• Lack of response to empiric antibiotic treatment and an imaging pattern of organizing pneumonia should raise suspicion of everolimus-induced pneumonitis in patients undergoing therapy with this drug. (medscape.com)
  • However, trials from the 1960s revealed its pulmonary toxicity, termed bleomycin-induced pneumonitis (BIP). (alertdiver.eu)
  • So, researchers are leveraging AI to read images clearly and determine tumors, and also to decline the risk of radiation-induced pneumonitis. (arkenea.com)
  • Studies thus far have demonstrated a correlation between pre- and post-treatment plasma TGF-β1 with the risk of developing radiation-induced pneumonitis [ 9 ]. (e-roj.org)
  • 8. Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease. (astrazenecaclinicaltrials.com)
  • Certain pesticides are established mutagens or have been shown to induce tumor growth and chromosomal abnormalities in vitro. (uclahealth.org)
  • At the conclusion of the long-term study, they found that there was no significant increase in chromosomal abnormalities during the solar eclipse. (securefamily.in)
  • The International statistical classification of diseases and related health problems, tenth revision (ICD-10), includes birth defects in Chapter XVII: Congenital malformations, deformations and chromosomal abnormalities. (who.int)
  • There are data suggesting that early recognition of chemotherapy-induced cardiomyopathy and prompt initiation of medical therapy can promote recovery of cardiac function. (ajmc.com)
  • Chromosome changes of the same type in primary AML occur in most cases os of chemotherapy-induced myelodysplasia and AML. (standardofcare.com)
  • prevention of chemotherapy-induced (greater than or equal to 5%) are: headache, malaise/fatigue, constipation, diarrhea. (nih.gov)
  • Tailed nuclei are signatures of radiation exposure in human tissue, microbiota, and aquatic invertebrates from the wake of recent nuclear disasters. (wikipedia.org)
  • Busulfan toxicity causes drug-induced pulmonary damage after prolonged exposure, usually after 3-4 years of therapy. (medscape.com)
  • 203 people were hospitalized immediately, of whom 31 died (28 of them died from acute radiation exposure). (mongabay.com)
  • Most of these were fire and rescue workers trying to bring the accident under control, who were not fully aware of how dangerous the radiation exposure (from the smoke) was. (mongabay.com)
  • The authors say this study provides the first evidence supporting the hypothesis that residential pesticide exposure from agricultural use is associated with an increased risk of thyroid cancer. (uclahealth.org)
  • Few studies have examined environmental exposures on thyroid cancer occurrence, except those focusing on radiation exposure. (uclahealth.org)
  • Our research suggests several novel associations between pesticide exposure and increased risk of thyroid cancer," she added. (uclahealth.org)
  • Additionally, exposure to other pesticides, in combination with paraquat in multipollutant models, also suggests an increased risk of thyroid cancer, she explained, and exposure to a greater number of unique pesticides over a 20-year period proportionately increased the risk. (uclahealth.org)
  • We report here that Ptch +/- mice develop primordial follicular neoplasms resembling human trichoblastomas, and that exposure to ultraviolet radiation or ionizing radiation results in an increase in the number and size of these tumors and a shift in their histologic features so that they more closely resemble human basal cell carcinoma. (nature.com)
  • Figure 2: BCC-like tumor average cross-sectional area increases with duration of UV exposure and dose of IR exposure. (nature.com)
  • CT in the evaluation of retinoblastoma is now considered obsolete as there is potential risk of developing secondary cancers from ionizing radiation exposure (especially in germline retinoblastoma) while providing no additional value over ultrasound for detection of calcification. (acoredu.com)
  • Although it is true that large doses of radiation exposure can be a risk factor for breast cancer, with today's screening mammograms, the breasts are exposed to a very small amount of radiation. (bcpinstitute.org)
  • One of the greatest threats of deep-space travel is prolonged exposure to unrelenting cosmic radiation , which can damage DNA and increase a space traveler's chances of developing diseases such as cancer in their lifetime. (smithsonianmag.com)
  • Previous studies suggested that radiation exposure could also cause cognitive impairment , including earlier onset of Alzheimer's-like dementia. (smithsonianmag.com)
  • Theoretically, these patients are already at risk of developing fibrosis from elevated TGF-β and this can be further exacerbated by radiation exposure. (e-roj.org)
  • Most of the published analysis techniques have been developed and validated using these acquisition paradigms, unless breath-hold time and radiation exposure were not a concern, such as in the study of phantoms or animals. (ersjournals.com)
