Inclusion chlamydial chlamydia trachomatis. Medical search. Frequent questions

This analysis detects the presence of all pathogenic Chlamydia (Chlamydia trachomatis, Chlamydophila pneumoniae, and Chlamydophila psittaci), but without separating them. (athenslab.gr)
Two genera of chlamydia are of clinical importance for humans, the genus Chlamydia which includes the species Chlamydia trachomatis , and the genus Chlamydophila which includes the species Chlamydophila pneumoniae and Chlamydophila psittaci . (athenslab.gr)
Chlamydophila pneumoniae (formerly known as Chlamydia pneumoniae) causes respiratory infections with a mild course. (athenslab.gr)
When added to C. pneumoniae-infected HeLa cells, the 3′ pyridyl oxindole compound retarded chlamydial replication. (mek-inhibitors.com)
Activation of the MEK/ERK pathway has been shown to be essential for chlamydial invasion of HeLa cells [43], and sustained activation of Raf-MEK-ERK-cPLA2 is also required for acquisition of glycerophospholipids and growth by C. pneumoniae [48]. (mek-inhibitors.com)
Tetracyclines are highly effective in the treatment of most chlamydial infections, including urogenital infections caused by Chlamydia trachomatis, respiratory tract infections caused by C. pneumoniae, respiratory tract infections caused by C. psittaci (psittacosis), and lymphogranuloma venereum caused by invasive serovars of C. trachomatis. (antiinfectivemeds.com)
8) What is the most sensitive laboratory diagnostic tests for Chlamydia pneumoniae ? (medicalbiochemist.com)
The sequential incubation of anti-GLXA antibody and complement with Chlamydia trachomatis serovar K or C. pneumoniae AR-39-infected HeLa 229 or macrophage cells resulted in significant cellular cytotoxicity, which preceded the formation of mature elementary bodies. (umass.edu)
For uninfected cells, co-incubation of GLXA, purified from supernatants of either C. trachomatis or C. pneumoniae-infected HeLa 229 cells, followed by the successive addition of mouse anti-GLXA antibody and complement, yielded similar levels of cellular cytotoxicity. (umass.edu)

A 28 kDa major immunogen of Chlamydia psittaci shares identity with Mip proteins of Legionella spp. (oregonstate.edu)
and Chlamydia trachomatis-cloning and characterization of the C. psittaci mip-like gene. (oregonstate.edu)
Chlamydia psittaci strain guinea-pig inclusion conjunctivitis (GPIC) produces a self-limiting ocular infection of guinea-pigs, and this condition is a representative animal model of ocular chlamydial disease. (oregonstate.edu)
Sequence analysis of PCR products produced using genomic DNA from an ovine abortion strain of C. psittaci and from C. trachomatis strain LGV-434 demonstrated that the arrangement of mip, spoU and trxA is common among these chlamydiae. (oregonstate.edu)
Chlamydophila psittaci (formerly called Chlamydia psittaci) is the causative agent of psittacosis , a disease characterized by pneumonia, headache, and hepatosplenomegaly. (athenslab.gr)
Chlamydia (C.) psittaci , the causative agent of avian chlamydiosis and human psittacosis, is a genetically heterogeneous species. (biomedcentral.com)
Chlamydia (C.) psittaci is known as the etiological agent of avian chlamydiosis and human psittacosis [ 1 ]. (biomedcentral.com)
Like other chlamydiae, C. psittaci can also cause asymptomatic infections. (biomedcentral.com)
Like all chlamydial organisms, C. psittaci is an obligate intracellular bacterium distinguished by a biphasic developmental cycle comprising extracellular and intracellular stages. (biomedcentral.com)
7) All of the statements given below are correct about Chlamydia psittaci , EXCEPT ? (medicalbiochemist.com)

