Increases osteoblast marker osteocalcin osteocalcin. Medical search. Frequent questions

It has been observed that higher serum osteocalcin levels are relatively well correlated with increases in bone mineral density during treatment with anabolic bone formation drugs for osteoporosis, such as teriparatide. (wikipedia.org)
This increase coincided with a transient increase in serum osteocalcin in week 6, indicative of adaptive bone formation at this time point. (cdc.gov)
Serum osteocalcin (1-43) is also generated by the catabolic breakdown of osteocalcin (1-49) in circulation, liver, and kidney. (epitopediagnostics.com)
Serum osteocalcin levels rose whilst a resorption marker (serum crosslaps) fell, but there was no control group. (biomedcentral.com)
Serum osteocalcin rose and the resorption marker urinary deoxypyrdinoline decreased. (biomedcentral.com)

it is usually caused by over-suppression of PTH and various other growth elements[8 10 11 Bone tissue biopsy findings add a low bone tissue formation price as evaluated by tetracycline WYE-687 fluorescence-labeling little if any mobile activity (paucity of osteoblasts and osteoclasts) and slim osteoid seams[6]. (exposed-skin-care.net)
Osteomalacia Osteomalacia is definitely characterized by a deficit in bone mineralization due to hypophosphatemia malnutrition vitamin D deficiency or aluminium toxicity[11 12 Characteristic findings on bone biopsy include wide unmineralized osteoid seams low bone formation absence of osteoblasts and osteoclasts[6]. (exposed-skin-care.net)
Previous studies showed that different plant-derived flavonoid compounds could stimulate osteoblasts function, and inhibit osteoclasts functions either alone or in combination. (biomedcentral.com)
Breast cancers frequently metastasise to the skeleton where they cause osteolytic bone destruction by stimulating osteoclasts to resorb bone and by preventing osteoblasts from producing new bone. (biomedcentral.com)
These metastatic tumours interfere with normal bone remodelling by stimulating osteoclasts to resorb bone and preventing new bone growth by inhibiting osteoblasts. (biomedcentral.com)
Thus, bone degradation is due to both increased activation of osteoclasts and suppression of osteoblasts. (biomedcentral.com)
We found that PLF was present primarily in the cellular periosteum, articular cartilage, osteoblasts, osteocytes and osteoclasts at weeks 3 and 6 in all distal bone sites examined. (cdc.gov)
Osteoporosis is usually caused when the delicate balance between the activity of bone building cells (osteoblasts) and bone-destroying cells (osteoclasts) in the skeleton is destabilised. (ahsc.org.uk)
Here, the researchers found that kisspeptin not only stimulated the activity of osteoblasts, but also inhibited the activity of osteoclasts - the bone-destroying cells. (ahsc.org.uk)
Osteoclasts and osteoblasts work in turn to remove old, damaged bone and then replace it, resulting in strong bones that are in a continuous process of renewal. (saveourbones.com)
When osteoclasts outpace osteoblasts, it causes a loss of bone mass and with it a loss of the structural quality of bone. (saveourbones.com)
The opposite problem can also occur, in which osteoblasts outpace osteoclasts- resulting in new bone deposited over old and damaged bone. (saveourbones.com)
The material that osteoblasts deposit into the pits left by osteoclasts takes time to reach full strength and integration into the existing bone. (saveourbones.com)

Runx2 is known to mediate activation of osteoclast activity and inhibition of osteoblast differentiation by metastatic breast cancer cells. (biomedcentral.com)
for instance, lactoferrin is reported to stimulate osteoblast proliferation and inhibit osteoclast activity in cell cultures. (uth.gr)
An imbalance in osteoblast/osteoclast activity may be due to oxidative stress and the accumulation of glycosylation end products, which contributes to chronic inflammation and bone resorbtion in patients with diabetes. (dntb.gov.ua)