  • Furthermore, the RF-field exposure of mice did not induce an increase in the number of micronuclei in erythrocytes of the bone marrow or peripheral blood, in keratinocytes, or in spleen lymphocytes compared to the sham-treated control. (itis.swiss)
  • However, imaging modalities also have associated risks, such as radiation exposure. (edusofthealth.com)
  • This blog post will discuss the benefits and risks of various imaging modalities, specifically focusing on the radiation exposure associated with X-rays and CT scans. (edusofthealth.com)
  • The most significant risk is radiation exposure, which can increase cancer risk. (edusofthealth.com)
  • The trouble is generally considered low, but it increases with the number of X-rays received and prolonged exposure. (edusofthealth.com)
  • The most significant risk is radiation exposure, which is much higher than a standard X-ray. (edusofthealth.com)
  • This increase in radiation exposure can increase the risk of cancer. (edusofthealth.com)
  • To minimize radiation exposure, it's important that patients only undergo imaging when it is medically necessary and that the lowest radiation dose possible is used. (edusofthealth.com)
  • Also, specific protocols such as "dose modulation" can be used to lower radiation exposure. (edusofthealth.com)
  • However, they also come with associated risks, particularly radiation exposure. (edusofthealth.com)
  • Additionally, the risk of radiation exposure can be minimized using the lowest radiation dose possible and techniques to lower the exposure. (edusofthealth.com)
  • One of the ways it can help is by reducing the need for radiation exposure. (edusofthealth.com)
  • This can reduce unnecessary radiation exposure and lower the risk of radiation-induced cancer. (edusofthealth.com)
  • This can help radiologists make more accurate diagnoses and reduce the need for additional imaging and radiation exposure. (edusofthealth.com)
  • This can help radiologists to more easily identify abnormalities, such as small tumours, and reduce the need for additional imaging and radiation exposure. (edusofthealth.com)
  • Quality assurance: AI can monitor image quality and identify issues that may lead to increased radiation exposure. (edusofthealth.com)
  • Robotic X-ray systems: AI can control robotic x-ray systems that can adjust the radiation dose, rotation, and position of the X-ray source to optimize imaging while minimizing radiation exposure. (edusofthealth.com)
  • While some sun exposure can be beneficial for generating vitamin D and improved moods, an excess of ultraviolet exposure can seriously harm our skin," Dr Noaf Saif Al Mahmood, dermatology specialist at SEHA's Ambulatory Healthcare Services, told Khaleej Times. (menafn.com)
  • A common etiology for meningiomas is radiation exposure in the range of 132-315 roentgens, which is equivalent to rad dose of 1-3 Gy. (medscape.com)
  • Characteristics of radiation-induced meningiomas include an average latent period of 36-38 years for patients who were exposed to low-dose radiation to the head, whereas patients who develop meningiomas after exposure to high-dose radiation may show signs as early as 5 years postradiation. (medscape.com)
  • Maternal illnesses like diabetes mellitus, conditions such as iodine and folic acid deficiency, and exposure to medicines and recreational drugs including alcohol and tobacco, certain environmental chemicals, and high doses of radiation are other factors that cause birth defects. (who.int)
  • However, the mechanisms underlying folding, and hence the etiology of folding abnormalities, are the subject of active debate. (wustl.edu)
  • However, the complete etiology of drug-induced myopathies remains unclear. (degruyter.com)
  • The aim of their research was to assess radiation-induced cytogenetic toxicity in bone marrow cells during a solar eclipse. (securefamily.in)
  • Associated with topoisomerase II agents usually not associated with myelodysplastic syndrome and frequently associated with 11q23 cytogenetic abnormality. (standardofcare.com)
  • Loss of DNA on chromosome 22 has been shown in 40% of meningiomas, and, in cytogenetic studies, genetic abnormalities at the level of chromosome 22 are seen frequently in meningiomas with loss of a copy of chromosome 22 as the most commonly reported abnormality. (medscape.com)
  • However, the rapid increase in thyroid cancers detected suggests that some of it at least is an artifact of the screening process. (mongabay.com)
  • Additionally, the risk of advanced thyroid cancers, which can increase risk of mortality and cancer recurrence, has been found to be higher in the state of California as compared to other states. (uclahealth.org)
  • Basal cell carcinomas, the commonest human skin cancers, consistently have abnormalities of the hedgehog signaling pathway and often have PTCH gene mutations. (nature.com)
  • With the prognosis for many cancers improving, we are seeing an appropriate sharpening of focus on the cardiovascular risks of patients who have survived cancer or are being treated for cancer, as well as a growing recognition of the impact this competing morbidity has on both short- and long-term health outcomes. (ajmc.com)
