• The fermented methanol extracts inhibited skin-aging-related enzymes such as collagenase, elastase, MMP-1, and MMP-2. (hindawi.com)
  • Moreover, extrinsic factors such as exposure to UV radiation lead to the activation of collagenase, elastase, and tyrosinase, thus resulting in skin aging, wrinkle formation and melanin production [ 7 , 8 ]. (hindawi.com)
  • Insufficient supply of oxygen and ongoing inflammation processes by high levels of reactive oxygen species and increased activity of proteolytic enzymes such as collagenase and elastase contribute to the degradation of the collagen and elastin matrix. (dsm.com)
  • Molecular docking analysis for different enzymes involved in aging (collagenase, elastase and hyaluronidase), antioxidant enzymes (superoxide dismutase, glutathione-s-transferase, glutathione peroxidase and catalase) and mitochondrial enzymes (nicotinamide adenine dinucleotide (NAD)+hydrogen (H) dehydrogenase, succinate dehydrogenase, cytochrome c oxidase and adenosine triphosphate synthase) was carried out for epigallocatechin gallate alone (1), withaferin A alone (2), epigallocatechin gallate and withaferin A in combination (3) and a reference molecule. (ijpsonline.com)
  • MMPs are a group of zinc-dependent extracellular proteinases which include collagenase and elastase, responsible for the degradation of collagen and elastin respectively[ 1 ]. (ijpsonline.com)
  • Furthermore, Regu-Age inhibits elastase and collagenase and corrects the appearance of puffiness, dark circles and wrinkles around the eyes. (platinumskincare.com)
  • Reduces collagenase and elastase, the enzymes that breakdown collagen and elastin activity. (humanistbeauty.com)
  • REGU®-AGE PF has been developed specifically to address these multiple conditions and delivers on the following parameters: inhibition of oxygen free radicals, stimulating effect on fibroblasts proliferation, inhibition of collagenases and elastases to protect the collagen and elastin matrix, improvement of capillary circulation. (dsm.com)
  • TGF-B1 activation results in increase in connective tissue synthesis and inhibition of collagenases. (peyroniesforum.net)
  • Natural products with estrogen-like activity are increasingly accepted, since they have good effects on collagen synthesis and/or inhibit collagenase activity, with a reassuring safety profile. (greenmedinfo.com)
  • In vivo, tissue inhibitors of metalloproteinases (TIMPs) inhibit collagenase activity. (medscape.com)
  • The enzymes involved in ECM degradation are matrix metalloproteinases (MMPs) such as interstitial collagenase (MMP-1) and 72-kDa gelatinase (MMP-2). (hindawi.com)
  • Therefore, measures for counteracting the enzymatic environment by enhancing dentin collagen's resistance to degradation have the potential to improve the durability of dental composite restorations. (cranberryinstitute.org)
  • All treatments significantly increased resistance to collagenase degradation and reduced the gelatinolytic MMP activity of dentin collagen compared to the untreated control. (cranberryinstitute.org)
  • Degradation of human collagen isoforms by Clostridium collagenase and the effects of degradation products on cell migration. (santyl.com)
  • These results suggest that IL-6 stimulated PA activity through an enhancement of tPA gene expression and may be involved in extracellular matrix degradation through the stimulation of the PA-plasmin system of human dental pulp (HDP) cells ( 7 ). (ispub.com)
  • Proteolytic activity and collagenolytic degradation of extracellular matrix at the bone-implant interface have been reported in conjunction with increased mRNA expression of metalloproteinases (MMPs) in otherwise healthy tissues. (allenpress.com)
  • 2 The cooperative effects of collagenases, gelatinases, and stromelysins-in combination with mechanical forces-suggest a role in MMP-dependent degradation of the extracellular matrix as an important determinant of implant failure due to excess occlusal forces. (allenpress.com)
  • Conclusions: MMP activity in TB differs by HIV-1 status and compartment, and releases matrix degradation products. (figshare.com)
  • The functional substances present in the unsaponifiable fraction stimulate the activity of fibroblasts by promoting the synthesis of soluble collagen. (soignepro.com)
