• In this study, we investigated the role of autophagy in glibenclamide-induced insulin secretion in pancreatic β cells. (hindawi.com)
  • Thus, SUs can close the K ATP channel in pancreatic β cells, followed by membrane depolarization and open the voltage-dependent Ca 2+ channels (VDCCs) to increase intracellular calcium (Ca 2+ ), resulting in insulin secretion and decreasing blood glucose [ 4 - 6 ]. (hindawi.com)
  • Also, vitamin D reduced the incidence of T1DM, enhanced insulin secretion, and relieved pancreatic inflammation in STZ-treated mice via enhancing autophagy in pancreatic β cells [ 10 ]. (hindawi.com)
  • Islet perifusion systems can be used to monitor the highly dynamic insulin release of pancreatic islets in glucose-stimulated insulin secretion (GSIS) assays. (frontiersin.org)
  • Here, we present a new generation of the microfluidic hanging-drop-based islet perifusion platform that was developed to study the alterations in insulin secretion dynamics from single pancreatic islet microtissues at high temporal resolution. (frontiersin.org)
  • The presented device will be a valuable tool in islet and diabetes research for studying dynamic insulin secretion from individual pancreatic islets. (frontiersin.org)
  • Studying this highly dynamic process of glucose-stimulated insulin secretion (GSIS) of pancreatic islets can give insights into the insulin release mechanisms of healthy and diabetic islets. (frontiersin.org)
  • Previous studies on the pathogenesis of T2D mainly focused on pancreatic β-cells function and insulin secretion regulation. (researchsquare.com)
  • Rab proteins are known to be important participants in insulin secretion by pancreatic β cells. (researchsquare.com)
  • In our previous study ( 16 ) , we found that Rab35 is closely related to the insulin secretion in pancreatic β cells, and Rab35 might be the target of miR-720 in pancreatic β cells. (researchsquare.com)
  • The results show that short- to medium-term glucocorticoid treatment of pancreatic islets derived from lean mice leads to an increased insulin release and may constitute an important parameter in changing towards a pro-diabetic phenotype. (ox.ac.uk)
  • We hypothesized that TNFα plays a direct role in the impairment of GLP-1 secretion from the enteroendocrine L-cell and that blocking TNFα can restore both GLP-1 secretion and glucose homeostasis. (nih.gov)
  • Studies in which [ 3 H]colchicine was used indicated that neither reduced colchicine levels in tissue nor reduced affinity of tubulin for colchicine caused the diminished impairment of secretion in immature liver. (nebraska.edu)
  • Long-term treatment with glucocorticoids induces severe impairment of glucose-stimulated insulin secretion. (ox.ac.uk)
  • In insulin-producing β cells, excess autophagy degrades insulin granules, resulting in decreased insulin contents and systemic glucose intolerance, whereas in insulin-responsive cells, activating autophagy decreases endoplasmic reticulum (ER) stress and improves insulin sensitivity [ 17 , 18 ]. (hindawi.com)
  • ghrelin secretion increases during fasting, decreases with refeeding, and is reduced by diet-induced obesity. (utmb.edu)
  • One of the main factors in causing symptoms of dry eye is thought to be that the viewing of VDTs decreases the frequency of blinking by one fourth compared to the normal frequency, thus increasing the amount of evaporation of lacrimal liquid. (justia.com)
  • Decreases in insulin sensitivity and insulin secretion were dose dependent for simvastatin and atorvastatin. (drperlmutter.com)
  • Statin treatment increased the risk of type 2 diabetes by 46%, attributable to decreases in insulin sensitivity and insulin secretion. (drperlmutter.com)
  • The syndrome of inappropriate antidiuretic hormone secretion (SIADH) involves the continued secretion or action of arginine vasopressin (AVP) despite normal or increased plasma volume. (medscape.com)
  • Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is characterized by excessive unsuppressible release of antidiuretic hormone (ADH) either from the posterior pituitary gland, or an abnormal non-pituitary source. (wikipedia.org)
  • Central DI is characterized by decreased secretion of antidiuretic hormone (ADH)-also known as arginine vasopressin (AVP)-which gives rise to polyuria and polydipsia by diminishing the person's ability to concentrate urine. (medscape.com)
  • The syndrome of inappropriate secretion of antidiuretic hormone develops when too much antidiuretic hormone ( vasopressin ) is released by the pituitary gland under certain inappropriate conditions, causing the body to retain fluid and lower the blood sodium level by dilution. (msdmanuals.com)