  • For many cancers, including breast cancer and lymphoma, chest radiation remains an important component of the treatment regimen. (ajmc.com)
  • If a pregnancy ends by elective abortion before 32 weeks, the increase in the numbers of Type 1 and 2 lobules that are formed in the first two trimesters of pregnancy do not go on to mature to Type 3 and Type 4 lobules, so there are more of the immature lobules which provide more places for cancers to start. (bcpinstitute.org)
  • Medical radiation has been a popular topic in the news recently and has raised concerns about the possibility of radiation-induced cancers. (ucsfhealth.org)
  • Known causes of haematological al y have not indicated an increased In 1974, IARC concluded that studies cancers in humans are ionizing ra- risk of AML. (who.int)
  • CMV infection has been shown to induce transient abnormalities of in vitro cellular-immune function in otherwise healthy human hosts (2,3). (cdc.gov)
  • The oncogenic CXCL12 mRNA and protein were more highly expressed in residual cancer cells from a hepatoma heterotopic murine tumor microenvironment and coculture of human hepatoma Huh7 and normal IMR90 cells after radiation. (molcells.org)
  • Taken together, radiation-induced histone alterations at the CXCL12 promoter in hepatoma cells are linked to CXCL12 upregulation and increased aggressiveness in the tumor microenvironment. (molcells.org)
  • Radiation is one of the principal methods of cancer treatment, but its effectiveness is often restricted by tumor resistance and aggressiveness. (molcells.org)
  • Resistance and aggressiveness can be intrinsic to the tumor before radiation treatment or acquired during treatment. (molcells.org)
  • Tumors have many adaptive responses to the continuously changing tumor microenvironment during radiation treatment. (molcells.org)
  • We present a patient with a history of Marfan syndrome requiring radiation for a diagnosis of a right brachial plexus malignant nerve sheath tumor. (e-roj.org)
  • Early recognition is important because drug-induced lung disease can often be reversed if appropriate therapy is instituted soon after the onset of symptoms. (medscape.com)
  • Although ultrasonography has no direct role in the management of drug-induced lung disease, it is useful in confirming pleural effusions and in assessing pleural intervention. (medscape.com)
  • However, drug-induced myopathy is among the most frequent causes of muscle disease. (degruyter.com)
  • The clinical picture of drug-induced myopathies may be highly variable. (degruyter.com)
  • Unfortunately, the available biomarkers for SKM injury do not fully meet the needs for satisfactory detection of drug-induced damage, both in clinical and research settings, mainly due to their low sensitivity and specificity. (degruyter.com)
  • Moreover, we will discuss mechanisms of drug-induced SKM injury, traditional laboratory testing for SKM injury, and novel skeletal myocyte biomarkers under investigation. (degruyter.com)
  • This can be incredibly useful in both clinical practice and for de-challenge/re-challenge investigational trials where the risk of drug-induced SKM injury is present. (degruyter.com)
  • The clinical picture of drug-induced myopathies may range from asymptomatic or mild myalgias, with or without muscle weakness, which are likely underreported, to chronic myopathy with severe weakness and rarely, even to massive rhabdomyolysis with acute kidney injury (AKI) [ 1 ]. (degruyter.com)
  • Drug-induced myopathies may result from various mechanisms. (degruyter.com)
  • 2ME also consistently induced abnormal curvature of the right and left forepaw digits. (cdc.gov)
  • If postpartum uterine involution is abnormal, it may adversely affect the health of the mother by impairing her future fertility and increasing her risk of hemorrhage, miscarriage, abortion, abnormal placentation, placenta accrete spectrum (PAS), uterine rupture, or death. (wustl.edu)
  • This article reviews the diagnostic approach to hematologic laboratory abnormalities and abnormal bleeding in adults, as well as basic preventive care and hemostatic management of adults with bleeding disorders. (medscape.com)
  • In addition, lung toxicity resulting from various drugs can induce similar changes. (medscape.com)
  • Increasing age, conjoint radiation therapy, and high concentrations of oxygen are associated with high rates of lung toxicity. (medscape.com)
  • The authors conclude that RF radiation can interact with 2ME to enhance 2ME developmental toxicity at a relatively low dose in rats. (cdc.gov)
  • Our case reports presents a review of the literature of patients with Marfan syndrome requiring radiation therapy and the limitations of serum markers on predicting long-term toxicity. (e-roj.org)
  • Either increases toxicity of the other by pharmacodynamic synergism. (medscape.com)
  • Marrow karyotype revealed a clonal chromosomal abnormality which included trisomy 8 and absence of the Y chromosome. (karger.com)
  • Abnormalities of chromosome 22 have been associated with type II neurofibromatosis. (medscape.com)