The impairment of proliferation, differentiation, and mineralization in osteoblast is the main pathophysiological mechanism of osteoporosis, which has been proven by previous studies ( 4 , 5 ). (frontiersin.org)
YK-11 also accelerates proliferation and mineralization and increases expression of the osteoblast differentiation markers osteoprotegerin and osteocalcin. (sarms.forsale)
Therefore, a sustainable drug is desirable to identify better and safe anabolic agents with low toxicity that act by either increasing the osteoblasts proliferation or inducing osteoblasts differentiation to enhance bone formation [ 8 ]. (biomedcentral.com)
However, whether GLP1 has a direct effect on the proliferation and differentiation of osteoblasts or any cellular mechanism for this potential role is unknown. (endocrinology-journals.org)
Cell proliferation was assessed using MTT assay, revealing that exendin-4 increased cell proliferation at effective concentrations between 10 −10 and 10 −5 M. Quantitative PCR analysis showed that exendin-4 increased the mRNA expression of the differentiation markers alkaline phosphatase (ALP), collagen-1 (COL1), osteocalcin (OC), and runt-related transcription factor 2 (RUNX2) under osteogenic conditions. (endocrinology-journals.org)
Additionally, we were able to reconstruct the three developmental phases during osteoblast differentiation: proliferation, matrix maturation, and mineralization, and illustrate the activation of the SMAD signaling pathways by TGF-β2 and BMPs. (biomedcentral.com)
We monitored these cells during their expansion ex vivo with respect to proliferation kinetics, surface marker profile and differentiation potential. (biomedcentral.com)
Osteocalcin promotes pancreatic β-cell proliferation and insulin secretion, and also affects the insulin sensitivity of peripheral tissues. (dntb.gov.ua)

The expression of gene transcripts for Runx2, Bmp2, Fgfr1, collagen type 1 (Col1), osteocalcin (Oc), and osteopontin (Op) were evaluated by real-time RT-PCR. (techscience.com)
Using Northern blot analysis and in situ hybridization on parallel sections of murine embryos and bones of newborn mice we compared the expression pattern of the recently cloned Itm2a and MMP-13 (collagenase-3) genes with that of established marker genes for bone formation, such as alkaline phosphatase (ALP), osteocalcin (OC), and collagen type X, during endochondral and intramembranous ossification. (nyu.edu)
MMP-13 expression was restricted to chondrocytes of the lower zone of hypertrophic cartilage also expressing collagen type X. In osteoblasts involved in endochondral and intramembranous ossification Itm2a was not present. (nyu.edu)
For the quantification of cellular differentiation at the molecular level, osteogenic differentiation of MSCs is controlled by the interaction of hormones and transcription factors: runt-related transcription factor-2 (RUNX2) effectuates the expression of bone-specific genes, e.g. osterix (OSX), collagen type 1 alpha-1 (COL1A1), osteocalcin (OC), and bone sialoprotein (BSP) by binding to the promoters of these genes. (biomedcentral.com)

Osteoblast cultures of neonates exposed to maternal hyperthyroidism also showed a larger total area of mineralized matrix and greater expression of gene transcripts for Oc and Op. Maternal hyperthyroidism increases the activity of matrix synthesis, alkaline phosphatase activity, and expression of gene transcripts for osteocalcin and osteopontin in the osteoblasts, extracted from the calvaria of the offspring, which may be one of the mechanisms of premature fusion of cranial sutures. (techscience.com)
Alkaline phosphatase (ALP), osteocalcin (OCN), osteopontin (OPN), and runt-related transcription factor 2 (Runx2) are commonly used to evaluate differentiation and maturation of osteoblasts. (frontiersin.org)
Runx2 is responsible for expression of osteogenic marker genes, including osteopontin, osteocalcin and ALP. (adenosine-receptor.com)
Generally, alkaline phosphatase (ALP), COL1A1, BSP, RUNX2, transforming growth factor-beta 1 (TGFB1), osteonectin (ON), and bone morphogenetic protein-2 (BMP2) are known to be early markers of osteoblastic differentiation, whereas OC and osteopontin (OPN) are expressed later in the differentiation process [ 20 ]. (biomedcentral.com)

Anti-resorptive medications (bisphosphonates and denosumab) primarily increase endocortical bone by bolstering mineralization of endosteal resorption pits and thereby increase cortical thickness and reduce cortical porosity. (biomedcentral.com)