  • Increase in the synthesis of osteoid tissue, hypomineralisation of this newly formed matrix, the increase in the ratio of α1/ α2 in the collagen fi bers, increased production of osteocalcin, PGE2, MMP and collagenase and decreased response to PTH are signs of abnormal osteoblast activity in OA. (dergisi.org)
  • It is also clear that psychological stressors lead to aberrant barrier function, with decreased epidermal lipid and structural protein synthesis, decreased hydration of the stratum corneum, and increased transepidermal water loss (Maarouf 2019), and can also result in immune system dysfunction leading to systemic and local inflammation (Liu 2017). (ernolaszlo.com)
  • Clinically shown to help detoxify and promote skin health and appearance by stimulating hyaluronic acid synthesis, supporting skin barrier function, and improving skin hydration levels. (humanistbeauty.com)
  • Preferred treatments include collagenase and various other proteases. (patsnap.com)
  • These changes in the periodontium may dramatically alter the tissue response to periodontal pathogens, resulting in increased tissue destruction and diminished repair potential. (health.am)
  • AD-MSC were isolated by collagenase treatment from adipose tissue from healthy individuals subjected to abdominal lipectomy surgery. (karger.com)
  • The aim of this study was to comparatively evaluate the effects of the four main paradigms of tES, including tDCS, transcranial alternating (tACS), pulsed (tPCS), and random noise (tRNS) stimulations on collagenase-induced sensorimotor impairments and striatum tissue damage in male rats. (biomedcentral.com)
  • Ceramide 1,3,6 - increase the hydration of the skin and accelerate the repair of damaged skin tissue. (platinumskincare.com)
  • Regu-Age's superb effect on the hemodynamic properties of blood significantly improve oxygen supply of skin tissue, as clinically demonstrated. (platinumskincare.com)
  • Collagenase (such as Xiaflex) is medicine that is injected to help dissolve some of the tight tissue. (healthlinkbc.ca)
  • A collagenase injection (such as Xiaflex) may dissolve some of the tight tissue. (healthlinkbc.ca)
  • The plasminogen activator (PA)-plasmin proteolytic system has recently received considerable attention because of its participation in a wide variety of biological activities and in pathological conditions involving tissue destruction. (ispub.com)
  • Islets are extracted (isolated) from the exocrine tissue of donor pancreases using neutral protease (NP) and collagenase-based enzymes, which digest the extracellular matrix (ECM) scaffold surrounding human islets. (ox.ac.uk)
  • Decreased production of long chain glycosaminoglycans (GAG's) with an increase in shorter chain Gag's, resulting in dehydration of tissue and loss of membrane function. (life-enthusiast.com)
  • Increased granulomatous second intention healing involving stromal elements (i.e. development of scar tissue) resulting in loss of cell/tissue function. (life-enthusiast.com)
  • Loss of cell and tissue function results in further inability to repair damage, leading to increased tendency to bruising, excessive inflammation, spasm, joint stiffness, digestive abnormalities and respiratory distress. (life-enthusiast.com)
  • Unlike some of the other cathepsins, cathepsin D has some protease activity at neutral pH. (wikipedia.org)
  • Kallikrein is a protease that cleaves high-molecular-weight-kininogen (HMWK) to generate cleaved HMWK and bradykinin, a potent vasodilator that increases vascular permeability resulting in swelling and pain associated with HAE. (medscape.com)
  • Blood retention in the upper layers of the skin, an insufficient oxygen supply, inflammation processes followed by higher levels of reactive oxygen species (ROS) and elevated proteolytic enzyme activity due to UV radiation result in degeneration of already weakened skin, leading to puffiness, dark circles, wrinkles and slackness. (platinumskincare.com)
  • The predominant collagenase was MMP-8, which was likely neutrophil derived and M. tuberculosis-antigen driven. (figshare.com)