  • Birth defects can be defined as structural or functional abnormalities, including metabolic disorders, which are present from birth. (who.int)
  • These include glyphosate - the active ingredient in widely used herbicides - and 19 pesticides that induce DNA cell damage in vitro. (uclahealth.org)
  • CONCLUSION: These findings demonstrated that C3G could alleviate IR in vitro and in vivo to increase insulin sensitivity, which may offer a new insight for regulating glucose metabolism during T2DM by using the natural dietary bioactive components. (bvsalud.org)
  • Increased production of urate may be caused by increased nucleoprotein turnover in hematologic conditions (eg, lymphoma, leukemia, hemolytic anemia) and in conditions with increased rates of cellular proliferation and cell death (eg, psoriasis, cytotoxic cancer therapy, radiation therapy). (msdmanuals.com)
  • Although free radical reactions occur within milliseconds, the cellular abnormalities they cause take form over months or even years, so the researchers waited six weeks before testing the irradiated mice to allow the cellular mischief to unfold. (smithsonianmag.com)
  • The term systemic sclerosis is used to describe a systemic autoimmune disease of unknown origin characterized by excessive deposition of collagen and other connective tissue macromolecules in skin and multiple internal organs, prominent and often severe fibroproliferative alterations in the microvasculature, and numerous humoral and cellular immunologic abnormalities. (medscape.com)
  • RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy. (nature.com)
  • Oxidative stress has numerous effects, including increased apoptosis, reduced motion parameters, and reduced sperm integrity. (mdpi.com)
  • DNA content analyses and Hoechst 33342 staining revealed that this compound induced apoptosis. (aacrjournals.org)
  • The cardiovascular risks of radiotherapy include coronary artery disease, valvular heart disease, pericardial disease, conduction system abnormalities, and myocardial fibrosis. (ajmc.com)
  • Most use quick and transient epigenetic mechanisms, but genetic processes can allow tumors to stably respond to radiation and survive. (molcells.org)
  • Possible dose effect relationships in the interaction of radiofrequency (RF) induced hyperthermia and 2-methoxyethanol (109864) (2ME) induced teratogenicity were studied in rats. (cdc.gov)
  • 1992. Radiation dose assessment from ingestion pathway in Saudi Arabia. (cdc.gov)
  • Even the newer lower-dose formulations, called "mini-pills," still increase breast cancer risk. (bcpinstitute.org)
  • UCSF is very aware of this concern and has adopted many different techniques for reducing radiation from CT scans, including the development of low-dose protocols and the purchase of special software specifically designed for radiation reduction. (ucsfhealth.org)
  • These additional CTs are performed using a low-dose technique that imparts a radiation dose of approximately 1/10th of a standard CT. (ucsfhealth.org)
  • Induced leukemia-the risk is dose dependent and increases exponentially with age after the age of 40 years. (standardofcare.com)
  • The risk of secondary leukemia is associated with the type of cytotoxic agents, cumulative dose, intensity of such agents and cumulative ionizing radiation doses. (standardofcare.com)
  • 5. Radiotherapy with a wide field of radiation within 4 weeks of the first dose of study treatment. (astrazenecaclinicaltrials.com)
  • Automated dose optimization: AI can be used to develop algorithms that optimize radiation dose while still producing high-quality images. (edusofthealth.com)
  • This can help ensure that the radiation dose is as low as possible while still producing high-quality images. (edusofthealth.com)
  • The MGH Cardio-Oncology Program introduced in 2011 is a joint initiative between the Heart and Cancer Centers at Massachusetts General Hospital that provides comprehensive cardiovascular care to cancer patients, with the goal of improving short- and long-term outcomes ( Figure ). (ajmc.com)
  • Now Charles Limoli , a professor of radiation oncology at the University of California Irvine School of Medicine, and his team have demonstrated that even relatively low doses of cosmic rays will induce a specific series of neural abnormalities that could manifest themselves during a round-trip mission to Mars, which is predicted to last for two to three years. (smithsonianmag.com)
  • The incidence of thyroid cancer has been increasing exponentially over the course of the last few decades," said Dr. Avital Harari , corresponding author and principal investigator for the study. (uclahealth.org)
  • The number of these targeted therapies has increased exponentially in the last decade, with many more in clinical trials. (ajmc.com)
  • These changes start in the first trimester, and culminate during the third trimester, a period during which fetal calcium requirements increase exponentially [2] . (who.int)
  • Mammograms involve the use of low doses of radiation that passes through the breast tissue, creating an image on an X-ray plate. (asiaposts.com)