This image reveals a close view of a patient's left eye with the upper lid retracted in order to reveal the inflamed conjunctival membrane lining the inside of both the upper and lower lids, due to what was determined to be a case of inclusion conjunctivitis, a type of conjunctival inflammation caused by the bacterium, Chlamydia trachomatis. (medscape.com)
Inclusion conjunctivitis is a particularly long-lasting form of conjunctivitis caused by certain strains of the bacterium Chlamydia trachomatis . (merckmanuals.com)
Chlamydia is a common sexually transmitted infection caused by the bacterium, C. trachomatis , which can be transmitted during vaginal, anal, or oral sex. (cdc.gov)

These results indicate a strong association between CIN and chlamydial cervicitis. (who.int)
Conclusions: A 3-day course of doxycycline appears to be as effective as a 7-day course of doxycycline for the treatment of uncomplicated chlamydia cervicitis. (calendar-canada.ca)
Burnett AM, Anderson CP, Zwank MD. Laboratory-confirmed gonorrhea and/or chlamydia rates in clinically diagnosed pelvic inflammatory disease and cervicitis. (medscape.com)

Chlamydiae are obligate intracellular organisms from bacteria that now comprise 3 species. (medscape.com)
The Host-Parasite Interactions Section studies the basic molecular and cellular biology of chlamydiae and other obligate intracellular parasites. (nih.gov)
Chlamydiae are obligate intracellular bacteria with a biphasic developmental cycle that involves cell types adapted for extracellular survival and intracellular multiplication. (nih.gov)
Chlamydia trachomatis is an obligate intracellular human pathogen that exhibits stage-specific gene transcription throughout a biphasic developmental cycle. (plos.org)
Discussion Chlamydiae are obligate intracellular pathogens that have a unique biphasic developmental cycle. (mek-inhibitors.com)

Coinfection with C. Trachomatis and Neisseria gonorrhoeae is common, with multiple recurrences that may result in serious complications. (labdoctor.org)

C trachomatis , which is almost exclusively a human pathogen, includes the agents of classic trachoma (ie, serotypes A, B, Ba, C). It also includes the agents of inclusion conjunctivitis or paratrachoma (ie, serotypes D-K). The latter organisms infect the epithelium of mucoid surfaces and were once identified as the trachoma-inclusion conjunctivitis agents (TRIC). (medscape.com)
The organism also causes 3 clinical syndromes, which include the following: trachoma, adult inclusion conjunctivitis, and neonatal conjunctivitis. (medscape.com)
Trachoma and neonatal conjunctivitis are discussed in other chapters so this discussion is restricted to adult inclusion conjunctivitis. (medscape.com)
Chlamydial eye involvement, known as trachoma, is endemic in many parts of the world and is a major cause of blindness. (aafp.org)
Ophthalmia neonatorum is caused by C. trachomatis subtypes D through K. Ophthalmia neonatorum is a less severe infection than adult conjunctivitis (trachoma), but if not treated early it can cause superficial keratitis, otitis, and pneumonia in the neonate. (aafp.org)
Although trachoma is an important manifestation of chlamydial eye infections internationally, with 6 million cases of blindness worldwide every year, the Centers for Disease Control and Prevention reports that blindness due to trachoma has been eliminated in the United States. (aafp.org)
Other syndromes caused by C. trachomatis include LGV and trachoma. (cdc.gov)
Chlamydia trachomatis is the etiological agent of several significant diseases of humans, including trachoma, the leading cause of infectious blindness worldwide. (nih.gov)
Bacterial conjunctivitis includes neisserial conjunctivitis ( hyperacute bacterial conjunctivitis ), acute bacterial conjunctivitis , and chlamydial conjunctivitis (including trachoma and inclusion conjunctivitis ), and it can be an ocular emergency. (amboss.com)