  • Circulating plasminogen activator inhibitor-1 (PAI-1) activity and interleukin-6 (IL-6) were measured in plasma samples and local inflammation was assessed by neutrophil infiltration. (unav.edu)
  • The effect of CM-352 could be related to MMP-10 inhibition since Mmp10 -/- mice showed lower hemorrhage volume, better neurological score, reduced IL-6 levels and neutrophil infiltration, and increased PAI-1 after experimental ICH. (unav.edu)
  • MMP-1 (neutrophil collagenase) and MMP-8 (fibroblast or keratocyte collagenase) are involved in cleaving collagen types I, II, and III. (medscape.com)
  • AGE-stimulated smooth-muscle proliferation increases the thickness of vessel walls. (health.am)
  • Efficacy study in vitro: assessment of the properties of resveratrol and resveratrol + N-acetyl-cysteine on proliferation and inhibition of collagen activity]. (greenmedinfo.com)
  • There was a dose-related increase in the rate of cell proliferation and in inhibition of collagenase activity. (greenmedinfo.com)
  • 6. Two phases in Peyronies Disease: Acute = active inflammation with increased proliferation of tunical fibroblasts (cells which produce collagen) which result in excessive deposition of collagen. (peyroniesforum.net)
  • Pharmacologically, melanogenesis can be controlled by inhibiting the activity of tyrosinase or other related melanogenic enzymes. (hindawi.com)
  • 2) inhibiting tyrosinase activity or the expression of melanogenic enzymes by chelating metals at their active sites, thereby further decreasing melanin production [ 5 , 6 ]. (hindawi.com)
  • Pancreatic cryosections were treated with Serva collagenase, NP, or the two enzymes combined, at clinically relevant concentrations. (ox.ac.uk)
  • These findings will assist the development of donor-specific enzymes, thereby increasing the overall success of islet isolation and benefiting many people with T1DM worldwide. (ox.ac.uk)
  • A fragment of MMP-2, which comprises the C-terminal hemopexin-like domain, termed PEX, prevents this enzyme binding to alphavbeta3 and blocks cell surface collagenolytic activity. (embl.de)
  • Kim M, Hamilton S, Guddat L, Overall C. Plant collagenase: unique collagenolytic activity of cysteine proteases from ginger. (santyl.com)
  • Cranberry Juice Extract Rapidly Protects Demineralized Dentin against Digestion and Inhibits Its Gelatinolytic Activity. (cranberryinstitute.org)
  • Which is the one that inhibits collagenase activity and helps controls disease? (studystack.com)
  • The collagen cross-linking, bio-stabilization, and gelatinolytic activities of MMPs 2 and 9 were studied by using Fourier-transform infrared spectroscopy, weight loss, hydroxyproline release, scanning/transmission electron microscopy, and in situ zymography. (cranberryinstitute.org)
  • We review the lines of investigation that have indicated a critical role for MMPs in TB pathogenesis, consider regulatory pathways driving MMPs and propose that inhibition of MMP activity is a realistic goal as adjunctive therapy to limit immunopathology in TB. (ersjournals.com)
  • Human orthopedic studies of failed hip implant sites have identified increased mRNA expression of several collagen-degrading matrix metalloproteinases (MMPs), while in vitro experiments have shown increases in MMP secretion after exposure to inflammatory mediators. (allenpress.com)
  • The expression and activity of mRNA for several MMPs (2, 3, 9, and 10) was assessed. (allenpress.com)
  • We also show here using a model blood vessel that the THR@ferria composite does not cause systematic thrombosis due to low activity, but being concentrated by an external magnetic field with simultaneous fibrinogen injection accelerates local hemostasis and stops the bleeding. (nature.com)
  • Patients and methods: We included 30 patients with Dupuytren disease enrolled in a prospective cohort study of collagenase injection. (lu.se)
  • Methods: ICH was induced by collagenase injection into the striatum of wild type (C57BL/6J) anticoagulated mice (warfarin or rivaroxaban) and Mmp10 -/- mice. (unav.edu)
  • Clinical outcomes associated with serial sharp debridement of diabetic foot ulcers with and without clostridial collagenase ointment. (santyl.com)
  • clostridial enterocolitis) or increase the severity of the disease. (msdmanuals.com)