  • The Ptch mutant mice provide the first mouse model, to our knowledge, of ultraviolet and ionizing radiation-induced basal cell carcinoma-like tumors, and also demonstrate that Ptch inactivation and hedgehog target gene activation are essential for basal cell carcinoma tumorigenesis. (nature.com)
  • Acquired resistance and aggressiveness can develop after receiving radiation treatment in tumors that were initially sensitive but adapt to become resistant and aggressive via mutations arising during treatment or various other responses such as altered expression of the therapeutic target and activation of alternative compensatory pathways. (molcells.org)
  • Moreover, tumors can have a wide spectrum of genetic and epigenetic heterogeneity, so radiation resistance and aggressiveness can arise through radiation-induced selection of small resistant subpopulations that become intensified. (molcells.org)
  • Additionally, the risk of thyroid cancer increased proportionally to the total number of pesticides subjects were exposed to 20 years before diagnosis or the research interview. (uclahealth.org)
  • Some experts attribute the increase to better detection methods, but other reports suggest environmental, genetic and lifestyle risk factors may also explain the upward trend. (uclahealth.org)
  • Seminal studies demonstrated the increased risk of left ventricular (LV) dysfunction or cardiomyopathy in survivors of childhood cancer who had been treated with anthracyclines and chest radiation. (ajmc.com)
  • The development of cardiotoxicity may also increase the risk of morbidity and mortality, as evidenced in an analysis of Medicare patients undergoing treatment for breast cancer. (ajmc.com)
  • Some research suggests that people with mental health problems are at increased risk during a solar eclipse. (securefamily.in)
  • Ionizing radiation, consanguinity, and nearness of birthplace of the spouse are risk factors for the death of offspring and for anomalies. (nih.gov)
  • Q: Why does abortion increase a woman's risk of breast cancer? (bcpinstitute.org)
  • The "Pill" hormones increase breast cancer risk, whether given orally as a pill, by injection, by absorption through the skin, or other means (e.g. (bcpinstitute.org)
  • Hormone replacement therapy (HRT), prescribed for the side effects of menopause, such as hot flashes and mood swings, also increases the risk of breast cancer. (bcpinstitute.org)
  • It is estimated that a woman would need at least 400 mammograms to increase her breast cancer risk at all. (bcpinstitute.org)
  • are at increased risk of gout. (msdmanuals.com)
  • In IBD, the Crohn's and Colitis Canada Genetic, Environmental, Microbial Project research consortium has been studying individuals at increased risk for Crohn's disease because of a first-degree family member with Crohn's disease. (medscape.com)
  • They found an increased abundance of Ruminococcus torques in the microbiomes of at-risk individuals who went on to develop the disease. (medscape.com)
  • When considered in this context, the risk of developing a cancer from a CT scan only slightly increases a person's overall risk from baseline. (ucsfhealth.org)
  • The pulmonary function tests should exclude any abnormalities which might cause the diver to be at risk for pulmonary barotrauma. (alertdiver.eu)
  • Since there is some evidence that chemotherapy increases the risk of developing cardiovascular diseases in patients with testicular cancer, our algorithm included an exercise bicycle test during which the level of aerobic fitness must be at least 80% of the predicted value. (alertdiver.eu)
  • Induced leukemia-differences in the ages of patients and differences in the accumulative doses of alkylating agents explain the wide variations in risk from study to study. (standardofcare.com)
  • If concomitant use of ondansetron with other serotonergic drugs is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome. (nih.gov)
  • Therefore, studies have suggested monitoring plasma TGF-β or TGF-β1 levels in normal patients to predict the risk of developing radiation induced fibrosis [ 9 , 10 , 11 ]. (e-roj.org)
  • It has been proposed that MFS patients requiring radiation therapy could be monitored throughout treatment via TGF-β levels, specifically TGF-β1, to determine the risk for fibrosis development [ 4 ]. (e-roj.org)
  • Thus, it seems to be justified to explore a link between the risk for fibrosis development in MFS patients receiving radiation treatment and rising TGF-β1 levels, as a tool to predict fibrosis in these patients. (e-roj.org)
  • Immunosuppressives may diminish therapeutic effects of vaccines and increase risk of adverse effects (increased risk of infection). (medscape.com)
  • Unlike xeroderma pigmentosum (described below), trichothiodystrophy is not associated with an increased risk of skin cancer. (medlineplus.gov)
  • As a result, people with xeroderma pigmentosum have a greatly increased risk of developing cancer. (medlineplus.gov)
