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  • haplotype
  • HLA-DR53 is not expressed on the HLA-B57DR7Dw11DQ9 (DQA1*02:01, DQB1*03:03) haplotype (as in the cell line DBB (IHW 9052) representing the conserved extended haplotype (CEH) 57.1) due to a base substitution at the 3' end of the first intron of the gene 9;10 . (dorak.info)
  • genotypes
  • HLA-DR and MT1, MT2, MT3 genotypes have been investigated in 123 Type 1 (insulin-dependent) diabetic subjects and their families. (springer.com)
  • HLA genotypes and autoantibodies to glutamic acid decarboxylase, insulinoma-associated protein 2 and insulin were determined in cord blood of children born to non-diabetic mothers in the Diabetes Prediction in Skåne (DiPiS) study. (springer.com)
  • In this report, we studied chemokine receptors (CCR2, CCR5), chemokine (SDF1), and HLA class I and II genotypes in LT-NP and attempted to find out whether any particular pattern of host genetics could be implicated in the LT-NP phenotype. (bloodjournal.org)
  • gene
  • A recessive gene closely linked to HLA and with 50% penetrance. (springer.com)
  • Genetic polymorphisms may alter protein structure and function through a single nucleotide base substitution in a gene's coding region, and may increase or decrease gene expression either by affecting mRNA stability when occurring in a gene's 3´ untranslated region or by altering transcription factor binding when occurring in the 5´ promoter region. (biomedcentral.com)
  • antibody
  • In an ex vivo rodent model, HLA class II antibody-dependent monocyte activation leads to severe pulmonary edema in a relevant period of time, whenever neutrophils are present and the endothelium is preactivated. (bloodjournal.org)
  • Having identified the biologic mechanism of HLA class II antibody-induced TRALI, strategies to avoid plasma from immunized donors, such as women with a history of pregnancy, appear to be justified preventive measures. (bloodjournal.org)
  • This was done to clarify the role of the HLA class II antigens in patients positive for anticardiolipin antibody who repeatedly have fetal miscarriages. (healthdocbox.com)
  • Antibody to brain antigens may be responsible for impairment of T cell function, due to plasma inhibitory effect and also cause epilepsy in immature brains. (eurekaselect.com)
  • tissue
  • All patients were subjected to serologic testing for herpes virus (IgG and IgM) and to HLA (A, B, C) and HLA-DR-DQ tissue typing to see if there was any correlation between the emergence of CNS pathology and these various antigens, thus to show a possible autoimmune-type immunogenetic basis for demyelination processes. (healthy.net)
  • All the patients were subjected to tissue typing for HLA (A, B, C) and HLA DR-DQ with the aim of defining the relative immunogenetic order. (healthy.net)
  • epitope
  • To date, linear or conformational epitopes of TSHR-ECD, as well as the molecular structure of the epitope-binding groove in HLA-DR, were reported to be related to the pathogenesis in GD. (frontiersin.org)
  • We review and update the role of immunogenic TSHR epitopes and HLA in GD, and offer perspectives on TSHR epitope specific treatments. (frontiersin.org)
  • Interaction by the complex of TSHR epitope, HLA-class II molecule, and T-cell receptor (TCR) is modified through binding of CD40 ligand to CD40 and of CTLA-4 to B7 ( 3 - 6 ). (frontiersin.org)
  • inflammation
  • In addition, exposure to airborne endotoxins, which is common in workplaces associated with HP, potentiates antigen-specific airway inflammation and allergen responses . (worldallergy.org)
  • Pneumonia is different from acute bronchitis (another disease that can cause fever, cough , chest pain, and shortness of breath) because acute bronchitis is caused by inflammation [emedicinehealth.com] Likewise, mice with Gram-negative and Gram-positive pneumonia had increased PGRN production in the lung and circulation. (symptoma.com)
  • Robust control of pre- and peritransplant islet inflammation could improve posttransplant islet survival and in turn enhance the benefits of islet cell transplantation for patients who are insulin dependent. (hindawi.com)
  • peripheral