  • The present invention provides methods of improving the osteogenic and/or chondrogenic activity of a bone matrix, e.g., a dermineralized bone matrix (DBM), by exposing the bone matrix to one or more treatments or conditions. (patsnap.com)
  • The invention further provides improved bone and cartilage matrix compositions that have been prepared according to the inventive methods and methods of treatment using the compositions. (patsnap.com)
  • The invention further provides methods of preparing, testing, and using the improved bone matrix compositions. (patsnap.com)
  • Cathepsin K is the most potent mammalian collagenase. (wikipedia.org)
  • Donor age significantly influences the Raman spectroscopic biomolecular fingerprint of human pancreatic extracellular matrix proteins following collagenase-based digestion. (ox.ac.uk)
  • Five cyclic peptides show inhibitory activity towards human cathepsins L, B, H, and K. Several inhibitors have reached clinical trials, targeting cathepsins K and S as promising therapeutics for osteoporosis, osteoarthritis, and chronic pain. (wikipedia.org)
  • The physiological characteristics of the fermented extracts, namely, tyrosinase inhibitory activity, antioxidant activity, antibacterial activity, and anti-skin-aging activity, were evaluated and compared with those of unfermented extracts. (hindawi.com)
  • The events in signal transduction that govern MMP expression and activity and expression of inhibitory proteins are crucial for understanding wound healing, tumorigenesis, and certain genetic diseases. (stanford.edu)
  • 6 ) suggest that low-density lipoprotein (LDL) regulates PAI-1, uPA, and tPA in biphasic patterns in HMC, and the up regulation of PAI-1, uPA, and tPA after long-term LDL exposure seems to be mediated by a delayed protein kinase C (PKC) activation associated with an increased PA inhibitory activity. (ispub.com)
  • Cathepsin K is involved in osteoporosis, a disease in which a decrease in bone density causes an increased risk for fracture. (wikipedia.org)
  • At 1 mM of CTM, the significant decrease in the levels of AIEC LF82 coincided with a stimulation of the metabolic activity of the background microbiota. (cranberryinstitute.org)
  • In general, the polarity-dependent mechanisms are recognized to cause membrane depolarization by anodal stimulation which increases cerebral excitability, or membrane hyperpolarization by cathodal stimulation leading to a decrease in neuronal excitability. (biomedcentral.com)
  • Taking DHEA by mouth does not seem to improve mental function or decrease mental decline in healthy older people, people with HIV, or in healthy young adults. (medlineplus.gov)
  • Moving the damaged area can cause an increase in pain and therefor the stress response, but as both treatments are flexible as to time of day, they can be times for after pain relief has been administered. (physio-pedia.com)
  • To induce ICH, 0.5 μl of collagenase was injected into the right striatum of male Sprague Dawley rats. (biomedcentral.com)
  • In the present study, we investigated whether early treatment with a single dose of IL-1 ß blocking antibodies could prevent Western diet (WD) induced changes to systemic monocyte populations and their cytokine secretion profile and herewith modulate collagenase induced osteoarthritis (CiOA) pathology . (bvsalud.org)
  • Zymography is a type of gel electrophoresis that uses a polyacrylamide gel co-polymerized with a substrate in order to detect enzyme activity. (wikipedia.org)
  • Conversely, poorly controlled diabetic subjects have significantly increased gingivitis, compared to either well-controlled diabetic or nondiabetic individuals. (health.am)
  • Monocytes and macrophages in diabetic individuals are often hyper-responsive to bacterial antigens.65 This up-regulation results in a significantly increased production of proinflammatory cytokines and mediators. (health.am)
  • WD feeding of C57Bl/6 mice led to increased serum levels of low-density lipoprotein (LDL) and innate immune activation in the form of an increased number of Ly6Chigh cells in bone marrow and blood and increased cytokine expression of IL-6 and TNF-α by bone marrow cells . (bvsalud.org)