  • In a genetic epidemiological and fertility survey among 70,000 inhabitants in a high-background radiation region (HBRR) and normal radiation region (NRR) in Kerala, India, 985 persons were found to have heritable anomalies. (nih.gov)
  • Mice homozygous for disruption of this gene show no gross abnormalities in appearance, behavior or fertility. (jax.org)
  • Increased urate production may also occur as a primary hereditary abnormality and in obesity, because urate production correlates with body surface area. (msdmanuals.com)
  • Because these types of changes have also been found in a range of neurodegenerative conditions and occur over the course of aging, it provides a logical backdrop for what radiation does to the brains of both rodents and humans," says Limoli. (smithsonianmag.com)
  • Over half of cancer patients undergo radiation therapy (RT). (nature.com)
  • A phase II study showed that patients with resected local-regionally advanced head and neck squamous cell carcinoma (HNSCC) had improved survival when pembrolizumab was added to adjuvant RT (NCT02641093). (nature.com)
  • 1,2 Similarly, there are increased risks of congestive heart failure in adults treated with anthracycline-based chemotherapy regimens, which in current practice includes patients with breast cancer, leukemia, lymphoma, sarcoma, and other cancer types. (ajmc.com)
  • However, in patients prior treated with bleomycin, one study showed that increased FiO2 (0.40-0.87) during the perioperative period made no significant contribution to complications of late-onset BIP or fibrosis and it was concluded that perioperative oxygen restriction was not necessary. (alertdiver.eu)
  • Gonadotropin therapy or the use of pulsatile gonadotropin-releasing hormone (GnRH) therapy may be required to induce ovulation in patients with infertility whose underlying pathology cannot be reversed. (medscape.com)
  • Marfan syndrome is one of the collagen vascular diseases that theoretically predisposes patients to excessive radiation-induced fibrosis yet there is minimal published literature regarding this clinical scenario. (e-roj.org)
  • Knock-out mice deficient in FBN-1 also demonstrate elevated TGF-β, as seen in MFS patients, which leads to development abnormalities in the lung [ 6 ]. (e-roj.org)
  • Based on the observations correlating elevated TGF-β with fibrosis, MFS patients are thought to be poor candidates for radiation therapy. (e-roj.org)
  • However, only one case report exists discussing two MFS patients receiving radiation treatment and TGF-β1 levels were not measured in these individuals [ 10 ]. (e-roj.org)
  • 4. Patients who had recurred from Stage I/II/III after complete surgery or had gross incomplete resections can be included if they didn't receive treatment with any chemotherapy, radiation therapy, immunotherapy, targeted therapy, or investigational agents. (who.int)
  • Patients with PID have increased susceptibility to recurrent and persistent infections, but other symptoms are also common. (lu.se)
  • When a suspicious abnormality is seen, however, further testing is necessary with tests such as a PET scan, biopsy or surgery, which carry some side effects. (ucsfhealth.org)
  • The medical technician inspects the final images, looking for abnormalities or suspicious lesions. (asiaposts.com)
  • monitor with electrocardiograms (ECGs) if concomitant electrolyte abnormalities, cardiac failure or arrhythmias, or use of other QT prolonging drugs. (nih.gov)
  • Certain alkylating agents like melphalan, platinum compounds, and topoisomerase II inhibitors like etoposide reported to confer a five fold increase risks for therapy related myelodysplasia or AML. (standardofcare.com)
  • Abnormalities in the lung parenchyma may partially or completely resolve after the drug is withdrawn. (medscape.com)
  • Thoracic HR-CT scanning, which has greater sensitivity than standard chest radiography to detect lung parenchymal abnormalities, is included in this algorithm. (alertdiver.eu)
  • Galactic cosmic radiation is made of high-energy particles originating from past supernova explosions that come zipping through our solar system. (smithsonianmag.com)
  • The team blasted the mice with low or high doses of energetic charged particles similar to those found in galactic cosmic radiation. (smithsonianmag.com)
  • Furthermore, it was clearly shown that disturbances in the hydraulic regime such as water hammers, operation of valves and rapid increases in flow velocity can result in enhanced PAH concentrations by the destabilisation of the biofilm matrix or high shear forces affecting the pipe walls resulting in the release of particles highly contaminated with PAHs which may be responsible for the contamination of the drinking water. (who.int)
  • He had had Hodgkins disease 3 years earlier, but had been successfully treated with radiation therapy alone. (cdc.gov)
  • Alkylating agents and topoisomerase II inhibitors induce therapy related leukemia. (standardofcare.com)
  • Fibrosis resulting from radiation therapy has been associated with increased levels of TGF-β [ 5 ]. (e-roj.org)