  • Levels of LXA4 are decreased in the airways of patients with CF. We have previously shown that in normal human bronchial epithelial cells, LXA4 produced a rapid and transient intracellular Ca2+ increase. (rcsi.com)
  • We have investigated here, the effect of LXA4 on Cl- secretion and the functional consequences on ASL height in bronchial epithelial cells obtained from CF and non-CF patient biopsies and in bronchial epithelial cell lines. (rcsi.com)
  • We found that LXA4 stimulated a rapid intracellular Ca2+ increase in all of the different CF bronchial epithelial cells tested. (rcsi.com)
  • We found, using confocal imaging, that LXA4 increased the ASL height in non-CF and in CF airway bronchial epithelia. (rcsi.com)
  • Our results provide, for the first time, evidence for a novel role of LXA4 in the stimulation of Ca2+ signalling, Ca2+-activated Cl- secretion and ASL height in non-CF and CF bronchial epithelia. (rcsi.com)
  • LA offset the rise in blood and liver TG by inhibiting liver lipogenic gene expression (e.g. sn-glycerol-3-phosphate acyltransferase-1 and diacylglycerol O-acyltransferase-2), lowering hepatic TG secretion, and stimulating clearance of TG-rich lipoproteins. (oregonstate.edu)
  • Adenoviral transduction of rats with PGC-1α resulted in a liver-specific increase in PGC-1α expression and produced an in vivo liver phenotype of increased FAO via increased mitochondrial function that also resulted in reduced hepatic TAG storage and decreased plasma TAG levels. (eurekamag.com)
  • In conclusion, overexpression of hepatic PGC-1α and subsequent increases in FAO through elevated mitochondrial content and/or function result in reduced TAG storage and secretion in the in vitro and in vivo milieu. (eurekamag.com)
  • Despite these technological advances, reports on applications of microfluidic perifusion systems for studying islets secretion are still few. (frontiersin.org)
  • Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms. (ox.ac.uk)
  • Transcript profiling revealed differential regulation of genes involved in mediation of signal transduction, insulin secretion, stress and inflammatory responses. (ox.ac.uk)
  • Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion. (oregonstate.edu)
  • We examined whether peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) overexpression and a subsequent increase in mitochondrial content and function in rat primary hepatocytes (in vitro) and Sprague-Dawley rats (in vivo) would comprehensively alter mitochondrial lipid metabolism, including complete (CO(2)) and incomplete (acid-soluble metabolites) fatty acid oxidation (FAO), tricarboxylic acid cycle flux, and triacylglycerol (TAG) storage and export. (eurekamag.com)
  • Anorexia Nausea Muscle aches Generalized muscle weakness Myoclonus Decreased reflexes Ataxia Pathological reflexes Tremor Asterixis Cheyne-Stokes respiration Dysarthria Lethargy Confusion Delirium Seizures Coma (from brain swelling) Death Causes of SIADH include conditions that dysregulate ADH secretion in the central nervous system, tumors that secrete ADH, drugs that increase ADH secretion, and many others. (wikipedia.org)
  • Many conditions increase the risk of developing SIADH. (msdmanuals.com)
  • PGC-1α overexpression in hepatocytes lowered expression of genes critical to VLDL assembly and secretion (apolipoprotein B and microsomal triglyceride transfer protein). (eurekamag.com)
  • Here, we increased the secretion of a heterologous α-amylase, a model protein used for studying the protein secretory pathway in yeast, by moderately overexpressing SEC16, which is involved in protein translocation from the endoplasmic reticulum to the Golgi apparatus. (dtu.dk)
  • BACKGROUND: Coingestion of protein and/or free amino acids with carbohydrate has been reported to accelerate postexercise muscle glycogen synthesis due to an increase in the insulin response. (maastrichtuniversity.nl)
  • PURPOSE: To determine the extent to which the combined ingestion of carbohydrate and a casein protein hydrolysate with or without additional free leucine can increase insulin levels during postexercise recovery in endurance-trained athletes. (maastrichtuniversity.nl)
  • CONCLUSIONS: The combined ingestion of a protein hydrolysate and/or free leucine with carbohydrate (0.8 g.kg.h) substantially augments insulin secretion, but does not affect plasma glucose disposal during the first 3.5 h of postexercise recovery in trained athletes. (maastrichtuniversity.nl)