  • This fresh gel skin care formulation for the area around the eyes is formulated with the skin bioactive REGU®-AGE PF, which reduces dark circles and eye puffiness by improving microcirculation. (dsm.com)
  • Additionally, molecular dynamics simulations were performed to estimate stability and flexibility of best complexes, while collagenase activity colorimetric assay was carried out to study the effects of (1), (2) and (3) on collagenase. (ijpsonline.com)
  • It is highly probable that therapeutic manipulation of one ecosystem affects the others, a phenomenon that needs to be analyzed in view of the increasing cellular and molecular complexity of therapy responses (Barker et al. (biomedcentral.com)
  • like other autoimmune diseases it is thought to involve an environmental trigger in an immuno-susceptible host leading to inflammation and damage, with increased production and deposition of collagen [ 3 ]. (biomedcentral.com)
  • Hyperglycemia results in increased gingival crevicular fluid glucose levels, which may significantly alter periodontal wound-healing events by changing the interaction between cells and their extracellular matrix within the periodontium. (health.am)
  • Increasing evidence suggests there is a 2-way relationship between stress and skin quality, with direct impacts on keratinocyte and fibroblast number and function as well as on the composition of the extracellular matrix. (ernolaszlo.com)
  • Levels of PEX in these vascularized tissues suggest that it interacts with endothelial cell alphavbeta3 where it serves as a natural inhibitor of MMP-2 activity, thereby regulating the invasive behavior of new blood vessels. (embl.de)
  • UVA1 radiation induces collagenase (matrix metalloproteinase-1) expression, T-cell apoptosis, and depletes Langerhans and mast cells in the dermis. (skintherapyletter.com)
  • PEX blocks MMP-2 activity on the chick chorioallantoic membrane where it disrupts angiogenesis and tumor growth. (embl.de)
  • This study aimed to evaluate the effects of polyphenol-rich extracts and a chemical cross-linker on the cross-linking interaction, resistance to digestion, and endogenous matrix metalloproteinase (MMP) activities of dentin collagen under clinically relevant conditions. (cranberryinstitute.org)
  • Compared with the unfermented extracts, the fermented extracts also contained greater antibacterial activity against tested stains including MRSA . (hindawi.com)
  • Aim: The present article aims to study and compare the antioxidant activity of aqueous solutions of leaves and flowers of Sambucus nigra L obtained at different exposure times and assess the antibacterial activity of these solutions against Escherichia coli ATCC 8739, Salmonella NCTC 6017, Listeria monocytogenes NCTC 11994, and Staphylococcus aureus ATCC 25093. (researchgate.net)
  • The diameters (in millimeters) of the growth inhibition zones of four pathogens were measured, and a comparative assessment of their antibacterial activity was made. (researchgate.net)
  • Effects of colchicine: Increases collagenase activity. (drjwv.com)
  • The Power C+ line reinforces its formula with 4 different types of Vitamin C. That improves the effects of this vitamin on the skin for longer and increases its antioxidant power. (cosmeticos24h.com)
  • This investigation evaluates the effects of mechanical deformation on in vitro osteoblasts by assessing changes in MMP gene expression and enzyme activity. (allenpress.com)
  • Using higher doses or using it long-term can increase the risk of serious side effects including cancer. (medlineplus.gov)
  • In just 6 weeks, you will see a dramatic reduction in wrinkles, more even skin tone and texture and increased skin firmness. (michellemckenney.com)
  • CONCLUSIONS: E-alert v2.0 further increased the use of appropriate thromboprophylaxis in hospitalised cancer patients, although was not associated with a reduction in VTE incidence. (unav.edu)
  • Prepared colloids show protrombotic activity and cause plasma coagulation in in vitro experiments. (nature.com)
  • Diabetes is associated with increased gingival inflammation in response to bacterial plaque, but the degree of glycemic control is an important variable in this relationship. (health.am)
