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  • synthesis
  • Among these features are deficits of working memory and decreased levels of glutamic acid decarboxylase 67, one of the enzyme isoforms that catalyzes the synthesis of GABA, and parvalbumin, a Ca 2+ -binding protein expressed by interneurons, primarily in the stratum pyramidale. (aspetjournals.org)
  • Gpr35
  • Here we show that kynurenic acid increases energy utilization by activating G protein-coupled receptor Gpr35, which stimulates lipid metabolism, thermogenic, and anti-inflammatory gene expression in adipose tissue. (nih.gov)
  • Kynurenic acid and Gpr35 enhance Pgc-1α1 expression and cellular respiration, and increase the levels of Rgs14 in adipocytes, which leads to enhanced beta-adrenergic receptor signaling. (nih.gov)
  • Anoder tryptophan metabowite, 5-hydroxyindoweacetic acid exerts its effects via de orphan G protein-coupwed receptor GPR35 . (appspot.com)
  • Huntington's
  • Neurodegenerative diseases such as Alzheimer's (AD), Parkinson's (PD), and Huntington's (HD) present a significant and increasing burden on society. (pnas.org)
  • contrast
  • In contrast to total PSA values, kynurenic acid was found a promising biomarker for the detection of prostate cancer particularly in cases where collection of urine samples was performed after prostatic massage. (mdpi.com)