Chlamydia trachomatis is responsible for 30-60% of non-gonococcal urethritis (NGU) cases in men. (athenslab.gr)
Common complications in chlamydia-infected women include cerciitis, urethritis, endometritis, pelvic inflammatory disease, and an increased incidence of ectopic pregnancies and infertility, and in men they include urethritis and epididymitis. (prsbio.com)
It is also the most frequent cause of non-gonococcal urethritis in men.Among women, the consequences of chlamydial infections are severe if left untreated.Approximately half of chlamydial infections are asymptomatic. (labdoctor.org)
Gonococcal and chlamydial urethritis may coexist.Demonstrating the presence of N.Gonorrhoeae is important in initiating appropriate therapy to prevent the spread of infection. (labdoctor.org)
10) Name the organism given below which is frequently associated with urethritis apart from Chlamydia trachomatis ? (medicalbiochemist.com)

Background Chlamydial inclusion conjunctivitis caused by genital serovars of Chlamydia trachomatis (CT) is well-recognised, and usually thought to result from auto-inoculation from genital CT infection or direct sexual contact. (bmj.com)
The positive C trachomatis status of all the specimens was confirmed upon receipt using a plasmid based in-house real time polymerase chain reaction (PCR) method which detects all serovars of C trachomatis before genotyping. (bmj.com)
Lymphogranuloma venereum (LGV) is a specific type of chlamydial infection caused by serovars L 1 -L 3 . (cdc.gov)
The language of the C. trachomatis infection case definition to include more current diagnostic technologies and to be inclusive of all possible clinical outcomes for jurisdictions to use when classifying chlamydial infections caused by LGV serovars. (cdc.gov)
LGV is a specific type of chlamydial infection, caused by the serovars L 1 , L 2 , and L 3 of C. trachomatis . (cdc.gov)

Chlamydial reinfections are very common-as many as 1 in 5 people will have a repeat infection with chlamydia within the first few months after they are treated for their initial infection. (calendar-canada.ca)

ABSTRACT The objective of this study was to determine the association between vaginal Chlamydia infection and cervical intraepithelial neoplasia (CIN). (who.int)

When chlamydia or gonorrhea infect the eye, the resulting conditions are called chlamydial conjunctivitis and gonococcal conjunctivitis, respectively. (advocatesaz.org)
Patients with gonococcal conjunctivitis or inclusion conjunctivitis may present with systemic features, e.g., genitourinary discharge. (amboss.com)

Periodic surveys of chlamydial prevalence can be conducted to confirm the validity of using these recommendations in specific clinical settings. (cdc.gov)
The prevalence of C. trachomatis infection generally exceeds 5% among pregnant women, regardless of race/ethnicity or socioeconomic status. (cdc.gov)
Chlamydia trachomatis infection has a high prevalence and an asymptomatic carrier rate. (prsbio.com)
The overal prevalence of positive tion was found between C. trachomatis C. trachomatis );and2)Giemsastaining serum antibodies for C. trachomatis in- and cervical neoplasia [ 4 ]. (who.int)
Screening programs have been demonstrated to reduce both the prevalence of C. trachomatis infection and rates of PID in women (79,80). (cdc.gov)
Although chlamydia prevalence data have provided a basis for setting age guidelines for routine annual screening and behavioral guidelines for targeted screening in women (11), no such consensus has been reached regarding control program definitions in men who have sex with women (12). (cdc.gov)
Although there are no recommendations to screen heterosexual men, it USPSTF suggests testing to test sexually active heterosexual men in clinical settings with a high prevalence of C. trachomatis (e.g. (cdc.gov)

Pelvic Inflammatory Disease, or PID, scarring of fallopian tubes, and potentially fatal ectopic pregnancy, as well as conjunctivitis and Chlamydial pneumonia in newborns) (4). (nccid.ca)
Variants in toll-like receptor 1 and 4 genes are associated with Chlamydia trachomatis among women with pelvic inflammatory disease. (medscape.com)
16) Which of the following syndrome is most commonly associated with complications of pelvic inflammatory disease caused by Chlamydia trachomatis ? (medicalbiochemist.com)

