is that it may help to reduce blood sugar without causing hypoglycaemia and may reduce body weight as well as preserve the ß-cells. (myhealth.gov.my)
  • Today I'm going to discuss dual incretin therapy. (medscape.com)
  • These results indicate that incretin-based therapies may be more effective in Asian population than in Caucasian. (ui.ac.id)
  • Methods A literature search was conducted to identify English-language publications for incretin-based therapies evaluating the following off-target end-points: body weight, BP, lipid profile, albuminuria, MACE, HF and beta-cell function. (medscape.com)