  • Moreover, the rapid rise of new therapeutics with the potential to cause SKM injury, such as immunotherapies and targeted therapies, as well as new treatments (such as gene therapy) specifically targeting muscular or neuromuscular diseases, demands an improved clinical strategy to identify myocyte injury and enable appropriate and timely clinical intervention. (degruyter.com)
  • Adults with bleeding disorders may present to their family physician with minor bleeding symptoms or hematologic laboratory abnormalities discovered during evaluation for surgery or another purpose. (medscape.com)
  • In cases of asymptomatic hematologic laboratory abnormalities, the particular abnormality should narrow down the potentially affected hemostatic component(s), ideally streamlining subsequent investigation. (medscape.com)
  • RESULTS: In this study, the anthocyanin C3G, extracted from red bayberry, was found to alleviate disorders of glucose metabolism, which resulted in increased insulin sensitivity in hepatocytes, and achieved by enhancing the glucose consumption as well as glycogen synthesis in insulin resistance (IR) hepatpcytes. (bvsalud.org)
  • Interactions of radiofrequency radiation-induced hyperthermia and 2-methoxyethanol teratogenicity in rats. (cdc.gov)
  • The aim of this study was to examine the possible induction of micronuclei in erythrocytes of the peripheral blood and bone marrow and in keratinocytes and spleen lymphocytes of mice exposed to radiofrequency (RF) radiation for 2 h per day over periods of 1 and 6 weeks, respectively. (itis.swiss)
  • In addition to sun sensitivity, xeroderma pigmentosum is sometimes associated with progressive neurological abnormalities. (medlineplus.gov)
  • In affected individuals with the Phe99Ser variant, neurological abnormalities have been relatively mild and have included hearing loss and poor coordination. (medlineplus.gov)
  • Studies suggest that the neurological abnormalities associated with this condition result from a buildup of DNA damage, although the brain is not exposed to UV rays. (medlineplus.gov)
  • 4 A recent analysis by Darby et al suggested a linear increase in the incidence of ischemic heart disease with higher estimated radiation doses to the heart. (ajmc.com)
  • One of the many findings: Liquidators' state of health worsened consi-derably since the accident, high levels of general somatic diseases, morbidity increased more than 17 times between 1991 and 2000. (wiseinternational.org)
  • There was a statistically significant increase of Down syndrome, autosomal dominant anomalies, and multifactorial diseases and an insignificant increase of autosomal recessive and X-linked recessive anomalies in the HBRR. (nih.gov)
  • It calls upon clinicians to have an increased awareness of the potential of barrier dysfunction in diseases, and to consider the barrier as a target for treatment. (medscape.com)
  • The role of AI in precision medicine is the same, it helps to improve treatment, diagnosis, and predicts diseases before it occurs, based on the data analyzed. (arkenea.com)
  • increased incidence of lymphoma unequivocal evidence. (who.int)
  • We also measured blood gases at the start of the exercise test and at maximum workload to assess diffusion abnormalities which are not necessarily evident in pulmonary diffusion tests at rest. (alertdiver.eu)
  • With AI in medical imaging software, radiologists and physicians will have no difficulty in spotting abnormalities or improving precision medicine. (arkenea.com)
  • A significant increase in the incidence of these forepaw anomalies was seen in fetuses from dams treated with 2ME and exposed to RF radiation sufficient to maintain Tc at 41 degrees for 1hr compared to either treatment alone. (cdc.gov)
  • Thyroid cancer incidence has increased substantially in the U.S. during the past 30 years, rising by 3% annually. (uclahealth.org)
  • Thyroid cancer incidence has increased substantially in the US during the past 30 years, rising by 3% annually. (coasttribune.com)
  • also be associated with an increased incidence of Guillain- molecular evolutionary genetics analysis version 6.0. (cdc.gov)
  • Out of the three known mammalian isomers of TGF-β, the development of radiation induced fibrosis is best correlated with TGF-β1 [ 7 ]. (e-roj.org)
  • Chromosomal changes in AML related to topoisomerase II inhibitors are rearrangement abnormalities without gain or loss of chromosomal material. (standardofcare.com)
  • It enables the timely deployment of primary prevention interventions which aim to prevent teratogen-induced birth defects (including those caused by congenital syphilis and rubella), defects caused by iodine deficiency disorder, neural tube defects (and possibly other malformations), and maternal-age-related chromosomal disorders (e.g. (who.int)
  • Yet despite radiation levels dangerous to humans, most natural areas in the region have rebounded, and by ecological standards, are functioning normally. (mongabay.com)
  • The Sun and the main sources of solar radiation on Earth - infrared and ultraviolet radiation - are continuously being researched around the world. (securefamily.in)