Chlamydia psittasi, primarily an animal pathogen, is associated with a respiratory disease caused by exposure to infected birds and is not transmitted through human interaction. (prsbio.com)
Chlamydial pneumonia, first isolated in 1983, is a human pathogen and is associated with respiratory infections and pneumonia. (prsbio.com)
Due to its capability of causing systemic infection with acute to chronic course in poultry, pet birds and some mammals, as well as its worldwide dissemination [ 2 ], it is probably the most important veterinary chlamydial pathogen. (biomedcentral.com)
Thus, it is thought that the success of C . trachomatis as a human pathogen may lie in its ability to survive these immunological stress situations by slowing growth and development until conditions in the cell have improved. (plos.org)
18) A vaginal swab specimen was taken from the 23 year old patient with symptoms of painful urination, a laboratory diagnosis of the chlamydial pathogen was performed. (medicalbiochemist.com)

As most genital chlamydia infections are asymptomatic, screening is the main way to detect and cases for treatment. (biomedcentral.com)

Gonorrhea is the most common co-infection with adult inclusion conjunctivitis. (medscape.com)
However, following Pap screening, there should be a clinical indication for reflex additional testing of liquid cytology specimens for chlamydia and gonorrhea since these specimen types are more widely used in older populations at low risk for infection. (cdc.gov)
Why would I need a test for Chlamydia or Gonorrhea? (labdoctor.org)
No, an examination is not needed to screen yourself for Chlamydia or Gonorrhea. (labdoctor.org)
Ceftriaxone with doxycycline or azithromycin for Gonorrhea and chlamydia. (calendar-canada.ca)
What antibiotic kills chlamydia and gonorrhea? (calendar-canada.ca)
STD trends in the United States: 2010 national data for gonorrhea, chlamydia, and syphilis. (medscape.com)

P2.132 Pharyngeal and Conjunctival Chlamydia Trachomatis Infections: Chicken or Egg? (bmj.com)
All patients with neisserial conjunctivitis , inclusion conjunctivitis , and acute bacterial conjunctivitis with severe symptoms or risk factors for severe infection (e.g., contact lens use, immunodeficiency ) should undergo diagnostic studies, including a conjunctival culture. (amboss.com)

C. trachomatis infection of neonates results from perinatal exposure to the mother's infected cervix. (cdc.gov)
Neonatal ocular prophylaxis with silver nitrate solution or antibiotic ointments is ineffective in preventing perinatal transmission of chlamydial infection from mother to infant. (cdc.gov)
Initial C. trachomatis perinatal infection involves mucous membranes of the eye, oropharynx, urogenital tract, and rectum. (cdc.gov)
Perinatal infections may result in inclusion conjunctivitis and pneumonia in newborns. (cdc.gov)
Massive perinatal infection of the newborn can lead to interstitial chlamydial pneumonia. (athenslab.gr)

Table 1 of the article shows that there is no corneal involvement with chlamydial inclusion conjuntivitis, and that Chlamydia trachomatis (serotypes D and K) is the causative organism. (aafp.org)

It is estimated that 1 in 300 patients who have genital chlamydial disease develop adult inclusion conjunctivitis. (medscape.com)
Inclusion conjunctivitis usually spreads by contact with genital secretions from a person who has a genital chlamydial infection. (merckmanuals.com)
another type of conjunctivitis caused by Chlamydia trachomatis , is not due to a genital chlamydial infection. (merckmanuals.com)

Molecular testing for Chlamydia is used for the rapid and highly accurate laboratory diagnosis of all infections caused by these microorganisms. (athenslab.gr)
Tetracyclines are used principally in the treatment of infections caused by susceptible Rickettsia, Chlamydia, Mycoplasma, and a variety of uncommon gram-negative and gram-positive bacteria. (antiinfectivemeds.com)

Chlamydia represents a risk for serious, long-term complications, disproportionately affecting women (e.g. (nccid.ca)

He has served as Secretary-Treasurer of the Chlamydia Basic Research Society and Mini-reviews Editor for Infection and Immunity. (ufl.edu)