The increased expression of BMP2 may be due to the production of osteocalcin and maturation of osteoblasts. (jarde.jp)

The function of Runx2/CBFβ-regulated genes in mediating the ability of MDA-MB-231 to inhibit osteoblast differentiation was subsequently established in primary bone marrow stromal cell cultures and MC-3T3 osteoblast cells. (biomedcentral.com)
11753686 " The mechanisms by which resveratrol and Sirt-1 mediate differentiation of MSCs to osteoblasts and inhibit adipogenesis, appear to involve, at least in part, the inhibition of PPAR-c and activation of Runx2. (adenosine-receptor.com)
He explained: "Most existing treatments we have for osteoporosis tend to eventually either inhibit both types of bone cells, or increase activity in both types of bone cells, because of the way the cells communicate. (ahsc.org.uk)
But with our laboratory study, kisspeptin appears to increase bone-forming activity and at the same time inhibit the bone-destroying activity. (ahsc.org.uk)

An MC3T3-E1-based microarray dataset (accessioned as GSE46400) downloaded from the Gene Expression Omnibus included MC3T3-E1 cells with or without 14-day osteoblast differentiation osteoblast induction. (frontiersin.org)
We identified 715 upregulated DEGs and 603 downregulated DEGs between MC3T3-E1 cells with and without osteoblast induction by analyzing the raw data of the GSE46400 dataset. (frontiersin.org)
The RT-qPCR also determined declined expressions of miR-204-5p and miR-24-3p concomitant with elevated expressions of miR-211-5p, miR-3470b, miR-466b-3p, and miR-466c-3p in the MC3T3-E1 cells, with osteoblast induction compared with undifferentiated MC3T3-E1 cells. (frontiersin.org)
MiR-211-5p upregulation by its mimic increased Arhgap11a expression in MC3T3-E1 cells. (frontiersin.org)
cells, but pre-osteoblastic cells from the osteoblast progenitor MC3T3-E1 are not. (adenosine-receptor.com)

Runx2 belongs to the Run family and is an essential upstream transcription factor during osteoblast differentiation. (frontiersin.org)
Osterix (OSX) is a transcription factor in the SP family, which is essential for osteoblast differentiation, and its expression is closely related to Runx2 ( 9 ). (frontiersin.org)
However, while Runx2-regulated genes that mediate osteoclast activation have been identified, how Runx2 determines inhibition of osteoblasts is unknown. (biomedcentral.com)
We show that Runx2/CBFβ mediates inhibition of osteoblast differentiation by MDA-MB-231 cells through induction of the Wnt signaling antagonist, sclerostin. (biomedcentral.com)
This study demonstrates that Runx2 and CBFβ are required for the expression of genes that mediate the ability of metastatic breast cancer cells to directly modulate both osteoclast and osteoblast function. (biomedcentral.com)
We also show that Runx2-dependent inhibition of osteoblast differentiation by breast cancer cells is mediated through the Wnt antagonist, sclerostin. (biomedcentral.com)
This differentiation was accompanied by expression of the osteoblastic transcription factor Runx2, which results in earlier initiation of the osteoblast differentiation programme. (adenosine-receptor.com)

The Tridax procumbens extracts (TPE) are known for their ethno-medicinal properties to increase osteogenic functioning in mesenchymal stem cells. (biomedcentral.com)
The results showed that MSC did not alter their osteogenic differentiation capacity, surface marker profile, and the expression profiles of MSC during expansion. (biomedcentral.com)
Osteogenic differentiation of osteoblasts is of great importance, and the regulatory mechanisms are urgent to be studied. (edu.pl)
Overexpressed RAD51 promoted osteogenic differentiation by activating IGF1R/PI3K/AKT signaling pathway in OP. RAD51 could be a potential therapeutic marker for OP. (edu.pl)

Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid) noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein. (wikipedia.org)
Over the past two decades, French geneticist and physician Gerard Karsenty has been studying the protein osteocalcin, which is found in high concentrations in the skeleton. (meltmethod.com)
Osteocalcin, also known as bone gamma carboxyglutamic acid and contains protein (BGLAP), is a non-collagenous protein found in bone and dentin. (meltmethod.com)
Osteocalcin is a messenger protein sent by the bone to the brain to regulate many crucial processes in the body. (meltmethod.com)
Granted osteocalcin isn't the only hormone or protein that plays a role in regulating insulin, fertility, and brain function but it does seem to be a very relevant element in many brain functions and neurotransmission. (meltmethod.com)
Osteocalcin (also known as bone Gla protein/BGP) is protein found in bone and dentin. (epitopediagnostics.com)
The expression of bone differentiation markers such as alkaline phosphatase, type 1 collagen, insulin-like growth factor (IGF) 1, IGF2, bone morphogenic protein 2 (BMP2) and osteocalcin at 3 weeks after induction were increased compared with pre-induction. (jarde.jp)
Herein, we investigated the effect of dovitinib on human recombinant bone morphogenetic protein (BMP)-2-induced osteoblast differentiation in a cell culture model. (molcells.org)
Keywords: osteoinduction osteoinductive led bone tissue regeneration bone tissue formation bone tissue induction BMP development factor dimensional adjustments regenerative therapy hard cells regeneration 1 Intro Bone morphogenetic protein (BMPs) have performed a pivotal part in modern medication by straight influencing the dedication and differentiation of osteoprogenitor cells towards osteoblasts [1]. (globaltechbiz.com)
Osteocalcin is a structural protein of the bone matrix, which is synthesized by osteoblasts and enters the bloodstream in the process of bone resorption. (dntb.gov.ua)
New methods of measuring bone density and bone markers such as osteocalcin [serum bone-Gla-protein (BGP)] have made it possible to detect failure in bone mineral turnover and remodelling. (the-medical-dictionary.com)
BGP is a vitamin Kdependent gamma-carboxylated protein synthesized by osteoblasts. (the-medical-dictionary.com)
Glucose has been reported to increase the de novo synthesis of diacylglycerol (DAG) and translocate and activate protein kinase C (PKC) in rat adipocytes. (jci.org)

In vitro differentiation induction of normal human periodontal ligament fibroblasts, HpdLF, into an osteoblast lineage was attempted and the changes in gene expression were examined. (jarde.jp)
Taking DHEA by mouth before in-vitro fertilization (IVF) might improve the chances of pregnancy and having a baby. (medlineplus.gov)

In the presence of resveratrol or/and nicotinamide, MSCs differentiate into osteoblasts and adipocytes in highdensity cultures. (adenosine-receptor.com)
In contrast to MSCs, pre-osteoblast cells were programmed to differentiate into their committed target osteoblast cells, as they were unable to differentiate into adipocytes. (adenosine-receptor.com)
Glucose rapidly increased DAG content and PKC enzyme activity in microsomes, but not in plasma membranes or other membranes, during a 30-min treatment of rat adipocytes. (jci.org)

This ELISA (enzyme-linked immunosorbent assay) kit is intended for the quantitative determination of both human osteocalcin (1-49) and osteocalcin (1-43), also referred to as N-terminal & mid-regional osteocalcin, in serum or plasma samples. (epitopediagnostics.com)

In fat cells, osteocalcin triggers the release of the hormone adiponectin, which increases sensitivity to insulin. (wikipedia.org)
It acts as a hormone in the body and helps the pancreas release insulin, while also directing fat cells to release another hormone called adiponectin, which increases sensitivity to insulin. (meltmethod.com)