  • NASA has sponsored numerous studies investigating the short-term and long-term effects of space radiation on each system in the body, revealing that these rays can have a devastating effect on biological tissue over a lifetime. (smithsonianmag.com)
  • ily showed an increase in the inci- studies suggest a relationship (e.g. (who.int)
  • Nearly 20 years ago Reactor number 4 at Chernobyl exploded, sending radiation across a large region of what is now the Ukraine, Belarus, and Russia. (mongabay.com)
  • Studying 228 birds of 23 different species captured in Chernobyl, Gaschak and colleagues from the University of South Carolina (US) and University Pierre et Marie Curie (France) measured the birds' levels of radioactive strontium and radioactive cesium, comparing migrating populations with those that remain in the area, as well as examining age, sex, and nesting preferences to determine the amounts and types of radiation accumulating in the birds. (mongabay.com)
  • Timothy Mousseau will present "Consequences of radiation for reproduction and survival of barn swallows Hirundo rustica from Chernobyl. (mongabay.com)
  • Late in 1995, the World Health Organisation linked nearly 700 cases of thyroid cancer among children and adolescents to the Chernobyl accident and among these some 10 deaths are attributed to radiation. (mongabay.com)
  • Specifically, the team discovered radiation-induced structural changes in the medial prefrontal cortex, a brain region responsible for higher-order processes known to be engaged during memory tasks . (smithsonianmag.com)
  • Multimodal, longitudinal MRI data from preterm infants will be used to assess whether patterns of cortical expansion are aligned with gradients of cortical maturation, and whether these gradients are sufficient to induce typical patterns of folding. (wustl.edu)
  • TGF-β1 induces collagen gene expression, collagen production, and inhibits collagen degradation [ 7 , 8 ]. (e-roj.org)
  • RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. (nature.com)
  • AI algorithm can be trained to spot abnormalities in medical imaging. (arkenea.com)
  • In a normal pregnancy, the estrogen levels in a woman's body increase 2,000% by the end of the first trimester. (bcpinstitute.org)
  • Improving lifelong health one pregnancy at a time. (ehd.org)
  • Other evidence to substantiate the implication of gender-specific hormones comes from data showing increased growth of meningiomas during pregnancy and size changes with menses. (medscape.com)
  • Preconception care aims to ensure the optimal physical and mental well-being of women and their partners at the onset of and during early pregnancy, to increase the likelihood of a normal pregnancy and the delivery of a healthy infant. (who.int)
  • Indeed, it is in anticipation to such requirements that maternal calcitriol levels increase during pregnancy. (who.int)
  • 1 Non-invasive functional imaging (ie, myocardial perfusion scintigraphy (MPS) with single photon emission CT, stress echocardiography, first-pass contrast-enhanced magnetic resonance (MR) perfusion or MRI imaging for stress-induced wall motion abnormalities) is recommended as a second-line investigation if CTCA is equivocal or non-diagnostic. (bmj.com)
  • Mammograms are X-ray images used to detect breast cancer and other abnormalities in women. (asiaposts.com)
  • Fight free radical damage: The more UV radiation you are exposed to, the more free radicals your body produces. (menafn.com)
  • This variant probably makes the TFIIH complex unstable and reduces its ability to repair DNA damage caused by UV radiation. (medlineplus.gov)
  • second, the extensive peer-reviewed published safety data when using filtered far-UVC light, and finally the recent decision of the ACGIH, based on the available experimental evidence, to significantly increase their recommended daily limits for far-UVC light. (uvxinc.com)
  • These include direct myotoxicity (caused by alcohol, cocaine, glucocorticoids, and statins, amongst others), immunologically-induced inflammatory myopathy (caused by D-penicillamine, statins, and anti-cancer drugs), and indirect SKM injury (occurs as a result of a variety of different mechanisms). (degruyter.com)
  • Pregnant Sprague-Dawley-rats were irradiated with continuous wave 10 megahertz RF radiation of sufficient intensity to increase the animals' colonic temperature (Tc) to 39.0, 40.0, or 41.0 degrees-C and to maintain it at the target values for up to 6 hours (hr) on gestational day 13. (cdc.gov)
  • Immunotherapy was shown to significantly increase the rate of the abscopal effect and prolong patient survival. (nature.com)
  • One study reported an increased survival benefit with simultaneous RT compared with sequential administration, 8 while another study found no significant difference between the two strategies, 9 possibly because simultaneous RT plus immunotherapy and the administration of an ICI before RT may kill cancer cells as well a substantial number of immune cells, leading to poor systemic response and toxic side effects. (nature.com)