  • [healthhype.com] In addition, he had a steadily increasing peripheral eosinophilia reaching a maximum of 40 percent with a leukocyte count of 14.8 x 10 3 /mL despite the absence of any signs [swjpcc.com] bronchitis , or, less often, acute pneumonia or pleural effusion sometimes occur. (symptoma.com)
  • disease
  • Why, then, in a disease which has attracted much attention for an HLA association since Lilly's original paper on mouse leukaemia in 1964 (Ref.2), and the first HLA association paper in childhood leukaemia 3 , no other strong HLA association has been reported? (dorak.info)
  • Ninety-eight percent of probands possessed either DR3 (relative risk = 5.0), or DR4 (relative risk = 6.8) or both antigens (relative risk = 14.3), emphasizing the strong association of the disease with these two antigens. (springer.com)
  • Batchelor JR, Morris PJ (1977) Joint report on HLA and disease: juvenile onset diabetes. (springer.com)
  • Bodmer WF (1980) The HLA system and disease. (springer.com)
  • According to the data of P. M. Alyeva (1993) DR5 antigen is a risk factor of disease development, and DR4 and DRw6 antigens are resistance factors. (bestskincare101.com)
  • Combination of HLA class I (HLA-A1, HLA-A2, HLA-B14, HLA-B17, HLA-B27) and class II antigens (HLA-DR5 and HLA-DR6) have been correlated with low rates of disease progression. (bloodjournal.org)
  • cytokines
  • Antigens that cause HP also have adjuvant properties that enable them to activate complement and release cytokines directly which also may be relevant [6, (worldallergy.org)
  • Increase of pro-inflamatory cytokines in serum and cerebrospinal fluid of epileptic patients were reported. (eurekaselect.com)
  • DLQI items Factor 1 Share full text access The epidermal barrier dysfunction hypothesis suggests that AD patients develop AD as a result of skin barrier defects that allow for the entry of antigens, resulting in the production of inflammatory cytokines. (bestskincare101.com)
  • fetal
  • These data suggest an interaction between HLA, gestational infections, islet autoantibodies and fetal growth. (springer.com)
  • inflammatory
  • However, a mutant TSST-1 protein that fails to bind HLA-DR did not elicit an inflammatory skin reaction. (smokershistory.com)
  • It is believed that the consequence of cAMP decreased level can be an increased release of inflammatory mediators from leukocytes, including histamine, which causes decrease in the functional activity of T-lymphocytes via H2-receptor. (bestskincare101.com)
  • We discuss several potent anti-inflammatory strategies that show promise for improving islet engraftment. (hindawi.com)
  • gluten
  • The publication of papers on the topic of gluten related disorders has substantially increased over the last few years. (hindawi.com)
  • The implementation of a gluten-free diet (GFD) improves the overall clinical course and influences the evolution of the associated diseases. (hindawi.com)
  • strongest
  • P = 0.000003), this association remains one of the strongest HLA - cancer associations ever reported. (dorak.info)
  • clinical course
  • FIND A FREE SPOTme® SKIN CANCER SCREENING Leadership Institute Manage Your Medications Heil PM, Maurer D, Klein B, Hultsch T, Stingl G. Omalizumab therapy in atopic dermatitis: depletion of IgE does not improve the clinical course - a randomized, placebo-controlled and double blind pilot study. (bestskincare101.com)
  • chronic
  • The chronic use of immunosuppressants after transplantation with its various side effects, opportunistic infections and the increased risk of malignancies have the potential to affect the skin. (clinmedjournals.org)
  • occur
  • HP develops as a result of the immunologically mediated events and the physiologic consequences that occur in the lung after inhalation of the responsible antigen in a sensitized individual. (worldallergy.org)
  • In HLA-DRB4, allelic differences occur and are not limited to exon 2 ( b 1 domain) but involve exon 3 ( b 2 domain) too. (dorak.info)
  • presence
  • 4-7 In contrast, the presence of HLA-B35, HLA-DR1, HLA-DR3, HLA-DQ1 antigens was significantly associated with a bad prognosis and a rapid progression to acquired immunodeficiency syndrome (AIDS). (bloodjournal.org)
  • The test checks for the presence of specific genetic material, called HLA-B*5701, which has been associated with the abacavir hypersensitivity reaction. (catie.ca)