To analyze the correlation among BMD, BMI and Osteocalcin in Postmenopausal women, to investigate the possibility of using osteocalcin examination to predict the mandibular bone osteoporosis. (walshmedicalmedia.com)
It is concluded that each examination of BMD, BMI, and Osteocalcin can be used to identify the risk of osteoporosis in postmenopausal women. (walshmedicalmedia.com)
World Health Organisation (WHO) defines osteoporosis as a disease that is characterized by low bone mass and microarchitectural destruction of bone tissue, leading to bone fragility and increased risk of fracture. (walshmedicalmedia.com)
Although dovitinib can bind several kinases at nanomolar concentrations, there are no reports relating to osteoporosis or osteoblast differentiation. (molcells.org)
Although, several therapies are available for the treatment of osteoporosis, the risk of side-effects and/or lack of increasing bone anabolic agents have increased the need for alternate therapies. (biomedcentral.com)
Men with hypogonadism have faster bone metabolism, an increased risk of osteoporosis and brittle fractures. (biomedcentral.com)
11beta-HSD1 is expressed in osteoblasts and may play a role in determining susceptibility to glucocorticoid-induced osteoporosis. (ox.ac.uk)
Vertebral fractures are the most common type of osteoporotic fracture in postmenopausal women.In both the osteoporosis treatment and prevention trials, raloxifene hydrochloride tablets therapy resulted in consistent, statistically significant suppression of bone resorption and bone formation, as reflected by changes in serum and urine markers of bone turnover (e.g., bone-specific alkaline phosphatase, osteocalcin, and collagen breakdown products). (drugcentral.org)
Osteoporosis (OP) is a skeleton disease induced by imbalance between osteoblast and osteoclast. (edu.pl)
Current osteoporosis medications increase bone density and reduce fracture risk but the mechanisms of these actions vary. (biomedcentral.com)

In humans, osteocalcin is encoded by the BGLAP gene. (wikipedia.org)
T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. (nih.gov)
Recombinant adeno-associated virus (rAAV) gene therapy has a broad clinical impact on improving patient outcomes for various genetic diseases, including the three FDA-approved AAV-drugs: Luxturna (treatment for Leber congenital amaurosis), Zolgensma (treatment for spinal muscular atrophy), and recently Hemgenix (treatment for Hemophilia B) 1 . (nature.com)
Gene expression was studied using RNA from cultured cells by quantitative PCR method and showed changes in the expression pattern of other Dlx genes and multiple bone specific genes including expression of osteocalcin ( OCN ), bone sialoprotein ( BSP ), Collagen I ( Col1a1 ) and alkaline phosphatese. (uconn.edu)
IGF-I replacement therapy normalized CTR gene expression and reduced markers of osteoclastic activity. (biomedcentral.com)

An acute stress response (ASR), colloquially known as the fight-or-flight response, stimulates osteocalcin release from bone within minutes in mice, rats, and humans. (wikipedia.org)
Since Sirt-1 inhibits the adipogenic transcription factor PPAR-c, it also stimulates mechanisms regulating osteoblast differentiation. (adenosine-receptor.com)
Matsuoka K, Park KA, Ito M, Ikeda K, Takeshita S. Osteoclast-derived complement component 3a stimulates osteoblast differentiation. (dntb.gov.ua)

FA activity was significantly higher at 14 and 21 days in cultures of osteoblasts extracted from offspring exposed to maternal hyperthyroidism, while MTT conversion was significantly lower at 21 days in this group. (techscience.com)
Bone mineral density and bone mineral content of the TPF-treated mice were significantly increased compared to the control mice. (biomedcentral.com)
Bone formation-related indices like osteoblast number, osteoblast surface, bone volume, mineralizing surface, mineral apposition rate and bone formation rate were significantly increased in the TPF-treated mice compared to the control mice. (biomedcentral.com)
The values of bone alkaline phosphatase and osteocalcin significantly decreased following two months of exercise program. (irb.hr)
rhBMP9 significantly induced ALP activity mRNA levels of collagen1α2 and ALP and osteocalcin (OCN) at three or 14 days. (globaltechbiz.com)
It is shown that the level of osteocalcin in the blood serum is significantly reduced compared to healthy controls, both in patients with type 1 diabetes mellitus and, especially, in type 2 diabetes mellitus. (dntb.gov.ua)