Chlamydial infection- Conjunctivitis caused by C. trachomatis is one of the leading causes of blindness worldwide. (infectiousdiseaseadvisor.com)

LGV became nationally notifiable in 1941 but was removed from the Nationally Notifiable Conditions list as a separate notifiable condition in 1995 when chlamydia was added. (cdc.gov)
However, with chlamydia being nationally notifiable and LGV being a specific type of chlamydia, as the case definition is currently written, LGV is nationally notifiable as chlamydia, but is not notifiable as a separate condition from chlamydia. (cdc.gov)

Diagnostic Considerations - Sensitive and specific methods to diagnose chlamydial ophthalmia for the neonate include isolation by tissue culture and nonculture tests, direct fluorescent antibody tests, and immunoassays. (cdc.gov)
The Chlamydia One-Step Test is designed for in vitro diagnostic use in the rapid and qualitative detection of Chlamydia trachomatis IgM antibody directly from human serum. (prsbio.com)
Participants study, participants were selected from negative for anti- Chlamydia antibody thetotalof609womenvisitingthegy- Statistical methods also had a negative evaluation for C. tra- naecology clinic in our hospital between Categorical variables were summarized chomatis inclusion bodies. (who.int)
Cell surface display of the chlamydial glycolipid exoantigen (GLXA) demonstrated by antibody-dependent complement-mediated cytotoxicity. (umass.edu)

Pathogenic Chlamydia, Borrelia, and Helicobacter species are currently under investigation, specifically the physiological mechanisms that confer persistence to these microbes, allowing them to evade clearance by the host and as well as killing by antibiotic treatment. (usuhs.edu)
2019. Fosmidomycin induces persistence in Chlamydia by inhibiting the synthesis of isoprenoid precursors necessary for peptidoglycan assembly. (usuhs.edu)
This mode of growth is known as persistence and how C . trachomatis senses stress and responds in this manner is an important area of research. (plos.org)

High rates of confirmation can be achieved using an independent real time PCR assay to examine rectal specimens which had initially tested C trachomatis positive using nucleic acid amplification tests and chlamydia tissue culture. (bmj.com)
Traditionally, chlamydial infection is diagnosed by detecting chlamydial inclusions in tissue culture cells. (prsbio.com)
Intracellular Chlamydia lacking both TmeA and TmeB, type III secreted anti-host proteins, generate fewer chlamydial progeny in tissue culture and have significantly decreased infectivity in mice. (uky.edu)

Chlamydiae are bacterial pathogens of very significant public health concern due to extensive morbidity, especially associated with female reproductive health. (biomedcentral.com)
The chlamydial species are Gram-negative bacterial pathogens critical to human health. (umass.edu)

Inclusion conjunctivitis, also known as chlamydial conjunctivitis, is more common in newborns. (medscape.com)
Chlamydial infections of the upper respiratory tract occur primarily in newborns exposed at parturition through an infected birth canal. (labdoctor.org)

Bersudsky V, Rehany U, Tendler Y, Leffler E, Selah S, Rumelt S. Diagnosis of chlamydial infection by direct enzyme-linked immunoassay and polymerase chain reaction in patients with acute follicular conjunctivitis. (medscape.com)
A specific diagnosis of C. trachomatis infection confirms the need for chlamydial treatment not only for the neonate, but also for the mother and her sex partner(s). (cdc.gov)
Successful management of Chlamydia relies on timely identification, diagnosis and treatment of infections (5). (nccid.ca)
2) Which of the following is a common specimen used for the diagnosis of sexually transmitted chlamydial infections that occur in both men and women? (medicalbiochemist.com)
3) What type of methods are important laboratory approaches for the diagnosis of genital Chlamydia spp infections? (medicalbiochemist.com)