  • The cathepsin A activity in lysates of metastatic lesions of malignant melanoma is significantly higher than in primary focus lysates. (wikipedia.org)
  • The authors retrospectively evaluated the final diagnosis of a bone scan and the results of an immunohistochemical staining for 92 kDa and 72 kDa type IV collagenases in, respectively, 30 and 30 patients with metastatic breast cancer, and, respectively, 27 and 26 patients with primary breast cancer. (korea.ac.kr)
  • UVA1 induces T-cell apoptosis, which is one of its proposed mechanisms for improving atopic dermatitis (AD), mycosis fungoides (MF), and localized scleroderma. (skintherapyletter.com)
  • These results could be attributed to an increase in the concentration of original active compounds and the biosynthesis of new compounds during fermentation. (hindawi.com)
  • Serum TGFβ1 concentration levels were measured by enzyme linked immunosorbent assay (ELISA), analyzed and correlated with disease subtypes and disease activity. (biomedcentral.com)
  • The mean concentration were elevated in all the disease subtypes, and did not correlate with disease duration or activity. (biomedcentral.com)
  • Serum concentration of TGFβ1 were elevated in patients with all subtypes of LS irrespective of clinical disease activity. (biomedcentral.com)
  • The line contains vitamin C derivatives and up to more than 7% pure Vitamin C. That being in high concentration, visibly improves the luminosity, vitality and youth of the skin. (cosmeticos24h.com)
  • Results: The infusions of fresh blossoms and fresh leaves of Sambucus nigra L had the highest antioxidant activity at the total contact time of 30 minutes (82.7 mmol TE/100 ml) and 35 minutes (36.5 mmol TE/100 ml), respectively. (researchgate.net)
  • The results indicated that the application of the four tES paradigms (tDCS, tACS, tRNS, and tPCS) significantly reversed motor disorders in collagenase-induced ICH groups. (biomedcentral.com)
  • Results: Using the COPM the patients identified 107 activity problems (55 in self-care, 19 in productivity and 33 in leisure). (lu.se)
  • Results: MMP activity differed between HIV-1-infected and -uninfected TB patients and corresponded with specific TB clinical phenotypes. (figshare.com)
  • In patients with HAE caused by C1-inhibitor deficiency or dysfunction, normal regulation of plasma kallikrein activity is not present, which leads to uncontrolled increases in plasma kallikrein activity and results in angioedema attacks. (medscape.com)
  • Protein expression was investigated by ELISA and immunofluorescence, transcription factor-DNA binding by ELISA, gene expression by real-time PCR, prostaglandin E 2 (PGE 2 ) by radioimmunoassay, and matrix metalloproteinase (MMP) activity and nitric oxide (NO) production by fluorometry. (karger.com)
  • Sheets AR, Demidova-Rice TN, Shi L, Ronfard V, Grover KV, Herman IM (2016) Identification and Characterization of Novel Matrix-Derived Bioactive Peptides: A Role for Collagenase from Santyl® Ointment in Post-Debridement Wound Healing? (santyl.com)
  • Excessive matrix metalloproteinase (MMP) activity is emerging as a key process but has not been systematically studied in HIV-associated TB. (figshare.com)
  • Matrix turnover in HIV-1-infected patients is increased before and during TB-IRIS, informing novel diagnostic strategies. (figshare.com)
  • The fermented methanol extract exhibited the highest antityrosinase activity, total phenolic content, and antioxidant activity. (hindawi.com)
  • The samples from Sambucus nigra L were analyzed to determine their total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP). (researchgate.net)
  • However, with UVA1 the treatment fluence is usually held constant for a given course of therapy in contrast to UVB and PUVA, where the dosing is increased incrementally with each successive exposure. (skintherapyletter.com)
  • Our study objectives were to determine the peripheral blood levels of TGFβ1 in children with LS and to determine the relationship of serum levels to disease activity. (biomedcentral.com)
  • This lack of significant differences in the primary bacteriologic agents of periodontal disease suggests that differences in host response may play a role in the increased prevalence and severity of periodontal destruction seen in patients with diabetes. (health.am)