Bone biopsy characteristically shows increased bone resorption considerable osteoclastic activity and endosteal fibrosis[6]. (exposed-skin-care.net)
Osteoblast mainly originates from mesenchymal stem cells (MSCs), and it is involved in bone formation, remodeling, and reconstruction via the formation of a bone matrix and regulation of bone resorption ( 6 ). (frontiersin.org)
Measurement of serum markers of bone metabolism (bone alkaline phosphatase and osteocalcin as bone formation markers and C-terminal telopeptide as bone resorption marker) during four months of organized moderate-intensity physical training in Labrador retriever and Golden retriever dogs aged between 11.7-24.4 months, showed variations of bone metabolism. (irb.hr)
The osteoporotic jaw bone will experience the decrease of jaw bone density, the increase alveolar jaw bone resorption, and also the increase risk of periodontal disease and tooth loss. (walshmedicalmedia.com)
The results showed that although CLA decreased gain in body weight by 35%, it however increased bone mass by both reducing bone resorption and increasing bone formation. (biomedcentral.com)
a resorption marker) suggest that a greater decrease in remodelling activity occurred with infliximab. (biomedcentral.com)
It decreases bone resorption and bone turnover, increases bone mineral density (BMD) and decreases fracture incidence. (drugcentral.org)
Decreases in estrogen levels after oophorectomy or menopause lead to increases in bone resorption and accelerated bone loss. (drugcentral.org)
In addition to loss of estrogen, this imbalance between resorption and formation may be due to age-related impairment of osteoblasts or their precursors. (drugcentral.org)
We can measure bone turnover by testing for levels of bone turnover markers, which occur as byproducts of bone resorption and formation. (saveourbones.com)
The markers of bone resorption include enzymes involved in the process of bone resorption and the material generated through resorption. (saveourbones.com)
There are four categories of bone resorption markers. (saveourbones.com)
Collagen degradation products are a class of bone resorption marker generated when the collagen in bones is broken down during the resorption process. (saveourbones.com)
Osteocyte activity markers can also be observed to measure resorption levels. (saveourbones.com)
Markers of bone resorption include collagen degradation products, non-collagenous proteins, osteoclastic enzymes, and osteocyte activity markers. (saveourbones.com)
Low doses of IGF-I constituted a real replacement therapy that normalized IGF-I serum levels improving the expression of most of these proteins closely involved in bone-forming, and reducing bone resorption by mechanisms related to osteoprotegerin, RANKL and PTH receptor. (biomedcentral.com)

Bone loss causes thinning of bones thereby increasing the risk of fractures [ 19 ]. (biomedcentral.com)
Decreased bone quality and increased risk of fractures are associated with changes in bone microarchitecture and local humoral environment. (dntb.gov.ua)

Moreover, AAV9-NEM localized strongly in vivo to cells lining the calcified trabecular bone and transduced primary murine osteoblasts in culture, while WT AAV9 transduced undifferentiated bone marrow stromal cells as well as osteoblasts. (nature.com)

proven that alkaline phosphatase activity (a marker for osteoblast differentiation) was highest in BMP9 whereas Kang et al. (globaltechbiz.com)

[ 10 ] Although the mutation is known, the actual pathways that lead to abnormal osteoblast differentiation and function remain to be fully elucidated. (medscape.com)
Analysis of serum markers Trap5b and CTX were done to see change in osteoclast differentiation and function respectively. (uconn.edu)
No difference was observed in these markers, suggesting osteoclast differentiation and function were not affected in these mice. (uconn.edu)

OPG is secreted primarily by osteoblasts and stromal cells. (biomedcentral.com)

Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. (biomedcentral.com)
When coupled with different tissue executive strategies they information the induction of mesenchymal progenitor cells to differentiate towards bone-forming osteoblasts. (globaltechbiz.com)

Activation of Sirt-1 in MSCs decreases adipocyte differentiation and increases osteoblastic differentiation in high-density cultures. (adenosine-receptor.com)
The identification of the continuum of sequential expression of Itm2a, ALP, MMP-13, and OC will now allow us to establish a series of marker genes that are highly suitable to characterize bone cells during chondrocytic and osteoblastic differentiation in vivo. (nyu.edu)