1 However, in the United Kingdom the testing of rectal specimens for Chlamydia trachomatis has been problematic for diagnostic laboratories because of the lack of a licensed nucleic acid amplification test (NAAT) platform for extragenital sites, a lack of culture facilities, and the continued and extensive use of enzyme immunoassay (EIA) methods. (bmj.com)
A participant with microbiologic cure is defined as having a negative Chlamydia trachomatis (CT) Nucleic Acid Amplification Test (NAAT) at Day 29 and no positive CT NAATs between study treatment and Day 29. (who.int)

Also see the Medscape Reference article Chlamydial Genitourinary Infections . (medscape.com)
3 are associated with Lymphogranuloma Venereum and the remaining 12 with trachomatis and genitourinary infection. (prsbio.com)

Inclusion blennorrhoea aka chlamydial conjunctivitis or swimming pool conjunctivitis, is a condition affecting infants born to women infected with inclusion conjunctivitis of the urogenital tract, frequently caused by Chlamydia trachomatis, a sexually transmitted organism and often going unnoticed as a mild infection. (wikipedia.org)

These include global regulation of chlamydial gene expression via histone-like proteins, vesicular trafficking, cytoskeletal interactions, cell signaling, chlamydial modification of the inclusion membrane, and interactions mediated by Type III secreted protein effectors, which control entry and subsequent events. (nih.gov)

Chlamydiae undergo their developmental cycle entirely within a parasitophorous vacuole, termed an inclusion, that is isolated from established routes of endocytic vesicle trafficking. (nih.gov)
The chlamydial developmental cycle involves the alternation between the metabolically inert elementary body (EB) and the replicating reticulate body (RB). (biomedcentral.com)
The model uses knowledge and data of the biological system wherever available and simulates the chlamydial developmental cycle under the assumptions of the hypothesis in order to predict various outcomes and implications under a number of scenarios. (biomedcentral.com)
Their developmental cycle is associated with the formation and release of the broadly conserved glycolipid exoantigen (GLXA), which has been implicated in the chlamydial elementary body-host cell interaction. (umass.edu)

Dr. Liechti is a contributing member of both the American Society for Microbiology and the Chlamydial Basic Research Society, and is the current faculty advisor to the USUHS Postdoctoral Association. (usuhs.edu)

Infection with genital Chlamydia trachomatis (Ct) is the most common notifiable sexually transmitted infection (STI) in Sweden. (biomedcentral.com)
Genital infection with Chlamydia trachomatis is the most common notifiable sexually transmissible infection in Sweden, and included in the Act of Communicable Diseases. (biomedcentral.com)

Coppens I, Abu el-Asrar AM, Maudgal PC, Missotten L. Incidence and clinical presentation of chlamydial keratoconjunctivitis: a preliminary study. (medscape.com)
The current paper presents the study protocol for the first Swedish clinical investigation of repeat Chlamydial infection. (biomedcentral.com)
The concern of the study is whether a Chlamydia infection at inclusion indicates an increased risk for Chlamydia at follow-up after 6-8 months, gender-specific risk factors for and clinical presentation of repeat infections. (biomedcentral.com)
The collected data will provide gender-specific information on the occurrence of and risk for repeat Chlamydia infection, the occurrence of nvCT, and clinical data and information on sexual behaviour and reproductive health, risk-taking and condom use. (biomedcentral.com)
Because variation from this clinical presentation is common, initial treatment and diagnostic tests should encompass C. trachomatis for all infants 1-3 months of age who have possible pneumonia. (cdc.gov)
Chlamydia is a sexually transmitted infection that has a variable clinical course based on the serotype causing infection. (cdc.gov)

Ocular exudate from infants being evaluated for chlamydial conjunctivitis should also be tested for N. gonorrhoeae. (cdc.gov)

Chlamydia includes three species: Chlamydia trachomatis, Chlamydia pneumonia, and Chlamydia psittasi. (prsbio.com)

