Increases cyclic amp dependent protein kinase riibeta subunit. Medical search. Frequent questions

They are tetrameric proteins that contain two catalytic subunits and two type II-specific regulatory subunits. (uchicago.edu)
The catalytic activity of PKA is tightly regulated by regulatory subunits that inhibit the catalytic subunit until released by cAMP binding. (bvsalud.org)
however, the role of phosphorylation in type I regulatory subunits remain uncertain. (bvsalud.org)

Phosphorylation of PRKAR1A leads to inhibition of PKA kinase activity and increased binding to the catalytic subunit in the presence of cAMP. (bvsalud.org)

Herpes simplex virus protein kinase US3 activates and functionally overlaps protein kinase A to block apoptosis. (uchicago.edu)
Reduction of KIF1C decreases PRKAR1A expression and activates the PKA, which causes an increase in ERK1/2 phosphorylation and SRC-mediated STAT3 activation, a reduction of CDH1, TP53, CDKN1A, and BAX, and eventually promotes tumor formation both in vitro and in vivo. (bvsalud.org)

Cyclic AMP-Dependent Protein Kinase Type II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
This graph shows the total number of publications written about "Cyclic AMP-Dependent Protein Kinase Type II" by people in this website by year, and whether "Cyclic AMP-Dependent Protein Kinase Type II" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "Cyclic AMP-Dependent Protein Kinase Type II" by people in Profiles. (uchicago.edu)
Here, we utilize human induced pluripotent stem cell cardiomyocytes (iPSC-CMs) to identify STK25 as a kinase of the type Iα regulatory subunit PRKAR1A. (bvsalud.org)

In vitro functional analysis of the variant confirmed its role in increasing protein kinase A activity and cyclic adenosine monophosphate levels. (bvsalud.org)
Stk25 knockout in mice diminishes Prkar1a phosphorylation, increases Pka activity, and augments contractile response to beta-adrenergic stimulation. (bvsalud.org)
HK2's role in tumorigenesis has been attributed to its glucose kinase activity. (bvsalud.org)
Here, we describe a kinase independent HK2 activity, which contributes to metastasis. (bvsalud.org)
In addition to GSK3 inhibition, HK2 kinase activity mediates SNAIL glycosylation, which prohibits its phosphorylation by GSK3. (bvsalud.org)

The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. (uchicago.edu)

11. Ala99ser mutation in RI alpha regulatory subunit of protein kinase A causes reduced kinase activation by cAMP and arrest of hormone-dependent breast cancer cell growth. (nih.gov)
Over fifty members of this family exist, most of which bind specifically to regulatory subunits of CYCLIC-AMP-DEPENDENT PROTEIN KINASE TYPE II such as CAMP PROTEIN KINASE RIIALPHA or CAMP PROTEIN KINASE RIIBETA. (nih.gov)
cAMP-dependent protein kinases are reversibly complexed with any of the four isoforms of regulatory (R) subunits, which contain either a substrate or a pseudosubstrate autoinhibitory domain. (ox.ac.uk)

9. Protein kinase A-Ialpha subunit-directed antisense inhibition of ovarian cancer cell growth: crosstalk with tyrosine kinase signaling pathway. (nih.gov)
Investigating other neuronal populations in the ARC we found that ~50% of pro-opiomelanocortin (Pomc) cells, 22% of tyrosine hydroxylase (Th) cells, 8% of agouti-related protein (Agrp) cells and 8% of somatostatin (Sst) cells express Ar. (bvsalud.org)

15. Oligonucleotide sequence-specific inhibition of gene expression, tumor growth inhibition, and modulation of cAMP signaling by an RNA-DNA hybrid antisense targeted to protein kinase A RIalpha subunit. (nih.gov)
In addition, it increases the basal cGMP level by inhibition of PDE V (Murray et al. (biolog.de)

3. Increased expression of the RIalpha subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer. (nih.gov)
13. Characterization of a cAMP-dependent protein kinase mutant resistant to cisplatin. (nih.gov)
Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop. (ox.ac.uk)

We observed that the conserved αH-αI loop residue Arg-283 in PrKX is crucial for its RI over RII preference, as a R283L mutant was able to form a holoenzyme complex with wild type RII subunits. (ox.ac.uk)
Changing the corresponding αH-αI loop residue in PKA Cα (L277R), significantly destabilized holoenzyme complexes in vitro, as cAMP-mediated holoenzyme activation was facilitated by a factor of 2-4, and lead to a decreased affinity of the mutant C subunit for R subunits, significantly affecting RII containing holoenzymes. (ox.ac.uk)

1. Overexpression of protein kinase A - RIalpha reduces lipofection efficiency of cisplatin-resistant human tumor cells. (nih.gov)
10. Compensatory stabilization of RIIbeta protein, cell cycle deregulation, and growth arrest in colon and prostate carcinoma cells by antisense-directed down-regulation of protein kinase A RIalpha protein. (nih.gov)
Detailed examination of the capacity of five PrKX-like kinases ranging from human to protozoa (Trypanosoma brucei) to form holoenzymes with human R subunits in living cells shows that this preference for pseudosubstrate inhibitors is evolutionarily conserved. (ox.ac.uk)

They play a role in focusing the PROTEIN KINASE A activity toward relevant substrates. (nih.gov)

12. MicroRNA-133b targets glutathione S-transferase π expression to increase ovarian cancer cell sensitivity to chemotherapy drugs. (nih.gov)

excellent cell membrane permeability, improved phosphodiesterase stability and high site selectivity preferring site B of cAK type II. (biolog.de)