In the pancreas, osteocalcin acts on beta cells, causing beta cells in the pancreas to release more insulin. (wikipedia.org)
Bone is one of the major target tissues for Insulin-like Growth Factor I (IGF-I). Low doses of IGF-I were able to improve liver-associated osteopenia. (biomedcentral.com)

Because osteocalcin has gla domains, its synthesis is vitamin K dependent. (wikipedia.org)
To evaluate the characteristics and synthesis activity of osteoblasts extracted from the calvaria of offspring of rats exposed to maternal hyperthyroidism. (techscience.com)
In contrast, few studies have identified mechanisms by which breast cancer cells suppress bone synthesis by osteoblasts. (biomedcentral.com)

MEASUREMENTS: Serum cortisone, cortisol and osteocalcin, and urinary type I collagen cross-linked N-telopeptide (NTX) were measured at baseline. (ox.ac.uk)

To identify subpopulations of resting, proliferating, and hypertrophic chondrocytes and osteoblasts involved in bone formation, we have identified here two novel marker genes present in endochondral and intramembranous ossification. (nyu.edu)

The TPF also promoted osteoblasts differentiation and bone formation demonstrated by increasing bone formation markers in cultured mouse primary osteoblasts. (biomedcentral.com)

For instance, one study which aimed to study the effectiveness of a glycoprotein called lactoferrin on bone formation used osteocalcin as a measure of osteoblast activity. (wikipedia.org)
However, while this approach reduces the bone lesions and improves the quality of patient life, therapies that restore osteoblast activity are required to achieve more complete repair of osteolytic lesions [ 1 ]. (biomedcentral.com)
The response of two formation markers can be explained by the different stage of osteoblast activity that they express. (irb.hr)
ALP) activity at seven days alizarin red staining at 14 days and real-time PCR for osteoblast differentiation ENMD-2076 markers. (globaltechbiz.com)
In intact osteoblasts enzyme activity, and thus cortisol generation, is dependent on substrate concentration with an almost linear increase in activity across the physiological range. (ox.ac.uk)
We have therefore attempted to measure the impact of 11beta-HSD1 activity on bone in vivo by examining the association of circulating cortisone with bone markers, bone mineral density (BMD) and bone loss in a cohort of women and men. (ox.ac.uk)
CONCLUSIONS: The most plausible explanation for the association of circulating cortisone levels with osteocalcin is the presence of 11beta-HSD1 activity within osteoblasts. (ox.ac.uk)
Kisspeptin, a naturally-occurring hormone, has been found to increase the activity of bone-forming cells in the body for the first time. (ahsc.org.uk)
During the study, they monitored bone parameters including the bone-activity marker, osteocalcin. (ahsc.org.uk)
The researchers saw that osteocalcin increased markedly by 24 per cent when kisspeptin was infused compared to a placebo, suggesting rapidly increased activity in bone-building cells. (ahsc.org.uk)
By testing for these bone turnover markers, we can get a snapshot of bone turnover activity. (saveourbones.com)

We demonstrated that AAV9 capsid modified with N -ethyl Maleimide (NEM) increased its tropism more towards murine bone marrow (osteoblast lineage ) while decreased transduction of liver tissue compared to the unmodified capsid. (nature.com)

The diagnosis of systemic mastocytosis was based on direct demonstration in bone marrow biopsy of an increased number of mast cells, marrow lesions containing mast cells, lymphocytes and eosinophils [3] and an increase in urinary excretion of methylimidazoleacetic acid [2]. (the-medical-dictionary.com)

In muscle, osteocalcin acts on myocytes to promote energy availability and utilization and in this manner favors exercise capacity. (wikipedia.org)