Chlamydia tests were performed by self-sampled specimens, analyzed by the ProbeTec (Becton Dickinson) method, Ct-positive specimens also analyzed with a nvCT-specific method. (biomedcentral.com)
Diagnostic Considerations - Specimens should be collected from the nasopharynx for chlamydial testing. (cdc.gov)
1782 rectal specimens confirmed as C trachomatis positive using a standard laboratory method, were forwarded to the Sexually Transmitted Bacteria Reference Laboratory (STBRL). (bmj.com)
All specimens were retested using a C trachomatis specific independent in-house real time polymerase chain reaction (PCR). (bmj.com)
The advantage of molecular Chlamydia tests is that they are generally more sensitive and specific than conventional culture (swabbing) and can identify more positive specimens. (labdoctor.org)

Adult inclusion conjunctivitis results from C trachomatis serotypes D-K, causing chronic follicular conjunctivitis that can occur in adults or in the neonate. (medscape.com)

Each participant completed a de- womenwithCINand12.9%among vaginal chlamydial infection and cervi- tailed questionnaire administered by controls,whichwasahighlysignificant cal intraepithelial neoplasia (CIN). (who.int)
Infants born to women with chlamydial infection of the cervix are at risk acquiring an infection during vaginal birth. (labdoctor.org)

For patient education resources, see the Sexually Transmitted Diseases Center , as well as Sexually Transmitted Diseases and Chlamydia . (medscape.com)
CIO Responsible for this publication: National Center for Prevention Services, Division of Sexually Transmitted Diseases and HIV Prevention Chlamydial Infections Among Infants Prenatal screening of pregnant women can prevent chlamydial infection among neonates. (cdc.gov)
Chlamydia (C. Trachomatis) infections are the leading cause of sexually transmitted diseases in the United States. (labdoctor.org)
Sexually transmitted diseases treatment guidelines, 2010: chlamydial infections. (medscape.com)
4) Chlamydia is one of the major pathogens that cause sexually transmitted diseases. (medicalbiochemist.com)

The recent resurgence of lymphogranuloma venereum (LGV) in Western Europe has highlighted the need to test high risk patients for rectal chlamydial infection. (bmj.com)

Chlamydia trachomatis are pathogenic microorganisms that affect exclusively humans. (athenslab.gr)
2016. Pathogenic Chlamydia use a narrow, midcell peptidoglycan ring regulated by MreB for replication. (usuhs.edu)
Interaction with this secretory pathway is thought to constitute a novel pathogenic mechanism whereby chlamydiae establish themselves in a site not destined to fuse with lysosomes. (nih.gov)
Understanding the initial events in chlamydial differentiation, including the transition in properties of the endocytic vesicle to one which intersects an exocytic pathway, remains a significant challenge in deciphering the pathogenic mechanisms of chlamydiae. (nih.gov)

Whereas the majority of intracellular parasites are thought to block maturation of the endocytic vesicle to a lysosome, chlamydiae rapidly dissociate themselves from this pathway and establish a functional interaction with an exocytic pathway that delivers sphingolipids and cholesterol from the Golgi apparatus to the plasma membrane. (nih.gov)
We have proposed a hypothesis to explain key chlamydial developmental events whereby RBs are replicating strictly whilst in contact with the host cell membrane-derived inclusion via type three secretion (T3S) injectisomes. (biomedcentral.com)
As the inclusion expands, the contact between each RB and the inclusion membrane decreases, eventually reaching a threshold, beyond which T3S is inactivated upon detachment and this is the signal for RB-to-EB differentiation. (biomedcentral.com)
We show that increasing the RB radius, and/or the maximum length of T3S needles mediating contact between RBs and the inclusion membrane, and/or the number of inclusions per infected cell, will contribute to the development of persistent infection. (biomedcentral.com)
An infecting EB will be internalized in a plasma membrane-derived vacuole of the host cell (known as an inclusion). (biomedcentral.com)

Chlamydial cell culture isolation rates from 51 unselected homosexual men were 9.3% from the urethra, 4.3% (pharynx), and 6.5% (rectum). (nih.gov)