  • Cardiovascular disease risk is increased in patients with type 1 diabetes. (health.am)
  • Severe forms of the disease can make everyday activities, such as picking up items, putting on gloves, or washing hands, difficult or impossible. (healthlinkbc.ca)
  • There are neither sensitive nor specific laboratory tests for measuring disease activity in localized scleroderma (LS). (biomedcentral.com)
  • Our aim was to determine whether serum concentrations of TGFβ1 are a good biomarker of disease activity in children with LS. (biomedcentral.com)
  • The lesions were further categorized by overall clinical assessment into active, inactive, and indeterminate groups according to disease activity. (biomedcentral.com)
  • Although TGFβ1 may play an important role in the pathogenesis of local skin fibrosis, circulating blood levels of molecules known to act locally may not be useful biomarkers of disease activity. (biomedcentral.com)
  • There are neither sensitive nor specific laboratory tests for measuring disease activity, and monitoring is done almost exclusively by clinical assessment, which is often challenging. (biomedcentral.com)
  • Identifying a laboratory marker of disease activity will aid in the management of affected children. (biomedcentral.com)
  • A consensus regarding diagnosis, disease subtype, and disease activity was jointly made. (biomedcentral.com)
  • Background: Patients with Dupuytren disease experience various activity limitations. (lu.se)
  • whereas, when ROS production increases and the cell's ability to neutralize ROS decreases, the overall effect on tissues is destructive (aging and disease). (life-enthusiast.com)
  • Purpose of the activity was to screen the people who are at risk of developing diabetes and educating the people to develop lifestyle to prevent this disease including healthy cooking. (adldpk.org)
  • Boosts cellular activity leading to significant increases in skin firmness and elasticity after only 4 weeks. (humanistbeauty.com)
  • The increased levels of health-associated acetate (+7.9 mM) and propionate levels (+3.5 mM) suggested selective utilization of CTM by host microorganisms. (cranberryinstitute.org)
  • Taking DHEA by mouth daily for up to 2 years doesn't seem to improve body shape, bone strength, muscle strength, or quality of life in people older than 60 who have low DHEA levels. (medlineplus.gov)
  • Actigen®O2 (Panax Ginseng Root Extract) combines the Chinese healing secrets of Ginseng with Gynostemma to increase respiration and protect and nourish dry skin. (platinumskincare.com)
  • Taking DHEA by mouth or applying it to the skin might improve skin appearance after menopause and in people over the age of 60 years. (medlineplus.gov)
  • A single dose of anti-IL-1ß antibodies prevents Western diet-induced immune activation during early stage collagenase-induced osteoarthritis, but does not ameliorate end-stage pathology. (bvsalud.org)
  • Lifting the fold of the eyelid at the top and lessening the crow's feet wrinkles on the sides, by strengthening the dermal structure and increasing its contractile properties. (platinumskincare.com)
  • Recently, an esophageal manometric study was conducted in asymptomatic esophageal diabetic patients that showed the following abnormalities: Diminution of resting LES pressure and amplitude of contraction of the lower segment of the esophageal body, increase of tertiary and segmental contractions and frequent double peak and multi peak contractions[ 3 ]. (wjgnet.com)
  • This study correlates nuclear bone scan findings and measurements of type IV collagenases for the evaluation of bony metastasis in patients with proven breast cancer. (korea.ac.kr)
  • 170 92 kDa (26 of 27), 72 kDa (26 of 26) type IV collagenase, showed no active bony, lung, or liver metastases. (korea.ac.kr)
  • Identification of clostridium histolyticum collagenase hyperreactive sites in type I, II, III collagens: lack of correlation with local triple helical stability. (santyl.com)
  • Ongoing detailed studies using RMS will assist the development of donor-specific enzyme blends, increasing the overall success of human islet isolation and benefiting many people with type 1 diabetes worldwide. (ox.ac.uk)