  • Parafollicular (PF) cells secrete 5-HT in response to stimulation of a G-protein-coupled Ca 2+ receptor (CaR) by increased extracellular Ca 2+ (↑[Ca 2+ ] e ). (jneurosci.org)
  • We tested the hypothesis that protein kinase C (PKC) participates in stimulus-secretion coupling. (jneurosci.org)
  • Colchicine and other antimicrotubular drugs have been shown to impair plasma protein secretion by fetal rat liver at late gestation (day 21) markedly less than by the mature organ. (nebraska.edu)
  • In the present study, the effect of colchicine on plasma protein secretion by liver slices was determined at several times during rat development. (nebraska.edu)
  • Inhibition of protein secretion increased to about 40% just before birth and remained unchanged throughout the perinatal period. (nebraska.edu)
  • These findings suggest that participation of microtubules in liver plasma protein secretion is reduced during development and that full participation is delayed beyond the perinatal period in this species. (nebraska.edu)
  • The immunomodulatory ability of MSCs is dependent on their secretion of cytokines and biological substances ( Prockop and Oh, 2012 ). (techscience.com)
  • UVB exposure alone induced significant cytotoxicity and secretion of cytokines/chemokines. (cdc.gov)
  • Mice given a high-fat diet (HFD) for 12 weeks developed impaired glucose tolerance, hyperinsulinemia, and increased TNFα mRNA expression in fat and ileal tissue. (nih.gov)
  • In contrast to animal models of insulin resistance, beta-cells from lean mice respond with an increased glucose-stimulated insulin secretion, with a peak effect around 18-24h of treatment. (ox.ac.uk)
  • Cystic Fibrosis (CF) is a genetic disease characterised by a deficit in epithelial Cl- secretion leading to airway dehydration and a reduced Airway Surface Liquid (ASL) height. (rcsi.com)
  • Verriere V, Higgins G, Al-Alawi M, Costello CW, Chiron R, Harvey BJ, Urbach V. Lipoxin A4 stimulates calcium-activated chloride secretion and increases airway surface liquid height in normal and cystic fibrosis airway epithelia. (rcsi.com)
  • In contrast, the phorbol downregulation-resistant component of secretion was abolished by pseudoZ, which inhibits the atypical PKCζ. (jneurosci.org)
  • An abnormal increase in blood glucose may be due to a defect in insulin self-secretion caused by the immune system (type 1 diabetes mellitus, T1DM), or resistance to the cellular effects of insulin, as well as insufficient insulin secretion (type 2 diabetes mellitus, T2DM) [ 1 ]. (hindawi.com)
  • Although phorbol downregulation caused PKCγ to disappear, secretion was only partially inhibited. (jneurosci.org)
  • Overexpression of miR-720 inhibited insulin secretion and miR-720 downregulation promoted insulin secretion. (researchsquare.com)
  • The aim of the present study was to test the hypotheses that 1) an increase in body adiposity will play an inhibitory role in the reduction of gastric ghrelin synthesis and secretion during chronic ingestion of a high-fat (HF) diet and 2) chronic ingestion of an HF diet will suppress the rise in circulating ghrelin levels in response to acute fasting. (utmb.edu)
  • Furthermore, describing how vitamin D levels fluctuate month-to-month may provide a basis for implementing public health strategies to increase 25(OH)D levels when deficiency is most acute. (cdc.gov)
  • More and more evidences ( 6 - 8 ) show that miRNAs are involved in the regulation of glucose metabolism, insulin synthesis and secretion, which are the core links in the development of T2D. (researchsquare.com)
  • Increased estrogen, by positive feedback, stimulates the anterior pituitary to secrete LH and follicle-stimulating hormone (FSH). (proprofs.com)
  • Ginger may lower blood sugar and improve factors related to the development of type 2 diabetes, such as insulin resistance. (medicalnewstoday.com)
  • Growing evidence indicates that the herb may have antidiabetic effects, such as improving glucose tolerance and insulin resistance , which may be beneficial for managing and treating type 2 diabetes . (medicalnewstoday.com)
  • The treatment with the extract, however, increased the gastrointestinal movement in a dose dependent manner which compared favourably well with senokot, a standard constipation drug. (clubalthea.com)
  • Normally, the small intestine and colon absorb 99% of fluid resulting from oral intake and gastrointestinal (GI) tract secretions-a total fluid load of about 9 of 10 L daily. (merckmanuals.com)