Nucleotide sequence analysis revealed that the gene coding for the 28 kDa protein was similar to the mip (macrophage infectivity potentiator) genes from Legionella pneumophila and Chlamydia trachomatis. (oregonstate.edu)
Our report characterizes a complete signaling module, the Rsb network, that is capable of controlling the growth rate or infectivity of Chlamydia . (plos.org)

Chlamydia is the most frequent identifiable infectious cause of ophthalmia neonatorum. (cdc.gov)
Ophthalmia Neonatorum Caused by C. trachomatis A chlamydial etiology should be considered for all infants with conjunctivitis through 30 days of age. (cdc.gov)

Estimating Household and Community Transmission of Ocular Chlamydia trachomatis. (medscape.com)

A model is proposed where the relative levels of active antagonist (RsbV1) and switch-protein anti-sigma factor (RsbW) control the availability of σ 66 and subsequently act as a molecular 'throttle' for Chlamydia growth and development. (plos.org)
Dr. Maurelli has over 30 years of research experience in the field of molecular genetics of bacterial pathogenesis, specifically in the study of Shigella and Chlamydia. (ufl.edu)
Molecular testing for Chlamydia trachomatis is currently the standard and is widely used. (labdoctor.org)

Management of Mothers and Their Sex Partners - The mothers of infants who have chlamydial infection and the mother's sex partners should be evaluated and treated following the treatment recommendations for adults with chlamydial infections (see Chlamydial Infections Among Adolescents and Adults). (cdc.gov)
For the treatment of urogenital chlamydial infections in adults and adolescents, the CDC and some clinicians recommend a single dose of oral azithromycin or a 7-day regimen of oral doxycycline. (antiinfectivemeds.com)
Alternatively, adults and adolescents with urogenital chlamydial infections can receive a 7-day oral regimen of erythromycin base, erythromycin ethylsuccinate, ofloxacin, or levofloxacin. (antiinfectivemeds.com)

Respiratory infections are probably the most common of all chlamydial infections. (athenslab.gr)
Chlamydia trachomatis is associated with infections of the mucous membranes of the urogenital system, the upper respiratory tract, and the eye. (labdoctor.org)

C. trachomatis and N. gonorrhoeae control efforts in men differ substantially from those recommended for women. (cdc.gov)

Chlamydia is a major cause of sexually transmitted infections worldwide. (ufl.edu)
Trachomatis, the number one cause of sexually transmitted disease in the United States, is responsible for an estimated 3-4 million new cases annually. (labdoctor.org)

Anatomy14

Organisms14

Diseases47

Chemicals and Drugs20

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Psychiatry and Psychology2

Phenomena and Processes8

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Named Groups2

Health Care7

Geographicals1

Pneumoniae9

Psittaci10

Bacterium3

Cervicitis3

Obligate intracellular5

Neisseria1

Trachoma9

Urethritis5

Serovars5

Repeat infection with Chlamydia1

Abstract1

Gonococcal2

Prevalence7

Pelvic inflamm3

Pathogen5

Asymptomatic1

Gonorrhea7

Conjunctival2

Perinatal5

Causative1

Genital chlamydial3

Infections caused2

Complications1

Infection and Immu1

Conjunctivitis caused1

Nationally notifiable2

Antibody4

Persistence3

Tissue culture3

Bacterial pathogens2

Newborns2

Diagnosis5

Nucleic2

Genitourinary2

Urogenital tract1

Proteins1

Developmental cycle4

American Society for1

Notifiable2

Clinical6

Exudate1

Species1

Specimens5

Serotypes1

Vaginal2

Sexually Transmit5

Lymphogranuloma venereum1

Pathogenic4

Membrane5

Isolation1

Infectivity2

Ophthalmia neonatorum2

Ocular1

Molecular3

Adolescents3

Respiratory2

Gonorrhoeae1

Cause of sexually2