As in rats, we observed a large number of GFP+ cells in gray matter and white matter tracts of the striatum and the corpus callosum, with 90-94% of GFP+ cells co-localizing with an oligodendroglial marker. (biomedcentral.com)
Critically, demyelination was observed in the white matter tracts of the corpus callosum and striatum of Olig001-α-syn but not Olig001-GFP injected animals, similar to the human disease. (biomedcentral.com)
Reductions in fixel-derived metrics occurs in major white matter tracts, noticeably in corpus callosum, internal capsule, and the corticospinal tract, which were closely co-localized with the regions of increased diffusivity in basal ganglia. (frontiersin.org)
For example, the subthalamic nucleus expresses mainly γSyn whereas the corpus callosum has αSyn and γSyn, but no βSyn ( Lavedan, 1998 ). (biorxiv.org)
Axons from medial cortical areas travel ventral to those originating from lateral vPFC regions both in the IC and the corpus callosum (CC). Despite the precision with which such organizational principles can be investigated in macaques, the extent to which they apply in humans is not clear. (jneurosci.org)
BALB/c mice demonstrate pronounced autism-relevant behavioral phenotype characterized by low level of social relations, high levels of anxiety and aggression, increased brain weight, undeveloped corpus callosum, and lower serotonin concentration in the brain [7,12]. (epiphanyasd.com)
Glial cytoplasmic inclusions1
Glial cytoplasmic inclusions (GCIs) of α-syn are thought to elicit changes in oligodendrocyte function, such as reduced neurotrophic support and demyelination, leading to neurodegeneration. (biomedcentral.com)
Hippocampus1
Although these studies have provided insights into individual components of the neuro-motor network at specific time points in disease pathogenesis, there remains a need to define the onset and progression of neuronal pathology at successive stages of disease in ALS in key subcortical structures receiving cortical outputs: the striatum, hippocampus ( Spalloni and Longone, 2015 ), brainstem, and spinal cord. (frontiersin.org)
Tracts1
Furthermore, the organizational principles followed by vPFC tracts in macaques are preserved in humans. (jneurosci.org)
Humans1
We test whether the organizational rules that vPFC connections follow in macaques are preserved in humans. (jneurosci.org)
Brain1
Regardless of the development of reactive gliosis within the striatum, loss of the grey matter is extensive and results in the compensatory enlargement of lateral brain ventricles. (hindawi.com)
Disease1
Parkinson's disease (PD) is a neurodegenerative disorder characterized by death of dopaminergic neurons in the substantia nigra (SN) and accumulation of α-Synuclein in intracellular inclusions known as Lewy bodies (LBs) [ 1 - 10 ]. (biomedcentral.com)
Expression2
Histological analysis 3-months after injection demonstrated widespread α-syn expression throughout the striatum as determined by LB509 and phosphorylated serine-129 α-syn immunoreactivity, all of which displayed as tropism similar to that seen with GFP. (biomedcentral.com)
Altered cell density in the hypocellular gap and proliferation marker expression suggest individuals with autism may follow a different growth-trajectory. (ox.ac.uk)
Patients2
disputed the utility of the above criteria after they applied them to their cohort of 33 patients followed longitudinally between 1990 and 2013. (medscape.com)
This was reflected in a significant difference in relationship between both measures for patients and controls at baseline ( t = 2.1, p = 0.04), that was not present at follow-up (t = 0.06, p = 0.96). (nature.com)
Neurodegenerative1
OPTN(+ )aggregates have preliminarily been identified in cytoplasmic inclusions in numerous neurodegenerative diseases, however, whether OPTN has a role in PD pathogenesis has yet to be tested. (nih.gov)
Structures2
Neuropathological evaluation revealed widespread neuronal and glial tau pathology in cortical and subcortical structures, including tufted astrocytes in the motor cortex, striatum and midbrain tegmentum. (bvsalud.org)
Magna (Galeni), Corpus pineale, area of Aquaeductus and surrounding structures (Figs. In some systems (e. (forex-consultant.com)
Years1
Five patients, all males, with ages ranging from 25 to 65 years, followed up by a mean of 45.6 months (17-72 months), fulfilled the inclusion criteria. (surgicalneurologyint.com)
Progressive1
The disorder is classified as a 4-repeat tauopathy, and although tau-immunoreactive neuronal and glial inclusions may be seen in progressive supranuclear palsy (PSP), Alzheimer disease, and Pick disease, these disorders may differ in the proportions of 4-repeat as compared with 3-repeat microtubule-associated tau protein isoforms, with CBD and PSP being the two predominantly 4-repeat tauopathies. (medscape.com)
Criteria2
If the DSM symptom criteria are strictly followed, the triad of inattention, impulsivity, and cognitive impairment can certainly be observed in disorders as phenomenologically separate as major depression, schizophrenia, bipolar disorder, and substance dependence. (medscape.com)
disputed the utility of the above criteria after they applied them to their cohort of 33 patients followed longitudinally between 1990 and 2013. (medscape.com)