  • Patients may have symptoms that suggest increased secretion of AVP, such as chronic pain, symptoms from central nervous system or pulmonary tumors or head injury, or drug use. (medscape.com)
  • The Women's Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 79 years of age) during 5 years of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone acetate (MPA 2.5 mg) relative to placebo. (theodora.com)
  • Excess acetylcholine produces a predictable cholinergic syndrome consisting of copious respiratory and oral secretions, diarrhea and vomiting, sweating, altered mental status, autonomic instability, and generalized weakness that can progress to paralysis and respiratory arrest. (cdc.gov)
  • The experimental throughput was increased fourfold by implementing a network of interconnected hanging drops, which allows for performing GSIS assays with four individual islet microtissues in parallel with a sampling interval of 30 s. (frontiersin.org)
  • Then we used miR-720 mimic, miR-720 inhibitor and dual luciferase reporter gene assays to prove miR-720 regulate insulin secretion by targeting Rab35 in MIN6 cells. (researchsquare.com)
  • More than 65 years ago, scientists learned of the brain's pea-sized pituitary gland, its secretion of growth hormones and the stimulants to which it responds. (sealthedeal2009.org)
  • Then virtually simultaneously, in the intracellular space, cells swell, i.e. intracellular volume increases. (wikipedia.org)
  • These results suggest that glibenclamide-induced autophagy plays an inhibitory role in promoting insulin secretion by activating the AMPK pathway instead of altering the mammalian target of rapamycin (mTOR). (hindawi.com)
  • 10-fold) increased by bendamustine at growth inhibitory concentrations. (elsevierpure.com)
  • Our findings indicate that an increased fat mass per se does not exert an inhibitory effect on ghrelin homeostasis during ingestion of the HF diet. (utmb.edu)
  • In humans, obesity is also associated with reduced nutrient-stimulated secretion of the intestinal incretin hormone, glucagon-like peptide-1 (GLP-1). (nih.gov)
  • 05). In conclusion, chronic exposure to TNFα directly impairs GLP-1 secretion at the level of the intestinal L-cell, an effect that is reversed by anti-TNFα therapy in association with improved glucose tolerance. (nih.gov)
  • The extract improved intestinal motility, increased fecal volume and normalized body weight in the constipated rats, which are indications of laxative property of the herb with the 200 mg/kg body weight of the extract showing the best efficacy. (clubalthea.com)
  • Thus, even small reductions (ie, 1%) in intestinal water absorption or increases in secretion can increase water content enough to cause diarrhea. (merckmanuals.com)
  • PGC-1α overexpression in primary hepatocytes produced an increase in markers of mitochondrial content and function (citrate synthase, mitochondrial DNA, and electron transport system complex proteins) and an increase in FAO, which was accompanied by reduced TAG storage and TAG secretion compared with control. (eurekamag.com)
  • Finally, the moderate overexpression of SEC16 was shown to improve the secretion of two other recombinant proteins, Trichoderma reesei endoglucanase I and Rhizopus oryzae glucan-1,4-α-glucosidase, indicating that this mechanism is of general relevance. (dtu.dk)
  • Single cell spike rate and secretion response to increasing synaptic stimulation. (figshare.com)
  • Stimulation of PF cells with ↑[Ca 2+ ] e increased the activity of immunoprecipitated PKCζ (but not PKCι/λ), and the activity of this PKCζ was inhibited by pseudoZ. (jneurosci.org)
  • We suggest that PKC isoforms mediate secretion of 5-HT by PF cells in response to stimulation of the CaR. (jneurosci.org)
  • Inhibition increased thereafter until the maximum effect (75%) was first observed 28 days after birth. (nebraska.edu)
  • At time of progression, these primary CLL cells show increasing resistance to pirtobrutinib in signaling inhibition, cell viability, and cytokine production. (lu.se)
  • Compared with healthy people, the expression of miR-720 in serum of colorectal cancer patients was significantly increased, and its expression level was related to male gender and lymph node metastasis of colorectal cancer patients. (researchsquare.com)
  • Here, we show that BBR increases the serum level of growth differentiation factor 15 (GDF15), which is a stress response. (cabi.org)
  • While water consumption decreased in the untreated constipated rats, the administration of aqueous extract of Aloe ferox significantly increased the water intake in constipated rats. (clubalthea.com)
