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  • murine
  • Studies revealed increased human serum levels of IL-6 in colorectal cancer patients ( 11 ) whilst a murine study revealed that IL-6 signalling is involved in tumour formation and administration of antibodies against IL-6R has been shown to inhibit tumour growth ( 12 ). (spandidos-publications.com)
  • Transferrin
  • Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. (semanticscholar.org)
  • Transferrin receptor-2 activation by its ligand holotransferrin led to extracellular signal regulated kinase (ERK)/mitogen activated protein kinase pathway stimulation and the ERK specific inhibitor U0-126 blunted holotransferrin-mediated induction of hepcidin. (haematologica.org)
  • Measurement of soluble transferrin receptor provides a marker of bone marrow iron stores and improves the diagnosis of iron-deficiency anaemia, therefore helping to differentiate between iron-deficiency anaemia and ACD [ 6 ] . (patient.info)
  • We propose to further explore mechanisms by which transferrin regulates hepcidin expression via its roles in the erythron and in the hepatocyte. (grantome.com)
  • Preliminary data demonstrate that exogenous transferrin (Tf) increases the relative concentration of monoferric Tf and decreases iron entry into erythroid precursors. (grantome.com)
  • 3. Examine the effects of changes in transferrin concentration on hepatocellular hepcidin expression. (grantome.com)
  • Increased Tf mitigates the effects of non-transferrin bound iron on hepcidin expression (Aim 3B). (grantome.com)
  • assays
  • The SW480 colorectal cancer cells were co-cultured with DAS in the presence or absence of leptin, IL-6 or hepcidin inhibitors and cellular viability and proliferation assays were performed. (spandidos-publications.com)
  • decreases
  • We have shown in animal studies that removing the ALK7 receptor improves insulin release by beta-cells in the pancreas, and at the same time decreases fat deposition in situations of high caloric intake, says Professor Carlos Ibez, who lead the two studies that are now published as back-to-back papers in the PNAS. (bio-medicine.org)
  • Stat3
  • We found that genistein's effect on Hepcidin expression did not depend on estrogen receptor signaling or increased cellular iron uptake, but was impaired by mutation of either BMP response elements or the Stat3-binding site in the Hepcidin promoter. (edu.au)
  • Chromatin immunoprecipitation and ELISA experiments revealed that genistein enhanced Stat3 binding to the Hepcidin promoter and increased phosphorylation of Stat3 in HepG2 cells. (edu.au)