As osteocalcin is produced by osteoblasts, it is often used as a marker for the bone formation process. (wikipedia.org)
In many studies, osteocalcin is used as a preliminary biomarker on the effectiveness of a given drug on bone formation. (wikipedia.org)
The results of this study show that aerobic exercise of moderate-intensity caused an initial decrease in bone formation followed by an increase of bone alkaline phosphatase and a further decrease of osteocalcin concentration. (irb.hr)
Process of bone formation by osteoblasts can be examined by bone marker such as Osteocalcin, as a parameter (alone or in combination with BMD) to determine metabolic bone disorders during bone formation and bone remodeling (bone turnover). (walshmedicalmedia.com)
Bone formation markers (serum: pre-and post supplementation) were analysed (alkaline phosphatase and osteocalcin) by ECLIA. (uth.gr)
The level of osteocalcin in the serum is used as a specific marker of bone formation. (dntb.gov.ua)
Circulating cortisone levels are associated with biochemical markers of bone formation and lumbar spine BMD: the Hertfordshire Cohort Study. (ox.ac.uk)
Bone is initially lost rapidly because the compensatory increase in bone formation is inadequate to offset resorptive losses. (drugcentral.org)

Well, it turns out as the brain helps regulate bone mass through signals sent from our bones, with the osteocalcin produced helping modulate this regulation and other functions of the brain. (meltmethod.com)

Novel approach to restore the normal bone remodeling and improve the bone quality may be needed in order to effectively decrease bone fracture rate in kidney transplant recipients. (exposed-skin-care.net)
Osteocalcin levels continued to decrease towards the end of the study. (irb.hr)
1,500 mg/dl, associated with a marked increase in VLDL, intermediate density lipoproteins (IDL), and LDL cholesterol, and a decrease in HDL cholesterol. (jci.org)
Taking DHEA by mouth does not seem to improve mental function or decrease mental decline in healthy older people, people with HIV, or in healthy young adults. (medlineplus.gov)

Anabolic medications (teriparatide and abaloparatide) increase the periosteal and endosteal perimeters without large changes in cortical thickness resulting in a larger more structurally sound bone. (biomedcentral.com)

In contrast to PLF, once Periostin was induced by task performance, it continued to be present at a uniformly high level between 3 and 12 weeks in the trabeculae, fibrous and cellular periosteum, osteoblasts and osteocytes. (cdc.gov)

Moreover, calcified nodules were detected and osteocalcin expression was confirmed at 3 weeks after induction, suggesting that the differentiation was progressing toward an osteoblast lineage. (jarde.jp)
The up-regulation of IGF1 or IGF2 may be due to activation of pathways for the induction of alkaline phosphatase and type 1 collagen, and the differentiation of HpdLF into an osteoblast lineage. (jarde.jp)

Increased risk of death due to stroke occurred in a trial in postmenopausal women with documented coronary heart disease or at increased risk for major coronary events. (nih.gov)
There were significant correlations among BMD, BMI, and Osteocalcin results in postmenopausal women. (walshmedicalmedia.com)
The suppression of bone turnover markers was evident by months and persisted throughout the 36-month and 24-month observation periods.In 31-week, open-label, radiocalcium kinetics study, 33 early postmenopausal women were randomized to treatment with once-daily raloxifene hydrochloride tablets 60 mg, cyclic estrogen/progestin (0.625 mg conjugated estrogens daily with mg medroxyprogesterone acetate daily for the first weeks of each month [hormone therapy]), or no treatment. (drugcentral.org)

Changes in biochemical markers of bone turnover from baseline or between the groups were not statistically different. (biomedcentral.com)

Anatomy8

Diseases5

Chemicals and Drugs18

Phenomena and Processes8

Information Science1

Serum osteocalcin5

Osteoclasts13

Osteoclast activity3

Proliferation8

Collagen type4

Osteopontin4

Mineralization1

Maturation of osteoblasts1

Inhibit4

MC3T3-E15

Runx27

Osteogenic4

Protein13

Vitro2

Adipocytes3

Human osteocalcin1

Sensitivity to insulin2

Osteoporosis10

Gene5

Stimulates3

Significantly6

Resorption16

Risk of fractures2

Trabecular bone1

Alkaline phosphatase activity1

Differentiation and function3

Stromal1

Mesenchymal2

Osteoblastic2

Insulin2

Synthesis3

Type I collag1

Genes1

Demonstrated by incr1

Activity11

Murine1

Urinary1

Myocytes1

Formation8

Modulate1

Decrease4

Anabolic1

Cellular1

Lineage2

Postmenopausal women3

Biochemical1