  • Airphysio is effective for individuals suffering from respiratory conditions like Asthma, Bronchiectasis, COPD, Cystic Fibrosis, and others that result in retained secretions. (zoopy.com)
  • This includes obesity-related factors that increase the likelihood of cardiovascular disease. (medicalnewstoday.com)
  • Berberine ameliorates obesity by inducing GDF15 secretion by brown adipocytes. (cabi.org)
  • Increase of miR-720 reduced Rab35 expression then activate PI3K/Akt/mTOR signal pathway, thus inhibiting insulin secretion. (researchsquare.com)
  • It is known to improve immune system, heal wounds quickly, alleviate toxins from the body etc. (selfgrowth.com)
  • Vibhitaki (Terminalia bellirica) improves the immune system. (selfgrowth.com)
  • Physiological mechanisms of the stimulating effect of insulin hypoglycemia on calcitonin secretion were studied in double-side adrenalectomized and pancreatectomized rats and under the blocking synaptic transmission in sympathetic ganglions or via peripheral cholino- and adreno-receptor structures. (scirp.org)
  • Insulin hypoglycemia didn't expose the increasing secretion of calcitonin in rats under adrenalectomy and pancreatectomy. (scirp.org)
  • Butakova (Moisa), S.S. (2005) Calcitonin Secretion under the Different State of Carbohydrate Metabolism in Ontogenesis in Rats. (scirp.org)
  • The effect of increased adiposity on gastric ghrelin homeostasis was assessed by comparison of stomach ghrelin production and plasma ghrelin levels in obese and nonobese rats fed the HF diet. (utmb.edu)
  • Similarly, the extract significantly increased the number, water content and weight of fecal pellets in the constipated rats in a dosage-dependent manner. (clubalthea.com)
  • However, many people consider any increased stool fluidity to be diarrhea. (merckmanuals.com)
  • Inappropriate (increased) ADH secretion causes an unrelenting increase in solute-free water ("free water") absorption by the kidneys, with two consequences. (wikipedia.org)
  • The three most common are increased osmotic load, increased secretions/decreased absorption, and decreased contact time/surface area. (merckmanuals.com)
  • HEKs exposure to the studied Me/MeO NCT (0-20 microg/cm2) resulted in a dose- and time-dependent reduction in cell viability, cell damage, activation of NF-kappaB, elevated ROS generation, release of inflammatory mediators, and increase in oxidative stress markers. (cdc.gov)
  • Ganglion-blocker pentamin (2.5 mg/100g body weight), blocker of M-cholino-receptors atropine (0.2 ml), α-adreno-blocker tropaphen (0.1 mg/100g), and β-adreno-blocker obzidan (0.1 mg/100g) evoked the inhibiting effect on calcitonin secretion in spite of simultaneously increasing of hypog-lycemia. (scirp.org)
  • We increased and decreased miR-720 expression using miR-720 mimic and inhibitor to identify the effect of miR-720 on insulin secretion in MIN6 cells, respectively. (researchsquare.com)
  • The LXA4 effect on ASL height was sensitive to bumetanide an inhibitor of transepithelial Cl- secretion. (rcsi.com)
  • The diuretic effect of parsley appears to be related to increased retention of potassium in the small intestine. (encyclopedia.com)
  • Excessive ADH causes an inappropriate increase in the reabsorption in the kidneys of solute-free water ("free water"): excess water moves from the distal convoluted tubules (DCTs) and collecting tubules of the nephrons - via activation of aquaporins, the site of the ADH receptors - back into the circulation. (wikipedia.org)
  • This invention relates to compositions that allow the eye to increase lacrimal secretion, specifically to increase the amount of lacrimal secretion that has been lessened by functional deterioration due to an excessive use of the eyes. (justia.com)
  • The inventors of this invention also found a new factor in causing dry eye, namely, that excessive viewing of VDTs deteriorates the function of lacrimal fluid, thus decreasing the amount of secretion of lacrimal liquid. (justia.com)
  • Statin treatment significantly increased 2 h glucose (2hPG) and glucose AUC of an OGTT at follow-up, with a nominally significant increase in fasting plasma glucose (FPG). (drperlmutter.com)
  • In HIV-infected patients, combination therapy with the nucleosides ZDV and lamivudine (3TC) has greater antiretroviral activity than ZDV alone and is active against many ZDV-resistant HIV strains without significantly increased toxicity (8). (cdc.gov)
  • Appropriate ADH secretion is regulated by osmoreceptors on the hypothalamic cells that synthesize and store ADH: plasma hypertonicity activates these receptors, ADH is released into the blood stream, the kidney increases solute-free water return to the circulation, and the hypertonicity is alleviated. (wikipedia.org)
  • ADH activates V2 receptors on the basolateral membrane of principal cells in the renal collecting duct, initiating a cyclic AMP-dependent process that culminates in increased production of water channels (aquaporin 2), and their insertion into the cells' luminal membranes. (wikipedia.org)
  • These drugs bind to α1 receptors and activate them, leading to vasoconstriction and increased blood pressure. (proprofs.com)
  • The increase in temperature occurs as a result of elevated progesterone levels during the luteal (secretory) phase of the menstrual cycle. (proprofs.com)
  • This is accompanied by increased, VAMP3-dependent secretion of MT1-MMP, enhanced degradation of extracellular matrix, and increased cell invasion. (nature.com)
  • As a result, PF cells secrete both transmitters when stimulated by their natural secretogogue, increased extracellular Ca 2+ (↑[Ca 2+ ] e ) ( Nunez and Gershon, 1978 ). (jneurosci.org)
  • Glibenclamide is known to promote insulin secretion by targeting β cells. (hindawi.com)
  • E ) Secretion per spike shows that secretion from phasic cells is achieved with much greater efficiency at synaptic input rates exceeding 200 Hz with optimal efficiency at about 400-600 Hz, corresponding to mean firing rates of 2-4 spikes/s (comprising relatively short sparse bursts). (figshare.com)
  • We show that loss of WDFY2 leads to enhanced secretion of MT1-MMP and allows cells to actively invade into ECM. (nature.com)
  • A similar reduction of ↑[Ca 2+ ] e -evoked secretion was produced by inhibitors of conventional and/or novel PKCs (Gö6976, calphostin C, and pseudoA), and these compounds did not inhibit secretion at all when applied to phorbol-downregulated cells. (jneurosci.org)
  • This study aimed to investigate whether miR-720 targets Rab35 to regulate insulin secretion in MIN6 cells and its molecular mechanism, and the clinical value of miR-720 as a specific biomarker of T2D. (researchsquare.com)
  • miR-720 regulated insulin secretion by targeting Rab35 in MIN6 cells. (researchsquare.com)
  • Therefore, the aim of the current study was to investigate whether miR-720 targets Rab35 to regulate insulin secretion in MIN6 cells and its molecular mechanism, and the clinical value of miR-720 as a specific biomarker of T2D. (researchsquare.com)
  • Increased insulin secretion is also obtained by incubation with the inactive glucocorticoid dehydrocorticosterone, pointing to an important role of the enzyme 11beta-hydroxysteroid dehydrogenase type 1 in mediating glucocorticoid effects in beta-cells. (ox.ac.uk)
  • The source of the increase in estradiol concentration shown at point C is the ovarian granulosa cells, which contain high concentrations of aromatase and convert testosterone to estradiol. (proprofs.com)
  • We demonstrate that primary CLL cells from responding patients on the pirtobrutinib trial show reduced BCR signaling, cell survival, and CCL3/CCL4 chemokine secretion. (lu.se)
  • The AirPhysio is an OPEP device that improves your lung function by using oscillating positive expiratory pressure (OPEP). (zoopy.com)
  • Moreover, the findings of a small preliminary 2016 study suggest ginseng may help improve frontal lobe function. (medicalnewstoday.com)
  • However, if there are abnormalities in the lacrimal secretion, resulting in changes in the amount or quality of secretion, thus resulting in an increase in the amount of evaporation of the lacrimal liquid or the like, the lacrimal liquid may not function well. (justia.com)
  • The phasic secretion profile (right) shows an initial steep increase which slows as the intra-burst spike rate reaches the optimal response frequency, and longer bursts allow less recovery from fatigue. (figshare.com)
  • D ) Examining secretion against spike rate the non-phasic model shows a progressive increase in secretion with increasing frequency. (figshare.com)
  • The increasing secretion of calcitonin and hypocalcemia under insulin hypoglycemia, induced with insulin injection (1 IU/100g), was established. (scirp.org)
  • On the other hand, increased heat conditions but with reduced sweat secretion can lead to GH deficiency. (sealthedeal2009.org)
  • C ) The non-phasic model (left) shows a similarly non-linear secretion response to increasing spike rate, showing a slow increase in secretion at low frequencies, followed by a facilitation driven rapid increase, which then slows along with the reduced spike rate response. (figshare.com)